Q6TUZ4 (DUT_YMTV5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Short name=dUTPase
EC=3.6.1.23

Alternative name(s):
dUTP pyrophosphatase

Gene names

Name:	DUT
Ordered Locus Names:	17L

Organism

Yaba monkey tumor virus (strain VR587) (YMTV) [Reference proteome]

Taxonomic identifier

928314 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Yatapoxvirus › Yaba monkey tumor virus

Virus host

Erythrocebus patas (Red guenon) (Cercopithecus patas) [TaxID: 9538]
Homo sapiens (Human) [TaxID: 9606]
Macaca (macaques) [TaxID: 9539]
Papio hamadryas (Hamadryas baboon) [TaxID: 9557]

Protein attributes

Sequence length	143 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the dUTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 143	143	Deoxyuridine 5'-triphosphate nucleotidohydrolase		PRO_0000182951

Sequences

	Sequence		Length	Mass (Da)
	Q6TUZ4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A67BB9059654C8DF	FASTA	143	15,658
	10 20 30 40 50 60 MSKFIVYVKK SSEFATIPTR SSKKSAGYDL YSAYDYLVRP KSRVLVKTDI CLSIPDECYG 70 80 90 100 110 120 RIASRSGLSL NNSIDIGGGV IDGDYRGVIG VIFINNGNSP HYIKRGDRIA QIVFERLANV 130 140 EIKEISNLDC TCRGDCGFGS SGI

References

[1]

"Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus." Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T., Li X., Barrett J.W., McFadden G. J. Virol. 77:13335-13347(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY386371 Genomic DNA. Translation: AAR07375.1.
RefSeq	NP_938274.1. NC_005179.1.
3D structure databases
ProteinModelPortal	Q6TUZ4.
SMR	Q6TUZ4. Positions 10-117.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2943676.
Phylogenomic databases
ProtClustDB	PHA3094.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. IPR008181. dUTP_pyroPase_sf. [Graphical view]
PANTHER	PTHR11241. PTHR11241. 1 hit.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00576. dut. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DUT_YMTV5

Accession

Primary (citable) accession number: Q6TUZ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	July 5, 2004
Last modified:	October 3, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program