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Q6TUJ5

- Q6TUJ5_LEIME

UniProt

Q6TUJ5 - Q6TUJ5_LEIME

Protein

Arginase

Gene

ARG

Organism
Leishmania mexicana
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-arginine + H2O = L-ornithine + urea.UniRule annotation

    Cofactori

    Binds 2 manganese ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi114 – 1141Manganese 1; via pros nitrogenImported
    Metal bindingi137 – 1371Manganese 1Imported
    Metal bindingi137 – 1371Manganese 2Imported
    Metal bindingi139 – 1391Manganese 2; via pros nitrogenImported
    Metal bindingi141 – 1411Manganese 1Imported
    Metal bindingi243 – 2431Manganese 1Imported
    Metal bindingi243 – 2431Manganese 2Imported
    Metal bindingi245 – 2451Manganese 2Imported

    GO - Molecular functioni

    1. arginase activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine metabolic process Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Arginine metabolismUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotationImported, Metal-bindingUniRule annotationImported

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ArginaseUniRule annotation (EC:3.5.3.1UniRule annotation)
    Gene namesi
    Name:ARGImported
    OrganismiLeishmania mexicanaImported
    Taxonomic identifieri5665 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4ITYX-ray1.80A13-329[»]
    4IU0X-ray1.77A13-329[»]
    4IU1X-ray1.95A13-329[»]
    4IU4X-ray1.80A13-329[»]
    4IU5X-ray1.95A13-329[»]
    ProteinModelPortaliQ6TUJ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the arginase family.UniRule annotation

    Family and domain databases

    Gene3Di3.40.800.10. 1 hit.
    InterProiIPR014033. Arginase.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view]
    PANTHERiPTHR11358. PTHR11358. 1 hit.
    PfamiPF00491. Arginase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036979. Arginase. 1 hit.
    PRINTSiPR00116. ARGINASE.
    TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
    PROSITEiPS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6TUJ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEHVQQYKFY KEKKMSIVLA PFSGGQPHSG VELGPDYLLK QGLQQDMEKL    50
    GWDTRLERVF DGKVVEARKA SDNGDRIGRV KRPRLTAECT EKIYKCVRRV 100
    AEQGRFPLTI GGDHSIALGT VAGVLSVHPD AGVIWVDAHA DINTMSGTVS 150
    GNLHGCPLSI LLGLDRENIP ECFSWVPQVL KPNKIAYIGL RAVDDEEKKI 200
    LHDLNIAAFS MHHVDRYGID KVVSMAIEAV SPKGTEPVMV SYDVDTIDPL 250
    YVPATGTPVR GGLSFREALF LCERIAECGR LVALDVVECN PLLAATESHV 300
    NDTISVGCAI ARCMMGETLL YTPHTSSKL 329
    Length:329
    Mass (Da):36,082
    Last modified:July 5, 2004 - v1
    Checksum:i98A2BCA12455AF0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY386701 Genomic DNA. Translation: AAR06176.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY386701 Genomic DNA. Translation: AAR06176.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4ITY X-ray 1.80 A 13-329 [» ]
    4IU0 X-ray 1.77 A 13-329 [» ]
    4IU1 X-ray 1.95 A 13-329 [» ]
    4IU4 X-ray 1.80 A 13-329 [» ]
    4IU5 X-ray 1.95 A 13-329 [» ]
    ProteinModelPortali Q6TUJ5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.800.10. 1 hit.
    InterProi IPR014033. Arginase.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view ]
    PANTHERi PTHR11358. PTHR11358. 1 hit.
    Pfami PF00491. Arginase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036979. Arginase. 1 hit.
    PRINTSi PR00116. ARGINASE.
    TIGRFAMsi TIGR01229. rocF_arginase. 1 hit.
    PROSITEi PS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Arginase plays a pivotal role in polyamine precursor metabolism in Leishmania. Characterization of gene deletion mutants."
      Roberts S.C., Tancer M.J., Polinsky M.R., Gibson K.M., Heby O., Ullman B.
      J. Biol. Chem. 279:23668-23678(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections."
      D'Antonio E.L., Ullman B., Roberts S.C., Dixit U.G., Wilson M.E., Hai Y., Christianson D.W.
      Arch. Biochem. Biophys. 535:163-176(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.77 ANGSTROMS) OF 13-329 IN COMPLEX WITH MANGANESE.

    Entry informationi

    Entry nameiQ6TUJ5_LEIME
    AccessioniPrimary (citable) accession number: Q6TUJ5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3