Q6TUY0 (PAP1_YMTV5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Poly(A) polymerase catalytic subunit
EC=2.7.7.19

Alternative name(s):
Poly(A) polymerase large subunit
Short name=PAP-L

Gene names

Name:	PAPL
Ordered Locus Names:	32L

Organism

Yaba monkey tumor virus (strain VR587) (YMTV) [Reference proteome]

Taxonomic identifier

928314 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Yatapoxvirus › Yaba monkey tumor virus

Virus host

Erythrocebus patas (Red guenon) (Cercopithecus patas) [TaxID: 9538]
Homo sapiens (Human) [TaxID: 9606]
Macaca (macaques) [TaxID: 9539]
Papio hamadryas (Hamadryas baboon) [TaxID: 9557]

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Polymerase that creates the 3'-poly(A) tail of mRNA's.
Catalytic activity	ATP + RNA(n) = diphosphate + RNA(n+1).
Subunit structure	Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit By similarity.
Sequence similarities	Belongs to the poxviridae poly(A) polymerase catalytic subunit family.

Ontologies

Keywords
Biological process	Transcription mRNA processing
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW polynucleotide adenylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 470	470	Poly(A) polymerase catalytic subunit		PRO_0000308942
Sites
	Active site	192	1	By similarity
	Active site	194	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6TUY0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 523D828081B1669B	FASTA	470	54,614
	10 20 30 40 50 60 MNNSITLTLK NYLGRMPTVN EYYMLKSQVR NIQKIMFFNK DIFISLIKKN KKKFFYEIKS 70 80 90 100 110 120 SPSEMRLHIL EYFMKQQKTS SIGKLYAIIE LQTILVSTYT DVLGVLTTKA PYVFPSNVRY 130 140 150 160 170 180 EPRSMKKIAH DILTTINVAT VSEKVMGRHN VSELVTNVNL LMEEYLRRHN KSCICYGSYS 190 200 210 220 230 240 LYLLNPSIEY GDIDIMQTNS RIFLINLAFL IKFITGHNVM LLKVPYLKNY MVLRDDEDKH 250 260 270 280 290 300 IIDSFNVRQD TMHSIPKILI DNIYIVDPTF QLLSMIKMFS QVDRLEDLAR NQEKATIKLA 310 320 330 340 350 360 TLLEYVRVKH GIIFNGKVTN MPMPSSFDHE KRIITVDTSR YNFSFKKCFV YLDENSLSSD 370 380 390 400 410 420 ILNLNADDAI DFENVSNSVF LINDEIMYTY FSNTILMSSK DEIHEISARG VSAHILMYQI 430 440 450 460 470 LTDGDYLIPL SDIVNSLMFK EKIPIFSIIP RDKKTGKHGI INIEKDIITH

References

[1]

"Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus." Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T., Li X., Barrett J.W., McFadden G. J. Virol. 77:13335-13347(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY386371 Genomic DNA. Translation: AAR07389.1.
RefSeq	NP_938288.1. NC_005179.1.
3D structure databases
ProteinModelPortal	Q6TUY0.
SMR	Q6TUY0. Positions 9-468.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2943665.
Phylogenomic databases
ProtClustDB	PHA2996.
Family and domain databases
InterPro	IPR024231. Pox_polyA_pol_nucTrfase. IPR004976. Poxvirus_polyA_pol_cat. IPR024397. Poxvirus_polyA_pol_cat_C. IPR024398. Poxvirus_polyA_pol_cat_N. [Graphical view]
Pfam	PF03296. Pox_polyA_pol. 1 hit. PF12629. Pox_polyA_pol_C. 1 hit. PF12630. Pox_polyA_pol_N. 1 hit. [Graphical view]
PIRSF	PIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PAP1_YMTV5

Accession

Primary (citable) accession number: Q6TUY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	July 5, 2004
Last modified:	October 19, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program