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Protein

Opsin-5

Gene

OPN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Keywords - Ligandi

Chromophore

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-419771. Opsins.

Names & Taxonomyi

Protein namesi
Recommended name:
Opsin-5
Alternative name(s):
G-protein coupled receptor 136
G-protein coupled receptor PGR12
Neuropsin
Transmembrane protein 13
Gene namesi
Name:OPN5
Synonyms:GPR136, PGR12, TMEM13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:19992. OPN5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 74CytoplasmicSequence analysisAdd BLAST20
Transmembranei75 – 95Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini96 – 108ExtracellularSequence analysisAdd BLAST13
Transmembranei109 – 129Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini130 – 150CytoplasmicSequence analysisAdd BLAST21
Transmembranei151 – 171Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini172 – 197ExtracellularSequence analysisAdd BLAST26
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 252CytoplasmicSequence analysisAdd BLAST34
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 288ExtracellularSequence analysisAdd BLAST15
Transmembranei289 – 309Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini310 – 353CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi221391.
OpenTargetsiENSG00000124818.
PharmGKBiPA134942887.

Polymorphism and mutation databases

BioMutaiOPN5.
DMDMi116242690.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978171 – 354Opsin-5Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation
Modified residuei296N6-(retinylidene)lysine1
Lipidationi315S-palmitoyl cysteineSequence analysis1
Lipidationi316S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

It is uncertain whether Cys-315 or Cys-316 is palmitoylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ6U736.
PRIDEiQ6U736.

PTM databases

iPTMnetiQ6U736.
PhosphoSitePlusiQ6U736.

Expressioni

Tissue specificityi

Detected in brain and retina and cell lines derived from neural retina.1 Publication

Gene expression databases

BgeeiENSG00000124818.
CleanExiHS_OPN5.
ExpressionAtlasiQ6U736. baseline and differential.
GenevisibleiQ6U736. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360255.

Structurei

3D structure databases

ProteinModelPortaliQ6U736.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000115272.
HOVERGENiHBG058348.
InParanoidiQ6U736.
KOiK08385.
PhylomeDBiQ6U736.
TreeFamiTF324998.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002962. Peropsin.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01244. PEROPSIN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6U736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALNHTALPQ DERLPHYLRD GDPFASKLSW EADLVAGFYL TIIGILSTFG
60 70 80 90 100
NGYVLYMSSR RKKKLRPAEI MTINLAVCDL GISVVGKPFT IISCFCHRWV
110 120 130 140 150
FGWIGCRWYG WAGFFFGCGS LITMTAVSLD RYLKICYLSY GVWLKRKHAY
160 170 180 190 200
ICLAAIWAYA SFWTTMPLVG LGDYVPEPFG TSCTLDWWLA QASVGGQVFI
210 220 230 240 250
LNILFFCLLL PTAVIVFSYV KIIAKVKSSS KEVAHFDSRI HSSHVLEMKL
260 270 280 290 300
TKVAMLICAG FLIAWIPYAV VSVWSAFGRP DSIPIQLSVV PTLLAKSAAM
310 320 330 340 350
YNPIIYQVID YKFACCQTGG LKATKKKSLE GFRLHTVTTV RKSSAVLEIH

EEWE
Length:354
Mass (Da):39,727
Last modified:October 17, 2006 - v3
Checksum:iBBF03FA2C0741005
GO

Sequence cautioni

The sequence CAI20454 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84 – 86Missing in AAP72128 (PubMed:14623098).Curated3
Sequence conflicti133 – 145Missing in AAO85127 (PubMed:12679517).CuratedAdd BLAST13
Sequence conflicti353 – 354WE → V in AAP72128 (PubMed:14623098).Curated2
Sequence conflicti353 – 354WE → V in CAI20454 (PubMed:14574404).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY377391 mRNA. Translation: AAR21109.1.
AY288419 mRNA. Translation: AAP72128.1.
AY255615 mRNA. Translation: AAO85127.1.
AL356421 Genomic DNA. No translation available.
AL161622 Genomic DNA. Translation: CAI20454.1. Sequence problems.
BC126194 mRNA. Translation: AAI26195.1.
BC126198 mRNA. Translation: AAI26199.1.
CCDSiCCDS4923.1.
RefSeqiNP_859528.1. NM_181744.3.
UniGeneiHs.213717.

Genome annotation databases

EnsembliENST00000371211; ENSP00000360255; ENSG00000124818.
GeneIDi221391.
KEGGihsa:221391.
UCSCiuc003ozc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY377391 mRNA. Translation: AAR21109.1.
AY288419 mRNA. Translation: AAP72128.1.
AY255615 mRNA. Translation: AAO85127.1.
AL356421 Genomic DNA. No translation available.
AL161622 Genomic DNA. Translation: CAI20454.1. Sequence problems.
BC126194 mRNA. Translation: AAI26195.1.
BC126198 mRNA. Translation: AAI26199.1.
CCDSiCCDS4923.1.
RefSeqiNP_859528.1. NM_181744.3.
UniGeneiHs.213717.

3D structure databases

ProteinModelPortaliQ6U736.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000360255.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ6U736.
PhosphoSitePlusiQ6U736.

Polymorphism and mutation databases

BioMutaiOPN5.
DMDMi116242690.

Proteomic databases

PaxDbiQ6U736.
PRIDEiQ6U736.

Protocols and materials databases

DNASUi221391.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371211; ENSP00000360255; ENSG00000124818.
GeneIDi221391.
KEGGihsa:221391.
UCSCiuc003ozc.4. human.

Organism-specific databases

CTDi221391.
DisGeNETi221391.
GeneCardsiOPN5.
H-InvDBHIX0164996.
HGNCiHGNC:19992. OPN5.
MIMi609042. gene.
neXtProtiNX_Q6U736.
OpenTargetsiENSG00000124818.
PharmGKBiPA134942887.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000115272.
HOVERGENiHBG058348.
InParanoidiQ6U736.
KOiK08385.
PhylomeDBiQ6U736.
TreeFamiTF324998.

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-419771. Opsins.

Miscellaneous databases

GeneWikiiOPN5.
GenomeRNAii221391.
PROiQ6U736.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124818.
CleanExiHS_OPN5.
ExpressionAtlasiQ6U736. baseline and differential.
GenevisibleiQ6U736. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002962. Peropsin.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01244. PEROPSIN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPN5_HUMAN
AccessioniPrimary (citable) accession number: Q6U736
Secondary accession number(s): A0AV33
, Q5T5B9, Q5T886, Q7Z603, Q86SL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.