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Q6U736 (OPN5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Opsin-5
Alternative name(s):
G-protein coupled receptor 136
G-protein coupled receptor PGR12
Neuropsin
Transmembrane protein 13
Gene names
Name:OPN5
Synonyms:GPR136, PGR12, TMEM13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Detected in brain and retina and cell lines derived from neural retina. Ref.1

Post-translational modification

It is uncertain whether Cys-315 or Cys-316 is palmitoylated.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Sequence caution

The sequence CAI20454.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Opsin-5
PRO_0000197817

Regions

Topological domain1 – 3333Extracellular Potential
Transmembrane34 – 5421Helical; Name=1; Potential
Topological domain55 – 7420Cytoplasmic Potential
Transmembrane75 – 9521Helical; Name=2; Potential
Topological domain96 – 10813Extracellular Potential
Transmembrane109 – 12921Helical; Name=3; Potential
Topological domain130 – 15021Cytoplasmic Potential
Transmembrane151 – 17121Helical; Name=4; Potential
Topological domain172 – 19726Extracellular Potential
Transmembrane198 – 21821Helical; Name=5; Potential
Topological domain219 – 25234Cytoplasmic Potential
Transmembrane253 – 27321Helical; Name=6; Potential
Topological domain274 – 28815Extracellular Potential
Transmembrane289 – 30921Helical; Name=7; Potential
Topological domain310 – 35344Cytoplasmic Potential

Amino acid modifications

Modified residue2961N6-(retinylidene)lysine
Lipidation3151S-palmitoyl cysteine Potential
Lipidation3161S-palmitoyl cysteine Potential
Glycosylation41N-linked (GlcNAc...) Potential
Disulfide bond106 ↔ 183 Potential

Experimental info

Sequence conflict84 – 863Missing in AAP72128. Ref.2
Sequence conflict133 – 14513Missing in AAO85127. Ref.3
Sequence conflict353 – 3542WE → V in AAP72128. Ref.2
Sequence conflict353 – 3542WE → V in CAI20454. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q6U736 [UniParc].

Last modified October 17, 2006. Version 3.
Checksum: BBF03FA2C0741005

FASTA35439,727
        10         20         30         40         50         60 
MALNHTALPQ DERLPHYLRD GDPFASKLSW EADLVAGFYL TIIGILSTFG NGYVLYMSSR 

        70         80         90        100        110        120 
RKKKLRPAEI MTINLAVCDL GISVVGKPFT IISCFCHRWV FGWIGCRWYG WAGFFFGCGS 

       130        140        150        160        170        180 
LITMTAVSLD RYLKICYLSY GVWLKRKHAY ICLAAIWAYA SFWTTMPLVG LGDYVPEPFG 

       190        200        210        220        230        240 
TSCTLDWWLA QASVGGQVFI LNILFFCLLL PTAVIVFSYV KIIAKVKSSS KEVAHFDSRI 

       250        260        270        280        290        300 
HSSHVLEMKL TKVAMLICAG FLIAWIPYAV VSVWSAFGRP DSIPIQLSVV PTLLAKSAAM 

       310        320        330        340        350 
YNPIIYQVID YKFACCQTGG LKATKKKSLE GFRLHTVTTV RKSSAVLEIH EEWE 

« Hide

References

« Hide 'large scale' references
[1]"Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue."
Tarttelin E.E., Bellingham J., Hankins M.W., Foster R.G., Lucas R.J.
FEBS Lett. 554:410-416(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 119-231.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY377391 mRNA. Translation: AAR21109.1.
AY288419 mRNA. Translation: AAP72128.1.
AY255615 mRNA. Translation: AAO85127.1.
AL356421 Genomic DNA. No translation available.
AL161622 Genomic DNA. Translation: CAI20454.1. Sequence problems.
BC126194 mRNA. Translation: AAI26195.1.
BC126198 mRNA. Translation: AAI26199.1.
CCDSCCDS4923.1.
RefSeqNP_859528.1. NM_181744.3.
UniGeneHs.213717.

3D structure databases

ProteinModelPortalQ6U736.
SMRQ6U736. Positions 56-313.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ6U736.

Polymorphism databases

DMDM116242690.

Proteomic databases

PaxDbQ6U736.
PRIDEQ6U736.

Protocols and materials databases

DNASU221391.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371211; ENSP00000360255; ENSG00000124818.
GeneID221391.
KEGGhsa:221391.
UCSCuc003ozc.3. human.

Organism-specific databases

CTD221391.
GeneCardsGC06P047749.
H-InvDBHIX0164996.
HGNCHGNC:19992. OPN5.
MIM609042. gene.
neXtProtNX_Q6U736.
PharmGKBPA134942887.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG145389.
HOGENOMHOG000115272.
HOVERGENHBG058348.
InParanoidQ6U736.
KOK08385.
PhylomeDBQ6U736.
TreeFamTF324998.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ6U736.
BgeeQ6U736.
CleanExHS_OPN5.
GenevestigatorQ6U736.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002962. Peropsin.
IPR027430. Retinal_BS.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01244. PEROPSIN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOPN5.
GenomeRNAi221391.
NextBio91301.
PROQ6U736.
SOURCESearch...

Entry information

Entry nameOPN5_HUMAN
AccessionPrimary (citable) accession number: Q6U736
Secondary accession number(s): A0AV33 expand/collapse secondary AC list , Q5T5B9, Q5T886, Q7Z603, Q86SL5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries