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Q6TUZ4

- DUT_YMTV5

UniProt

Q6TUZ4 - DUT_YMTV5

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Yaba monkey tumor virus (strain VR587) (YMTV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Name:DUT
    Ordered Locus Names:17L
    OrganismiYaba monkey tumor virus (strain VR587) (YMTV)
    Taxonomic identifieri928314 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeYatapoxvirus
    Virus hostiErythrocebus patas (Red guenon) (Cercopithecus patas) [TaxID: 9538]
    Homo sapiens (Human) [TaxID: 9606]
    Macaca (macaques) [TaxID: 9539]
    Papio hamadryas (Hamadryas baboon) [TaxID: 9557]
    ProteomesiUP000008596: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 143143Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182951Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6TUZ4.
    SMRiQ6TUZ4. Positions 10-117.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6TUZ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKFIVYVKK SSEFATIPTR SSKKSAGYDL YSAYDYLVRP KSRVLVKTDI    50
    CLSIPDECYG RIASRSGLSL NNSIDIGGGV IDGDYRGVIG VIFINNGNSP 100
    HYIKRGDRIA QIVFERLANV EIKEISNLDC TCRGDCGFGS SGI 143
    Length:143
    Mass (Da):15,658
    Last modified:July 5, 2004 - v1
    Checksum:iA67BB9059654C8DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY386371 Genomic DNA. Translation: AAR07375.1.
    RefSeqiNP_938274.1. NC_005179.1.

    Genome annotation databases

    GeneIDi2943676.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY386371 Genomic DNA. Translation: AAR07375.1 .
    RefSeqi NP_938274.1. NC_005179.1.

    3D structure databases

    ProteinModelPortali Q6TUZ4.
    SMRi Q6TUZ4. Positions 10-117.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2943676.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus."
      Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T., Li X., Barrett J.W., McFadden G.
      J. Virol. 77:13335-13347(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_YMTV5
    AccessioniPrimary (citable) accession number: Q6TUZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3