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Protein

Arginase

Gene

ARG

Organism
Leishmania mexicana
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi137ManganeseCombined sources1
Metal bindingi141ManganeseCombined sources1
Metal bindingi243ManganeseCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processArginine metabolismUniRule annotation
LigandManganeseUniRule annotationCombined sources, Metal-bindingUniRule annotationCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
ArginaseUniRule annotation (EC:3.5.3.1UniRule annotation)
Gene namesi
Name:ARGImported
OrganismiLeishmania mexicanaImported
Taxonomic identifieri5665 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ITYX-ray1.80A13-329[»]
4IU0X-ray1.77A13-329[»]
4IU1X-ray1.95A13-329[»]
4IU4X-ray1.80A13-329[»]
4IU5X-ray1.95A13-329[»]
5HJ9X-ray1.28A13-329[»]
5HJAX-ray1.65A13-329[»]
ProteinModelPortaliQ6TUJ5
SMRiQ6TUJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2965 Eukaryota
COG0010 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR014033 Arginase
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PRINTSiPR00116 ARGINASE
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01229 rocF_arginase, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6TUJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHVQQYKFY KEKKMSIVLA PFSGGQPHSG VELGPDYLLK QGLQQDMEKL
60 70 80 90 100
GWDTRLERVF DGKVVEARKA SDNGDRIGRV KRPRLTAECT EKIYKCVRRV
110 120 130 140 150
AEQGRFPLTI GGDHSIALGT VAGVLSVHPD AGVIWVDAHA DINTMSGTVS
160 170 180 190 200
GNLHGCPLSI LLGLDRENIP ECFSWVPQVL KPNKIAYIGL RAVDDEEKKI
210 220 230 240 250
LHDLNIAAFS MHHVDRYGID KVVSMAIEAV SPKGTEPVMV SYDVDTIDPL
260 270 280 290 300
YVPATGTPVR GGLSFREALF LCERIAECGR LVALDVVECN PLLAATESHV
310 320
NDTISVGCAI ARCMMGETLL YTPHTSSKL
Length:329
Mass (Da):36,082
Last modified:July 5, 2004 - v1
Checksum:i98A2BCA12455AF0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY386701 Genomic DNA Translation: AAR06176.1

Similar proteinsi

Entry informationi

Entry nameiQ6TUJ5_LEIME
AccessioniPrimary (citable) accession number: Q6TUJ5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

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