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Protein

Opsin-5

Gene

OPN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological process
LigandChromophore

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-419771 Opsins

Names & Taxonomyi

Protein namesi
Recommended name:
Opsin-5
Alternative name(s):
G-protein coupled receptor 136
G-protein coupled receptor PGR12
Neuropsin
Transmembrane protein 13
Gene namesi
Name:OPN5
Synonyms:GPR136, PGR12, TMEM13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124818.14
HGNCiHGNC:19992 OPN5
MIMi609042 gene
neXtProtiNX_Q6U736

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 74CytoplasmicSequence analysisAdd BLAST20
Transmembranei75 – 95Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini96 – 108ExtracellularSequence analysisAdd BLAST13
Transmembranei109 – 129Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini130 – 150CytoplasmicSequence analysisAdd BLAST21
Transmembranei151 – 171Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini172 – 197ExtracellularSequence analysisAdd BLAST26
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 252CytoplasmicSequence analysisAdd BLAST34
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 288ExtracellularSequence analysisAdd BLAST15
Transmembranei289 – 309Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini310 – 353CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi221391
OpenTargetsiENSG00000124818
PharmGKBiPA134942887

Polymorphism and mutation databases

BioMutaiOPN5
DMDMi116242690

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978171 – 354Opsin-5Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation
Modified residuei296N6-(retinylidene)lysine1
Lipidationi315S-palmitoyl cysteineSequence analysis1
Lipidationi316S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

It is uncertain whether Cys-315 or Cys-316 is palmitoylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ6U736
PRIDEiQ6U736
ProteomicsDBi67396

PTM databases

iPTMnetiQ6U736
PhosphoSitePlusiQ6U736

Expressioni

Tissue specificityi

Detected in brain and retina and cell lines derived from neural retina.1 Publication

Gene expression databases

BgeeiENSG00000124818
CleanExiHS_OPN5
ExpressionAtlasiQ6U736 baseline and differential
GenevisibleiQ6U736 HS

Organism-specific databases

HPAiHPA026084

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360255

Structurei

3D structure databases

ProteinModelPortaliQ6U736
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
HOGENOMiHOG000115272
HOVERGENiHBG058348
InParanoidiQ6U736
KOiK08385
PhylomeDBiQ6U736
TreeFamiTF324998

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002962 Peropsin
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01244 PEROPSIN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q6U736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALNHTALPQ DERLPHYLRD GDPFASKLSW EADLVAGFYL TIIGILSTFG
60 70 80 90 100
NGYVLYMSSR RKKKLRPAEI MTINLAVCDL GISVVGKPFT IISCFCHRWV
110 120 130 140 150
FGWIGCRWYG WAGFFFGCGS LITMTAVSLD RYLKICYLSY GVWLKRKHAY
160 170 180 190 200
ICLAAIWAYA SFWTTMPLVG LGDYVPEPFG TSCTLDWWLA QASVGGQVFI
210 220 230 240 250
LNILFFCLLL PTAVIVFSYV KIIAKVKSSS KEVAHFDSRI HSSHVLEMKL
260 270 280 290 300
TKVAMLICAG FLIAWIPYAV VSVWSAFGRP DSIPIQLSVV PTLLAKSAAM
310 320 330 340 350
YNPIIYQVID YKFACCQTGG LKATKKKSLE GFRLHTVTTV RKSSAVLEIH

EEWE
Length:354
Mass (Da):39,727
Last modified:October 17, 2006 - v3
Checksum:iBBF03FA2C0741005
GO

Sequence cautioni

The sequence CAI20454 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84 – 86Missing in AAP72128 (PubMed:14623098).Curated3
Sequence conflicti133 – 145Missing in AAO85127 (PubMed:12679517).CuratedAdd BLAST13
Sequence conflicti353 – 354WE → V in AAP72128 (PubMed:14623098).Curated2
Sequence conflicti353 – 354WE → V in CAI20454 (PubMed:14574404).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY377391 mRNA Translation: AAR21109.1
AY288419 mRNA Translation: AAP72128.1
AY255615 mRNA Translation: AAO85127.1
AL356421 Genomic DNA No translation available.
AL161622 Genomic DNA Translation: CAI20454.1 Sequence problems.
BC126194 mRNA Translation: AAI26195.1
BC126198 mRNA Translation: AAI26199.1
CCDSiCCDS4923.1
RefSeqiNP_859528.1, NM_181744.3
UniGeneiHs.213717

Genome annotation databases

EnsembliENST00000371211; ENSP00000360255; ENSG00000124818
ENST00000638973; ENSP00000491960; ENSG00000124818
GeneIDi221391
KEGGihsa:221391
UCSCiuc003ozc.4 human

Similar proteinsi

Entry informationi

Entry nameiOPN5_HUMAN
AccessioniPrimary (citable) accession number: Q6U736
Secondary accession number(s): A0AV33
, Q5T5B9, Q5T886, Q7Z603, Q86SL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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