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Q6U736

- OPN5_HUMAN

UniProt

Q6U736 - OPN5_HUMAN

Protein

Opsin-5

Gene

OPN5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. photoreceptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. phototransduction Source: UniProtKB-KW
    2. protein-chromophore linkage Source: UniProtKB-KW
    3. visual perception Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

    Keywords - Biological processi

    Keywords - Ligandi

    Chromophore

    Enzyme and pathway databases

    ReactomeiREACT_18426. Opsins.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Opsin-5
    Alternative name(s):
    G-protein coupled receptor 136
    G-protein coupled receptor PGR12
    Neuropsin
    Transmembrane protein 13
    Gene namesi
    Name:OPN5
    Synonyms:GPR136, PGR12, TMEM13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:19992. OPN5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134942887.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354Opsin-5PRO_0000197817Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 183PROSITE-ProRule annotation
    Modified residuei296 – 2961N6-(retinylidene)lysine
    Lipidationi315 – 3151S-palmitoyl cysteineSequence Analysis
    Lipidationi316 – 3161S-palmitoyl cysteineSequence Analysis

    Post-translational modificationi

    It is uncertain whether Cys-315 or Cys-316 is palmitoylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ6U736.
    PRIDEiQ6U736.

    PTM databases

    PhosphoSiteiQ6U736.

    Expressioni

    Tissue specificityi

    Detected in brain and retina and cell lines derived from neural retina.1 Publication

    Gene expression databases

    ArrayExpressiQ6U736.
    BgeeiQ6U736.
    CleanExiHS_OPN5.
    GenevestigatoriQ6U736.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6U736.
    SMRiQ6U736. Positions 56-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini55 – 7420CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini96 – 10813ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini130 – 15021CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 19726ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 25234CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini274 – 28815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini310 – 35344CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei289 – 30921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG145389.
    HOGENOMiHOG000115272.
    HOVERGENiHBG058348.
    InParanoidiQ6U736.
    KOiK08385.
    PhylomeDBiQ6U736.
    TreeFamiTF324998.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002962. Peropsin.
    IPR027430. Retinal_BS.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01244. PEROPSIN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6U736-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALNHTALPQ DERLPHYLRD GDPFASKLSW EADLVAGFYL TIIGILSTFG    50
    NGYVLYMSSR RKKKLRPAEI MTINLAVCDL GISVVGKPFT IISCFCHRWV 100
    FGWIGCRWYG WAGFFFGCGS LITMTAVSLD RYLKICYLSY GVWLKRKHAY 150
    ICLAAIWAYA SFWTTMPLVG LGDYVPEPFG TSCTLDWWLA QASVGGQVFI 200
    LNILFFCLLL PTAVIVFSYV KIIAKVKSSS KEVAHFDSRI HSSHVLEMKL 250
    TKVAMLICAG FLIAWIPYAV VSVWSAFGRP DSIPIQLSVV PTLLAKSAAM 300
    YNPIIYQVID YKFACCQTGG LKATKKKSLE GFRLHTVTTV RKSSAVLEIH 350
    EEWE 354
    Length:354
    Mass (Da):39,727
    Last modified:October 17, 2006 - v3
    Checksum:iBBF03FA2C0741005
    GO

    Sequence cautioni

    The sequence CAI20454.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti84 – 863Missing in AAP72128. (PubMed:14623098)Curated
    Sequence conflicti133 – 14513Missing in AAO85127. (PubMed:12679517)CuratedAdd
    BLAST
    Sequence conflicti353 – 3542WE → V in AAP72128. (PubMed:14623098)Curated
    Sequence conflicti353 – 3542WE → V in CAI20454. (PubMed:14574404)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY377391 mRNA. Translation: AAR21109.1.
    AY288419 mRNA. Translation: AAP72128.1.
    AY255615 mRNA. Translation: AAO85127.1.
    AL356421 Genomic DNA. No translation available.
    AL161622 Genomic DNA. Translation: CAI20454.1. Sequence problems.
    BC126194 mRNA. Translation: AAI26195.1.
    BC126198 mRNA. Translation: AAI26199.1.
    CCDSiCCDS4923.1.
    RefSeqiNP_859528.1. NM_181744.3.
    UniGeneiHs.213717.

    Genome annotation databases

    EnsembliENST00000371211; ENSP00000360255; ENSG00000124818.
    GeneIDi221391.
    KEGGihsa:221391.
    UCSCiuc003ozc.3. human.

    Polymorphism databases

    DMDMi116242690.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY377391 mRNA. Translation: AAR21109.1 .
    AY288419 mRNA. Translation: AAP72128.1 .
    AY255615 mRNA. Translation: AAO85127.1 .
    AL356421 Genomic DNA. No translation available.
    AL161622 Genomic DNA. Translation: CAI20454.1 . Sequence problems.
    BC126194 mRNA. Translation: AAI26195.1 .
    BC126198 mRNA. Translation: AAI26199.1 .
    CCDSi CCDS4923.1.
    RefSeqi NP_859528.1. NM_181744.3.
    UniGenei Hs.213717.

    3D structure databases

    ProteinModelPortali Q6U736.
    SMRi Q6U736. Positions 56-313.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q6U736.

    Polymorphism databases

    DMDMi 116242690.

    Proteomic databases

    PaxDbi Q6U736.
    PRIDEi Q6U736.

    Protocols and materials databases

    DNASUi 221391.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371211 ; ENSP00000360255 ; ENSG00000124818 .
    GeneIDi 221391.
    KEGGi hsa:221391.
    UCSCi uc003ozc.3. human.

    Organism-specific databases

    CTDi 221391.
    GeneCardsi GC06P047749.
    H-InvDB HIX0164996.
    HGNCi HGNC:19992. OPN5.
    MIMi 609042. gene.
    neXtProti NX_Q6U736.
    PharmGKBi PA134942887.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145389.
    HOGENOMi HOG000115272.
    HOVERGENi HBG058348.
    InParanoidi Q6U736.
    KOi K08385.
    PhylomeDBi Q6U736.
    TreeFami TF324998.

    Enzyme and pathway databases

    Reactomei REACT_18426. Opsins.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii OPN5.
    GenomeRNAii 221391.
    NextBioi 91301.
    PROi Q6U736.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6U736.
    Bgeei Q6U736.
    CleanExi HS_OPN5.
    Genevestigatori Q6U736.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002962. Peropsin.
    IPR027430. Retinal_BS.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01244. PEROPSIN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue."
      Tarttelin E.E., Bellingham J., Hankins M.W., Foster R.G., Lucas R.J.
      FEBS Lett. 554:410-416(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
      Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
      FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 119-231.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiOPN5_HUMAN
    AccessioniPrimary (citable) accession number: Q6U736
    Secondary accession number(s): A0AV33
    , Q5T5B9, Q5T886, Q7Z603, Q86SL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 95 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3