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Protein

Putative insulin-like growth factor 2 antisense gene protein

Gene

IGF2-AS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Putative insulin-like growth factor 2 antisense gene protein
Alternative name(s):
IGF2 antisense RNA 1
IGF2 antisense gene protein 1
PEG8/IGF2AS protein
Putative insulin-like growth factor 2 antisense gene protein 1
Short name:
IGF2-AS1
Gene namesi
Name:IGF2-AS
Synonyms:IGF2-AS1, IGF2AS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14062. IGF2-AS.

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi126302557.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168Putative insulin-like growth factor 2 antisense gene proteinPRO_0000076224Add
BLAST

Proteomic databases

PRIDEiQ6U949.

Expressioni

Developmental stagei

Overexpressed in Wilms' tumor samples.

Gene expression databases

BgeeiQ6U949.
CleanExiHS_IGF2AS.

Structurei

3D structure databases

ProteinModelPortaliQ6U949.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000113007.
InParanoidiQ6U949.
PhylomeDBiQ6U949.
TreeFamiTF341861.

Sequencei

Sequence statusi: Complete.

Q6U949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRKWRGFR GAQQERAQPP AASPQPCPAP HAGLPGGSRR RAPAPAGQQQ
60 70 80 90 100
MRAESRSGAQ RRRGSARRGA HREAGGCVRG RTRSSGSERS NALWQAVDAA
110 120 130 140 150
EALALSSPLR RPWDQAQHFT NPAPFSKGPQ SAPPSPPAGR RRRGADLALT
160
PLAGEGHTRW RQPGRPGK
Length:168
Mass (Da):18,035
Last modified:February 20, 2007 - v2
Checksum:i4641D52BCBFE64D2
GO

Sequence cautioni

The sequence BAA90470.1 differs from that shown. Reason: Frameshift at position 162. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti163 – 1631P → T in BAA90470 (PubMed:10731720).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061S → I.1 Publication
Corresponds to variant rs17883406 [ dbSNP | Ensembl ].
VAR_024844
Natural varianti112 – 1121P → T.1 Publication
Corresponds to variant rs17883142 [ dbSNP | Ensembl ].
VAR_024845
Natural varianti125 – 1251F → V.3 Publications
Corresponds to variant rs1003483 [ dbSNP | Ensembl ].
VAR_024846
Natural varianti150 – 1501T → A.3 Publications
Corresponds to variant rs1003484 [ dbSNP | Ensembl ].
VAR_024847

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030733 mRNA. Translation: BAA90470.1. Frameshift.
AY149295 mRNA. Translation: AAP50262.1.
AY375532 Genomic DNA. Translation: AAQ86595.1.
AC132217 Genomic DNA. No translation available.
BC142634 mRNA. Translation: AAI42635.1.
BC142691 mRNA. Translation: AAI42692.1.
PIRiJC7217.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030733 mRNA. Translation: BAA90470.1. Frameshift.
AY149295 mRNA. Translation: AAP50262.1.
AY375532 Genomic DNA. Translation: AAQ86595.1.
AC132217 Genomic DNA. No translation available.
BC142634 mRNA. Translation: AAI42635.1.
BC142691 mRNA. Translation: AAI42692.1.
PIRiJC7217.

3D structure databases

ProteinModelPortaliQ6U949.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

DMDMi126302557.

Proteomic databases

PRIDEiQ6U949.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiIGF2-AS.
HGNCiHGNC:14062. IGF2-AS.
MIMi610146. gene.
neXtProtiNX_Q6U949.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000113007.
InParanoidiQ6U949.
PhylomeDBiQ6U949.
TreeFamiTF341861.

Miscellaneous databases

PROiQ6U949.
SOURCEiSearch...

Gene expression databases

BgeeiQ6U949.
CleanExiHS_IGF2AS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression and imprinting status of human PEG8/IGF2AS, a paternally expressed antisense transcript from the IGF2 locus, in Wilms' tumors."
    Okutsu T., Kuroiwa Y., Kagitani F., Kai M., Aisaka K., Tsutsumi O., Kaneko Y., Yokomori K., Surani M.A., Kohda T., Kaneko-Ishino T., Ishino F.
    J. Biochem. 127:475-483(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-125 AND ALA-150.
    Tissue: Kidney.
  2. "Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor."
    Vu T.H., Chuyen N.V., Li T., Hoffman A.R.
    Cancer Res. 63:1900-1905(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-125 AND ALA-150.
  3. SeattleSNPs variation discovery resource
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-106; THR-112; VAL-125 AND ALA-150.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiIG2AS_HUMAN
AccessioniPrimary (citable) accession number: Q6U949
Secondary accession number(s): A5PKV8
, A6NNQ2, Q7Z712, Q9P2W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: February 20, 2007
Last modified: March 16, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.