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Q6U841 (S4A10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium-driven chloride bicarbonate exchanger
Alternative name(s):
Solute carrier family 4 member 10
Gene names
Name:SLC4A10
Synonyms:NCBE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1118 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: Localizes to the basolateral membrane By similarity.

Sequence similarities

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6U841-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6U841-2)

The sequence of this isoform differs from the canonical sequence as follows:
     287-316: Missing.
Isoform 3 (identifier: Q6U841-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MEIKDQGAQMEPLLPT → MQSLGVSGNRKVMQSGTCEPFQSLSHQ
     287-316: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q6U841-4)

The sequence of this isoform differs from the canonical sequence as follows:
     370-408: FLFILLGPLG...VFHDVAYKAK → YFMMLPIKLK...LLENGIQAFE
     409-1118: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11181118Sodium-driven chloride bicarbonate exchanger
PRO_0000245240

Regions

Topological domain1 – 509509Cytoplasmic Potential
Transmembrane510 – 53021Helical; Potential
Topological domain531 – 5388Extracellular Potential
Transmembrane539 – 55921Helical; Potential
Topological domain560 – 5623Cytoplasmic Potential
Transmembrane563 – 58321Helical; Potential
Topological domain584 – 59613Extracellular Potential
Transmembrane597 – 61721Helical; Potential
Topological domain618 – 6269Cytoplasmic Potential
Transmembrane627 – 64721Helical; Potential
Topological domain648 – 72073Extracellular Potential
Transmembrane721 – 74121Helical; Potential
Topological domain742 – 76221Cytoplasmic Potential
Transmembrane763 – 78321Helical; Potential
Topological domain784 – 80926Extracellular Potential
Transmembrane810 – 83021Helical; Potential
Topological domain831 – 85525Cytoplasmic Potential
Transmembrane856 – 87621Helical; Potential
Topological domain877 – 91236Extracellular Potential
Transmembrane913 – 93321Helical; Potential
Topological domain934 – 9352Cytoplasmic Potential
Transmembrane936 – 95621Helical; Potential
Topological domain957 – 99842Extracellular Potential
Transmembrane999 – 101921Helical; Potential
Topological domain1020 – 111899Cytoplasmic Potential

Natural variations

Alternative sequence1 – 1616MEIKD…PLLPT → MQSLGVSGNRKVMQSGTCEP FQSLSHQ in isoform 3.
VSP_044993
Alternative sequence287 – 31630Missing in isoform 2 and isoform 3.
VSP_019653
Alternative sequence370 – 40839FLFIL…AYKAK → YFMMLPIKLKIVMTWYQELM SFWIRLLFSLLENGIQAFE in isoform 4.
VSP_054471
Alternative sequence409 – 1118710Missing in isoform 4.
VSP_054472

Experimental info

Sequence conflict3361V → L in BAB18301. Ref.1
Sequence conflict6991T → I in BAH11596. Ref.3
Sequence conflict10081V → A in BAH11596. Ref.3
Sequence conflict10091F → S in BAB18301. Ref.1
Sequence conflict10151A → S in BAB18301. Ref.1
Sequence conflict10331S → C in BAB18301. Ref.1
Sequence conflict10481E → G in BAH11596. Ref.3
Sequence conflict10491D → Y in BAB18301. Ref.1
Sequence conflict1057 – 10582SM → CV in BAB18301. Ref.1
Sequence conflict10601A → P in BAB18301. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 2376529C2CBE04E2

FASTA1,118125,946
        10         20         30         40         50         60 
MEIKDQGAQM EPLLPTRNDE EAVVDRGGTR SILKTHFEKE DLEGHRTLFI GVHVPLGGRK 

        70         80         90        100        110        120 
SHRRHRHRGH KHRKRDRERD SGLEDGRESP SFDTPSQRVQ FILGTEDDDE EHIPHDLFTE 

       130        140        150        160        170        180 
LDEICWREGE DAEWRETARW LKFEEDVEDG GERWSKPYVA TLSLHSLFEL RSCILNGTVL 

       190        200        210        220        230        240 
LDMHANTLEE IADMVLDQQV SSGQLNEDVR HRVHEALMKQ HHHQNQKKLT NRIPIVRSFA 

       250        260        270        280        290        300 
DIGKKQSEPN SMDKNAGQVV SPQSAPACVE NKNDVSRENS TVDFSKGLGG QQKGHTSPCG 

       310        320        330        340        350        360 
MKQRHEKGPP HQQEREVDLH FMKKIPPGAE ASNILVGELE FLDRTVVAFV RLSPAVLLQG 

       370        380        390        400        410        420 
LAEVPIPTRF LFILLGPLGK GQQYHEIGRS IATLMTDEVF HDVAYKAKDR NDLVSGIDEF 

       430        440        450        460        470        480 
LDQVTVLPPG EWDPSIRIEP PKNVPSQEKR KIPAVPNGTA AHGEAEPHGG HSGPELQRTG 

       490        500        510        520        530        540 
RIFGGLILDI KRKAPYFWSD FRDAFSLQCL ASFLFLYCAC MSPVITFGGL LGEATEGRIS 

       550        560        570        580        590        600 
AIESLFGASM TGIAYSLFGG QPLTILGSTG PVLVFEKILF KFCKEYGLSY LSLRASIGLW 

       610        620        630        640        650        660 
TATLCIILVA TDASSLVCYI TRFTEEAFAS LICIIFIYEA LEKLFELSEA YPINMHNDLE 

       670        680        690        700        710        720 
LLTQYSCNCV EPHNPSNGTL KEWRESNISA SDIIWENLTV SECKSLHGEY VGRACGHDHP 

       730        740        750        760        770        780 
YVPDVLFWSV ILFFSTVTLS ATLKQFKTSR YFPTKVRSIV SDFAVFLTIL CMVLIDYAIG 

       790        800        810        820        830        840 
IPSPKLQVPS VFKPTRDDRG WFVTPLGPNP WWTVIAAIIP ALLCTILIFM DQQITAVIIN 

       850        860        870        880        890        900 
RKEHKLKKGC GYHLDLLMVA VMLGVCSIMG LPWFVAATVL SITHVNSLKL ESECSAPGEQ 

       910        920        930        940        950        960 
PKFLGIREQR VTGLMIFILM GSSVFMTSIL KFIPMPVLYG VFLYMGASSL KGIQFFDRIK 

       970        980        990       1000       1010       1020 
LFWMPAKHQP DFIYLRHVPL RKVHLFTIIQ MSCLGLLWII KVSRAAIVFP MMVLALVFVR 

      1030       1040       1050       1060       1070       1080 
KLMDLLFTKR ELSWLDDLMP ESKKKKLEDA EKEEEQSMLA MEDEGTVQLP LEGHYRDDPS 

      1090       1100       1110 
VINISDEMSK TALWRNLLIT ADNSKDKESS FPSKSSPS 

« Hide

Isoform 2 [UniParc].

Checksum: 900D304004CC7208
Show »

FASTA1,088122,641
Isoform 3 [UniParc].

Checksum: B3A73B8131408E8E
Show »

FASTA1,099123,777
Isoform 4 [UniParc].

Checksum: 1C70E5B511C6A6CE
Show »

FASTA40846,839

References

« Hide 'large scale' references
[1]"The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization."
Wang C.-Z., Yano H., Nagashima K., Seino S.
J. Biol. Chem. 275:35486-35490(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Cloning and functional characterisation of human kidney 'NCBE'."
Choi I., Kobayashi C., Rojas J.R., Boron W.F.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Kidney.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
Tissue: Brain and Cerebellum.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Cerebellum and Testis.
[7]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 897-1118 (ISOFORM 1).
Tissue: Amygdala.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB040457 mRNA. Translation: BAB18301.1.
AY376402 mRNA. Translation: AAQ83632.1.
AK293793 mRNA. Translation: BAH11596.1.
AK294767 mRNA. Translation: BAH11876.1.
AC008063 Genomic DNA. No translation available.
AC062022 Genomic DNA. No translation available.
AC092841 Genomic DNA. No translation available.
AC009487 Genomic DNA. No translation available.
AC092654 Genomic DNA. No translation available.
AC096654 Genomic DNA. Translation: AAX88962.1.
CH471058 Genomic DNA. Translation: EAX11364.1.
BC136269 mRNA. Translation: AAI36270.1.
BC143714 mRNA. Translation: AAI43715.1.
AL713680 mRNA. Translation: CAD28484.1.
AL832525 mRNA. Translation: CAD38630.1.
CCDSCCDS46438.1. [Q6U841-2]
CCDS54411.1. [Q6U841-1]
CCDS54412.1. [Q6U841-3]
RefSeqNP_001171486.1. NM_001178015.1. [Q6U841-1]
NP_001171487.1. NM_001178016.1. [Q6U841-3]
NP_071341.2. NM_022058.3. [Q6U841-2]
UniGeneHs.333958.

3D structure databases

ProteinModelPortalQ6U841.
SMRQ6U841. Positions 117-429, 493-533.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121475. 1 interaction.
IntActQ6U841. 2 interactions.

Protein family/group databases

TCDB2.A.31.2.14. the anion exchanger (ae) family.

PTM databases

PhosphoSiteQ6U841.

Polymorphism databases

DMDM74710237.

Proteomic databases

MaxQBQ6U841.
PaxDbQ6U841.
PRIDEQ6U841.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000375514; ENSP00000364664; ENSG00000144290. [Q6U841-3]
ENST00000415876; ENSP00000395797; ENSG00000144290. [Q6U841-2]
ENST00000446997; ENSP00000393066; ENSG00000144290. [Q6U841-1]
ENST00000535165; ENSP00000437527; ENSG00000144290.
GeneID57282.
KEGGhsa:57282.
UCSCuc002ubx.4. human. [Q6U841-1]
uc002uby.4. human. [Q6U841-2]

Organism-specific databases

CTD57282.
GeneCardsGC02P162444.
HGNCHGNC:13811. SLC4A10.
HPAHPA034755.
MIM605556. gene.
neXtProtNX_Q6U841.
PharmGKBPA37810.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG268067.
HOGENOMHOG000280684.
HOVERGENHBG004326.
InParanoidQ6U841.
KOK13861.
OMANTHANDP.
OrthoDBEOG7TMZR0.
PhylomeDBQ6U841.
TreeFamTF313630.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

BgeeQ6U841.
CleanExHS_SLC4A10.
GenevestigatorQ6U841.

Family and domain databases

Gene3D3.40.1100.10. 2 hits.
InterProIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERPTHR11453. PTHR11453. 1 hit.
PfamPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMSSF55804. SSF55804. 2 hits.
TIGRFAMsTIGR00834. ae. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSLC4A10. human.
GenomeRNAi57282.
NextBio35479014.
PROQ6U841.
SOURCESearch...

Entry information

Entry nameS4A10_HUMAN
AccessionPrimary (citable) accession number: Q6U841
Secondary accession number(s): B7Z1R0 expand/collapse secondary AC list , B7Z2J0, B7ZLC5, B9EG69, F8W675, Q4ZFX6, Q8TCP2, Q9HCQ6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM