Unreviewed, UniProtKB/TrEMBL Q6U8A4 (Q6U8A4_HUMAN)

Names and origin

Protein names	Recommended name:     Ubiquitin carboxyl-terminal hydrolase RuleBase RU004435V0     EC=3.1.2.15
Organism	Homo sapiens (Human) EMBL AAQ82908.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1112 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol. RuleBase RU004435V0
Sequence similarities	Belongs to the peptidase C19 family. RuleBase RU004434V0 Contains 1 MATH domain. RuleBase RU004402V0

Ontologies

Keywords
Biological process	Ubl conjugation pathway RuleBase RU004434V0
Molecular function	Hydrolase Protease Thiol protease RuleBase RU004434V0
Gene Ontology (GO)
Uncategorized	ubiquitin cycle Inferred from electronic annotation. Source: UniProtKB-KW
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAQ82908.1

Sequences

	Sequence		Length	Mass (Da)
	Q6U8A4-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: D7D7A56AD369EB39	FASTA	1,112	129,004
	10 20 30 40 50 60 SGCSHSDVGE RTSPIPQQRP LQSHAEMAGN HRLGLEAGDT DDPPRITQNP VINGNVALSD 70 80 90 100 110 120 GHNTAEEDME DDTSWRSEAT FQFTVERFSR LSESVLSPPC FVRNLPWKIM VMPRFYPDRP 130 140 150 160 170 180 HQKSVGFFLQ CNAESDSTSW SCHAQAVLKI INYRDDEKSF SRRISHLFFH KENDWGFSNF 190 200 210 220 230 240 MAWSEVTDPE KGFIDDDKVT FEVFVQADAP HGVAWDSKKH TGYVGLKNQG ATCYMNSLLQ 250 260 270 280 290 300 TLFFTNQLRK AVYMMPTEGD DSSKSVPLAL QRVFYELQHS DKPVGTKKLT KSFGWETLDS 310 320 330 340 350 360 FMQHDVQELC RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKEVDYR SDRREDYYDI 370 380 390 400 410 420 QLSVKGKKNI FESFVDYVAV EQLDGDNKYD AGEHGLQEAE KGVKFLTLPP VLHLQLKRFM 430 440 450 460 470 480 YDPQTDQNIK INDRFEFPEQ LPLDEFLQKT DPKDPANYIL HAVLVHSGDN HGGHYVVYLN 490 500 510 520 530 540 PKGDGKWCKF DDDVVSRCTK EEAIEHNYGG HDDDLSVRHC TNAYMLVYIR ESKLSEVLQA 550 560 570 580 590 600 VTDHDIPQQL VERLQEEKRI EAQKRKERQE AHLYMQVQIV AEDQFCGHQG NDMYDEEKVK 610 620 630 640 650 660 YTVFKVLKNS SLAELVQSLS QTMGFPQDQI RLWPMQARSN GTKRPAMLDN EADGNKTMIE 670 680 690 700 710 720 LSDNENPWTI FLETVDPELA ASGATLPKFD KDHDVMLFLK MYDPKTRSLN YCGHIYTPIS 730 740 750 760 770 780 CKIRDLLPVM CDRAGFIQDT SLILYEEVKP NLTERIQDYD VSLDKALDEL MDGDIIVFQK 790 800 810 820 830 840 DDPENDNSEL PTAKEYFRDL YHRVDVIFCD KTIPNDPGFV VTLSNRMNYF QVAKTVAQRL 850 860 870 880 890 900 NTDPMLLQFF KSQGYRDGPG NPLRHNYEGT LRDLLQFFKP RQPKKLYYQQ LKMKITDFEN 910 920 930 940 950 960 RRSFKCIWLN SQFREEEITL YPDKHGCVRD LLEECKKAVE LGEKASGKLR LLEIVSYKII 970 980 990 1000 1010 1020 GVHQEDELLE CLSPATSRTF RIEEIPLDQV DIDKENEMLV TVAHFHKEVF GTFGIPFLLR 1030 1040 1050 1060 1070 1080 IHQGEHFREV MKRIQSLLDI QEKEFEKFKF AIVMMGRHQY INEDEYEVNL KDFEPQPGNM 1090 1100 1110 SHPRPWLGLD HFNKAPKRSR YTYLEKAIKI HN

References

[1]	"Cloning of a new isoform of ubiquitin specific protease 7 in testis." Lu L., Huang X.Y., Yin L.L., Xu M., Li J.M., Zhou Z.M., Sha J.H. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Testis EMBL AAQ82908.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY376241 mRNA. Translation: AAQ82908.1.
UniGene	Hs.386939
3D structure databases
SMR	Q6U8A4. Positions 73-563, 218-564.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000187555. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:12630. USP7.
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q6U8A4.
HOVERGEN	Q6U8A4.
Gene expression databases
ArrayExpress	Q6U8A4.
Family and domain databases
InterPro	IPR002083. MATH. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00917. MATH. 1 hit. PF00443. UCH. 1 hit. [Graphical view]
SMART	SM00061. MATH. 1 hit. [Graphical view]
PROSITE	PS50144. MATH. 1 hit. PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
Other Resources
LinkHub	Q6U8A4.

Entry information

Entry name

Q6U8A4_HUMAN

Accession

Primary (citable) accession number: Q6U8A4

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	July 22, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)