Q6U841 (S4A10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium-driven chloride bicarbonate exchanger

Alternative name(s):
Solute carrier family 4 member 10

Gene names

Name:	SLC4A10
Synonyms:	NCBE

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1118 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein. Note: Localizes to the basolateral membrane By similarity.
Sequence similarities	Belongs to the anion exchanger (TC 2.A.31) family. [View classification]

Ontologies

Keywords
Biological process	Antiport Ion transport Sodium transport Symport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	bicarbonate transport Non-traceable author statement Ref.1. Source: UniProtKB chloride transport Non-traceable author statement Ref.1. Source: UniProtKB regulation of pH Inferred from electronic annotation. Source: Compara sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	basolateral plasma membrane Inferred from electronic annotation. Source: Compara integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	inorganic anion exchanger activity Inferred from electronic annotation. Source: InterPro symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6U841-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6U841-2)

The sequence of this isoform differs from the canonical sequence as follows:
     287-316: Missing.

Isoform 3 (identifier: Q6U841-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MEIKDQGAQMEPLLPT → MQSLGVSGNRKVMQSGTCEPFQSLSHQ
     287-316: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1118	1118	Sodium-driven chloride bicarbonate exchanger		PRO_0000245240
Regions
	Topological domain	1 – 509	509	Cytoplasmic Potential
	Transmembrane	510 – 530	21	Helical; Potential
	Topological domain	531 – 538	8	Extracellular Potential
	Transmembrane	539 – 559	21	Helical; Potential
	Topological domain	560 – 562	3	Cytoplasmic Potential
	Transmembrane	563 – 583	21	Helical; Potential
	Topological domain	584 – 596	13	Extracellular Potential
	Transmembrane	597 – 617	21	Helical; Potential
	Topological domain	618 – 626	9	Cytoplasmic Potential
	Transmembrane	627 – 647	21	Helical; Potential
	Topological domain	648 – 720	73	Extracellular Potential
	Transmembrane	721 – 741	21	Helical; Potential
	Topological domain	742 – 762	21	Cytoplasmic Potential
	Transmembrane	763 – 783	21	Helical; Potential
	Topological domain	784 – 809	26	Extracellular Potential
	Transmembrane	810 – 830	21	Helical; Potential
	Topological domain	831 – 855	25	Cytoplasmic Potential
	Transmembrane	856 – 876	21	Helical; Potential
	Topological domain	877 – 912	36	Extracellular Potential
	Transmembrane	913 – 933	21	Helical; Potential
	Topological domain	934 – 935	2	Cytoplasmic Potential
	Transmembrane	936 – 956	21	Helical; Potential
	Topological domain	957 – 998	42	Extracellular Potential
	Transmembrane	999 – 1019	21	Helical; Potential
	Topological domain	1020 – 1118	99	Cytoplasmic Potential
Amino acid modifications
	Modified residue	89	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 16	16	MEIKD…PLLPT → MQSLGVSGNRKVMQSGTCEP FQSLSHQ in isoform 3.		VSP_044993
	Alternative sequence	287 – 316	30	Missing in isoform 2 and isoform 3.		VSP_019653
Experimental info
	Sequence conflict	336	1	V → L in BAB18301. Ref.1
	Sequence conflict	699	1	T → I in BAH11596. Ref.3
	Sequence conflict	1008	1	V → A in BAH11596. Ref.3
	Sequence conflict	1009	1	F → S in BAB18301. Ref.1
	Sequence conflict	1015	1	A → S in BAB18301. Ref.1
	Sequence conflict	1033	1	S → C in BAB18301. Ref.1
	Sequence conflict	1048	1	E → G in BAH11596. Ref.3
	Sequence conflict	1049	1	D → Y in BAB18301. Ref.1
	Sequence conflict	1057 – 1058	2	SM → CV in BAB18301. Ref.1
	Sequence conflict	1060	1	A → P in BAB18301. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 2376529C2CBE04E2	FASTA	1,118	125,946
	10 20 30 40 50 60 MEIKDQGAQM EPLLPTRNDE EAVVDRGGTR SILKTHFEKE DLEGHRTLFI GVHVPLGGRK 70 80 90 100 110 120 SHRRHRHRGH KHRKRDRERD SGLEDGRESP SFDTPSQRVQ FILGTEDDDE EHIPHDLFTE 130 140 150 160 170 180 LDEICWREGE DAEWRETARW LKFEEDVEDG GERWSKPYVA TLSLHSLFEL RSCILNGTVL 190 200 210 220 230 240 LDMHANTLEE IADMVLDQQV SSGQLNEDVR HRVHEALMKQ HHHQNQKKLT NRIPIVRSFA 250 260 270 280 290 300 DIGKKQSEPN SMDKNAGQVV SPQSAPACVE NKNDVSRENS TVDFSKGLGG QQKGHTSPCG 310 320 330 340 350 360 MKQRHEKGPP HQQEREVDLH FMKKIPPGAE ASNILVGELE FLDRTVVAFV RLSPAVLLQG 370 380 390 400 410 420 LAEVPIPTRF LFILLGPLGK GQQYHEIGRS IATLMTDEVF HDVAYKAKDR NDLVSGIDEF 430 440 450 460 470 480 LDQVTVLPPG EWDPSIRIEP PKNVPSQEKR KIPAVPNGTA AHGEAEPHGG HSGPELQRTG 490 500 510 520 530 540 RIFGGLILDI KRKAPYFWSD FRDAFSLQCL ASFLFLYCAC MSPVITFGGL LGEATEGRIS 550 560 570 580 590 600 AIESLFGASM TGIAYSLFGG QPLTILGSTG PVLVFEKILF KFCKEYGLSY LSLRASIGLW 610 620 630 640 650 660 TATLCIILVA TDASSLVCYI TRFTEEAFAS LICIIFIYEA LEKLFELSEA YPINMHNDLE 670 680 690 700 710 720 LLTQYSCNCV EPHNPSNGTL KEWRESNISA SDIIWENLTV SECKSLHGEY VGRACGHDHP 730 740 750 760 770 780 YVPDVLFWSV ILFFSTVTLS ATLKQFKTSR YFPTKVRSIV SDFAVFLTIL CMVLIDYAIG 790 800 810 820 830 840 IPSPKLQVPS VFKPTRDDRG WFVTPLGPNP WWTVIAAIIP ALLCTILIFM DQQITAVIIN 850 860 870 880 890 900 RKEHKLKKGC GYHLDLLMVA VMLGVCSIMG LPWFVAATVL SITHVNSLKL ESECSAPGEQ 910 920 930 940 950 960 PKFLGIREQR VTGLMIFILM GSSVFMTSIL KFIPMPVLYG VFLYMGASSL KGIQFFDRIK 970 980 990 1000 1010 1020 LFWMPAKHQP DFIYLRHVPL RKVHLFTIIQ MSCLGLLWII KVSRAAIVFP MMVLALVFVR 1030 1040 1050 1060 1070 1080 KLMDLLFTKR ELSWLDDLMP ESKKKKLEDA EKEEEQSMLA MEDEGTVQLP LEGHYRDDPS 1090 1100 1110 VINISDEMSK TALWRNLLIT ADNSKDKESS FPSKSSPS
	Isoform 2 [UniParc]. Checksum: 900D304004CC7208	FASTA	1,088	122,641
	10 20 30 40 50 60 MEIKDQGAQM EPLLPTRNDE EAVVDRGGTR SILKTHFEKE DLEGHRTLFI GVHVPLGGRK 70 80 90 100 110 120 SHRRHRHRGH KHRKRDRERD SGLEDGRESP SFDTPSQRVQ FILGTEDDDE EHIPHDLFTE 130 140 150 160 170 180 LDEICWREGE DAEWRETARW LKFEEDVEDG GERWSKPYVA TLSLHSLFEL RSCILNGTVL 190 200 210 220 230 240 LDMHANTLEE IADMVLDQQV SSGQLNEDVR HRVHEALMKQ HHHQNQKKLT NRIPIVRSFA 250 260 270 280 290 300 DIGKKQSEPN SMDKNAGQVV SPQSAPACVE NKNDVSRENS TVDFSKVDLH FMKKIPPGAE 310 320 330 340 350 360 ASNILVGELE FLDRTVVAFV RLSPAVLLQG LAEVPIPTRF LFILLGPLGK GQQYHEIGRS 370 380 390 400 410 420 IATLMTDEVF HDVAYKAKDR NDLVSGIDEF LDQVTVLPPG EWDPSIRIEP PKNVPSQEKR 430 440 450 460 470 480 KIPAVPNGTA AHGEAEPHGG HSGPELQRTG RIFGGLILDI KRKAPYFWSD FRDAFSLQCL 490 500 510 520 530 540 ASFLFLYCAC MSPVITFGGL LGEATEGRIS AIESLFGASM TGIAYSLFGG QPLTILGSTG 550 560 570 580 590 600 PVLVFEKILF KFCKEYGLSY LSLRASIGLW TATLCIILVA TDASSLVCYI TRFTEEAFAS 610 620 630 640 650 660 LICIIFIYEA LEKLFELSEA YPINMHNDLE LLTQYSCNCV EPHNPSNGTL KEWRESNISA 670 680 690 700 710 720 SDIIWENLTV SECKSLHGEY VGRACGHDHP YVPDVLFWSV ILFFSTVTLS ATLKQFKTSR 730 740 750 760 770 780 YFPTKVRSIV SDFAVFLTIL CMVLIDYAIG IPSPKLQVPS VFKPTRDDRG WFVTPLGPNP 790 800 810 820 830 840 WWTVIAAIIP ALLCTILIFM DQQITAVIIN RKEHKLKKGC GYHLDLLMVA VMLGVCSIMG 850 860 870 880 890 900 LPWFVAATVL SITHVNSLKL ESECSAPGEQ PKFLGIREQR VTGLMIFILM GSSVFMTSIL 910 920 930 940 950 960 KFIPMPVLYG VFLYMGASSL KGIQFFDRIK LFWMPAKHQP DFIYLRHVPL RKVHLFTIIQ 970 980 990 1000 1010 1020 MSCLGLLWII KVSRAAIVFP MMVLALVFVR KLMDLLFTKR ELSWLDDLMP ESKKKKLEDA 1030 1040 1050 1060 1070 1080 EKEEEQSMLA MEDEGTVQLP LEGHYRDDPS VINISDEMSK TALWRNLLIT ADNSKDKESS FPSKSSPS
	Isoform 3 [UniParc]. Checksum: B3A73B8131408E8E	FASTA	1,099	123,777
	10 20 30 40 50 60 MQSLGVSGNR KVMQSGTCEP FQSLSHQRND EEAVVDRGGT RSILKTHFEK EDLEGHRTLF 70 80 90 100 110 120 IGVHVPLGGR KSHRRHRHRG HKHRKRDRER DSGLEDGRES PSFDTPSQRV QFILGTEDDD 130 140 150 160 170 180 EEHIPHDLFT ELDEICWREG EDAEWRETAR WLKFEEDVED GGERWSKPYV ATLSLHSLFE 190 200 210 220 230 240 LRSCILNGTV LLDMHANTLE EIADMVLDQQ VSSGQLNEDV RHRVHEALMK QHHHQNQKKL 250 260 270 280 290 300 TNRIPIVRSF ADIGKKQSEP NSMDKNAGQV VSPQSAPACV ENKNDVSREN STVDFSKVDL 310 320 330 340 350 360 HFMKKIPPGA EASNILVGEL EFLDRTVVAF VRLSPAVLLQ GLAEVPIPTR FLFILLGPLG 370 380 390 400 410 420 KGQQYHEIGR SIATLMTDEV FHDVAYKAKD RNDLVSGIDE FLDQVTVLPP GEWDPSIRIE 430 440 450 460 470 480 PPKNVPSQEK RKIPAVPNGT AAHGEAEPHG GHSGPELQRT GRIFGGLILD IKRKAPYFWS 490 500 510 520 530 540 DFRDAFSLQC LASFLFLYCA CMSPVITFGG LLGEATEGRI SAIESLFGAS MTGIAYSLFG 550 560 570 580 590 600 GQPLTILGST GPVLVFEKIL FKFCKEYGLS YLSLRASIGL WTATLCIILV ATDASSLVCY 610 620 630 640 650 660 ITRFTEEAFA SLICIIFIYE ALEKLFELSE AYPINMHNDL ELLTQYSCNC VEPHNPSNGT 670 680 690 700 710 720 LKEWRESNIS ASDIIWENLT VSECKSLHGE YVGRACGHDH PYVPDVLFWS VILFFSTVTL 730 740 750 760 770 780 SATLKQFKTS RYFPTKVRSI VSDFAVFLTI LCMVLIDYAI GIPSPKLQVP SVFKPTRDDR 790 800 810 820 830 840 GWFVTPLGPN PWWTVIAAII PALLCTILIF MDQQITAVII NRKEHKLKKG CGYHLDLLMV 850 860 870 880 890 900 AVMLGVCSIM GLPWFVAATV LSITHVNSLK LESECSAPGE QPKFLGIREQ RVTGLMIFIL 910 920 930 940 950 960 MGSSVFMTSI LKFIPMPVLY GVFLYMGASS LKGIQFFDRI KLFWMPAKHQ PDFIYLRHVP 970 980 990 1000 1010 1020 LRKVHLFTII QMSCLGLLWI IKVSRAAIVF PMMVLALVFV RKLMDLLFTK RELSWLDDLM 1030 1040 1050 1060 1070 1080 PESKKKKLED AEKEEEQSML AMEDEGTVQL PLEGHYRDDP SVINISDEMS KTALWRNLLI 1090 TADNSKDKES SFPSKSSPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization." Wang C.-Z., Yano H., Nagashima K., Seino S. J. Biol. Chem. 275:35486-35490(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Cloning and functional characterisation of human kidney 'NCBE'." Choi I., Kobayashi C., Rojas J.R., Boron W.F. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Kidney.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Cerebellum.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Cerebellum and Testis.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 897-1118 (ISOFORM 1). Tissue: Amygdala.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB040457 mRNA. Translation: BAB18301.1. AY376402 mRNA. Translation: AAQ83632.1. AK293793 mRNA. Translation: BAH11596.1. AC008063 Genomic DNA. No translation available. AC062022 Genomic DNA. No translation available. AC092841 Genomic DNA. No translation available. AC009487 Genomic DNA. No translation available. AC092654 Genomic DNA. No translation available. AC096654 Genomic DNA. Translation: AAX88962.1. CH471058 Genomic DNA. Translation: EAX11364.1. BC136269 mRNA. Translation: AAI36270.1. BC143714 mRNA. Translation: AAI43715.1. AL713680 mRNA. Translation: CAD28484.1. AL832525 mRNA. Translation: CAD38630.1.
IPI	IPI00004944. IPI00746904. IPI01012251.
RefSeq	NP_001171486.1. NM_001178015.1. NP_001171487.1. NM_001178016.1. NP_071341.2. NM_022058.3.
UniGene	Hs.333958.
3D structure databases
ProteinModelPortal	Q6U841.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6U841. 2 interactions.
PTM databases
PhosphoSite	Q6U841.
Polymorphism databases
DMDM	74710237.
Proteomic databases
PaxDb	Q6U841.
PRIDE	Q6U841.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000375514; ENSP00000364664; ENSG00000144290. ENST00000415876; ENSP00000395797; ENSG00000144290. ENST00000446997; ENSP00000393066; ENSG00000144290.
GeneID	57282.
KEGG	hsa:57282.
UCSC	uc002ubx.4. human. uc002uby.4. human.
Organism-specific databases
CTD	57282.
GeneCards	GC02P162281.
HGNC	HGNC:13811. SLC4A10.
HPA	HPA034755.
MIM	605556. gene.
neXtProt	NX_Q6U841.
PharmGKB	PA37810.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG268067.
HOGENOM	HOG000280684.
HOVERGEN	HBG004326.
InParanoid	Q6U841.
KO	K13861.
OMA	FYFSDFK.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q6U841.
Bgee	Q6U841.
CleanEx	HS_SLC4A10.
Genevestigator	Q6U841.
Family and domain databases
Gene3D	3.40.1100.10. 2 hits.
InterPro	IPR013769. Band3_cytoplasmic_dom. IPR011531. HCO3_transpt_C. IPR003020. HCO3_transpt_euk. IPR003024. Na/HCO3_transpt. IPR016152. PTrfase/Anion_transptr. [Graphical view]
PANTHER	PTHR11453. PTHR11453. 1 hit.
Pfam	PF07565. Band_3_cyto. 1 hit. PF00955. HCO3_cotransp. 1 hit. [Graphical view]
PRINTS	PR01231. HCO3TRNSPORT. PR01232. NAHCO3TRSPRT.
SUPFAM	SSF55804. PTrfase/Anion_transptr. 1 hit.
TIGRFAMs	TIGR00834. ae. 1 hit.
PROSITE	PS00219. ANION_EXCHANGER_1. False negative. PS00220. ANION_EXCHANGER_2. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC4A10. human.
GenomeRNAi	57282.
NextBio	63406.
SOURCE	Search...

Entry information

Entry name

S4A10_HUMAN

Accession

Primary (citable) accession number: Q6U841
Secondary accession number(s): B7Z1R0 , B7ZLC5, B9EG69, F8W675, Q4ZFX6, Q8TCP2, Q9HCQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.