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Protein

Sodium-driven chloride bicarbonate exchanger

Gene

SLC4A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-HSA-425381. Bicarbonate transporters.

Protein family/group databases

TCDBi2.A.31.2.14. the anion exchanger (ae) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-driven chloride bicarbonate exchanger
Alternative name(s):
Solute carrier family 4 member 10
Gene namesi
Name:SLC4A10
Synonyms:NCBE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:13811. SLC4A10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 509CytoplasmicSequence analysisAdd BLAST509
Transmembranei510 – 530HelicalSequence analysisAdd BLAST21
Topological domaini531 – 538ExtracellularSequence analysis8
Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Topological domaini560 – 562CytoplasmicSequence analysis3
Transmembranei563 – 583HelicalSequence analysisAdd BLAST21
Topological domaini584 – 596ExtracellularSequence analysisAdd BLAST13
Transmembranei597 – 617HelicalSequence analysisAdd BLAST21
Topological domaini618 – 626CytoplasmicSequence analysis9
Transmembranei627 – 647HelicalSequence analysisAdd BLAST21
Topological domaini648 – 720ExtracellularSequence analysisAdd BLAST73
Transmembranei721 – 741HelicalSequence analysisAdd BLAST21
Topological domaini742 – 762CytoplasmicSequence analysisAdd BLAST21
Transmembranei763 – 783HelicalSequence analysisAdd BLAST21
Topological domaini784 – 809ExtracellularSequence analysisAdd BLAST26
Transmembranei810 – 830HelicalSequence analysisAdd BLAST21
Topological domaini831 – 855CytoplasmicSequence analysisAdd BLAST25
Transmembranei856 – 876HelicalSequence analysisAdd BLAST21
Topological domaini877 – 912ExtracellularSequence analysisAdd BLAST36
Transmembranei913 – 933HelicalSequence analysisAdd BLAST21
Topological domaini934 – 935CytoplasmicSequence analysis2
Transmembranei936 – 956HelicalSequence analysisAdd BLAST21
Topological domaini957 – 998ExtracellularSequence analysisAdd BLAST42
Transmembranei999 – 1019HelicalSequence analysisAdd BLAST21
Topological domaini1020 – 1118CytoplasmicSequence analysisAdd BLAST99

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57282.
OpenTargetsiENSG00000144290.
PharmGKBiPA37810.

Chemistry databases

DrugBankiDB01390. Sodium bicarbonate.

Polymorphism and mutation databases

BioMutaiSLC4A10.
DMDMi74710237.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002452401 – 1118Sodium-driven chloride bicarbonate exchangerAdd BLAST1118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89PhosphoserineBy similarity1
Modified residuei94PhosphothreonineBy similarity1
Modified residuei276PhosphoserineBy similarity1
Modified residuei1057PhosphoserineBy similarity1
Modified residuei1085PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6U841.
PaxDbiQ6U841.
PeptideAtlasiQ6U841.
PRIDEiQ6U841.

PTM databases

iPTMnetiQ6U841.
PhosphoSitePlusiQ6U841.
SwissPalmiQ6U841.

Expressioni

Gene expression databases

BgeeiENSG00000144290.
CleanExiHS_SLC4A10.
ExpressionAtlasiQ6U841. baseline and differential.

Organism-specific databases

HPAiHPA034755.

Interactioni

Protein-protein interaction databases

BioGridi121475. 1 interactor.
IntActiQ6U841. 2 interactors.
STRINGi9606.ENSP00000393066.

Structurei

3D structure databases

ProteinModelPortaliQ6U841.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
GeneTreeiENSGT00760000119021.
HOGENOMiHOG000280684.
HOVERGENiHBG004326.
InParanoidiQ6U841.
KOiK13861.
OMAiRIFGGMI.
OrthoDBiEOG091G01FT.
PhylomeDBiQ6U841.
TreeFamiTF313630.

Family and domain databases

Gene3Di3.40.1100.10. 2 hits.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6U841-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIKDQGAQM EPLLPTRNDE EAVVDRGGTR SILKTHFEKE DLEGHRTLFI
60 70 80 90 100
GVHVPLGGRK SHRRHRHRGH KHRKRDRERD SGLEDGRESP SFDTPSQRVQ
110 120 130 140 150
FILGTEDDDE EHIPHDLFTE LDEICWREGE DAEWRETARW LKFEEDVEDG
160 170 180 190 200
GERWSKPYVA TLSLHSLFEL RSCILNGTVL LDMHANTLEE IADMVLDQQV
210 220 230 240 250
SSGQLNEDVR HRVHEALMKQ HHHQNQKKLT NRIPIVRSFA DIGKKQSEPN
260 270 280 290 300
SMDKNAGQVV SPQSAPACVE NKNDVSRENS TVDFSKGLGG QQKGHTSPCG
310 320 330 340 350
MKQRHEKGPP HQQEREVDLH FMKKIPPGAE ASNILVGELE FLDRTVVAFV
360 370 380 390 400
RLSPAVLLQG LAEVPIPTRF LFILLGPLGK GQQYHEIGRS IATLMTDEVF
410 420 430 440 450
HDVAYKAKDR NDLVSGIDEF LDQVTVLPPG EWDPSIRIEP PKNVPSQEKR
460 470 480 490 500
KIPAVPNGTA AHGEAEPHGG HSGPELQRTG RIFGGLILDI KRKAPYFWSD
510 520 530 540 550
FRDAFSLQCL ASFLFLYCAC MSPVITFGGL LGEATEGRIS AIESLFGASM
560 570 580 590 600
TGIAYSLFGG QPLTILGSTG PVLVFEKILF KFCKEYGLSY LSLRASIGLW
610 620 630 640 650
TATLCIILVA TDASSLVCYI TRFTEEAFAS LICIIFIYEA LEKLFELSEA
660 670 680 690 700
YPINMHNDLE LLTQYSCNCV EPHNPSNGTL KEWRESNISA SDIIWENLTV
710 720 730 740 750
SECKSLHGEY VGRACGHDHP YVPDVLFWSV ILFFSTVTLS ATLKQFKTSR
760 770 780 790 800
YFPTKVRSIV SDFAVFLTIL CMVLIDYAIG IPSPKLQVPS VFKPTRDDRG
810 820 830 840 850
WFVTPLGPNP WWTVIAAIIP ALLCTILIFM DQQITAVIIN RKEHKLKKGC
860 870 880 890 900
GYHLDLLMVA VMLGVCSIMG LPWFVAATVL SITHVNSLKL ESECSAPGEQ
910 920 930 940 950
PKFLGIREQR VTGLMIFILM GSSVFMTSIL KFIPMPVLYG VFLYMGASSL
960 970 980 990 1000
KGIQFFDRIK LFWMPAKHQP DFIYLRHVPL RKVHLFTIIQ MSCLGLLWII
1010 1020 1030 1040 1050
KVSRAAIVFP MMVLALVFVR KLMDLLFTKR ELSWLDDLMP ESKKKKLEDA
1060 1070 1080 1090 1100
EKEEEQSMLA MEDEGTVQLP LEGHYRDDPS VINISDEMSK TALWRNLLIT
1110
ADNSKDKESS FPSKSSPS
Length:1,118
Mass (Da):125,946
Last modified:July 5, 2004 - v1
Checksum:i2376529C2CBE04E2
GO
Isoform 2 (identifier: Q6U841-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-316: Missing.

Show »
Length:1,088
Mass (Da):122,641
Checksum:i900D304004CC7208
GO
Isoform 3 (identifier: Q6U841-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MEIKDQGAQMEPLLPT → MQSLGVSGNRKVMQSGTCEPFQSLSHQ
     287-316: Missing.

Note: No experimental confirmation available.
Show »
Length:1,099
Mass (Da):123,777
Checksum:iB3A73B8131408E8E
GO
Isoform 4 (identifier: Q6U841-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     370-408: FLFILLGPLG...VFHDVAYKAK → YFMMLPIKLK...LLENGIQAFE
     409-1118: Missing.

Note: No experimental confirmation available.
Show »
Length:408
Mass (Da):46,839
Checksum:i1C70E5B511C6A6CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti336V → L in BAB18301 (PubMed:10993873).Curated1
Sequence conflicti699T → I in BAH11596 (PubMed:14702039).Curated1
Sequence conflicti1008V → A in BAH11596 (PubMed:14702039).Curated1
Sequence conflicti1009F → S in BAB18301 (PubMed:10993873).Curated1
Sequence conflicti1015A → S in BAB18301 (PubMed:10993873).Curated1
Sequence conflicti1033S → C in BAB18301 (PubMed:10993873).Curated1
Sequence conflicti1048E → G in BAH11596 (PubMed:14702039).Curated1
Sequence conflicti1049D → Y in BAB18301 (PubMed:10993873).Curated1
Sequence conflicti1057 – 1058SM → CV in BAB18301 (PubMed:10993873).Curated2
Sequence conflicti1060A → P in BAB18301 (PubMed:10993873).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0449931 – 16MEIKD…PLLPT → MQSLGVSGNRKVMQSGTCEP FQSLSHQ in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_019653287 – 316Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST30
Alternative sequenceiVSP_054471370 – 408FLFIL…AYKAK → YFMMLPIKLKIVMTWYQELM SFWIRLLFSLLENGIQAFE in isoform 4. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_054472409 – 1118Missing in isoform 4. 1 PublicationAdd BLAST710

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040457 mRNA. Translation: BAB18301.1.
AY376402 mRNA. Translation: AAQ83632.1.
AK293793 mRNA. Translation: BAH11596.1.
AK294767 mRNA. Translation: BAH11876.1.
AC008063 Genomic DNA. No translation available.
AC062022 Genomic DNA. No translation available.
AC092841 Genomic DNA. No translation available.
AC009487 Genomic DNA. No translation available.
AC092654 Genomic DNA. No translation available.
AC096654 Genomic DNA. Translation: AAX88962.1.
CH471058 Genomic DNA. Translation: EAX11364.1.
BC136269 mRNA. Translation: AAI36270.1.
BC143714 mRNA. Translation: AAI43715.1.
AL713680 mRNA. Translation: CAD28484.1.
AL832525 mRNA. Translation: CAD38630.1.
CCDSiCCDS46438.1. [Q6U841-2]
CCDS54411.1. [Q6U841-1]
CCDS54412.1. [Q6U841-3]
RefSeqiNP_001171486.1. NM_001178015.1. [Q6U841-1]
NP_001171487.1. NM_001178016.1. [Q6U841-3]
NP_071341.2. NM_022058.3. [Q6U841-2]
UniGeneiHs.333958.

Genome annotation databases

EnsembliENST00000375514; ENSP00000364664; ENSG00000144290. [Q6U841-3]
ENST00000415876; ENSP00000395797; ENSG00000144290. [Q6U841-2]
ENST00000446997; ENSP00000393066; ENSG00000144290. [Q6U841-1]
GeneIDi57282.
KEGGihsa:57282.
UCSCiuc002ubx.5. human. [Q6U841-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040457 mRNA. Translation: BAB18301.1.
AY376402 mRNA. Translation: AAQ83632.1.
AK293793 mRNA. Translation: BAH11596.1.
AK294767 mRNA. Translation: BAH11876.1.
AC008063 Genomic DNA. No translation available.
AC062022 Genomic DNA. No translation available.
AC092841 Genomic DNA. No translation available.
AC009487 Genomic DNA. No translation available.
AC092654 Genomic DNA. No translation available.
AC096654 Genomic DNA. Translation: AAX88962.1.
CH471058 Genomic DNA. Translation: EAX11364.1.
BC136269 mRNA. Translation: AAI36270.1.
BC143714 mRNA. Translation: AAI43715.1.
AL713680 mRNA. Translation: CAD28484.1.
AL832525 mRNA. Translation: CAD38630.1.
CCDSiCCDS46438.1. [Q6U841-2]
CCDS54411.1. [Q6U841-1]
CCDS54412.1. [Q6U841-3]
RefSeqiNP_001171486.1. NM_001178015.1. [Q6U841-1]
NP_001171487.1. NM_001178016.1. [Q6U841-3]
NP_071341.2. NM_022058.3. [Q6U841-2]
UniGeneiHs.333958.

3D structure databases

ProteinModelPortaliQ6U841.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121475. 1 interactor.
IntActiQ6U841. 2 interactors.
STRINGi9606.ENSP00000393066.

Chemistry databases

DrugBankiDB01390. Sodium bicarbonate.

Protein family/group databases

TCDBi2.A.31.2.14. the anion exchanger (ae) family.

PTM databases

iPTMnetiQ6U841.
PhosphoSitePlusiQ6U841.
SwissPalmiQ6U841.

Polymorphism and mutation databases

BioMutaiSLC4A10.
DMDMi74710237.

Proteomic databases

MaxQBiQ6U841.
PaxDbiQ6U841.
PeptideAtlasiQ6U841.
PRIDEiQ6U841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375514; ENSP00000364664; ENSG00000144290. [Q6U841-3]
ENST00000415876; ENSP00000395797; ENSG00000144290. [Q6U841-2]
ENST00000446997; ENSP00000393066; ENSG00000144290. [Q6U841-1]
GeneIDi57282.
KEGGihsa:57282.
UCSCiuc002ubx.5. human. [Q6U841-1]

Organism-specific databases

CTDi57282.
DisGeNETi57282.
GeneCardsiSLC4A10.
HGNCiHGNC:13811. SLC4A10.
HPAiHPA034755.
MIMi605556. gene.
neXtProtiNX_Q6U841.
OpenTargetsiENSG00000144290.
PharmGKBiPA37810.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
GeneTreeiENSGT00760000119021.
HOGENOMiHOG000280684.
HOVERGENiHBG004326.
InParanoidiQ6U841.
KOiK13861.
OMAiRIFGGMI.
OrthoDBiEOG091G01FT.
PhylomeDBiQ6U841.
TreeFamiTF313630.

Enzyme and pathway databases

ReactomeiR-HSA-425381. Bicarbonate transporters.

Miscellaneous databases

ChiTaRSiSLC4A10. human.
GenomeRNAii57282.
PROiQ6U841.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144290.
CleanExiHS_SLC4A10.
ExpressionAtlasiQ6U841. baseline and differential.

Family and domain databases

Gene3Di3.40.1100.10. 2 hits.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS4A10_HUMAN
AccessioniPrimary (citable) accession number: Q6U841
Secondary accession number(s): B7Z1R0
, B7Z2J0, B7ZLC5, B9EG69, F8W675, Q4ZFX6, Q8TCP2, Q9HCQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.