SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6U2D6

- Q6U2D6_RAT

UniProt

Q6U2D6 - Q6U2D6_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: Chemokine (C-C motif) receptor 7
Gene
Ccr7, rCG_34318
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. C-C motif chemokine 19 receptor activity Source: Ensembl
  2. C-C motif chemokine 21 receptor activity Source: Ensembl

GO - Biological processi

  1. chemotaxis Source: Ensembl
  2. immune response Source: Ensembl
  3. inflammatory response Source: InterPro
  4. interleukin-12 secretion Source: Ensembl
  5. mature dendritic cell differentiation Source: Ensembl
  6. negative thymic T cell selection Source: Ensembl
  7. positive regulation of T cell costimulation Source: Ensembl
  8. positive regulation of T cell receptor signaling pathway Source: Ensembl
  9. positive regulation of dendritic cell antigen processing and presentation Source: Ensembl
  10. positive regulation of dendritic cell chemotaxis Source: Ensembl
  11. positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation Source: Ensembl
  12. positive regulation of humoral immune response Source: Ensembl
  13. positive regulation of hypersensitivity Source: Ensembl
  14. positive regulation of immunological synapse formation Source: Ensembl
  15. positive regulation of interleukin-12 production Source: Ensembl
  16. positive regulation of neutrophil chemotaxis Source: Ensembl
  17. regulation of interferon-gamma production Source: Ensembl
  18. regulation of interleukin-1 beta secretion Source: Ensembl
  19. response to lipopolysaccharide Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotationSAAS annotations, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Chemokine (C-C motif) receptor 7Imported
Submitted name:
Chemokine receptor 7-like proteinImported
Submitted name:
Protein Ccr7Imported
Gene namesi
Name:Ccr7Imported
ORF Names:rCG_34318Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi735151. Ccr7.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriQ6U2D6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014163.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

eggNOGiNOG149643.
GeneTreeiENSGT00730000110640.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ6U2D6.
KOiK04182.
OMAiCFKKDVR.
OrthoDBiEOG79CXZN.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF29. PTHR24227:SF29. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6U2D6-1 [UniParc]FASTAAdd to Basket

« Hide

MDLGKPTKNV LVVALLVIFQ VCFCQDEVTD DYIGENTTVD YTLYESVCFK    50
KDVRNFKAWF LPLMYSVICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL 100
AVADILFLMI LPFWAYSEAK SWIFGAYLCK SIFGIYKLSF FSGMLLLLCI 150
SIDRYVAIVQ AVSAHRHRAR VLLISKLSCI GIWTLAFFLS IPELLYSGLQ 200
KNSGEDTWRC SLVSAQVEAL IAIQVAQMVV GFVLPMLAMS FCYLVIIRTL 250
LQARNFERNK AIKVIIAVVV VFVVFQLPYN GVVLAQTVAN FNITNSSCEA 300
SKQLNIAYDV TYSLASVRCC VNPFLYAFIG VKFRSDLFKL FKDLGCLSQE 350
RLRQWSSCRH VRHTSVSMEA ETTTTFSP 378
Length:378
Mass (Da):42,822
Last modified:July 5, 2004 - v1
Checksum:iA015E711DC4B521F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06065523 Genomic DNA. No translation available.
AABR06065524 Genomic DNA. No translation available.
AABR06065525 Genomic DNA. No translation available.
BC089762 mRNA. Translation: AAH89762.1.
AY379972 mRNA. Translation: AAR24573.1.
CH473948 Genomic DNA. Translation: EDM05972.1.
RefSeqiNP_955783.1. NM_199489.4.
UniGeneiRn.229736.

Genome annotation databases

EnsembliENSRNOT00000014163; ENSRNOP00000014163; ENSRNOG00000010665.
GeneIDi287673.
KEGGirno:287673.
UCSCiRGD:735151. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06065523 Genomic DNA. No translation available.
AABR06065524 Genomic DNA. No translation available.
AABR06065525 Genomic DNA. No translation available.
BC089762 mRNA. Translation: AAH89762.1 .
AY379972 mRNA. Translation: AAR24573.1 .
CH473948 Genomic DNA. Translation: EDM05972.1 .
RefSeqi NP_955783.1. NM_199489.4.
UniGenei Rn.229736.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000014163.

Chemistry

GuidetoPHARMACOLOGYi 64.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000014163 ; ENSRNOP00000014163 ; ENSRNOG00000010665 .
GeneIDi 287673.
KEGGi rno:287673.
UCSCi RGD:735151. rat.

Organism-specific databases

CTDi 1236.
RGDi 735151. Ccr7.

Phylogenomic databases

eggNOGi NOG149643.
GeneTreei ENSGT00730000110640.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi Q6U2D6.
KOi K04182.
OMAi CFKKDVR.
OrthoDBi EOG79CXZN.
TreeFami TF330966.

Miscellaneous databases

NextBioi 626779.
PROi Q6U2D6.

Gene expression databases

Genevestigatori Q6U2D6.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF29. PTHR24227:SF29. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Full-length nucleotide and amino acid sequence of the coding region of the rat homolog of chemokine receptor 7."
    Quintini G., Voland B., Hoffmeyer A.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
    Tissue: Lymph nodeImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: ThymusImported.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ6U2D6_RAT
AccessioniPrimary (citable) accession number: Q6U2D6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi