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Q6U5S4 (GCH4_KLEPN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
ORF Names:LV189
Encoded onPlasmid pLVPK
OrganismKlebsiella pneumoniae
Taxonomic identifier573 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Sequence caution

The sequence AAR07797.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termPlasmid
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000147712

Sites

Site1471May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6U5S4 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 5396818BE23DCCB4

FASTA29932,801
        10         20         30         40         50         60 
MLPDIQSTKG DGEGESLSWV GMEQIDLPID IAGRPVSAKV NAGINLLSSP EAEKGIHMSR 

        70         80         90        100        110        120 
LYLLLDELTQ GEITPALLQH VLKAFLVSHQ GRSDEASIEI SGDLLLSRKS LNSNHSGWKA 

       130        140        150        160        170        180 
YPLTLSAELR QSFTVTLKVG IPYSSTCPAS AALSRHVAGL QFSKDFGNRI DRLPAAEIAD 

       190        200        210        220        230        240 
WLVEKGMPAT PHSQRSWAWV DIRLNPEAKS LPVLELIDYA EVALGTAVQT VVKRSDEQAF 

       250        260        270        280        290 
AVANGQNLMF CEDAARRLNN VFRCASFCEA FDIRVEHQES LHPHNAVARI HWKGSKNVT 

« Hide

References

[1]"Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43."
Chen Y.-T., Chang H.-Y., Lai Y.-C., Pan C.-C., Tsai S.-F., Peng H.-L.
Gene 337:189-198(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CG43.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY378100 Genomic DNA. Translation: AAR07797.1. Different initiation.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_KLEPN
AccessionPrimary (citable) accession number: Q6U5S4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways