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Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Yaba monkey tumor virus (strain VR587) (YMTV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei192 – 1921By similarity
Active sitei194 – 1941By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing, Transcription

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
Alternative name(s):
Poly(A) polymerase large subunit
Short name:
PAP-L
Gene namesi
Name:PAPL
Ordered Locus Names:32L
OrganismiYaba monkey tumor virus (strain VR587) (YMTV)
Taxonomic identifieri928314 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeYatapoxvirus
Virus hostiErythrocebus patas (Red guenon) (Cercopithecus patas) [TaxID: 9538]
Homo sapiens (Human) [TaxID: 9606]
Macaca (macaques) [TaxID: 9539]
Papio hamadryas (Hamadryas baboon) [TaxID: 9557]
ProteomesiUP000008596 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Poly(A) polymerase catalytic subunitPRO_0000308942Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6TUY0.
SMRiQ6TUY0. Positions 9-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6TUY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNSITLTLK NYLGRMPTVN EYYMLKSQVR NIQKIMFFNK DIFISLIKKN
60 70 80 90 100
KKKFFYEIKS SPSEMRLHIL EYFMKQQKTS SIGKLYAIIE LQTILVSTYT
110 120 130 140 150
DVLGVLTTKA PYVFPSNVRY EPRSMKKIAH DILTTINVAT VSEKVMGRHN
160 170 180 190 200
VSELVTNVNL LMEEYLRRHN KSCICYGSYS LYLLNPSIEY GDIDIMQTNS
210 220 230 240 250
RIFLINLAFL IKFITGHNVM LLKVPYLKNY MVLRDDEDKH IIDSFNVRQD
260 270 280 290 300
TMHSIPKILI DNIYIVDPTF QLLSMIKMFS QVDRLEDLAR NQEKATIKLA
310 320 330 340 350
TLLEYVRVKH GIIFNGKVTN MPMPSSFDHE KRIITVDTSR YNFSFKKCFV
360 370 380 390 400
YLDENSLSSD ILNLNADDAI DFENVSNSVF LINDEIMYTY FSNTILMSSK
410 420 430 440 450
DEIHEISARG VSAHILMYQI LTDGDYLIPL SDIVNSLMFK EKIPIFSIIP
460 470
RDKKTGKHGI INIEKDIITH
Length:470
Mass (Da):54,614
Last modified:July 5, 2004 - v1
Checksum:i523D828081B1669B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY386371 Genomic DNA. Translation: AAR07389.1.
RefSeqiNP_938288.1. NC_005179.1.

Genome annotation databases

GeneIDi2943665.
KEGGivg:2943665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY386371 Genomic DNA. Translation: AAR07389.1.
RefSeqiNP_938288.1. NC_005179.1.

3D structure databases

ProteinModelPortaliQ6TUY0.
SMRiQ6TUY0. Positions 9-468.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2943665.
KEGGivg:2943665.

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus."
    Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T., Li X., Barrett J.W., McFadden G.
    J. Virol. 77:13335-13347(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPAP1_YMTV5
AccessioniPrimary (citable) accession number: Q6TUY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.