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Protein

Arrestin domain-containing protein 3

Gene

Arrdc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin domain-containing protein 3
Alternative name(s):
Liver regeneration-related protein LRRG00048
Gene namesi
Name:Arrdc3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1359478 Arrdc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443521 – 414Arrestin domain-containing protein 3Add BLAST414

Proteomic databases

PaxDbiQ6TXF1
PRIDEiQ6TXF1

PTM databases

PhosphoSitePlusiQ6TXF1

Expressioni

Gene expression databases

BgeeiENSRNOG00000045649

Interactioni

Subunit structurei

Interacts (via PPxY motifs) with NEDD4 (via WW domains). Interacts with ADRB2. Interacts with ADRB3. Interacts with HGS (via PPxY motifs). Does not bind TXN (thioredoxin). Interacts with ITCH.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067658

Structurei

3D structure databases

ProteinModelPortaliQ6TXF1
SMRiQ6TXF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi346 – 349PPxY motif 1Curated4
Motifi391 – 394PPxY motif 2Curated4

Sequence similaritiesi

Belongs to the arrestin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3780 Eukaryota
ENOG41102NY LUCA
GeneTreeiENSGT00550000074356
HOVERGENiHBG066469
InParanoidiQ6TXF1
OMAiPWLLPMK
OrthoDBiEOG091G0B0Y
PhylomeDBiQ6TXF1

Family and domain databases

Gene3Di2.60.40.640, 2 hits
InterProiView protein in InterPro
IPR011021 Arrestin-like_N
IPR014752 Arrestin_C
IPR011022 Arrestin_C-like
IPR014756 Ig_E-set
PfamiView protein in Pfam
PF02752 Arrestin_C, 1 hit
PF00339 Arrestin_N, 1 hit
SMARTiView protein in SMART
SM01017 Arrestin_C, 1 hit
SUPFAMiSSF81296 SSF81296, 2 hits

Sequencei

Sequence statusi: Complete.

Q6TXF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLGKVKSLT ISFDCLNDSN VPVYSSGDTV SGRVNLEVTG EIRVKSLKIH
60 70 80 90 100
ARGHAKVRWT ESRNAGSNTA YTQNYTEEVE YFNHKDILIG HERDDDNCEE
110 120 130 140 150
GFSTIHSGRH EYAFSFELPQ TPLATSFEGR HGSVRYWVKA ELHRPWLLPV
160 170 180 190 200
KLKKEFTVFE HIDINTPSLL SPQAGTKEKT LCCWFCTSGP ISLSAKIERK
210 220 230 240 250
GYTPGESIQI FAEIENCSSR MVVPKAAIYQ TQAFYAKGKM KEVKQLVANL
260 270 280 290 300
RGESLSSGKT ETWDGKLLKI PPVSPSILDC SIIRVEYSLM VYVDIPGAMD
310 320 330 340 350
LLLSLPLVIG TIPLHPFGSR TSSVSSQCSM NMNWLGLSLP ERPEAPPSYA
360 370 380 390 400
EVVTEEQRRN NLAPVSACDD FERALQGPLF AYIQEFRFLP PPLYSEIDPN
410
PDQSSEDRPS CPSR
Length:414
Mass (Da):46,301
Last modified:July 5, 2004 - v1
Checksum:i8294F213ADA21590
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY383703 mRNA Translation: AAQ96261.1
RefSeqiNP_001007798.1, NM_001007797.1
UniGeneiRn.161886

Genome annotation databases

EnsembliENSRNOT00000072849; ENSRNOP00000067658; ENSRNOG00000045649
GeneIDi309945
KEGGirno:309945

Similar proteinsi

Entry informationi

Entry nameiARRD3_RAT
AccessioniPrimary (citable) accession number: Q6TXF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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