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Protein

Electron transfer flavoprotein subunit beta

Gene

ETFB

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9AMP; via carbonyl oxygenBy similarity1
Binding sitei66AMP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 42AMPBy similarity4
Nucleotide bindingi123 – 134AMPBy similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport
LigandNucleotide-binding

Enzyme and pathway databases

ReactomeiR-SSC-611105. Respiratory electron transport.
R-SSC-8876725. Protein methylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Electron transfer flavoprotein subunit betaCurated
Short name:
Beta-ETFBy similarity
Gene namesi
Name:ETFBBy similarity
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002315252 – 255Electron transfer flavoprotein subunit betaAdd BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei200N6,N6,N6-trimethyllysine; by ETFBKMT; alternateBy similarity1
Modified residuei200N6-acetyllysine; alternateBy similarity1
Modified residuei200N6-methyllysine; alternateBy similarity1
Modified residuei203N6,N6,N6-trimethyllysine; by ETFBKMTBy similarity1
Modified residuei210N6-acetyllysine; alternateBy similarity1
Modified residuei210N6-succinyllysine; alternateBy similarity1
Modified residuei223PhosphoserineBy similarity1
Modified residuei226PhosphoserineBy similarity1
Modified residuei238N6-acetyllysineBy similarity1
Modified residuei248N6-acetyllysine; alternateBy similarity1
Modified residuei248N6-succinyllysine; alternateBy similarity1

Post-translational modificationi

Methylated. Trimethylation at Lys-200 and Lys-203 may negatively regulate the activity in electron transfer from acyl-CoA dehydrogenases.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PeptideAtlasiQ6UAQ8.
PRIDEiQ6UAQ8.

Expressioni

Gene expression databases

BgeeiENSSSCG00000003229.
GenevisibleiQ6UAQ8. SS.

Interactioni

Subunit structurei

Heterodimer composed of ETFA and ETFB (PubMed:6847633). Identified in a complex that contains ETFA, ETFB and ETFRF1. Interacts with ACADM (By similarity).By similarity1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6UAQ8.
SMRiQ6UAQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni183 – 205Recognition loopBy similarityAdd BLAST23

Domaini

The recognition loop recognizes a hydrophobic patch at the surface of interacting dehydrogenases and acts as a static anchor at the interface.By similarity

Sequence similaritiesi

Belongs to the ETF beta-subunit/FixA family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000009936.
HOVERGENiHBG005614.
InParanoidiQ6UAQ8.
KOiK03521.
OMAiRIPNMRG.
OrthoDBiEOG091G0KHH.
TreeFamiTF314039.

Family and domain databases

CDDicd01714. ETF_beta. 1 hit.
Gene3Di3.40.50.620. 1 hit.
InterProiView protein in InterPro
IPR000049. ET-Flavoprotein_bsu_CS.
IPR014730. ETF_a/b_N.
IPR012255. ETF_b.
IPR033948. ETF_beta_N.
IPR014729. Rossmann-like_a/b/a_fold.
PANTHERiPTHR21294. PTHR21294. 1 hit.
PfamiView protein in Pfam
PF01012. ETF. 1 hit.
PIRSFiPIRSF000090. Beta-ETF. 1 hit.
SMARTiView protein in SMART
SM00893. ETF. 1 hit.
PROSITEiView protein in PROSITE
PS01065. ETF_BETA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UAQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELRALVAV KRVIDFAVKI RVKPDRTGVV MDGVKHSMNP FCEIAVEEAV
60 70 80 90 100
RLKEKKLVKE VIAVSCGPAQ CQETIRTALA MGADRGIHVE VPAAEAHHLG
110 120 130 140 150
PLQVARVLAK LAQKEKVDLV LLGKQAIDDD CNQTGQMTAG FLDWPQGTFA
160 170 180 190 200
SQVTLEGDKV KVEREIDGGL ETLRLKLPAV VTADLRLNEP RYATLPNIMK
210 220 230 240 250
AKKKKIEVIK AGDLGVDLTS KLSVVSVEDP PQRVAGVKVE TTEDLVAKLR

EIGRI
Length:255
Mass (Da):27,764
Last modified:January 23, 2007 - v3
Checksum:i30C3786463FB5AB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY374470 mRNA. Translation: AAQ84565.1.
RefSeqiNP_001192208.1. NM_001205279.1.
UniGeneiSsc.1459.

Genome annotation databases

EnsembliENSSSCT00000003588; ENSSSCP00000003505; ENSSSCG00000003229.
GeneIDi396614.
KEGGissc:396614.

Similar proteinsi

Entry informationi

Entry nameiETFB_PIG
AccessioniPrimary (citable) accession number: Q6UAQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 82 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome