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Q6U5S4

- GCH4_KLEPN

UniProt

Q6U5S4 - GCH4_KLEPN

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, LV189
Organism
Klebsiella pneumoniae
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei147 – 1471May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
ORF Names:LV189
Encoded oniPlasmid pLVPK0 Publication
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299GTP cyclohydrolase FolE2UniRule annotation
PRO_0000147712Add
BLAST

Family & Domainsi

Sequence similaritiesi

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6U5S4-1 [UniParc]FASTAAdd to Basket

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MLPDIQSTKG DGEGESLSWV GMEQIDLPID IAGRPVSAKV NAGINLLSSP    50
EAEKGIHMSR LYLLLDELTQ GEITPALLQH VLKAFLVSHQ GRSDEASIEI 100
SGDLLLSRKS LNSNHSGWKA YPLTLSAELR QSFTVTLKVG IPYSSTCPAS 150
AALSRHVAGL QFSKDFGNRI DRLPAAEIAD WLVEKGMPAT PHSQRSWAWV 200
DIRLNPEAKS LPVLELIDYA EVALGTAVQT VVKRSDEQAF AVANGQNLMF 250
CEDAARRLNN VFRCASFCEA FDIRVEHQES LHPHNAVARI HWKGSKNVT 299
Length:299
Mass (Da):32,801
Last modified:May 5, 2009 - v2
Checksum:i5396818BE23DCCB4
GO

Sequence cautioni

The sequence AAR07797.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY378100 Genomic DNA. Translation: AAR07797.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY378100 Genomic DNA. Translation: AAR07797.1 . Different initiation.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43."
    Chen Y.-T., Chang H.-Y., Lai Y.-C., Pan C.-C., Tsai S.-F., Peng H.-L.
    Gene 337:189-198(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CG43.

Entry informationi

Entry nameiGCH4_KLEPN
AccessioniPrimary (citable) accession number: Q6U5S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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