Q6U5S4 (GCH4_KLEPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16

Gene names

Name:	folE2
ORF Names:	LV189

Encoded on

Plasmid pLVPK

Organism

Klebsiella pneumoniae

Taxonomic identifier

573 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.
Sequence caution	The sequence AAR07797.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Plasmid
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	GTP cyclohydrolase folE2 HAMAP-Rule MF_01527		PRO_0000147712
Sites
	Site	147	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6U5S4 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 5396818BE23DCCB4	FASTA	299	32,801
	10 20 30 40 50 60 MLPDIQSTKG DGEGESLSWV GMEQIDLPID IAGRPVSAKV NAGINLLSSP EAEKGIHMSR 70 80 90 100 110 120 LYLLLDELTQ GEITPALLQH VLKAFLVSHQ GRSDEASIEI SGDLLLSRKS LNSNHSGWKA 130 140 150 160 170 180 YPLTLSAELR QSFTVTLKVG IPYSSTCPAS AALSRHVAGL QFSKDFGNRI DRLPAAEIAD 190 200 210 220 230 240 WLVEKGMPAT PHSQRSWAWV DIRLNPEAKS LPVLELIDYA EVALGTAVQT VVKRSDEQAF 250 260 270 280 290 AVANGQNLMF CEDAARRLNN VFRCASFCEA FDIRVEHQES LHPHNAVARI HWKGSKNVT

References

[1]	"Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43." Chen Y.-T., Chang H.-Y., Lai Y.-C., Pan C.-C., Tsai S.-F., Peng H.-L. Gene 337:189-198(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CG43.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY378100 Genomic DNA. Translation: AAR07797.1. Different initiation.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
ProtClustDB	PRK13674.
Enzyme and pathway databases
UniPathway	UPA00848; UER00151.
Family and domain databases
Gene3D	3.10.270.10. 2 hits.
HAMAP	MF_01527_B. GTP_cyclohydrol_B.
InterPro	IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH4_KLEPN

Accession

Primary (citable) accession number: Q6U5S4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	May 5, 2009
Last modified:	April 3, 2013
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program