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Protein

Serine/threonine-protein kinase Sgk1

Gene

SGK1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei128 – 1281ATPPROSITE-ProRule annotation
Active sitei223 – 2231Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi105 – 1139ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis, Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-2672351. Stimuli-sensing channels.
R-GGA-6804757. Regulation of TP53 Degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Sgk1 (EC:2.7.11.1)
Alternative name(s):
Serum/glucocorticoid-regulated kinase 1
Gene namesi
Name:SGK1
Synonyms:SGK
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Serine/threonine-protein kinase Sgk1PRO_0000380130Add
BLAST

Proteomic databases

PaxDbiQ6U1I9.

Expressioni

Gene expression databases

BgeeiENSGALG00000013971.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000031130.

Structurei

3D structure databases

ProteinModelPortaliQ6U1I9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 356258Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini357 – 43276AGC-kinase C-terminalAdd
BLAST

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126961.
HOGENOMiHOG000233033.
InParanoidiQ6U1I9.
KOiK13302.
OMAiEVKEPCN.
OrthoDBiEOG091G06FF.
PhylomeDBiQ6U1I9.
TreeFamiTF320906.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6U1I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVKAAEASG PALTYSKMRG MVAILIAFMK QRRMGLNDFI QKIATNSYAC
60 70 80 90 100
KHPEVQSILK ISQPQEPELM NANPSPPPSP SQQINLGPSS NPHAKPSDFH
110 120 130 140 150
FLKVIGKGSF GKVLLARHKA EEQFYAVKVL QKKAILKKKE EKHIMSERNV
160 170 180 190 200
LLKNVKHPFL VGLHFSFQTA DKLYFVLDYI NGGELFYHLQ RERCFLEPRA
210 220 230 240 250
RFYAAEIASA LGYLHSLNIV YRDLKPENIL LDSQGHIVLT DFGLCKENIE
260 270 280 290 300
HNGTTSTFCG TPEYLAPEVL HKQPYDRTVD WWCLGAVLYE MLYGLPPFYS
310 320 330 340 350
RNTAEMYDNI LNKPLQLKPN ITNSARHLLE GLLQKDRTKR LGAKEDFTEI
360 370 380 390 400
KNHIFFSPIN WDDLINKKIT PPFNPNVSGP SDLRHFDPEF TDEPVPNSIG
410 420 430
QSPDSILITA SVKEAAEAFL GFSYAPPVDS FL
Length:432
Mass (Da):48,890
Last modified:July 5, 2004 - v1
Checksum:i83AB52AFF2609953
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY380825 mRNA. Translation: AAQ88435.1.
RefSeqiNP_989807.1. NM_204476.1.
UniGeneiGga.9334.

Genome annotation databases

EnsembliENSGALT00000031766; ENSGALP00000031130; ENSGALG00000013971.
GeneIDi395133.
KEGGigga:395133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY380825 mRNA. Translation: AAQ88435.1.
RefSeqiNP_989807.1. NM_204476.1.
UniGeneiGga.9334.

3D structure databases

ProteinModelPortaliQ6U1I9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000031130.

Proteomic databases

PaxDbiQ6U1I9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000031766; ENSGALP00000031130; ENSGALG00000013971.
GeneIDi395133.
KEGGigga:395133.

Organism-specific databases

CTDi6446.

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126961.
HOGENOMiHOG000233033.
InParanoidiQ6U1I9.
KOiK13302.
OMAiEVKEPCN.
OrthoDBiEOG091G06FF.
PhylomeDBiQ6U1I9.
TreeFamiTF320906.

Enzyme and pathway databases

ReactomeiR-GGA-2672351. Stimuli-sensing channels.
R-GGA-6804757. Regulation of TP53 Degradation.

Miscellaneous databases

PROiQ6U1I9.

Gene expression databases

BgeeiENSGALG00000013971.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSGK1_CHICK
AccessioniPrimary (citable) accession number: Q6U1I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.