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Q6U5S4

- GCH4_KLEPN

UniProt

Q6U5S4 - GCH4_KLEPN

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Klebsiella pneumoniae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei147 – 1471May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    ORF Names:LV189
    Encoded oniPlasmid pLVPK0 Publication
    OrganismiKlebsiella pneumoniae
    Taxonomic identifieri573 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299GTP cyclohydrolase FolE2PRO_0000147712Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6U5S4-1 [UniParc]FASTAAdd to Basket

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    MLPDIQSTKG DGEGESLSWV GMEQIDLPID IAGRPVSAKV NAGINLLSSP    50
    EAEKGIHMSR LYLLLDELTQ GEITPALLQH VLKAFLVSHQ GRSDEASIEI 100
    SGDLLLSRKS LNSNHSGWKA YPLTLSAELR QSFTVTLKVG IPYSSTCPAS 150
    AALSRHVAGL QFSKDFGNRI DRLPAAEIAD WLVEKGMPAT PHSQRSWAWV 200
    DIRLNPEAKS LPVLELIDYA EVALGTAVQT VVKRSDEQAF AVANGQNLMF 250
    CEDAARRLNN VFRCASFCEA FDIRVEHQES LHPHNAVARI HWKGSKNVT 299
    Length:299
    Mass (Da):32,801
    Last modified:May 5, 2009 - v2
    Checksum:i5396818BE23DCCB4
    GO

    Sequence cautioni

    The sequence AAR07797.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY378100 Genomic DNA. Translation: AAR07797.1. Different initiation.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY378100 Genomic DNA. Translation: AAR07797.1 . Different initiation.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43."
      Chen Y.-T., Chang H.-Y., Lai Y.-C., Pan C.-C., Tsai S.-F., Peng H.-L.
      Gene 337:189-198(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CG43.

    Entry informationi

    Entry nameiGCH4_KLEPN
    AccessioniPrimary (citable) accession number: Q6U5S4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Plasmid

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3