SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6U7I1

- UBP7_CHICK

UniProt

Q6U7I1 - UBP7_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ubiquitin carboxyl-terminal hydrolase 7

Gene
USP7
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolase that deubiquitinates target proteins. May induces p53/TP53-dependent cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei223 – 2231Nucleophile By similarity
Active sitei464 – 4641Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. protein deubiquitination Source: UniProtKB
  3. regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Gene namesi
Name:USP7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. NucleusPML body By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB
  3. PML body Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11011101Ubiquitin carboxyl-terminal hydrolase 7PRO_0000268008Add
BLAST

Post-translational modificationi

Phosphorylated By similarity.
Polyneddylated By similarity.
Polyubiquitinated By similarity.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6U7I1.
PRIDEiQ6U7I1.

Structurei

3D structure databases

ProteinModelPortaliQ6U7I1.
SMRiQ6U7I1. Positions 63-554.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 195128MATHAdd
BLAST
Domaini214 – 521308USPAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 208156Interaction with p53/TP53 and MDM2 By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 106Poly-Gln

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 MATH domain.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000160240.
HOVERGENiHBG018029.
KOiK11838.
PhylomeDBiQ6U7I1.

Family and domain databases

InterProiIPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view]
PfamiPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6U7I1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNHHQQQQHQ KPGEQQLSEP EDMEMEAGDA DDPPRITQNP VINGNVAMAD     50
GHNNTEEDME DDTSWRSEAT FQFTVERFNR LSESVLSPPC FVRNLPWKIM 100
VMPRLYPDRP HQKSVGFFLQ CNAESDSTSW SCHAQAVLKI INYKDDEKSF 150
SRRISHLFFH KENDWGFSNF MAWSEVTDPE KGFIEEDKVT FEVYVQADAP 200
HGVAWDSKKH TGYVGLKNQG ATCYMNSLLQ TLFFTNQLRK AVYMMPTEGD 250
DSSKSVPLAL QRVFYELQHS DKPVGTKKLT KSFGWETLDS FMQHDVQELC 300
RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKHVDYR SERIEDYYDI 350
QLSIKGKKNI FESFIDYVAV EQLDGDNKYD AGEHGLQEAE KGVKFLTLPP 400
VLHLQLMRFM YDPQTDQNIK INDRFEFPEQ LPLDEFLQKT DPKDPANYIL 450
HAVLVHSGDN HGGHYVVYLN PKGDGKWCKF DDDVVSRCTK EEAIEHNYGG 500
HDDDLSVRHC TNAYMLVYIR ESKLSEVLQP VTDHDIPQQL VERLQEEKRI 550
EAQKRKERQE AHLYMQVQIV AEDQFCGHQG NDMYDEEKVK YTVFKVLKNS 600
TLTEFVQNLS QTMGFPQDQI RLWPMQARSN GTKRPAMLDN EADGNKTMIE 650
LSDNENPWTI FLETVDPEMA ATGATLPKFD KDHDVMLFLK MYDPKTRSLN 700
YCGHIYTPIS CKIRDLLPVM CERAGFPQET NLILYEEVKP NLTERIQDYD 750
VSLDKALDEL MDGDIIVFQK DDPENDSSEL PTAKEYFRDL YSRVDVIFCD 800
KTIPNDPGFV VTLSNRMNYF QVAKTVAQRL NTDPMLLQFF KSQGYRDGPG 850
NPLRHNYEGT LRDLLQFFKP RQPKKLYYQQ LKMKITDFEN RRSFKCTWLN 900
SQFREEEITV YPDKHGCVRD LLEECKKVVE LSEKGSGKLR LLEIVSYKII 950
GVHQEDELLE CLSPATSRTF RIEEIPLAQV DIDKENEMLI TVAHFHKEVF 1000
GTFGIPFLLR IHQGGHFREV MKRIQTMLDI QEKEFEKFKF AIVMMGRHTY 1050
LNEDEYEVNL KDFEPQPGNM SHPRPWLGLD HFNKAPKDRY TYLEKAYKIH 1100
N 1101
Length:1,101
Mass (Da):128,297
Last modified:July 5, 2004 - v1
Checksum:i71A8FA4B02A4D2E9
GO
Isoform 2 (identifier: Q6U7I1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     683-687: HDVML → RKLMC
     688-1101: Missing.

Note: No experimental confirmation available.

Show »
Length:687
Mass (Da):79,491
Checksum:i52ED6FB5726DF487
GO
Isoform 3 (identifier: Q6U7I1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-677: TKRPAMLDNE...EMAATGATLP → KRNSSSSSSI...QLVFLESGHS
     678-1101: Missing.

Note: No experimental confirmation available.

Show »
Length:677
Mass (Da):78,117
Checksum:i1692F3128AE8521C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei632 – 67746TKRPA…GATLP → KRNSSSSSSITWSTGIVAKD KMLIILISTPVGTIYSQLVF LESGHS in isoform 3. VSP_021955Add
BLAST
Alternative sequencei678 – 1101424Missing in isoform 3. VSP_021956Add
BLAST
Alternative sequencei683 – 6875HDVML → RKLMC in isoform 2. VSP_021957
Alternative sequencei688 – 1101414Missing in isoform 2. VSP_021958Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY376869 mRNA. Translation: AAQ74886.1.
AY376870 mRNA. Translation: AAQ74887.1.
AY376871 mRNA. Translation: AAQ74888.1.
RefSeqiNP_989802.1. NM_204471.1. [Q6U7I1-1]
UniGeneiGga.9341.

Genome annotation databases

GeneIDi395126.
KEGGigga:395126.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY376869 mRNA. Translation: AAQ74886.1 .
AY376870 mRNA. Translation: AAQ74887.1 .
AY376871 mRNA. Translation: AAQ74888.1 .
RefSeqi NP_989802.1. NM_204471.1. [Q6U7I1-1 ]
UniGenei Gga.9341.

3D structure databases

ProteinModelPortali Q6U7I1.
SMRi Q6U7I1. Positions 63-554.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C19.016.

Proteomic databases

PaxDbi Q6U7I1.
PRIDEi Q6U7I1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395126.
KEGGi gga:395126.

Organism-specific databases

CTDi 7874.

Phylogenomic databases

eggNOGi COG5077.
HOGENOMi HOG000160240.
HOVERGENi HBG018029.
KOi K11838.
PhylomeDBi Q6U7I1.

Miscellaneous databases

NextBioi 20815218.
PROi Q6U7I1.

Family and domain databases

InterProi IPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view ]
Pfami PF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view ]
SMARTi SM00061. MATH. 1 hit.
[Graphical view ]
SUPFAMi SSF49599. SSF49599. 1 hit.
PROSITEi PS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Ubiquitin-specific protease in chick."
    Lee M.H., Chung C.H.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiUBP7_CHICK
AccessioniPrimary (citable) accession number: Q6U7I1
Secondary accession number(s): Q6U7I2, Q6U7I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi