Q6U8A4 (Q6U8A4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Recommended name: Ubiquitin carboxyl-terminal hydrolase RuleBase RU004435 EC=3.4.19.12 RuleBase RU004435
Organism	Homo sapiens (Human) EMBL AAQ82908.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1112 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). RuleBase RU004435
Sequence similarities	Belongs to the peptidase C19 family. RuleBase RU004434 Contains 1 MATH domain. RuleBase RU004402

Ontologies

Keywords
Biological process	Ubl conjugation pathway RuleBase RU004434
Molecular function	Hydrolase Protease Thiol protease RuleBase RU004434
Gene Ontology (GO)
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAQ82908.1

Sequences

	Sequence		Length	Mass (Da)
	Q6U8A4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: D7D7A56AD369EB39	FASTA	1,112	129,004
	10 20 30 40 50 60 SGCSHSDVGE RTSPIPQQRP LQSHAEMAGN HRLGLEAGDT DDPPRITQNP VINGNVALSD 70 80 90 100 110 120 GHNTAEEDME DDTSWRSEAT FQFTVERFSR LSESVLSPPC FVRNLPWKIM VMPRFYPDRP 130 140 150 160 170 180 HQKSVGFFLQ CNAESDSTSW SCHAQAVLKI INYRDDEKSF SRRISHLFFH KENDWGFSNF 190 200 210 220 230 240 MAWSEVTDPE KGFIDDDKVT FEVFVQADAP HGVAWDSKKH TGYVGLKNQG ATCYMNSLLQ 250 260 270 280 290 300 TLFFTNQLRK AVYMMPTEGD DSSKSVPLAL QRVFYELQHS DKPVGTKKLT KSFGWETLDS 310 320 330 340 350 360 FMQHDVQELC RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKEVDYR SDRREDYYDI 370 380 390 400 410 420 QLSVKGKKNI FESFVDYVAV EQLDGDNKYD AGEHGLQEAE KGVKFLTLPP VLHLQLKRFM 430 440 450 460 470 480 YDPQTDQNIK INDRFEFPEQ LPLDEFLQKT DPKDPANYIL HAVLVHSGDN HGGHYVVYLN 490 500 510 520 530 540 PKGDGKWCKF DDDVVSRCTK EEAIEHNYGG HDDDLSVRHC TNAYMLVYIR ESKLSEVLQA 550 560 570 580 590 600 VTDHDIPQQL VERLQEEKRI EAQKRKERQE AHLYMQVQIV AEDQFCGHQG NDMYDEEKVK 610 620 630 640 650 660 YTVFKVLKNS SLAELVQSLS QTMGFPQDQI RLWPMQARSN GTKRPAMLDN EADGNKTMIE 670 680 690 700 710 720 LSDNENPWTI FLETVDPELA ASGATLPKFD KDHDVMLFLK MYDPKTRSLN YCGHIYTPIS 730 740 750 760 770 780 CKIRDLLPVM CDRAGFIQDT SLILYEEVKP NLTERIQDYD VSLDKALDEL MDGDIIVFQK 790 800 810 820 830 840 DDPENDNSEL PTAKEYFRDL YHRVDVIFCD KTIPNDPGFV VTLSNRMNYF QVAKTVAQRL 850 860 870 880 890 900 NTDPMLLQFF KSQGYRDGPG NPLRHNYEGT LRDLLQFFKP RQPKKLYYQQ LKMKITDFEN 910 920 930 940 950 960 RRSFKCIWLN SQFREEEITL YPDKHGCVRD LLEECKKAVE LGEKASGKLR LLEIVSYKII 970 980 990 1000 1010 1020 GVHQEDELLE CLSPATSRTF RIEEIPLDQV DIDKENEMLV TVAHFHKEVF GTFGIPFLLR 1030 1040 1050 1060 1070 1080 IHQGEHFREV MKRIQSLLDI QEKEFEKFKF AIVMMGRHQY INEDEYEVNL KDFEPQPGNM 1090 1100 1110 SHPRPWLGLD HFNKAPKRSR YTYLEKAIKI HN

References

[1]	"Cloning of a new isoform of ubiquitin specific protease 7 in testis." Lu L., Huang X.Y., Yin L.L., Xu M., Li J.M., Zhou Z.M., Sha J.H. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Testis EMBL AAQ82908.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY376241 mRNA. Translation: AAQ82908.1.
IPI	IPI00646721.
RefSeq	NP_003461.2. NM_003470.2.
UniGene	Hs.386939.
3D structure databases
ProteinModelPortal	Q6U8A4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6U8A4.
Proteomic databases
PRIDE	Q6U8A4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7874.
KEGG	hsa:7874.
UCSC	uc002czk.2. human.
Organism-specific databases
CTD	7874.
PharmGKB	PA37255.
Phylogenomic databases
GeneTree	ENSGT00600000084170.
HOGENOM	HBG385658.
HOVERGEN	HBG018029.
PhylomeDB	Q6U8A4.
Gene expression databases
ArrayExpress	Q6U8A4.
Family and domain databases
InterPro	IPR002083. MATH. IPR024729. Pept_C19_dom. IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. IPR008974. TRAF-like. [Graphical view]
KO	K11838.
Pfam	PF00917. MATH. 1 hit. PF00443. UCH. 1 hit. PF12436. USP7. 1 hit. [Graphical view]
SMART	SM00061. MATH. 1 hit. [Graphical view]
SUPFAM	SSF49599. Traf_like. 1 hit.
PROSITE	PS50144. MATH. 1 hit. PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6U8A4_HUMAN

Accession

Primary (citable) accession number: Q6U8A4

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.