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Q6U2D6

- Q6U2D6_RAT

UniProt

Q6U2D6 - Q6U2D6_RAT

Protein
Submitted name:

Chemokine (C-C motif) receptor 7

Gene

Ccr7

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. C-C motif chemokine 19 receptor activity Source: Ensembl
    2. C-C motif chemokine 21 receptor activity Source: Ensembl

    GO - Biological processi

    1. chemotaxis Source: Ensembl
    2. immune response Source: Ensembl
    3. inflammatory response Source: InterPro
    4. interleukin-12 secretion Source: Ensembl
    5. mature dendritic cell differentiation Source: Ensembl
    6. negative thymic T cell selection Source: Ensembl
    7. positive regulation of dendritic cell antigen processing and presentation Source: Ensembl
    8. positive regulation of dendritic cell chemotaxis Source: Ensembl
    9. positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation Source: Ensembl
    10. positive regulation of humoral immune response Source: Ensembl
    11. positive regulation of hypersensitivity Source: Ensembl
    12. positive regulation of immunological synapse formation Source: Ensembl
    13. positive regulation of interleukin-12 production Source: Ensembl
    14. positive regulation of neutrophil chemotaxis Source: Ensembl
    15. positive regulation of T cell costimulation Source: Ensembl
    16. positive regulation of T cell receptor signaling pathway Source: Ensembl
    17. regulation of interferon-gamma production Source: Ensembl
    18. regulation of interleukin-1 beta secretion Source: Ensembl
    19. response to lipopolysaccharide Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Chemokine (C-C motif) receptor 7Imported
    Submitted name:
    Chemokine receptor 7-like proteinImported
    Submitted name:
    Protein Ccr7Imported
    Gene namesi
    Name:Ccr7Imported
    ORF Names:rCG_34318Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi735151. Ccr7.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. intracellular Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    GenevestigatoriQ6U2D6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000014163.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    eggNOGiNOG149643.
    GeneTreeiENSGT00730000110640.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiQ6U2D6.
    KOiK04182.
    OMAiCFKKDVR.
    OrthoDBiEOG79CXZN.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001718. Chemokine_CCR7.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF29. PTHR24227:SF29. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR00641. CHEMOKINER7.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6U2D6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLGKPTKNV LVVALLVIFQ VCFCQDEVTD DYIGENTTVD YTLYESVCFK    50
    KDVRNFKAWF LPLMYSVICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL 100
    AVADILFLMI LPFWAYSEAK SWIFGAYLCK SIFGIYKLSF FSGMLLLLCI 150
    SIDRYVAIVQ AVSAHRHRAR VLLISKLSCI GIWTLAFFLS IPELLYSGLQ 200
    KNSGEDTWRC SLVSAQVEAL IAIQVAQMVV GFVLPMLAMS FCYLVIIRTL 250
    LQARNFERNK AIKVIIAVVV VFVVFQLPYN GVVLAQTVAN FNITNSSCEA 300
    SKQLNIAYDV TYSLASVRCC VNPFLYAFIG VKFRSDLFKL FKDLGCLSQE 350
    RLRQWSSCRH VRHTSVSMEA ETTTTFSP 378
    Length:378
    Mass (Da):42,822
    Last modified:July 5, 2004 - v1
    Checksum:iA015E711DC4B521F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06065523 Genomic DNA. No translation available.
    AABR06065524 Genomic DNA. No translation available.
    AABR06065525 Genomic DNA. No translation available.
    BC089762 mRNA. Translation: AAH89762.1.
    AY379972 mRNA. Translation: AAR24573.1.
    CH473948 Genomic DNA. Translation: EDM05972.1.
    RefSeqiNP_955783.1. NM_199489.4.
    UniGeneiRn.229736.

    Genome annotation databases

    EnsembliENSRNOT00000014163; ENSRNOP00000014163; ENSRNOG00000010665.
    GeneIDi287673.
    KEGGirno:287673.
    UCSCiRGD:735151. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06065523 Genomic DNA. No translation available.
    AABR06065524 Genomic DNA. No translation available.
    AABR06065525 Genomic DNA. No translation available.
    BC089762 mRNA. Translation: AAH89762.1 .
    AY379972 mRNA. Translation: AAR24573.1 .
    CH473948 Genomic DNA. Translation: EDM05972.1 .
    RefSeqi NP_955783.1. NM_199489.4.
    UniGenei Rn.229736.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000014163.

    Chemistry

    GuidetoPHARMACOLOGYi 64.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000014163 ; ENSRNOP00000014163 ; ENSRNOG00000010665 .
    GeneIDi 287673.
    KEGGi rno:287673.
    UCSCi RGD:735151. rat.

    Organism-specific databases

    CTDi 1236.
    RGDi 735151. Ccr7.

    Phylogenomic databases

    eggNOGi NOG149643.
    GeneTreei ENSGT00730000110640.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi Q6U2D6.
    KOi K04182.
    OMAi CFKKDVR.
    OrthoDBi EOG79CXZN.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 626779.
    PROi Q6U2D6.

    Gene expression databases

    Genevestigatori Q6U2D6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001718. Chemokine_CCR7.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF29. PTHR24227:SF29. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR00641. CHEMOKINER7.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Full-length nucleotide and amino acid sequence of the coding region of the rat homolog of chemokine receptor 7."
      Quintini G., Voland B., Hoffmeyer A.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
      Tissue: Lymph nodeImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: ThymusImported.
    3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    6. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ6U2D6_RAT
    AccessioniPrimary (citable) accession number: Q6U2D6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3