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Protein

Ankyrin repeat domain-containing protein 12

Gene

ANKRD12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 12
Alternative name(s):
Ankyrin repeat-containing cofactor 2
GAC-1 protein
Gene namesi
Name:ANKRD12
Synonyms:ANCO2, KIAA0874
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:29135. ANKRD12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134899860.

Polymorphism and mutation databases

BioMutaiANKRD12.
DMDMi160358772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20622062Ankyrin repeat domain-containing protein 12PRO_0000066908Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491PhosphoserineCombined sources
Modified residuei543 – 5431PhosphoserineCombined sources
Modified residuei630 – 6301PhosphoserineCombined sources
Modified residuei861 – 8611PhosphoserineCombined sources
Modified residuei1401 – 14011PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6UB98.
MaxQBiQ6UB98.
PaxDbiQ6UB98.
PeptideAtlasiQ6UB98.
PRIDEiQ6UB98.

PTM databases

iPTMnetiQ6UB98.
PhosphoSiteiQ6UB98.

Expressioni

Gene expression databases

BgeeiENSG00000101745.
CleanExiHS_ANKRD12.
ExpressionAtlasiQ6UB98. baseline and differential.
GenevisibleiQ6UB98. HS.

Organism-specific databases

HPAiHPA040705.

Interactioni

Subunit structurei

Interacts with the PAS region of the p160 coactivators.1 Publication

Protein-protein interaction databases

BioGridi116857. 14 interactions.
IntActiQ6UB98. 12 interactions.
STRINGi9606.ENSP00000262126.

Structurei

3D structure databases

ProteinModelPortaliQ6UB98.
SMRiQ6UB98. Positions 140-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati184 – 21330ANK 1Add
BLAST
Repeati217 – 24630ANK 2Add
BLAST
Repeati250 – 28031ANK 3Add
BLAST

Sequence similaritiesi

Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IJ47. Eukaryota.
ENOG4110UQU. LUCA.
GeneTreeiENSGT00760000119090.
HOGENOMiHOG000033954.
HOVERGENiHBG106885.
InParanoidiQ6UB98.
OMAiIQPYSSE.
OrthoDBiEOG091G05O7.
PhylomeDBiQ6UB98.
TreeFamiTF326440.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UB98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKSGFTKPI QSENSDSDSN MVEKPYGRKS KDKIASYSKT PKIERSDVSK
60 70 80 90 100
EMKEKSSMKR KLPFTISPSR NEERDSDTDS DPGHTSENWG ERLISSYRTY
110 120 130 140 150
SEKEGPEKKK TKKEAGNKKS TPVSILFGYP LSERKQMALL MQMTARDNSP
160 170 180 190 200
DSTPNHPSQT TPAQKKTPSS SSRQKDKVNK RNERGETPLH MAAIRGDVKQ
210 220 230 240 250
VKELISLGAN VNVKDFAGWT PLHEACNVGY YDVAKILIAA GADVNTQGLD
260 270 280 290 300
DDTPLHDSAS SGHRDIVKLL LRHGGNPFQA NKHGERPVDV AETEELELLL
310 320 330 340 350
KREVPLSDDD ESYTDSEEAQ SVNPSSVDEN IDSETEKDSL ICESKQILPS
360 370 380 390 400
KTPLPSALDE YEFKDDDDEE INKMIDDRHI LRKEQRKENE PEAEKTHLFA
410 420 430 440 450
KQEKAFYPKS FKSKKQKPSR VLYSSTESSD EEALQNKKIS TSCSVIPETS
460 470 480 490 500
NSDMQTKKEY VVSGEHKQKG KVKRKLKNQN KNKENQELKQ EKEGKENTRI
510 520 530 540 550
TNLTVNTGLD CSEKTREEGN FRKSFSPKDD TSLHLFHIST GKSPKHSCGL
560 570 580 590 600
SEKQSTPLKQ EHTKTCLSPG SSEMSLQPDL VRYDNTESEF LPESSSVKSC
610 620 630 640 650
KHKEKSKHQK DFHLEFGEKS NAKIKDEDHS PTFENSDCTL KKMDKEGKTL
660 670 680 690 700
KKHKLKHKER EKEKHKKEIE GEKEKYKTKD SAKELQRSVE FDREFWKENF
710 720 730 740 750
FKSDETEDLF LNMEHESLTL EKKSKLEKNI KDDKSTKEKH VSKERNFKEE
760 770 780 790 800
RDKIKKESEK SFREEKIKDL KEERENIPTD KDSEFTSLGM SAIEESIGLH
810 820 830 840 850
LVEKEIDIEK QEKHIKESKE KPEKRSQIKE KDIEKMERKT FEKEKKIKHE
860 870 880 890 900
HKSEKDKLDL SECVDKIKEK DKLYSHHTEK CHKEGEKSKN TAAIKKTDDR
910 920 930 940 950
EKSREKMDRK HDKEKPEKER HLAESKEKHL MEKKNKQSDN SEYSKSEKGK
960 970 980 990 1000
NKEKDRELDK KEKSRDKESI NITNSKHIQE EKKSSIVDGN KAQHEKPLSL
1010 1020 1030 1040 1050
KEKTKDEPLK TPDGKEKDKK DKDIDRYKER DKHKDKIQIN SLLKLKSEAD
1060 1070 1080 1090 1100
KPKPKSSPAS KDTRPKEKRL VNDDLMQTSF ERMLSLKDLE IEQWHKKHKE
1110 1120 1130 1140 1150
KIKQKEKERL RNRNCLELKI KDKEKTKHTP TESKNKELTR SKSSEVTDAY
1160 1170 1180 1190 1200
TKEKQPKDAV SNRSQSVDTK NVMTLGKSSF VSDNSLNRSP RSENEKPGLS
1210 1220 1230 1240 1250
SRSVSMISVA SSEDSCHTTV TTPRPPVEYD SDFMLESSES QMSFSQSPFL
1260 1270 1280 1290 1300
SIAKSPALHE RELDSLADLP ERIKPPYANR LSTSHLRSSS VEDVKLIISE
1310 1320 1330 1340 1350
GRPTIEVRRC SMPSVICEHT KQFQTISEES NQGSLLTVPG DTSPSPKPEV
1360 1370 1380 1390 1400
FSNVPERDLS NVSNIHSSFA TSPTGASNSK YVSADRNLIK NTAPVNTVMD
1410 1420 1430 1440 1450
SPVHLEPSSQ VGVIQNKSWE MPVDRLETLS TRDFICPNSN IPDQESSLQS
1460 1470 1480 1490 1500
FCNSENKVLK ENADFLSLRQ TELPGNSCAQ DPASFMPPQQ PCSFPSQSLS
1510 1520 1530 1540 1550
DAESISKHMS LSYVANQEPG ILQQKNAVQI ISSALDTDNE STKDTENTFV
1560 1570 1580 1590 1600
LGDVQKTDAF VPVYSDSTIQ EASPNFEKAY TLPVLPSEKD FNGSDASTQL
1610 1620 1630 1640 1650
NTHYAFSKLT YKSSSGHEVE NSTTDTQVIS HEKENKLESL VLTHLSRCDS
1660 1670 1680 1690 1700
DLCEMNAGMP KGNLNEQDPK HCPESEKCLL SIEDEESQQS ILSSLENHSQ
1710 1720 1730 1740 1750
QSTQPEMHKY GQLVKVELEE NAEDDKTENQ IPQRMTRNKA NTMANQSKQI
1760 1770 1780 1790 1800
LASCTLLSEK DSESSSPRGR IRLTEDDDPQ IHHPRKRKVS RVPQPVQVSP
1810 1820 1830 1840 1850
SLLQAKEKTQ QSLAAIVDSL KLDEIQPYSS ERANPYFEYL HIRKKIEEKR
1860 1870 1880 1890 1900
KLLCSVIPQA PQYYDEYVTF NGSYLLDGNP LSKICIPTIT PPPSLSDPLK
1910 1920 1930 1940 1950
ELFRQQEVVR MKLRLQHSIE REKLIVSNEQ EVLRVHYRAA RTLANQTLPF
1960 1970 1980 1990 2000
SACTVLLDAE VYNVPLDSQS DDSKTSVRDR FNARQFMSWL QDVDDKFDKL
2010 2020 2030 2040 2050
KTCLLMRQQH EAAALNAVQR LEWQLKLQEL DPATYKSISI YEIQEFYVPL
2060
VDVNDDFELT PI
Length:2,062
Mass (Da):235,652
Last modified:October 23, 2007 - v3
Checksum:i3CAFAA05E4AA1753
GO
Isoform 2 (identifier: Q6UB98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-101: Missing.

Show »
Length:2,039
Mass (Da):233,012
Checksum:i70841CCC1DA4CECA
GO

Sequence cautioni

The sequence BAB15014 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti604 – 6041E → K in CAH56382 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti171 – 1711S → T.2 Publications
VAR_019425
Natural varianti277 – 2771P → A.
Corresponds to variant rs2298548 [ dbSNP | Ensembl ].
VAR_026042
Natural varianti390 – 3901E → D.
Corresponds to variant rs35101529 [ dbSNP | Ensembl ].
VAR_048271
Natural varianti507 – 5071T → I.
Corresponds to variant rs17498752 [ dbSNP | Ensembl ].
VAR_048272
Natural varianti531 – 5311T → S.
Corresponds to variant rs7243088 [ dbSNP | Ensembl ].
VAR_048273
Natural varianti818 – 8181S → N.
Corresponds to variant rs2298546 [ dbSNP | Ensembl ].
VAR_022088
Natural varianti906 – 9061K → R.1 Publication
Corresponds to variant rs4798791 [ dbSNP | Ensembl ].
VAR_024173
Natural varianti998 – 9981L → S.
Corresponds to variant rs34996750 [ dbSNP | Ensembl ].
VAR_048274
Natural varianti1758 – 17581S → P.
Corresponds to variant rs3744822 [ dbSNP | Ensembl ].
VAR_048275

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei79 – 10123Missing in isoform 2. 2 PublicationsVSP_010901Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317425 mRNA. Translation: AAG38609.1.
AY373757 mRNA. Translation: AAR25662.1.
AY533564 mRNA. Translation: AAS45545.2.
AL834204 mRNA. Translation: CAH56382.1.
AK024808 mRNA. Translation: BAB15014.1. Sequence problems.
AB020681 mRNA. Translation: BAA74897.1.
CCDSiCCDS11843.1. [Q6UB98-1]
CCDS42411.1. [Q6UB98-2]
RefSeqiNP_001077094.1. NM_001083625.2. [Q6UB98-2]
NP_001190985.1. NM_001204056.1. [Q6UB98-2]
NP_056023.3. NM_015208.4. [Q6UB98-1]
XP_005258149.1. XM_005258092.3. [Q6UB98-1]
XP_005258150.1. XM_005258093.3. [Q6UB98-1]
UniGeneiHs.464585.

Genome annotation databases

EnsembliENST00000262126; ENSP00000262126; ENSG00000101745. [Q6UB98-1]
ENST00000400020; ENSP00000382897; ENSG00000101745. [Q6UB98-2]
GeneIDi23253.
KEGGihsa:23253.
UCSCiuc002knv.4. human. [Q6UB98-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317425 mRNA. Translation: AAG38609.1.
AY373757 mRNA. Translation: AAR25662.1.
AY533564 mRNA. Translation: AAS45545.2.
AL834204 mRNA. Translation: CAH56382.1.
AK024808 mRNA. Translation: BAB15014.1. Sequence problems.
AB020681 mRNA. Translation: BAA74897.1.
CCDSiCCDS11843.1. [Q6UB98-1]
CCDS42411.1. [Q6UB98-2]
RefSeqiNP_001077094.1. NM_001083625.2. [Q6UB98-2]
NP_001190985.1. NM_001204056.1. [Q6UB98-2]
NP_056023.3. NM_015208.4. [Q6UB98-1]
XP_005258149.1. XM_005258092.3. [Q6UB98-1]
XP_005258150.1. XM_005258093.3. [Q6UB98-1]
UniGeneiHs.464585.

3D structure databases

ProteinModelPortaliQ6UB98.
SMRiQ6UB98. Positions 140-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116857. 14 interactions.
IntActiQ6UB98. 12 interactions.
STRINGi9606.ENSP00000262126.

PTM databases

iPTMnetiQ6UB98.
PhosphoSiteiQ6UB98.

Polymorphism and mutation databases

BioMutaiANKRD12.
DMDMi160358772.

Proteomic databases

EPDiQ6UB98.
MaxQBiQ6UB98.
PaxDbiQ6UB98.
PeptideAtlasiQ6UB98.
PRIDEiQ6UB98.

Protocols and materials databases

DNASUi23253.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262126; ENSP00000262126; ENSG00000101745. [Q6UB98-1]
ENST00000400020; ENSP00000382897; ENSG00000101745. [Q6UB98-2]
GeneIDi23253.
KEGGihsa:23253.
UCSCiuc002knv.4. human. [Q6UB98-1]

Organism-specific databases

CTDi23253.
GeneCardsiANKRD12.
H-InvDBHIX0014323.
HGNCiHGNC:29135. ANKRD12.
HPAiHPA040705.
MIMi610616. gene.
neXtProtiNX_Q6UB98.
PharmGKBiPA134899860.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ47. Eukaryota.
ENOG4110UQU. LUCA.
GeneTreeiENSGT00760000119090.
HOGENOMiHOG000033954.
HOVERGENiHBG106885.
InParanoidiQ6UB98.
OMAiIQPYSSE.
OrthoDBiEOG091G05O7.
PhylomeDBiQ6UB98.
TreeFamiTF326440.

Miscellaneous databases

ChiTaRSiANKRD12. human.
GenomeRNAii23253.
PROiQ6UB98.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101745.
CleanExiHS_ANKRD12.
ExpressionAtlasiQ6UB98. baseline and differential.
GenevisibleiQ6UB98. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR12_HUMAN
AccessioniPrimary (citable) accession number: Q6UB98
Secondary accession number(s): O94951
, Q658K1, Q6QMF7, Q9H231, Q9H784
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 23, 2007
Last modified: September 7, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.