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Q6TRW4

- PDS5B_RAT

UniProt

Q6TRW4 - PDS5B_RAT

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Protein

Sister chromatid cohesion protein PDS5 homolog B

Gene

Pds5b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi1247 – 125913A.T hook 1Sequence AnalysisAdd
BLAST
DNA bindingi1287 – 129913A.T hook 2Sequence AnalysisAdd
BLAST
DNA bindingi1371 – 138313A.T hook 3Sequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro

GO - Biological processi

  1. mitotic sister chromatid cohesion Source: UniProtKB
  2. negative regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5 homolog B
Alternative name(s):
Androgen-induced proliferation inhibitor
Androgen-induced prostate proliferative shutoff-associated protein AS3
Gene namesi
Name:Pds5b
Synonyms:Aprin, As31 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1310838. Pds5b.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14471447Sister chromatid cohesion protein PDS5 homolog BPRO_0000287426Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1136 – 11361N6-acetyllysineBy similarity
Modified residuei1162 – 11621PhosphoserineBy similarity
Modified residuei1166 – 11661PhosphoserineBy similarity
Modified residuei1176 – 11761PhosphoserineBy similarity
Modified residuei1182 – 11821PhosphoserineBy similarity
Modified residuei1191 – 11911PhosphoserineBy similarity
Modified residuei1257 – 12571PhosphoserineBy similarity
Modified residuei1259 – 12591PhosphoserineBy similarity
Modified residuei1283 – 12831PhosphoserineBy similarity
Modified residuei1357 – 13571PhosphoserineBy similarity
Modified residuei1366 – 13661PhosphothreonineBy similarity
Modified residuei1369 – 13691PhosphothreonineBy similarity
Modified residuei1378 – 13781PhosphoserineBy similarity
Modified residuei1380 – 13801PhosphothreonineBy similarity
Modified residuei1382 – 13821PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6TRW4.
PRIDEiQ6TRW4.

PTM databases

PhosphoSiteiQ6TRW4.

Expressioni

Tissue specificityi

Highly expressed in intact prostate with levels decreasing after castration. Expressed exclusively in prostate cells inhibited from proliferating by long-term androgen exposure.1 Publication

Gene expression databases

GenevestigatoriQ6TRW4.

Interactioni

Subunit structurei

Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPAL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6TRW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati383 – 41937HEATSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the PDS5 family.Curated
Contains 3 A.T hook DNA-binding domains.Sequence Analysis
Contains 1 HEAT repeat.Sequence Analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG268017.
HOGENOMiHOG000230672.
HOVERGENiHBG108241.
InParanoidiQ6TRW4.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR017956. AT_hook_DNA-bd_motif.
[Graphical view]
SMARTiSM00384. AT_hook. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q6TRW4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHSKTRTND GKITYPPGVK EISDKISKEE MVRRLKMVVK TFMDMDQDSE
60 70 80 90 100
EEKELYLNLA LHLASDFFLK HPDKDVRLLV ACCLADIFRI YAPEAPYTSP
110 120 130 140 150
DKLKDIFMFI TRQLKGLEDT KSPQFNRYFY LLENIAWVKS YNICFELEDS
160 170 180 190 200
NEIFTQLYRT LFSVINNGHN QKVHMHMVDL MSSIICEGDT VSQELLDTVL
210 220 230 240 250
VNLVPAHKNL NKQAYDLAKA LLKRTAQAIE PYITNFFNQV LMLGKTSISD
260 270 280 290 300
LSEHVFDLIL ELYNIDSHLL LSVLPQLEFK LKSNDNEERL QVVKLLAKMF
310 320 330 340 350
GAKDSELASQ NKPLWQCYLG RFNDIHVPIR LECVKFASHC LMNHPDLAKD
360 370 380 390 400
LTEYLKVRSH DPEEAIRHDV IVSIVTAAKK DILLVNDHLL NFVRERTLDK
410 420 430 440 450
RWRVRKEAMM GLAQIYKKYA LQSAAGKDAA KQICWVKDKL LHIYYQNSID
460 470 480 490 500
DRLLVERIFA QYMVPHNLET TERMKCLYYL YATLDLNAVK ALNEMWKCQN
510 520 530 540 550
LLRHQVKDLL DLIKQPKTDA SVKAIFSKVM VITRNLPDPG KAQDFMKKFT
560 570 580 590 600
QVLEDDEKIR KQLEALVSPT CSCKQAEGCV REITKKLGNP KQPTNPFLEM
610 620 630 640 650
IKFLLERIAP VHIDTESISA LIKQVNKSID GTADDEDEGV PTDQAIRAGL
660 670 680 690 700
ELLKVLSFTH PISFHSAETF ESLLACLKMD DEKVAEAALQ IFKNTGSKIE
710 720 730 740 750
EDFPHIRSAL LPVLHHKSKK GPPRQAKYAI HCIHAIFSSK ETQFAQIFEP
760 770 780 790 800
LHKSLDPSNL EHLITPLVTI GHIALLAPDQ FAAPLKSLVA TFIVKDLLMN
810 820 830 840 850
DRLPGKKTTK LWVPDEEVSP ETMVKIQAIK MMVRWLLGMK NNHSKSGTST
860 870 880 890 900
LRLLTTILHS DGDLTEQGKI SKPDMSRLRL AAGSAIVKLA QEPCYHEIIT
910 920 930 940 950
LEQYQLCALA INDECYQVRQ VFAQKLHKGL SRLRLPLEYM AICALCAKDP
960 970 980 990 1000
VKERRAHARQ CLVKNITVRR EYLKQHAAVS EKLLSLLPEY VVPYTIHLLA
1010 1020 1030 1040 1050
HDPDYVKVQD IEQLKDVKEC LWFVLEILMA KNENNSHAFI RKMVENIKQT
1060 1070 1080 1090 1100
KDAQGPDDTK MNEKLYTVCD VAMNIIMSKS TTYSLESPKD PVLPARFFTQ
1110 1120 1130 1140 1150
PDKNFSNTKN YLPPEMKSFF TPGKPKTANV LGAVNKPLSS AGKQSQTKSS
1160 1170 1180 1190 1200
RMETVSNASS SSNPSSPGRI KGRLDSTEMD HSENEDYTMS SPLPGKKSDK
1210 1220 1230 1240 1250
REDSDLVRSE LEKPRSRKKA SVTDPEEKLG MDDLSKLVQE QKPKGSQRGR
1260 1270 1280 1290 1300
KRGHAASESE EQQWPEEKRH KEELLGNEDE QNSPPKKGKR GRPPKPLGGT
1310 1320 1330 1340 1350
SKEEPVVKTS KKGNKKKPAP PVVDEDEEEE RQMGNTEQKS KSKQQRTSKR
1360 1370 1380 1390 1400
AQQRAESPET SAVESTQSTP QKGRGRPSKT PSPSQPKKNI RVGRSKQVAT
1410 1420 1430 1440
KENDSSEEMD VLQASSPVSD DTTQEGAEEE DISAGNVRRR SSKRERR

Note: Gene prediction based on EST data.Curated

Length:1,447
Mass (Da):164,459
Last modified:May 15, 2007 - v2
Checksum:i9EC8B4A03C320428
GO
Isoform 21 Publication (identifier: Q6TRW4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1354-1390: RAESPETSAVESTQSTPQKGRGRPSKTPSPSQPKKNI → S

Show »
Length:1,411
Mass (Da):160,614
Checksum:i74871AAFFA93E1ED
GO
Isoform 31 Publication (identifier: Q6TRW4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1207-1208: Missing.

Show »
Length:1,445
Mass (Da):164,204
Checksum:i5C63A886EC3E7C8F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1207 – 12082Missing in isoform 3. 1 PublicationVSP_052407
Alternative sequencei1354 – 139037RAESP…PKKNI → S in isoform 2. 1 PublicationVSP_052408Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03082233 Genomic DNA. No translation available.
AABR03082545 Genomic DNA. No translation available.
AY388627 mRNA. Translation: AAQ91374.1.
AY820182 mRNA. Translation: AAV68352.1.
AY820183 mRNA. Translation: AAV68353.1.
AY831451 Genomic DNA. Translation: AAW69306.1.
AY831452 mRNA. Translation: AAW69307.1.
AY836673 mRNA. Translation: AAW69308.1.
UniGeneiRn.105768.

Genome annotation databases

UCSCiRGD:1310838. rat. [Q6TRW4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03082233 Genomic DNA. No translation available.
AABR03082545 Genomic DNA. No translation available.
AY388627 mRNA. Translation: AAQ91374.1 .
AY820182 mRNA. Translation: AAV68352.1 .
AY820183 mRNA. Translation: AAV68353.1 .
AY831451 Genomic DNA. Translation: AAW69306.1 .
AY831452 mRNA. Translation: AAW69307.1 .
AY836673 mRNA. Translation: AAW69308.1 .
UniGenei Rn.105768.

3D structure databases

ProteinModelPortali Q6TRW4.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6TRW4.

Proteomic databases

PaxDbi Q6TRW4.
PRIDEi Q6TRW4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:1310838. rat. [Q6TRW4-1 ]

Organism-specific databases

RGDi 1310838. Pds5b.

Phylogenomic databases

eggNOGi NOG268017.
HOGENOMi HOG000230672.
HOVERGENi HBG108241.
InParanoidi Q6TRW4.

Miscellaneous databases

PROi Q6TRW4.

Gene expression databases

Genevestigatori Q6TRW4.

Family and domain databases

Gene3Di 1.25.10.10. 4 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR017956. AT_hook_DNA-bd_motif.
[Graphical view ]
SMARTi SM00384. AT_hook. 2 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 5 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway1 Publication.
  2. "Aprin expression in rat olfactory epithelium."
    Weiler E., Farbman A.I.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-283, NUCLEOTIDE SEQUENCE [MRNA] OF 1110-1378 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1110-1264 (ISOFORM 3), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1327-1381 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1334-1420 (ISOFORM 2).
    Strain: Sprague-DawleyImported and WistarImported.
    Tissue: LiverImported and TestisImported.
  3. "Expression of novel genes linked to the androgen-induced, proliferative shutoff in prostate cancer cells."
    Geck P., Szelei J., Jimenez J., Lin T.-M., Sonnenschein C., Soto A.M.
    J. Steroid Biochem. Mol. Biol. 63:211-218(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Mechanism of androgen action on cell proliferation: AS3 protein as a mediator of proliferative arrest in the rat prostate."
    Maffini M.V., Geck P., Powell C.E., Sonnenschein C., Soto A.M.
    Endocrinology 143:2708-2714(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPDS5B_RAT
AccessioniPrimary (citable) accession number: Q6TRW4
Secondary accession number(s): Q5G5U1
, Q5G6V7, Q5G6V8, Q5PY35, Q5PY36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: October 29, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3