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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Yaba monkey tumor virus (strain VR587) (YMTV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:DUT
Ordered Locus Names:17L
OrganismiYaba monkey tumor virus (strain VR587) (YMTV)
Taxonomic identifieri928314 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeYatapoxvirus
Virus hostiErythrocebus patas (Red guenon) (Cercopithecus patas) [TaxID: 9538]
Homo sapiens (Human) [TaxID: 9606]
Macaca (macaques) [TaxID: 9539]
Papio hamadryas (Hamadryas baboon) [TaxID: 9557]
Proteomesi
  • UP000008596 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001829511 – 143Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST143

Structurei

3D structure databases

ProteinModelPortaliQ6TUZ4.
SMRiQ6TUZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Phylogenomic databases

OrthoDBiVOG09000135.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
InterProiView protein in InterPro
IPR029054. dUTPase-like.
IPR008181. dUTPase_1.
IPR033704. dUTPase_trimeric.
PfamiView protein in Pfam
PF00692. dUTPase. 1 hit.
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6TUZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKFIVYVKK SSEFATIPTR SSKKSAGYDL YSAYDYLVRP KSRVLVKTDI
60 70 80 90 100
CLSIPDECYG RIASRSGLSL NNSIDIGGGV IDGDYRGVIG VIFINNGNSP
110 120 130 140
HYIKRGDRIA QIVFERLANV EIKEISNLDC TCRGDCGFGS SGI
Length:143
Mass (Da):15,658
Last modified:July 5, 2004 - v1
Checksum:iA67BB9059654C8DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY386371 Genomic DNA. Translation: AAR07375.1.
RefSeqiNP_938274.1. NC_005179.1.

Genome annotation databases

GeneIDi2943676.
KEGGivg:2943676.

Similar proteinsi

Entry informationi

Entry nameiDUT_YMTV5
AccessioniPrimary (citable) accession number: Q6TUZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families