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Q6TUJ5 (Q6TUJ5_LEIME) Unreviewed, UniProtKB/TrEMBL

Last modified December 11, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:ARG EMBL AAR06176.1
OrganismLeishmania mexicana EMBL AAR06176.1
Taxonomic identifier5665 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Cofactor

Manganese By similarity. RuleBase RU003684

Sequence similarities

Belongs to the arginase family. RuleBase RU003684

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding1141Manganese 1; via pros nitrogen PDB 4ITY PDB 4IU0 PDB 4IU1 PDB 4IU4 PDB 4IU5
Metal binding1371Manganese 1 PDB 4ITY PDB 4IU0 PDB 4IU1 PDB 4IU4 PDB 4IU5
Metal binding1371Manganese 2 PDB 4ITY PDB 4IU0 PDB 4IU1 PDB 4IU4 PDB 4IU5
Metal binding1391Manganese 2; via pros nitrogen PDB 4ITY PDB 4IU0 PDB 4IU1 PDB 4IU4 PDB 4IU5
Metal binding1411Manganese 1 PDB 4ITY PDB 4IU0 PDB 4IU1 PDB 4IU4 PDB 4IU5
Metal binding2431Manganese 1 PDB 4ITY PDB 4IU0 PDB 4IU1 PDB 4IU4 PDB 4IU5
Metal binding2431Manganese 2 PDB 4ITY PDB 4IU0 PDB 4IU1 PDB 4IU4 PDB 4IU5
Metal binding2451Manganese 2 PDB 4ITY PDB 4IU0 PDB 4IU1 PDB 4IU4 PDB 4IU5

Sequences

Sequence LengthMass (Da)Tools
Q6TUJ5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 98A2BCA12455AF0B

FASTA32936,082
        10         20         30         40         50         60 
MEHVQQYKFY KEKKMSIVLA PFSGGQPHSG VELGPDYLLK QGLQQDMEKL GWDTRLERVF 

        70         80         90        100        110        120 
DGKVVEARKA SDNGDRIGRV KRPRLTAECT EKIYKCVRRV AEQGRFPLTI GGDHSIALGT 

       130        140        150        160        170        180 
VAGVLSVHPD AGVIWVDAHA DINTMSGTVS GNLHGCPLSI LLGLDRENIP ECFSWVPQVL 

       190        200        210        220        230        240 
KPNKIAYIGL RAVDDEEKKI LHDLNIAAFS MHHVDRYGID KVVSMAIEAV SPKGTEPVMV 

       250        260        270        280        290        300 
SYDVDTIDPL YVPATGTPVR GGLSFREALF LCERIAECGR LVALDVVECN PLLAATESHV 

       310        320 
NDTISVGCAI ARCMMGETLL YTPHTSSKL 

« Hide

References

[1]"Arginase plays a pivotal role in polyamine precursor metabolism in Leishmania. Characterization of gene deletion mutants."
Roberts S.C., Tancer M.J., Polinsky M.R., Gibson K.M., Heby O., Ullman B.
J. Biol. Chem. 279:23668-23678(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections."
D'Antonio E.L., Ullman B., Roberts S.C., Dixit U.G., Wilson M.E., Hai Y., Christianson D.W.
Arch. Biochem. Biophys. 535:163-176(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.77 ANGSTROMS) OF 13-329 IN COMPLEX WITH MANGANESE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY386701 Genomic DNA. Translation: AAR06176.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4ITYX-ray1.80A13-329[»]
4IU0X-ray1.77A13-329[»]
4IU1X-ray1.95A13-329[»]
4IU4X-ray1.80A13-329[»]
4IU5X-ray1.95A13-329[»]
ProteinModelPortalQ6TUJ5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.800.10. 1 hit.
InterProIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERPTHR11358. PTHR11358. 1 hit.
PTHR11358:SF2. PTHR11358:SF2. 1 hit.
PfamPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFPIRSF036979. Arginase. 1 hit.
PRINTSPR00116. ARGINASE.
TIGRFAMsTIGR01229. rocF_arginase. 1 hit.
PROSITEPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ6TUJ5_LEIME
AccessionPrimary (citable) accession number: Q6TUJ5
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: December 11, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)