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Protein

Ubiquitin carboxyl-terminal hydrolase 7

Gene

USP7

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolase that deubiquitinates target proteins. May induces p53/TP53-dependent cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei223 – 2231NucleophilePROSITE-ProRule annotation
Active sitei464 – 4641Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. protein deubiquitination Source: UniProtKB
  3. regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Gene namesi
Name:USP7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. NucleusPML body By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB
  3. PML body Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11011101Ubiquitin carboxyl-terminal hydrolase 7PRO_0000268008Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity
Polyneddylated.By similarity
Polyubiquitinated.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6U7I1.
PRIDEiQ6U7I1.

Structurei

3D structure databases

ProteinModelPortaliQ6U7I1.
SMRiQ6U7I1. Positions 63-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 195128MATHPROSITE-ProRule annotationAdd
BLAST
Domaini214 – 521308USPAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 208156Interaction with p53/TP53 and MDM2By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 106Poly-Gln

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 MATH domain.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000160240.
HOVERGENiHBG018029.
InParanoidiQ6U7I1.
KOiK11838.
PhylomeDBiQ6U7I1.

Family and domain databases

InterProiIPR002083. MATH.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6U7I1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNHHQQQQHQ KPGEQQLSEP EDMEMEAGDA DDPPRITQNP VINGNVAMAD
60 70 80 90 100
GHNNTEEDME DDTSWRSEAT FQFTVERFNR LSESVLSPPC FVRNLPWKIM
110 120 130 140 150
VMPRLYPDRP HQKSVGFFLQ CNAESDSTSW SCHAQAVLKI INYKDDEKSF
160 170 180 190 200
SRRISHLFFH KENDWGFSNF MAWSEVTDPE KGFIEEDKVT FEVYVQADAP
210 220 230 240 250
HGVAWDSKKH TGYVGLKNQG ATCYMNSLLQ TLFFTNQLRK AVYMMPTEGD
260 270 280 290 300
DSSKSVPLAL QRVFYELQHS DKPVGTKKLT KSFGWETLDS FMQHDVQELC
310 320 330 340 350
RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKHVDYR SERIEDYYDI
360 370 380 390 400
QLSIKGKKNI FESFIDYVAV EQLDGDNKYD AGEHGLQEAE KGVKFLTLPP
410 420 430 440 450
VLHLQLMRFM YDPQTDQNIK INDRFEFPEQ LPLDEFLQKT DPKDPANYIL
460 470 480 490 500
HAVLVHSGDN HGGHYVVYLN PKGDGKWCKF DDDVVSRCTK EEAIEHNYGG
510 520 530 540 550
HDDDLSVRHC TNAYMLVYIR ESKLSEVLQP VTDHDIPQQL VERLQEEKRI
560 570 580 590 600
EAQKRKERQE AHLYMQVQIV AEDQFCGHQG NDMYDEEKVK YTVFKVLKNS
610 620 630 640 650
TLTEFVQNLS QTMGFPQDQI RLWPMQARSN GTKRPAMLDN EADGNKTMIE
660 670 680 690 700
LSDNENPWTI FLETVDPEMA ATGATLPKFD KDHDVMLFLK MYDPKTRSLN
710 720 730 740 750
YCGHIYTPIS CKIRDLLPVM CERAGFPQET NLILYEEVKP NLTERIQDYD
760 770 780 790 800
VSLDKALDEL MDGDIIVFQK DDPENDSSEL PTAKEYFRDL YSRVDVIFCD
810 820 830 840 850
KTIPNDPGFV VTLSNRMNYF QVAKTVAQRL NTDPMLLQFF KSQGYRDGPG
860 870 880 890 900
NPLRHNYEGT LRDLLQFFKP RQPKKLYYQQ LKMKITDFEN RRSFKCTWLN
910 920 930 940 950
SQFREEEITV YPDKHGCVRD LLEECKKVVE LSEKGSGKLR LLEIVSYKII
960 970 980 990 1000
GVHQEDELLE CLSPATSRTF RIEEIPLAQV DIDKENEMLI TVAHFHKEVF
1010 1020 1030 1040 1050
GTFGIPFLLR IHQGGHFREV MKRIQTMLDI QEKEFEKFKF AIVMMGRHTY
1060 1070 1080 1090 1100
LNEDEYEVNL KDFEPQPGNM SHPRPWLGLD HFNKAPKDRY TYLEKAYKIH

N
Length:1,101
Mass (Da):128,297
Last modified:July 5, 2004 - v1
Checksum:i71A8FA4B02A4D2E9
GO
Isoform 2 (identifier: Q6U7I1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     683-687: HDVML → RKLMC
     688-1101: Missing.

Note: No experimental confirmation available.

Show »
Length:687
Mass (Da):79,491
Checksum:i52ED6FB5726DF487
GO
Isoform 3 (identifier: Q6U7I1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-677: TKRPAMLDNE...EMAATGATLP → KRNSSSSSSI...QLVFLESGHS
     678-1101: Missing.

Note: No experimental confirmation available.

Show »
Length:677
Mass (Da):78,117
Checksum:i1692F3128AE8521C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei632 – 67746TKRPA…GATLP → KRNSSSSSSITWSTGIVAKD KMLIILISTPVGTIYSQLVF LESGHS in isoform 3. 1 PublicationVSP_021955Add
BLAST
Alternative sequencei678 – 1101424Missing in isoform 3. 1 PublicationVSP_021956Add
BLAST
Alternative sequencei683 – 6875HDVML → RKLMC in isoform 2. 1 PublicationVSP_021957
Alternative sequencei688 – 1101414Missing in isoform 2. 1 PublicationVSP_021958Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY376869 mRNA. Translation: AAQ74886.1.
AY376870 mRNA. Translation: AAQ74887.1.
AY376871 mRNA. Translation: AAQ74888.1.
RefSeqiNP_989802.1. NM_204471.1. [Q6U7I1-1]
UniGeneiGga.9341.

Genome annotation databases

GeneIDi395126.
KEGGigga:395126.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY376869 mRNA. Translation: AAQ74886.1.
AY376870 mRNA. Translation: AAQ74887.1.
AY376871 mRNA. Translation: AAQ74888.1.
RefSeqiNP_989802.1. NM_204471.1. [Q6U7I1-1]
UniGeneiGga.9341.

3D structure databases

ProteinModelPortaliQ6U7I1.
SMRiQ6U7I1. Positions 63-554.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC19.016.

Proteomic databases

PaxDbiQ6U7I1.
PRIDEiQ6U7I1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395126.
KEGGigga:395126.

Organism-specific databases

CTDi7874.

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000160240.
HOVERGENiHBG018029.
InParanoidiQ6U7I1.
KOiK11838.
PhylomeDBiQ6U7I1.

Miscellaneous databases

NextBioi20815218.
PROiQ6U7I1.

Family and domain databases

InterProiIPR002083. MATH.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Ubiquitin-specific protease in chick."
    Lee M.H., Chung C.H.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiUBP7_CHICK
AccessioniPrimary (citable) accession number: Q6U7I1
Secondary accession number(s): Q6U7I2, Q6U7I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: March 4, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.