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Q6U736

- OPN5_HUMAN

UniProt

Q6U736 - OPN5_HUMAN

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Protein

Opsin-5

Gene

OPN5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. photoreceptor activity Source: UniProtKB-KW

GO - Biological processi

  1. phototransduction Source: UniProtKB-KW
  2. protein-chromophore linkage Source: UniProtKB-KW
  3. visual perception Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Keywords - Ligandi

Chromophore

Enzyme and pathway databases

ReactomeiREACT_18426. Opsins.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Opsin-5
Alternative name(s):
G-protein coupled receptor 136
G-protein coupled receptor PGR12
Neuropsin
Transmembrane protein 13
Gene namesi
Name:OPN5
Synonyms:GPR136, PGR12, TMEM13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:19992. OPN5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularSequence AnalysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini55 – 7420CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini96 – 10813ExtracellularSequence AnalysisAdd
BLAST
Transmembranei109 – 12921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini130 – 15021CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei151 – 17121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini172 – 19726ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 25234CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini274 – 28815ExtracellularSequence AnalysisAdd
BLAST
Transmembranei289 – 30921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini310 – 35344CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134942887.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Opsin-5PRO_0000197817Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation
Modified residuei296 – 2961N6-(retinylidene)lysine
Lipidationi315 – 3151S-palmitoyl cysteineSequence Analysis
Lipidationi316 – 3161S-palmitoyl cysteineSequence Analysis

Post-translational modificationi

It is uncertain whether Cys-315 or Cys-316 is palmitoylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ6U736.
PRIDEiQ6U736.

PTM databases

PhosphoSiteiQ6U736.

Expressioni

Tissue specificityi

Detected in brain and retina and cell lines derived from neural retina.1 Publication

Gene expression databases

BgeeiQ6U736.
CleanExiHS_OPN5.
ExpressionAtlasiQ6U736. baseline.
GenevestigatoriQ6U736.

Structurei

3D structure databases

ProteinModelPortaliQ6U736.
SMRiQ6U736. Positions 56-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG145389.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000115272.
HOVERGENiHBG058348.
InParanoidiQ6U736.
KOiK08385.
PhylomeDBiQ6U736.
TreeFamiTF324998.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002962. Peropsin.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01244. PEROPSIN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6U736-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALNHTALPQ DERLPHYLRD GDPFASKLSW EADLVAGFYL TIIGILSTFG
60 70 80 90 100
NGYVLYMSSR RKKKLRPAEI MTINLAVCDL GISVVGKPFT IISCFCHRWV
110 120 130 140 150
FGWIGCRWYG WAGFFFGCGS LITMTAVSLD RYLKICYLSY GVWLKRKHAY
160 170 180 190 200
ICLAAIWAYA SFWTTMPLVG LGDYVPEPFG TSCTLDWWLA QASVGGQVFI
210 220 230 240 250
LNILFFCLLL PTAVIVFSYV KIIAKVKSSS KEVAHFDSRI HSSHVLEMKL
260 270 280 290 300
TKVAMLICAG FLIAWIPYAV VSVWSAFGRP DSIPIQLSVV PTLLAKSAAM
310 320 330 340 350
YNPIIYQVID YKFACCQTGG LKATKKKSLE GFRLHTVTTV RKSSAVLEIH

EEWE
Length:354
Mass (Da):39,727
Last modified:October 17, 2006 - v3
Checksum:iBBF03FA2C0741005
GO

Sequence cautioni

The sequence CAI20454.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti84 – 863Missing in AAP72128. (PubMed:14623098)Curated
Sequence conflicti133 – 14513Missing in AAO85127. (PubMed:12679517)CuratedAdd
BLAST
Sequence conflicti353 – 3542WE → V in AAP72128. (PubMed:14623098)Curated
Sequence conflicti353 – 3542WE → V in CAI20454. (PubMed:14574404)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY377391 mRNA. Translation: AAR21109.1.
AY288419 mRNA. Translation: AAP72128.1.
AY255615 mRNA. Translation: AAO85127.1.
AL356421 Genomic DNA. No translation available.
AL161622 Genomic DNA. Translation: CAI20454.1. Sequence problems.
BC126194 mRNA. Translation: AAI26195.1.
BC126198 mRNA. Translation: AAI26199.1.
CCDSiCCDS4923.1.
RefSeqiNP_859528.1. NM_181744.3.
UniGeneiHs.213717.

Genome annotation databases

EnsembliENST00000371211; ENSP00000360255; ENSG00000124818.
GeneIDi221391.
KEGGihsa:221391.
UCSCiuc003ozc.3. human.

Polymorphism databases

DMDMi116242690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY377391 mRNA. Translation: AAR21109.1 .
AY288419 mRNA. Translation: AAP72128.1 .
AY255615 mRNA. Translation: AAO85127.1 .
AL356421 Genomic DNA. No translation available.
AL161622 Genomic DNA. Translation: CAI20454.1 . Sequence problems.
BC126194 mRNA. Translation: AAI26195.1 .
BC126198 mRNA. Translation: AAI26199.1 .
CCDSi CCDS4923.1.
RefSeqi NP_859528.1. NM_181744.3.
UniGenei Hs.213717.

3D structure databases

ProteinModelPortali Q6U736.
SMRi Q6U736. Positions 56-313.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q6U736.

Polymorphism databases

DMDMi 116242690.

Proteomic databases

PaxDbi Q6U736.
PRIDEi Q6U736.

Protocols and materials databases

DNASUi 221391.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371211 ; ENSP00000360255 ; ENSG00000124818 .
GeneIDi 221391.
KEGGi hsa:221391.
UCSCi uc003ozc.3. human.

Organism-specific databases

CTDi 221391.
GeneCardsi GC06P047749.
H-InvDB HIX0164996.
HGNCi HGNC:19992. OPN5.
MIMi 609042. gene.
neXtProti NX_Q6U736.
PharmGKBi PA134942887.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145389.
GeneTreei ENSGT00760000118977.
HOGENOMi HOG000115272.
HOVERGENi HBG058348.
InParanoidi Q6U736.
KOi K08385.
PhylomeDBi Q6U736.
TreeFami TF324998.

Enzyme and pathway databases

Reactomei REACT_18426. Opsins.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii OPN5.
GenomeRNAii 221391.
NextBioi 91301.
PROi Q6U736.
SOURCEi Search...

Gene expression databases

Bgeei Q6U736.
CleanExi HS_OPN5.
ExpressionAtlasi Q6U736. baseline.
Genevestigatori Q6U736.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002962. Peropsin.
IPR027430. Retinal_BS.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01244. PEROPSIN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue."
    Tarttelin E.E., Bellingham J., Hankins M.W., Foster R.G., Lucas R.J.
    FEBS Lett. 554:410-416(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
    Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
    FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 119-231.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiOPN5_HUMAN
AccessioniPrimary (citable) accession number: Q6U736
Secondary accession number(s): A0AV33
, Q5T5B9, Q5T886, Q7Z603, Q86SL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3