Ubiquitin carboxyl-terminal hydrolase 7

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Q6U7I1 (UBP7_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 54. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 7
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7

Gene names

Name:

USP7

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	1101 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Hydrolase that deubiquitinates target proteins. May induces p53/TP53-dependent cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development By similarity.
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subcellular location	Nucleus By similarity. Cytoplasm By similarity. Nucleus › PML body By similarity.
Post-translational modification	Phosphorylated By similarity. Polyneddylated By similarity. Polyubiquitinated By similarity.
Sequence similarities	Belongs to the peptidase C19 family. Contains 1 MATH domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Molecular function	Developmental protein Hydrolase Protease Thiol protease
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW protein deubiquitination Inferred from sequence or structural similarity. Source: UniProtKB regulation of sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	PML body Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ubiquitin thiolesterase activity Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin-specific protease activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6U7I1-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6U7I1-2) The sequence of this isoform differs from the canonical sequence as follows: 683-687: HDVML → RKLMC 688-1101: Missing.
Note: No experimental confirmation available.

Isoform 3 (identifier: Q6U7I1-3) The sequence of this isoform differs from the canonical sequence as follows: 632-677: TKRPAMLDNE...EMAATGATLP → KRNSSSSSSI...QLVFLESGHS 678-1101: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1101

1101

Ubiquitin carboxyl-terminal hydrolase 7

PRO_0000268008

Regions

Domain

68 – 195

128

MATH

Region

53 – 208

156

Interaction with p53/TP53 and MDM2 By similarity

Compositional bias

5 – 10

Poly-Gln

Sites

Active site

223

Nucleophile By similarity

Active site

464

Proton acceptor By similarity

Natural variations

Alternative sequence

632 – 677

TKRPA…GATLP → KRNSSSSSSITWSTGIVAKD KMLIILISTPVGTIYSQLVF LESGHS in isoform 3.

VSP_021955

Alternative sequence

678 – 1101

424

Missing in isoform 3.

VSP_021956

Alternative sequence

683 – 687

HDVML → RKLMC in isoform 2.

VSP_021957

Alternative sequence

688 – 1101

414

Missing in isoform 2.

VSP_021958

Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 71A8FA4B02A4D2E9 Show »	FASTA	1,101	128,297
10 20 30 40 50 60 MNHHQQQQHQ KPGEQQLSEP EDMEMEAGDA DDPPRITQNP VINGNVAMAD GHNNTEEDME 70 80 90 100 110 120 DDTSWRSEAT FQFTVERFNR LSESVLSPPC FVRNLPWKIM VMPRLYPDRP HQKSVGFFLQ 130 140 150 160 170 180 CNAESDSTSW SCHAQAVLKI INYKDDEKSF SRRISHLFFH KENDWGFSNF MAWSEVTDPE 190 200 210 220 230 240 KGFIEEDKVT FEVYVQADAP HGVAWDSKKH TGYVGLKNQG ATCYMNSLLQ TLFFTNQLRK 250 260 270 280 290 300 AVYMMPTEGD DSSKSVPLAL QRVFYELQHS DKPVGTKKLT KSFGWETLDS FMQHDVQELC 310 320 330 340 350 360 RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKHVDYR SERIEDYYDI QLSIKGKKNI 370 380 390 400 410 420 FESFIDYVAV EQLDGDNKYD AGEHGLQEAE KGVKFLTLPP VLHLQLMRFM YDPQTDQNIK 430 440 450 460 470 480 INDRFEFPEQ LPLDEFLQKT DPKDPANYIL HAVLVHSGDN HGGHYVVYLN PKGDGKWCKF 490 500 510 520 530 540 DDDVVSRCTK EEAIEHNYGG HDDDLSVRHC TNAYMLVYIR ESKLSEVLQP VTDHDIPQQL 550 560 570 580 590 600 VERLQEEKRI EAQKRKERQE AHLYMQVQIV AEDQFCGHQG NDMYDEEKVK YTVFKVLKNS 610 620 630 640 650 660 TLTEFVQNLS QTMGFPQDQI RLWPMQARSN GTKRPAMLDN EADGNKTMIE LSDNENPWTI 670 680 690 700 710 720 FLETVDPEMA ATGATLPKFD KDHDVMLFLK MYDPKTRSLN YCGHIYTPIS CKIRDLLPVM 730 740 750 760 770 780 CERAGFPQET NLILYEEVKP NLTERIQDYD VSLDKALDEL MDGDIIVFQK DDPENDSSEL 790 800 810 820 830 840 PTAKEYFRDL YSRVDVIFCD KTIPNDPGFV VTLSNRMNYF QVAKTVAQRL NTDPMLLQFF 850 860 870 880 890 900 KSQGYRDGPG NPLRHNYEGT LRDLLQFFKP RQPKKLYYQQ LKMKITDFEN RRSFKCTWLN 910 920 930 940 950 960 SQFREEEITV YPDKHGCVRD LLEECKKVVE LSEKGSGKLR LLEIVSYKII GVHQEDELLE 970 980 990 1000 1010 1020 CLSPATSRTF RIEEIPLAQV DIDKENEMLI TVAHFHKEVF GTFGIPFLLR IHQGGHFREV 1030 1040 1050 1060 1070 1080 MKRIQTMLDI QEKEFEKFKF AIVMMGRHTY LNEDEYEVNL KDFEPQPGNM SHPRPWLGLD 1090 1100 HFNKAPKDRY TYLEKAYKIH N « Hide
Isoform 2 [UniParc]. Checksum: 52ED6FB5726DF487 Show »	FASTA	687	79,491
10 20 30 40 50 60 MNHHQQQQHQ KPGEQQLSEP EDMEMEAGDA DDPPRITQNP VINGNVAMAD GHNNTEEDME 70 80 90 100 110 120 DDTSWRSEAT FQFTVERFNR LSESVLSPPC FVRNLPWKIM VMPRLYPDRP HQKSVGFFLQ 130 140 150 160 170 180 CNAESDSTSW SCHAQAVLKI INYKDDEKSF SRRISHLFFH KENDWGFSNF MAWSEVTDPE 190 200 210 220 230 240 KGFIEEDKVT FEVYVQADAP HGVAWDSKKH TGYVGLKNQG ATCYMNSLLQ TLFFTNQLRK 250 260 270 280 290 300 AVYMMPTEGD DSSKSVPLAL QRVFYELQHS DKPVGTKKLT KSFGWETLDS FMQHDVQELC 310 320 330 340 350 360 RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKHVDYR SERIEDYYDI QLSIKGKKNI 370 380 390 400 410 420 FESFIDYVAV EQLDGDNKYD AGEHGLQEAE KGVKFLTLPP VLHLQLMRFM YDPQTDQNIK 430 440 450 460 470 480 INDRFEFPEQ LPLDEFLQKT DPKDPANYIL HAVLVHSGDN HGGHYVVYLN PKGDGKWCKF 490 500 510 520 530 540 DDDVVSRCTK EEAIEHNYGG HDDDLSVRHC TNAYMLVYIR ESKLSEVLQP VTDHDIPQQL 550 560 570 580 590 600 VERLQEEKRI EAQKRKERQE AHLYMQVQIV AEDQFCGHQG NDMYDEEKVK YTVFKVLKNS 610 620 630 640 650 660 TLTEFVQNLS QTMGFPQDQI RLWPMQARSN GTKRPAMLDN EADGNKTMIE LSDNENPWTI 670 680 FLETVDPEMA ATGATLPKFD KDRKLMC « Hide
Isoform 3 [UniParc]. Checksum: 1692F3128AE8521C Show »	FASTA	677	78,117
10 20 30 40 50 60 MNHHQQQQHQ KPGEQQLSEP EDMEMEAGDA DDPPRITQNP VINGNVAMAD GHNNTEEDME 70 80 90 100 110 120 DDTSWRSEAT FQFTVERFNR LSESVLSPPC FVRNLPWKIM VMPRLYPDRP HQKSVGFFLQ 130 140 150 160 170 180 CNAESDSTSW SCHAQAVLKI INYKDDEKSF SRRISHLFFH KENDWGFSNF MAWSEVTDPE 190 200 210 220 230 240 KGFIEEDKVT FEVYVQADAP HGVAWDSKKH TGYVGLKNQG ATCYMNSLLQ TLFFTNQLRK 250 260 270 280 290 300 AVYMMPTEGD DSSKSVPLAL QRVFYELQHS DKPVGTKKLT KSFGWETLDS FMQHDVQELC 310 320 330 340 350 360 RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKHVDYR SERIEDYYDI QLSIKGKKNI 370 380 390 400 410 420 FESFIDYVAV EQLDGDNKYD AGEHGLQEAE KGVKFLTLPP VLHLQLMRFM YDPQTDQNIK 430 440 450 460 470 480 INDRFEFPEQ LPLDEFLQKT DPKDPANYIL HAVLVHSGDN HGGHYVVYLN PKGDGKWCKF 490 500 510 520 530 540 DDDVVSRCTK EEAIEHNYGG HDDDLSVRHC TNAYMLVYIR ESKLSEVLQP VTDHDIPQQL 550 560 570 580 590 600 VERLQEEKRI EAQKRKERQE AHLYMQVQIV AEDQFCGHQG NDMYDEEKVK YTVFKVLKNS 610 620 630 640 650 660 TLTEFVQNLS QTMGFPQDQI RLWPMQARSN GKRNSSSSSS ITWSTGIVAK DKMLIILIST 670 PVGTIYSQLV FLESGHS « Hide

References

[1]	"Ubiquitin-specific protease in chick." Lee M.H., Chung C.H. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Skeletal muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY376869 mRNA. Translation: AAQ74886.1. AY376870 mRNA. Translation: AAQ74887.1. AY376871 mRNA. Translation: AAQ74888.1.
IPI	IPI00819098. IPI00819855. IPI00821642.
RefSeq	NP_989802.1. NM_204471.1.
UniGene	Gga.9341.
3D structure databases
HSSP	HSSP built from PDB template 1NB8 based on UniProtKB Q93009.
ProteinModelPortal	Q6U7I1.
SMR	Q6U7I1. Positions 63-554.
ModBase	Search...
Protein family/group databases
MEROPS	C19.016.
Proteomic databases
PaxDb	Q6U7I1.
PRIDE	Q6U7I1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	395126.
KEGG	gga:395126.
Organism-specific databases
CTD	7874.
Phylogenomic databases
eggNOG	COG5077.
HOGENOM	HOG000160240.
HOVERGEN	HBG018029.
KO	K11838.
Family and domain databases
InterPro	IPR002083. MATH. IPR024729. Pept_C19_dom. IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. IPR008974. TRAF-like. [Graphical view]
Pfam	PF00917. MATH. 1 hit. PF00443. UCH. 1 hit. PF12436. USP7. 1 hit. [Graphical view]
SMART	SM00061. MATH. 1 hit. [Graphical view]
SUPFAM	SSF49599. Traf_like. 1 hit.
PROSITE	PS50144. MATH. 1 hit. PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20815218.

Entry information

Entry name

UBP7_CHICK

Accession

Primary (citable) accession number: Q6U7I1
Secondary accession number(s): Q6U7I2, Q6U7I3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents