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Q6U7I1

- UBP7_CHICK

UniProt

Q6U7I1 - UBP7_CHICK

Protein

Ubiquitin carboxyl-terminal hydrolase 7

Gene

USP7

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Hydrolase that deubiquitinates target proteins. May induces p53/TP53-dependent cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei223 – 2231NucleophilePROSITE-ProRule annotation
    Active sitei464 – 4641Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. protein deubiquitination Source: UniProtKB
    3. regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Developmental protein, Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.016.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 7
    Ubiquitin thioesterase 7
    Ubiquitin-specific-processing protease 7
    Gene namesi
    Name:USP7
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. NucleusPML body By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB
    3. PML body Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11011101Ubiquitin carboxyl-terminal hydrolase 7PRO_0000268008Add
    BLAST

    Post-translational modificationi

    Phosphorylated.By similarity
    Polyneddylated.By similarity
    Polyubiquitinated.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ6U7I1.
    PRIDEiQ6U7I1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6U7I1.
    SMRiQ6U7I1. Positions 63-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini68 – 195128MATHPROSITE-ProRule annotationAdd
    BLAST
    Domaini214 – 521308USPAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni53 – 208156Interaction with p53/TP53 and MDM2By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 106Poly-Gln

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 MATH domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5077.
    HOGENOMiHOG000160240.
    HOVERGENiHBG018029.
    KOiK11838.
    PhylomeDBiQ6U7I1.

    Family and domain databases

    InterProiIPR002083. MATH.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR008974. TRAF-like.
    IPR028889. UCH/PAN2.
    IPR024729. USP7_ICP0-binding_dom.
    IPR029346. USP_C.
    [Graphical view]
    PfamiPF00917. MATH. 1 hit.
    PF00443. UCH. 1 hit.
    PF14533. USP7_C2. 1 hit.
    PF12436. USP7_ICP0_bdg. 1 hit.
    [Graphical view]
    SMARTiSM00061. MATH. 1 hit.
    [Graphical view]
    SUPFAMiSSF49599. SSF49599. 1 hit.
    PROSITEiPS50144. MATH. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6U7I1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNHHQQQQHQ KPGEQQLSEP EDMEMEAGDA DDPPRITQNP VINGNVAMAD     50
    GHNNTEEDME DDTSWRSEAT FQFTVERFNR LSESVLSPPC FVRNLPWKIM 100
    VMPRLYPDRP HQKSVGFFLQ CNAESDSTSW SCHAQAVLKI INYKDDEKSF 150
    SRRISHLFFH KENDWGFSNF MAWSEVTDPE KGFIEEDKVT FEVYVQADAP 200
    HGVAWDSKKH TGYVGLKNQG ATCYMNSLLQ TLFFTNQLRK AVYMMPTEGD 250
    DSSKSVPLAL QRVFYELQHS DKPVGTKKLT KSFGWETLDS FMQHDVQELC 300
    RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKHVDYR SERIEDYYDI 350
    QLSIKGKKNI FESFIDYVAV EQLDGDNKYD AGEHGLQEAE KGVKFLTLPP 400
    VLHLQLMRFM YDPQTDQNIK INDRFEFPEQ LPLDEFLQKT DPKDPANYIL 450
    HAVLVHSGDN HGGHYVVYLN PKGDGKWCKF DDDVVSRCTK EEAIEHNYGG 500
    HDDDLSVRHC TNAYMLVYIR ESKLSEVLQP VTDHDIPQQL VERLQEEKRI 550
    EAQKRKERQE AHLYMQVQIV AEDQFCGHQG NDMYDEEKVK YTVFKVLKNS 600
    TLTEFVQNLS QTMGFPQDQI RLWPMQARSN GTKRPAMLDN EADGNKTMIE 650
    LSDNENPWTI FLETVDPEMA ATGATLPKFD KDHDVMLFLK MYDPKTRSLN 700
    YCGHIYTPIS CKIRDLLPVM CERAGFPQET NLILYEEVKP NLTERIQDYD 750
    VSLDKALDEL MDGDIIVFQK DDPENDSSEL PTAKEYFRDL YSRVDVIFCD 800
    KTIPNDPGFV VTLSNRMNYF QVAKTVAQRL NTDPMLLQFF KSQGYRDGPG 850
    NPLRHNYEGT LRDLLQFFKP RQPKKLYYQQ LKMKITDFEN RRSFKCTWLN 900
    SQFREEEITV YPDKHGCVRD LLEECKKVVE LSEKGSGKLR LLEIVSYKII 950
    GVHQEDELLE CLSPATSRTF RIEEIPLAQV DIDKENEMLI TVAHFHKEVF 1000
    GTFGIPFLLR IHQGGHFREV MKRIQTMLDI QEKEFEKFKF AIVMMGRHTY 1050
    LNEDEYEVNL KDFEPQPGNM SHPRPWLGLD HFNKAPKDRY TYLEKAYKIH 1100
    N 1101
    Length:1,101
    Mass (Da):128,297
    Last modified:July 5, 2004 - v1
    Checksum:i71A8FA4B02A4D2E9
    GO
    Isoform 2 (identifier: Q6U7I1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         683-687: HDVML → RKLMC
         688-1101: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:687
    Mass (Da):79,491
    Checksum:i52ED6FB5726DF487
    GO
    Isoform 3 (identifier: Q6U7I1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         632-677: TKRPAMLDNE...EMAATGATLP → KRNSSSSSSI...QLVFLESGHS
         678-1101: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:677
    Mass (Da):78,117
    Checksum:i1692F3128AE8521C
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei632 – 67746TKRPA…GATLP → KRNSSSSSSITWSTGIVAKD KMLIILISTPVGTIYSQLVF LESGHS in isoform 3. 1 PublicationVSP_021955Add
    BLAST
    Alternative sequencei678 – 1101424Missing in isoform 3. 1 PublicationVSP_021956Add
    BLAST
    Alternative sequencei683 – 6875HDVML → RKLMC in isoform 2. 1 PublicationVSP_021957
    Alternative sequencei688 – 1101414Missing in isoform 2. 1 PublicationVSP_021958Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY376869 mRNA. Translation: AAQ74886.1.
    AY376870 mRNA. Translation: AAQ74887.1.
    AY376871 mRNA. Translation: AAQ74888.1.
    RefSeqiNP_989802.1. NM_204471.1. [Q6U7I1-1]
    UniGeneiGga.9341.

    Genome annotation databases

    GeneIDi395126.
    KEGGigga:395126.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY376869 mRNA. Translation: AAQ74886.1 .
    AY376870 mRNA. Translation: AAQ74887.1 .
    AY376871 mRNA. Translation: AAQ74888.1 .
    RefSeqi NP_989802.1. NM_204471.1. [Q6U7I1-1 ]
    UniGenei Gga.9341.

    3D structure databases

    ProteinModelPortali Q6U7I1.
    SMRi Q6U7I1. Positions 63-554.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.016.

    Proteomic databases

    PaxDbi Q6U7I1.
    PRIDEi Q6U7I1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395126.
    KEGGi gga:395126.

    Organism-specific databases

    CTDi 7874.

    Phylogenomic databases

    eggNOGi COG5077.
    HOGENOMi HOG000160240.
    HOVERGENi HBG018029.
    KOi K11838.
    PhylomeDBi Q6U7I1.

    Miscellaneous databases

    NextBioi 20815218.
    PROi Q6U7I1.

    Family and domain databases

    InterProi IPR002083. MATH.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR008974. TRAF-like.
    IPR028889. UCH/PAN2.
    IPR024729. USP7_ICP0-binding_dom.
    IPR029346. USP_C.
    [Graphical view ]
    Pfami PF00917. MATH. 1 hit.
    PF00443. UCH. 1 hit.
    PF14533. USP7_C2. 1 hit.
    PF12436. USP7_ICP0_bdg. 1 hit.
    [Graphical view ]
    SMARTi SM00061. MATH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49599. SSF49599. 1 hit.
    PROSITEi PS50144. MATH. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ubiquitin-specific protease in chick."
      Lee M.H., Chung C.H.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiUBP7_CHICK
    AccessioniPrimary (citable) accession number: Q6U7I1
    Secondary accession number(s): Q6U7I2, Q6U7I3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3