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Q6TUY0

- PAP1_YMTV5

UniProt

Q6TUY0 - PAP1_YMTV5

Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Yaba monkey tumor virus (strain VR587) (YMTV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Polymerase that creates the 3'-poly(A) tail of mRNA's.

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei192 – 1921By similarity
    Active sitei194 – 1941By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing, Transcription

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
    Alternative name(s):
    Poly(A) polymerase large subunit
    Short name:
    PAP-L
    Gene namesi
    Name:PAPL
    Ordered Locus Names:32L
    OrganismiYaba monkey tumor virus (strain VR587) (YMTV)
    Taxonomic identifieri928314 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeYatapoxvirus
    Virus hostiErythrocebus patas (Red guenon) (Cercopithecus patas) [TaxID: 9538]
    Homo sapiens (Human) [TaxID: 9606]
    Macaca (macaques) [TaxID: 9539]
    Papio hamadryas (Hamadryas baboon) [TaxID: 9557]
    ProteomesiUP000008596: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 470470Poly(A) polymerase catalytic subunitPRO_0000308942Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6TUY0.
    SMRiQ6TUY0. Positions 9-468.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view]
    PfamiPF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6TUY0-1 [UniParc]FASTAAdd to Basket

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    MNNSITLTLK NYLGRMPTVN EYYMLKSQVR NIQKIMFFNK DIFISLIKKN    50
    KKKFFYEIKS SPSEMRLHIL EYFMKQQKTS SIGKLYAIIE LQTILVSTYT 100
    DVLGVLTTKA PYVFPSNVRY EPRSMKKIAH DILTTINVAT VSEKVMGRHN 150
    VSELVTNVNL LMEEYLRRHN KSCICYGSYS LYLLNPSIEY GDIDIMQTNS 200
    RIFLINLAFL IKFITGHNVM LLKVPYLKNY MVLRDDEDKH IIDSFNVRQD 250
    TMHSIPKILI DNIYIVDPTF QLLSMIKMFS QVDRLEDLAR NQEKATIKLA 300
    TLLEYVRVKH GIIFNGKVTN MPMPSSFDHE KRIITVDTSR YNFSFKKCFV 350
    YLDENSLSSD ILNLNADDAI DFENVSNSVF LINDEIMYTY FSNTILMSSK 400
    DEIHEISARG VSAHILMYQI LTDGDYLIPL SDIVNSLMFK EKIPIFSIIP 450
    RDKKTGKHGI INIEKDIITH 470
    Length:470
    Mass (Da):54,614
    Last modified:July 5, 2004 - v1
    Checksum:i523D828081B1669B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY386371 Genomic DNA. Translation: AAR07389.1.
    RefSeqiNP_938288.1. NC_005179.1.

    Genome annotation databases

    GeneIDi2943665.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY386371 Genomic DNA. Translation: AAR07389.1 .
    RefSeqi NP_938288.1. NC_005179.1.

    3D structure databases

    ProteinModelPortali Q6TUY0.
    SMRi Q6TUY0. Positions 9-468.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2943665.

    Family and domain databases

    InterProi IPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view ]
    Pfami PF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015693. VAC-48L_nuct. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus."
      Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T., Li X., Barrett J.W., McFadden G.
      J. Virol. 77:13335-13347(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiPAP1_YMTV5
    AccessioniPrimary (citable) accession number: Q6TUY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3