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Protein

40S ribosomal protein S3a

Gene

Cyld

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role during erythropoiesis through regulation of transcription factor DDIT3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal proteinUniRule annotation
Biological processDifferentiationUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-168638. NOD1/2 Signaling Pathway.
R-RNO-5357786. TNFR1-induced proapoptotic signaling.
R-RNO-5357905. Regulation of TNFR1 signaling.
R-RNO-5357956. TNFR1-induced NFkappaB signaling pathway.
R-RNO-5689880. Ub-specific processing proteases.
R-RNO-936440. Negative regulators of RIG-I/MDA5 signaling.

Protein family/group databases

MEROPSiC67.001.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S3aUniRule annotation
Gene namesi
Name:CyldImported
Synonyms:LOC100362727Imported, RPS3AUniRule annotation
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1308346. Cyld.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation

  • Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Expressioni

Gene expression databases

ExpressionAtlasiQ6TXJ6. baseline.
GenevisibleiQ6TXJ6. RN.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6TXJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini137 – 448USPInterPro annotationAdd BLAST312

Sequence similaritiesi

Belongs to the eukaryotic ribosomal protein eS1 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000018123.
TreeFamiTF300037.

Family and domain databases

HAMAPiMF_03122. Ribosomal_S3Ae_euk. 1 hit.
InterProiView protein in InterPro
IPR027500. Ribosomal_S1/3_euk.
IPR001593. Ribosomal_S3Ae.
IPR028889. USP_dom.
PfamiView protein in Pfam
PF01015. Ribosomal_S3Ae. 1 hit.
SMARTiView protein in SMART
SM01397. Ribosomal_S3Ae. 1 hit.
PROSITEiView protein in PROSITE
PS50235. USP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6TXJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRKNQHPT KGGKKGAKKK VVDPFSKKDW YDVKAPAMFN IRSIRKTLVT
60 70 80 90 100
RTQGAKTAPD GLEGRVFEGR LADLQNDEDS FRKVKLNTED VQGKNFHGMD
110 120 130 140 150
LTRDRMCSVV KKWQTTMIEA LVDVKTTDGY LLRLFCVGFT KKYNNQIRKI
160 170 180 190 200
SYSQVYQIQK KMMEIMTREV QTNDLKEVVN KLILGSIGKD IEKVCQSIHP
210 220 230 240 250
LHDVFVRKVK MLKKPKFELG KPMELHGEGG GSHKTTAFGG YLSEVVEENT
260 270 280 290 300
PPKMEKEGLE IMIGKKKGIQ GHYNSCYLDS TLFWQCRICG GLAMYECREC
310 320 330 340 350
YDDPDISAGK IKQFCKTCST QVHLHPRRLN HTYHPVSLPK DLPDWDWRHG
360 370 380 390 400
CIPCQKMELF AVLCIETSHY VAFVKYGKDD SAWLFFDSMA DRDGGQNGFN
410 420 430 440 450
IPQVTPCPEV GEYLKMSLED LHSLDSRRIQ GCARRLLCDA YMCMYQSPTM

SLYK
Length:454
Mass (Da):52,009
Last modified:July 5, 2004 - v1
Checksum:i8828E384B9F8F69F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07043075 Genomic DNA. No translation available.
AY383658 mRNA. Translation: AAQ96216.1.
UniGeneiRn.128760.
Rn.168938.

Genome annotation databases

EnsembliENSRNOT00000091626; ENSRNOP00000070060; ENSRNOG00000014048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07043075 Genomic DNA. No translation available.
AY383658 mRNA. Translation: AAQ96216.1.
UniGeneiRn.128760.
Rn.168938.

3D structure databases

ProteinModelPortaliQ6TXJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC67.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000091626; ENSRNOP00000070060; ENSRNOG00000014048.

Organism-specific databases

RGDi1308346. Cyld.

Phylogenomic databases

GeneTreeiENSGT00390000018123.
TreeFamiTF300037.

Enzyme and pathway databases

ReactomeiR-RNO-168638. NOD1/2 Signaling Pathway.
R-RNO-5357786. TNFR1-induced proapoptotic signaling.
R-RNO-5357905. Regulation of TNFR1 signaling.
R-RNO-5357956. TNFR1-induced NFkappaB signaling pathway.
R-RNO-5689880. Ub-specific processing proteases.
R-RNO-936440. Negative regulators of RIG-I/MDA5 signaling.

Gene expression databases

ExpressionAtlasiQ6TXJ6. baseline.
GenevisibleiQ6TXJ6. RN.

Family and domain databases

HAMAPiMF_03122. Ribosomal_S3Ae_euk. 1 hit.
InterProiView protein in InterPro
IPR027500. Ribosomal_S1/3_euk.
IPR001593. Ribosomal_S3Ae.
IPR028889. USP_dom.
PfamiView protein in Pfam
PF01015. Ribosomal_S3Ae. 1 hit.
SMARTiView protein in SMART
SM01397. Ribosomal_S3Ae. 1 hit.
PROSITEiView protein in PROSITE
PS50235. USP_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6TXJ6_RAT
AccessioniPrimary (citable) accession number: Q6TXJ6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 12, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.