Q6U736 (OPN5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Opsin-5

Alternative name(s):
G-protein coupled receptor 136
G-protein coupled receptor PGR12
Neuropsin
Transmembrane protein 13

Gene names

Name:	OPN5
Synonyms:	GPR136, PGR12, TMEM13

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Detected in brain and retina and cell lines derived from neural retina. Ref.1
Post-translational modification	It is uncertain whether Cys-315 or Cys-316 is palmitoylated.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Sequence caution	The sequence CAI20454.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Sensory transduction
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Chromophore
Molecular function	G-protein coupled receptor Photoreceptor protein Receptor Retinal protein Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phototransduction Inferred from electronic annotation. Source: UniProtKB-KW protein-chromophore linkage Inferred from electronic annotation. Source: UniProtKB-KW visual perception Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW photoreceptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Opsin-5		PRO_0000197817
Regions
	Topological domain	1 – 33	33	Extracellular Potential
	Transmembrane	34 – 54	21	Helical; Name=1; Potential
	Topological domain	55 – 74	20	Cytoplasmic Potential
	Transmembrane	75 – 95	21	Helical; Name=2; Potential
	Topological domain	96 – 108	13	Extracellular Potential
	Transmembrane	109 – 129	21	Helical; Name=3; Potential
	Topological domain	130 – 150	21	Cytoplasmic Potential
	Transmembrane	151 – 171	21	Helical; Name=4; Potential
	Topological domain	172 – 197	26	Extracellular Potential
	Transmembrane	198 – 218	21	Helical; Name=5; Potential
	Topological domain	219 – 252	34	Cytoplasmic Potential
	Transmembrane	253 – 273	21	Helical; Name=6; Potential
	Topological domain	274 – 288	15	Extracellular Potential
	Transmembrane	289 – 309	21	Helical; Name=7; Potential
	Topological domain	310 – 353	44	Cytoplasmic Potential
Amino acid modifications
	Modified residue	296	1	N6-(retinylidene)lysine
	Lipidation	315	1	S-palmitoyl cysteine Potential
	Lipidation	316	1	S-palmitoyl cysteine Potential
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Disulfide bond	106 ↔ 183		Potential
Experimental info
	Sequence conflict	84 – 86	3	Missing in AAP72128. Ref.2
	Sequence conflict	133 – 145	13	Missing in AAO85127. Ref.3
	Sequence conflict	353 – 354	2	WE → V in AAP72128. Ref.2
	Sequence conflict	353 – 354	2	WE → V in CAI20454. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q6U736 [UniParc]. Last modified October 17, 2006. Version 3. Checksum: BBF03FA2C0741005	FASTA	354	39,727
	10 20 30 40 50 60 MALNHTALPQ DERLPHYLRD GDPFASKLSW EADLVAGFYL TIIGILSTFG NGYVLYMSSR 70 80 90 100 110 120 RKKKLRPAEI MTINLAVCDL GISVVGKPFT IISCFCHRWV FGWIGCRWYG WAGFFFGCGS 130 140 150 160 170 180 LITMTAVSLD RYLKICYLSY GVWLKRKHAY ICLAAIWAYA SFWTTMPLVG LGDYVPEPFG 190 200 210 220 230 240 TSCTLDWWLA QASVGGQVFI LNILFFCLLL PTAVIVFSYV KIIAKVKSSS KEVAHFDSRI 250 260 270 280 290 300 HSSHVLEMKL TKVAMLICAG FLIAWIPYAV VSVWSAFGRP DSIPIQLSVV PTLLAKSAAM 310 320 330 340 350 YNPIIYQVID YKFACCQTGG LKATKKKSLE GFRLHTVTTV RKSSAVLEIH EEWE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue." Tarttelin E.E., Bellingham J., Hankins M.W., Foster R.G., Lucas R.J. FEBS Lett. 554:410-416(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives." Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B. FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 119-231.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY377391 mRNA. Translation: AAR21109.1. AY288419 mRNA. Translation: AAP72128.1. AY255615 mRNA. Translation: AAO85127.1. AL356421 Genomic DNA. No translation available. AL161622 Genomic DNA. Translation: CAI20454.1. Sequence problems. BC126194 mRNA. Translation: AAI26195.1. BC126198 mRNA. Translation: AAI26199.1.
IPI	IPI00395810.
RefSeq	NP_859528.1. NM_181744.3.
UniGene	Hs.213717.
3D structure databases
ProteinModelPortal	Q6U736.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q6U736.
Polymorphism databases
DMDM	116242690.
Proteomic databases
PaxDb	Q6U736.
PRIDE	Q6U736.
Protocols and materials databases
DNASU	221391.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371211; ENSP00000360255; ENSG00000124818.
GeneID	221391.
KEGG	hsa:221391.
UCSC	uc003ozc.3. human.
Organism-specific databases
CTD	221391.
GeneCards	GC06P047749.
H-InvDB	HIX0164996.
HGNC	HGNC:19992. OPN5.
MIM	609042. gene.
neXtProt	NX_Q6U736.
PharmGKB	PA134942887.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG145389.
HOGENOM	HOG000115272.
HOVERGEN	HBG058348.
InParanoid	Q6U736.
KO	K08385.
PhylomeDB	Q6U736.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q6U736.
Bgee	Q6U736.
CleanEx	HS_OPN5.
Genevestigator	Q6U736.
GermOnline	ENSG00000124818. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001760. Opsin. IPR002962. Peropsin. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01244. PEROPSIN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. PS00238. OPSIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	221391.
NextBio	91301.
SOURCE	Search...

Entry information

Entry name

OPN5_HUMAN

Accession

Primary (citable) accession number: Q6U736
Secondary accession number(s): A0AV33 , Q5T5B9, Q5T886, Q7Z603, Q86SL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 84 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.