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Protein

Zinc finger protein 322

Gene

ZNF322

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcriptional regulation as an activator.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri43 – 6523C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri71 – 9323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri99 – 12123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri127 – 14923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri155 – 17723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri183 – 20523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri211 – 23323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri239 – 26123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri267 – 28923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 10; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 11; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 322
Alternative name(s):
Zinc finger protein 322A
Zinc finger protein 388
Zinc finger protein 489
Gene namesi
Name:ZNF322
Synonyms:ZNF322A, ZNF388, ZNF489
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:23640. ZNF322.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134861342.

Polymorphism and mutation databases

BioMutaiZNF322.
DMDMi82582384.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Zinc finger protein 322PRO_0000047529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei391 – 3911PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6U7Q0.
PeptideAtlasiQ6U7Q0.
PRIDEiQ6U7Q0.

PTM databases

iPTMnetiQ6U7Q0.
PhosphoSiteiQ6U7Q0.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in heart and skeletal muscle.1 Publication

Developmental stagei

Expressed in embryo as early as the 11th week of gestation.1 Publication

Gene expression databases

BgeeiENSG00000181315.
CleanExiHS_ZNF322A.
ExpressionAtlasiQ6U7Q0. baseline and differential.
GenevisibleiQ6U7Q0. HS.

Organism-specific databases

HPAiHPA043161.
HPA046692.

Interactioni

Protein-protein interaction databases

BioGridi122813. 1 interaction.
STRINGi9606.ENSP00000418897.

Structurei

3D structure databases

ProteinModelPortaliQ6U7Q0.
SMRiQ6U7Q0. Positions 30-373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri43 – 6523C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri71 – 9323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri99 – 12123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri127 – 14923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri155 – 17723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri183 – 20523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri211 – 23323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri239 – 26123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri267 – 28923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 10; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 11; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000123153.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6U7Q0.
OMAiSTCESGF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6U7Q0.
TreeFamiTF338126.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6U7Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTSEEKCNQ RTQKRKIYNV CPRKGKKIFI HMHEIIQIDG HIYQCLECKQ
60 70 80 90 100
NFCENLALIM CERTHTGEKP YKCDMCEKTF VQSSDLTSHQ RIHNYEKPYK
110 120 130 140 150
CSKCEKSFWH HLALSGHQRT HAGKKFYTCD ICGKNFGQSS DLLVHQRSHT
160 170 180 190 200
GEKPYLCSEC DKCFSRSTNL IRHRRTHTGE KPFKCLECEK AFSGKSDLIS
210 220 230 240 250
HQRTHTGERP YKCNKCEKSY RHRSAFIVHK RVHTGEKPYK CGACEKCFGQ
260 270 280 290 300
KSDLIVHQRV HTGEKPYKCL ECMRSFTRSA NLIRHQATHT HTFKCLEYEK
310 320 330 340 350
SFNCSSDLIV HQRIHMEEKP HQWSACESGF LLGMDFVAQQ KMRTQTEELH
360 370 380 390 400
YKYTVCDKSF HQSSALLQHQ TVHIGEKPFV CNVSEKGLEL SPPHASEASQ

MS
Length:402
Mass (Da):46,941
Last modified:November 22, 2005 - v2
Checksum:iA9A54EC8884BD27D
GO

Sequence cautioni

The sequence BAB15637 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331H → R in AAQ85127 (PubMed:15555580).Curated
Sequence conflicti73 – 731C → S in BAB15637 (PubMed:14702039).Curated
Sequence conflicti94 – 941N → H in AAQ85127 (PubMed:15555580).Curated
Sequence conflicti101 – 1011C → R in AAQ85127 (PubMed:15555580).Curated
Sequence conflicti373 – 3731H → R in AAQ85127 (PubMed:15555580).Curated
Sequence conflicti398 – 3981A → V in AAQ85127 (PubMed:15555580).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY376736 mRNA. Translation: AAQ85127.1.
AK027046 mRNA. Translation: BAB15637.1. Different initiation.
AK290038 mRNA. Translation: BAF82727.1.
BC050425 mRNA. Translation: AAH50425.2.
BC074772 mRNA. Translation: AAH74772.1.
BC119669 mRNA. Translation: AAI19670.1.
CCDSiCCDS4617.1.
RefSeqiNP_001229726.1. NM_001242797.1.
NP_001229727.1. NM_001242798.1.
NP_001229728.1. NM_001242799.1.
NP_078915.2. NM_024639.4.
UniGeneiHs.126280.
Hs.530271.
Hs.709963.

Genome annotation databases

EnsembliENST00000415922; ENSP00000418897; ENSG00000181315.
ENST00000456172; ENSP00000478899; ENSG00000181315.
ENST00000471278; ENSP00000419728; ENSG00000181315.
ENST00000607204; ENSP00000483223; ENSG00000181315.
ENST00000622479; ENSP00000482607; ENSG00000181315.
GeneIDi79692.
KEGGihsa:79692.
UCSCiuc003nil.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY376736 mRNA. Translation: AAQ85127.1.
AK027046 mRNA. Translation: BAB15637.1. Different initiation.
AK290038 mRNA. Translation: BAF82727.1.
BC050425 mRNA. Translation: AAH50425.2.
BC074772 mRNA. Translation: AAH74772.1.
BC119669 mRNA. Translation: AAI19670.1.
CCDSiCCDS4617.1.
RefSeqiNP_001229726.1. NM_001242797.1.
NP_001229727.1. NM_001242798.1.
NP_001229728.1. NM_001242799.1.
NP_078915.2. NM_024639.4.
UniGeneiHs.126280.
Hs.530271.
Hs.709963.

3D structure databases

ProteinModelPortaliQ6U7Q0.
SMRiQ6U7Q0. Positions 30-373.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122813. 1 interaction.
STRINGi9606.ENSP00000418897.

PTM databases

iPTMnetiQ6U7Q0.
PhosphoSiteiQ6U7Q0.

Polymorphism and mutation databases

BioMutaiZNF322.
DMDMi82582384.

Proteomic databases

PaxDbiQ6U7Q0.
PeptideAtlasiQ6U7Q0.
PRIDEiQ6U7Q0.

Protocols and materials databases

DNASUi79692.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000415922; ENSP00000418897; ENSG00000181315.
ENST00000456172; ENSP00000478899; ENSG00000181315.
ENST00000471278; ENSP00000419728; ENSG00000181315.
ENST00000607204; ENSP00000483223; ENSG00000181315.
ENST00000622479; ENSP00000482607; ENSG00000181315.
GeneIDi79692.
KEGGihsa:79692.
UCSCiuc003nil.4. human.

Organism-specific databases

CTDi79692.
GeneCardsiZNF322.
HGNCiHGNC:23640. ZNF322.
HPAiHPA043161.
HPA046692.
MIMi610847. gene.
neXtProtiNX_Q6U7Q0.
PharmGKBiPA134861342.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000123153.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6U7Q0.
OMAiSTCESGF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6U7Q0.
TreeFamiTF338126.

Miscellaneous databases

ChiTaRSiZNF322. human.
GenomeRNAii79692.
PROiQ6U7Q0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181315.
CleanExiHS_ZNF322A.
ExpressionAtlasiQ6U7Q0. baseline and differential.
GenevisibleiQ6U7Q0. HS.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN322_HUMAN
AccessioniPrimary (citable) accession number: Q6U7Q0
Secondary accession number(s): A8K1X3
, Q0VDH6, Q6B0G2, Q86W72, Q9H5I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.