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Protein

Succinate dehydrogenase assembly factor 3, mitochondrial

Gene

Sdhaf3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit Sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.By similarity

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase assembly factor 3, mitochondrialBy similarity
Short name:
SDH assembly factor 3By similarity
Short name:
SDHAF3By similarity
Alternative name(s):
Liver regeneration-related protein LRRGT00092
Gene namesi
Name:Sdhaf3By similarity
Synonyms:Acn9By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1305143. Sdhaf3.

Subcellular locationi

  • Mitochondrion matrix By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionSequence analysisAdd
BLAST
Chaini31 – 12595Succinate dehydrogenase assembly factor 3, mitochondrialPRO_0000042712Add
BLAST

Proteomic databases

PaxDbiQ6TUF2.
PRIDEiQ6TUF2.

Expressioni

Gene expression databases

GenevisibleiQ6TUF2. RN.

Interactioni

Subunit structurei

Interacts with Sdhb within an Sdha-Sdhb subcomplex.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015286.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I LYR family. SDHAF3 subfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4100. Eukaryota.
ENOG4111Y90. LUCA.
GeneTreeiENSGT00390000010029.
HOGENOMiHOG000039506.
HOVERGENiHBG080818.
InParanoidiQ6TUF2.
OMAiEFRRHKS.
OrthoDBiEOG72NRS8.
PhylomeDBiQ6TUF2.
TreeFamiTF105635.

Family and domain databases

InterProiIPR008381. ACN9.
[Graphical view]
PANTHERiPTHR13137. PTHR13137. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6TUF2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGRHVSRVR SLYRRILQLH RALPPDLKAL GDQYVKDEFR RHKTVGPGEA
60 70 80 90 100
QRFLKEWETY AAVLWQQAKD SRQSSSGKAC FGTSLPEEKL NDFRDEQIGQ
110 120
LQELMQEATK PNRQFSITES TKPHL
Length:125
Mass (Da):14,525
Last modified:November 8, 2005 - v2
Checksum:iB7CEAAADA68269DC
GO
Isoform 2 (identifier: Q6TUF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: MTGRHVSRVR...EAQRFLKEWE → MARSGWQKFD...SFGSFGGNEI

Note: No experimental confirmation available.
Show »
Length:111
Mass (Da):12,289
Checksum:iA2B5370C7BC0053B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5858MTGRH…LKEWE → MARSGWQKFDCVVVTARGSD TSTLAKDADENRPPSFGSFG GNEI in isoform 2. 1 PublicationVSP_016050Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY387078 mRNA. Translation: AAQ91048.1.
AABR03035336 Genomic DNA. No translation available.
AABR03033448 Genomic DNA. No translation available.
RefSeqiNP_001041379.1. NM_001047914.1. [Q6TUF2-2]
UniGeneiRn.101965.

Genome annotation databases

EnsembliENSRNOT00000015286; ENSRNOP00000015286; ENSRNOG00000011283. [Q6TUF2-1]
ENSRNOT00000050827; ENSRNOP00000040707; ENSRNOG00000011283. [Q6TUF2-2]
GeneIDi362323.
KEGGirno:362323.
UCSCiRGD:1305143. rat. [Q6TUF2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY387078 mRNA. Translation: AAQ91048.1.
AABR03035336 Genomic DNA. No translation available.
AABR03033448 Genomic DNA. No translation available.
RefSeqiNP_001041379.1. NM_001047914.1. [Q6TUF2-2]
UniGeneiRn.101965.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015286.

Proteomic databases

PaxDbiQ6TUF2.
PRIDEiQ6TUF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015286; ENSRNOP00000015286; ENSRNOG00000011283. [Q6TUF2-1]
ENSRNOT00000050827; ENSRNOP00000040707; ENSRNOG00000011283. [Q6TUF2-2]
GeneIDi362323.
KEGGirno:362323.
UCSCiRGD:1305143. rat. [Q6TUF2-1]

Organism-specific databases

CTDi57001.
RGDi1305143. Sdhaf3.

Phylogenomic databases

eggNOGiKOG4100. Eukaryota.
ENOG4111Y90. LUCA.
GeneTreeiENSGT00390000010029.
HOGENOMiHOG000039506.
HOVERGENiHBG080818.
InParanoidiQ6TUF2.
OMAiEFRRHKS.
OrthoDBiEOG72NRS8.
PhylomeDBiQ6TUF2.
TreeFamiTF105635.

Miscellaneous databases

PROiQ6TUF2.

Gene expression databases

GenevisibleiQ6TUF2. RN.

Family and domain databases

InterProiIPR008381. ACN9.
[Graphical view]
PANTHERiPTHR13137. PTHR13137. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Liver regeneration after PH."
    Xu C.S., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiSDHF3_RAT
AccessioniPrimary (citable) accession number: Q6TUF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: June 8, 2016
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.