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Q6U7I1 (UBP7_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 7

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Gene names
Name:USP7
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length1101 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hydrolase that deubiquitinates target proteins. May induces p53/TP53-dependent cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. NucleusPML body By similarity.

Post-translational modification

Phosphorylated By similarity.

Polyneddylated By similarity.

Polyubiquitinated By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 MATH domain.

Contains 1 USP domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6U7I1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6U7I1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     683-687: HDVML → RKLMC
     688-1101: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q6U7I1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     632-677: TKRPAMLDNE...EMAATGATLP → KRNSSSSSSI...QLVFLESGHS
     678-1101: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11011101Ubiquitin carboxyl-terminal hydrolase 7
PRO_0000268008

Regions

Domain68 – 195128MATH
Domain214 – 521308USP
Region53 – 208156Interaction with p53/TP53 and MDM2 By similarity
Compositional bias5 – 106Poly-Gln

Sites

Active site2231Nucleophile By similarity
Active site4641Proton acceptor By similarity

Natural variations

Alternative sequence632 – 67746TKRPA…GATLP → KRNSSSSSSITWSTGIVAKD KMLIILISTPVGTIYSQLVF LESGHS in isoform 3.
VSP_021955
Alternative sequence678 – 1101424Missing in isoform 3.
VSP_021956
Alternative sequence683 – 6875HDVML → RKLMC in isoform 2.
VSP_021957
Alternative sequence688 – 1101414Missing in isoform 2.
VSP_021958

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 71A8FA4B02A4D2E9

FASTA1,101128,297
        10         20         30         40         50         60 
MNHHQQQQHQ KPGEQQLSEP EDMEMEAGDA DDPPRITQNP VINGNVAMAD GHNNTEEDME 

        70         80         90        100        110        120 
DDTSWRSEAT FQFTVERFNR LSESVLSPPC FVRNLPWKIM VMPRLYPDRP HQKSVGFFLQ 

       130        140        150        160        170        180 
CNAESDSTSW SCHAQAVLKI INYKDDEKSF SRRISHLFFH KENDWGFSNF MAWSEVTDPE 

       190        200        210        220        230        240 
KGFIEEDKVT FEVYVQADAP HGVAWDSKKH TGYVGLKNQG ATCYMNSLLQ TLFFTNQLRK 

       250        260        270        280        290        300 
AVYMMPTEGD DSSKSVPLAL QRVFYELQHS DKPVGTKKLT KSFGWETLDS FMQHDVQELC 

       310        320        330        340        350        360 
RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKHVDYR SERIEDYYDI QLSIKGKKNI 

       370        380        390        400        410        420 
FESFIDYVAV EQLDGDNKYD AGEHGLQEAE KGVKFLTLPP VLHLQLMRFM YDPQTDQNIK 

       430        440        450        460        470        480 
INDRFEFPEQ LPLDEFLQKT DPKDPANYIL HAVLVHSGDN HGGHYVVYLN PKGDGKWCKF 

       490        500        510        520        530        540 
DDDVVSRCTK EEAIEHNYGG HDDDLSVRHC TNAYMLVYIR ESKLSEVLQP VTDHDIPQQL 

       550        560        570        580        590        600 
VERLQEEKRI EAQKRKERQE AHLYMQVQIV AEDQFCGHQG NDMYDEEKVK YTVFKVLKNS 

       610        620        630        640        650        660 
TLTEFVQNLS QTMGFPQDQI RLWPMQARSN GTKRPAMLDN EADGNKTMIE LSDNENPWTI 

       670        680        690        700        710        720 
FLETVDPEMA ATGATLPKFD KDHDVMLFLK MYDPKTRSLN YCGHIYTPIS CKIRDLLPVM 

       730        740        750        760        770        780 
CERAGFPQET NLILYEEVKP NLTERIQDYD VSLDKALDEL MDGDIIVFQK DDPENDSSEL 

       790        800        810        820        830        840 
PTAKEYFRDL YSRVDVIFCD KTIPNDPGFV VTLSNRMNYF QVAKTVAQRL NTDPMLLQFF 

       850        860        870        880        890        900 
KSQGYRDGPG NPLRHNYEGT LRDLLQFFKP RQPKKLYYQQ LKMKITDFEN RRSFKCTWLN 

       910        920        930        940        950        960 
SQFREEEITV YPDKHGCVRD LLEECKKVVE LSEKGSGKLR LLEIVSYKII GVHQEDELLE 

       970        980        990       1000       1010       1020 
CLSPATSRTF RIEEIPLAQV DIDKENEMLI TVAHFHKEVF GTFGIPFLLR IHQGGHFREV 

      1030       1040       1050       1060       1070       1080 
MKRIQTMLDI QEKEFEKFKF AIVMMGRHTY LNEDEYEVNL KDFEPQPGNM SHPRPWLGLD 

      1090       1100 
HFNKAPKDRY TYLEKAYKIH N 

« Hide

Isoform 2 [UniParc].

Checksum: 52ED6FB5726DF487
Show »

FASTA68779,491
Isoform 3 [UniParc].

Checksum: 1692F3128AE8521C
Show »

FASTA67778,117

References

[1]"Ubiquitin-specific protease in chick."
Lee M.H., Chung C.H.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Skeletal muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY376869 mRNA. Translation: AAQ74886.1.
AY376870 mRNA. Translation: AAQ74887.1.
AY376871 mRNA. Translation: AAQ74888.1.
RefSeqNP_989802.1. NM_204471.1. [Q6U7I1-1]
UniGeneGga.9341.

3D structure databases

ProteinModelPortalQ6U7I1.
SMRQ6U7I1. Positions 63-554.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC19.016.

Proteomic databases

PaxDbQ6U7I1.
PRIDEQ6U7I1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395126.
KEGGgga:395126.

Organism-specific databases

CTD7874.

Phylogenomic databases

eggNOGCOG5077.
HOGENOMHOG000160240.
HOVERGENHBG018029.
KOK11838.
PhylomeDBQ6U7I1.

Family and domain databases

InterProIPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view]
PfamPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMSSF49599. SSF49599. 1 hit.
PROSITEPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815218.
PROQ6U7I1.

Entry information

Entry nameUBP7_CHICK
AccessionPrimary (citable) accession number: Q6U7I1
Secondary accession number(s): Q6U7I2, Q6U7I3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries