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Q6TUZ4 (DUT_YMTV5) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:DUT
Ordered Locus Names:17L
OrganismYaba monkey tumor virus (strain VR587) (YMTV) [Reference proteome]
Taxonomic identifier928314 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeYatapoxvirus
Virus hostErythrocebus patas (Red guenon) (Cercopithecus patas) [TaxID: 9538]
Homo sapiens (Human) [TaxID: 9606]
Macaca (macaques) [TaxID: 9539]
Papio hamadryas (Hamadryas baboon) [TaxID: 9557]

Protein attributes

Sequence length143 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 143143Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182951

Sequences

Sequence LengthMass (Da)Tools
Q6TUZ4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: A67BB9059654C8DF

FASTA14315,658
        10         20         30         40         50         60 
MSKFIVYVKK SSEFATIPTR SSKKSAGYDL YSAYDYLVRP KSRVLVKTDI CLSIPDECYG 

        70         80         90        100        110        120 
RIASRSGLSL NNSIDIGGGV IDGDYRGVIG VIFINNGNSP HYIKRGDRIA QIVFERLANV 

       130        140 
EIKEISNLDC TCRGDCGFGS SGI 

« Hide

References

[1]"Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus."
Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T., Li X., Barrett J.W., McFadden G.
J. Virol. 77:13335-13347(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY386371 Genomic DNA. Translation: AAR07375.1.
RefSeqNP_938274.1. NC_005179.1.

3D structure databases

ProteinModelPortalQ6TUZ4.
SMRQ6TUZ4. Positions 10-117.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2943676.

Phylogenomic databases

ProtClustDBPHA3094.

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDUT_YMTV5
AccessionPrimary (citable) accession number: Q6TUZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: October 16, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families