Reviewed, UniProtKB/Swiss-Prot Q6UBI3 (PERQ_SUASA)

Names and origin

Protein names

Recommended name:
    Peroxiredoxin Q, chloroplastic
    EC=1.11.1.15
Alternative name(s):
    Thioredoxin reductase

Gene names

Name:

PRXQ

Organism

Suaeda salsa (Seepweed) (Chenopodium salsum)

Taxonomic identifier

126914 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › Caryophyllales › Amaranthaceae › Suaeda

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Reduces hydrogen peroxide with reducing equivalents provided through the thioredoxin system By similarity.
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
Subunit structure	Monomer.
Subcellular location	Plastid › chloroplast thylakoid By similarity.
Induction	Up-regulated by NaCl, mannitol, low temperature, H2O2, methyl viologen, and abscisic acid (ABA). Ref.1
Post-translational modification	The Cys-109-SH group is the primary site of oxidation by H2O2, and the oxidized Cys-109 (probably Cys-SOH) rapidly reacts with Cys-114-SH to form an intramolecular disulfide. This disulfide is subsequently reduced by thioredoxin to restore the reduced active form of the enzyme.
Sequence similarities	Belongs to the ahpC/TSA family. PrxQ subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Chloroplast Plastid
Domain	Redox-active center Transit peptide
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloroplast thylakoid Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 64	64	Chloroplast Potential
	Chain	65 – 214	150	Peroxiredoxin Q, chloroplastic		PRO_0000285113
Regions
	Domain	67 – 214	148	Thioredoxin
Sites
	Active site	109	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	109 ↔ 114		Redox-active

Sequences

	Sequence		Length	Mass (Da)
	Q6UBI3-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 83D5F660082AC855	FASTA	214	23,589
	10 20 30 40 50 60 MATLSLPNHS PTFALPSQTP KPHSSQNLSI ISKSAHSQFC GIKLSHSSSL SPPLYPRSYK 70 80 90 100 110 120 ASIVAKVSEG SMPPAFTLKD QDGKNVSLSK FKGKPVVVYF YPADETPGCT KQACAFRDSY 130 140 150 160 170 180 EKFKKAGAEV IGISGDDSSS HKAFKQKYKL PYTLLSDEGN KVRKDWGVPS DLFGALPGRQ 190 200 210 TYVLDRNGVV RLVYNNQFQP EKHIDETLKF LQSL

References

[1]	"Molecular cloning and characterization of a stress-induced peroxiredoxin Q gene in halophyte Suaeda salsa." Guo X.-L., Cao Y.-R., Cao Z.-Y., Zhao Y.-X., Zhang H. Plant Sci. 167:969-975(2004) [Agricola: IND43645556] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY373447 mRNA. Translation: AAQ67661.1.
3D structure databases
ModBase	Search...
Protein family/group databases
PeroxiBase	4306. SsaPrxQ.
Enzyme and pathway databases
BRENDA	1.11.1.15. 291105.
Family and domain databases
InterPro	IPR000866. Alkyl_hydroperoxide_Rdtase. IPR017936. Thioredoxin-like. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00578. AhpC-TSA. 1 hit. [Graphical view]
PROSITE	PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PERQ_SUASA

Accession

Primary (citable) accession number: Q6UBI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)