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Protein

Embryonic polyadenylate-binding protein 2-B

Gene

Pabpn1l-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds the poly(A) tail of mRNA. Unable to interact with the cap-binding complex and is therefore unlikely to be involved in translation initiation.By similarity1 Publication

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Embryonic polyadenylate-binding protein 2-B
Short name:
Embryonic poly(A)-binding protein 2-B
Short name:
XePABP2-B
Short name:
ePABP-2B
Short name:
ePABP2-B
Alternative name(s):
Embryonic poly(A)-binding protein type II-B
Gene namesi
Name:Pabpn1l-b
Synonyms:epabp2-b, pabpnl1-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1000606. pabpn1l.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002394641 – 218Embryonic polyadenylate-binding protein 2-BAdd BLAST218

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Restricted to oogenesis, early embryogenesis and the adult ovary. Levels decrease after the onset of zygotic transcription (at protein level).1 Publication

Interactioni

Subunit structurei

Homodimer; Upon poly(A) binding, undergoes a dimer-monomer transition that removes the polyproline motif from the RNA recognition site and allows it to be replaced by the adenosine nucleotides of poly(A).1 Publication

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi84 – 92Combined sources9
Beta strandi94 – 100Combined sources7
Helixi106 – 114Combined sources9
Beta strandi119 – 127Combined sources9
Beta strandi134 – 143Combined sources10
Helixi144 – 151Combined sources8
Turni152 – 155Combined sources4
Beta strandi164 – 169Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JWNNMR-A/B60-180[»]
ProteinModelPortaliQ6TY21.
SMRiQ6TY21.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6TY21.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 170RRMPROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG107480.
KOiK14396.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6TY21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERVSEEPG LDKGDRAEEC ELDDPELKAI RMRVREMEEE AERLKGLSGQ
60 70 80 90 100
DKSIGVSTRP CMQTTHSKMT AGAYTEGPPQ PLSAEEKKEI DKRSVYVGNV
110 120 130 140 150
DYGSTAQDLE AHFSSCGSIN RITILCDKFS GHPKGYAYIE FAERNSVDAA
160 170 180 190 200
VAMDETVFRG RTIKVLPKRT NMPGISSTDR GGFRGRPRGN RGNYQRGQRP
210
RGRPFRGRGR PGPLNNPY
Length:218
Mass (Da):24,270
Last modified:July 5, 2004 - v1
Checksum:i3571AC009E95EDBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382837 mRNA. Translation: AAR26263.1.
RefSeqiNP_001084418.1. NM_001090949.1.
UniGeneiXl.86989.

Genome annotation databases

GeneIDi403372.
KEGGixla:403372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382837 mRNA. Translation: AAR26263.1.
RefSeqiNP_001084418.1. NM_001090949.1.
UniGeneiXl.86989.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JWNNMR-A/B60-180[»]
ProteinModelPortaliQ6TY21.
SMRiQ6TY21.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403372.
KEGGixla:403372.

Organism-specific databases

CTDi403372.
XenbaseiXB-GENE-1000606. pabpn1l.

Phylogenomic databases

HOVERGENiHBG107480.
KOiK14396.

Miscellaneous databases

EvolutionaryTraceiQ6TY21.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEPA2B_XENLA
AccessioniPrimary (citable) accession number: Q6TY21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.