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Protein

Sister chromatid cohesion protein PDS5 homolog B

Gene

Pds5b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1247 – 1259A.T hook 1Sequence analysisAdd BLAST13
DNA bindingi1287 – 1299A.T hook 2Sequence analysisAdd BLAST13
DNA bindingi1371 – 1383A.T hook 3Sequence analysisAdd BLAST13

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5 homolog B
Alternative name(s):
Androgen-induced proliferation inhibitor
Androgen-induced prostate proliferative shutoff-associated protein AS3
Gene namesi
Name:Pds5b
Synonyms:Aprin, As31 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310838. Pds5b.

Subcellular locationi

GO - Cellular componenti

  • chromatin Source: GO_Central
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002874261 – 1447Sister chromatid cohesion protein PDS5 homolog BAdd BLAST1447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1136N6-acetyllysineBy similarity1
Modified residuei1140PhosphoserineBy similarity1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1166PhosphoserineCombined sources1
Modified residuei1176PhosphoserineBy similarity1
Modified residuei1182PhosphoserineBy similarity1
Modified residuei1191PhosphoserineBy similarity1
Modified residuei1221PhosphoserineCombined sources1
Modified residuei1257PhosphoserineCombined sources1
Modified residuei1259PhosphoserineBy similarity1
Modified residuei1283PhosphoserineCombined sources1
Modified residuei1357PhosphoserineCombined sources1
Modified residuei1365PhosphoserineBy similarity1
Modified residuei1366PhosphothreonineBy similarity1
Modified residuei1368PhosphoserineBy similarity1
Modified residuei1369PhosphothreonineCombined sources1
Modified residuei1380PhosphothreonineBy similarity1
Modified residuei1382PhosphoserineBy similarity1
Modified residuei1416PhosphoserineBy similarity1
Modified residuei1419PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6TRW4.
PeptideAtlasiQ6TRW4.
PRIDEiQ6TRW4.

PTM databases

iPTMnetiQ6TRW4.
PhosphoSitePlusiQ6TRW4.

Expressioni

Tissue specificityi

Highly expressed in intact prostate with levels decreasing after castration. Expressed exclusively in prostate cells inhibited from proliferating by long-term androgen exposure.1 Publication

Interactioni

Subunit structurei

Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063199.

Structurei

3D structure databases

ProteinModelPortaliQ6TRW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati383 – 419HEATSequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the PDS5 family.Curated
Contains 3 A.T hook DNA-binding domains.Sequence analysis
Contains 1 HEAT repeat.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1525. Eukaryota.
ENOG410XQW7. LUCA.
HOGENOMiHOG000230672.
HOVERGENiHBG108241.
InParanoidiQ6TRW4.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q6TRW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHSKTRTND GKITYPPGVK EISDKISKEE MVRRLKMVVK TFMDMDQDSE
60 70 80 90 100
EEKELYLNLA LHLASDFFLK HPDKDVRLLV ACCLADIFRI YAPEAPYTSP
110 120 130 140 150
DKLKDIFMFI TRQLKGLEDT KSPQFNRYFY LLENIAWVKS YNICFELEDS
160 170 180 190 200
NEIFTQLYRT LFSVINNGHN QKVHMHMVDL MSSIICEGDT VSQELLDTVL
210 220 230 240 250
VNLVPAHKNL NKQAYDLAKA LLKRTAQAIE PYITNFFNQV LMLGKTSISD
260 270 280 290 300
LSEHVFDLIL ELYNIDSHLL LSVLPQLEFK LKSNDNEERL QVVKLLAKMF
310 320 330 340 350
GAKDSELASQ NKPLWQCYLG RFNDIHVPIR LECVKFASHC LMNHPDLAKD
360 370 380 390 400
LTEYLKVRSH DPEEAIRHDV IVSIVTAAKK DILLVNDHLL NFVRERTLDK
410 420 430 440 450
RWRVRKEAMM GLAQIYKKYA LQSAAGKDAA KQICWVKDKL LHIYYQNSID
460 470 480 490 500
DRLLVERIFA QYMVPHNLET TERMKCLYYL YATLDLNAVK ALNEMWKCQN
510 520 530 540 550
LLRHQVKDLL DLIKQPKTDA SVKAIFSKVM VITRNLPDPG KAQDFMKKFT
560 570 580 590 600
QVLEDDEKIR KQLEALVSPT CSCKQAEGCV REITKKLGNP KQPTNPFLEM
610 620 630 640 650
IKFLLERIAP VHIDTESISA LIKQVNKSID GTADDEDEGV PTDQAIRAGL
660 670 680 690 700
ELLKVLSFTH PISFHSAETF ESLLACLKMD DEKVAEAALQ IFKNTGSKIE
710 720 730 740 750
EDFPHIRSAL LPVLHHKSKK GPPRQAKYAI HCIHAIFSSK ETQFAQIFEP
760 770 780 790 800
LHKSLDPSNL EHLITPLVTI GHIALLAPDQ FAAPLKSLVA TFIVKDLLMN
810 820 830 840 850
DRLPGKKTTK LWVPDEEVSP ETMVKIQAIK MMVRWLLGMK NNHSKSGTST
860 870 880 890 900
LRLLTTILHS DGDLTEQGKI SKPDMSRLRL AAGSAIVKLA QEPCYHEIIT
910 920 930 940 950
LEQYQLCALA INDECYQVRQ VFAQKLHKGL SRLRLPLEYM AICALCAKDP
960 970 980 990 1000
VKERRAHARQ CLVKNITVRR EYLKQHAAVS EKLLSLLPEY VVPYTIHLLA
1010 1020 1030 1040 1050
HDPDYVKVQD IEQLKDVKEC LWFVLEILMA KNENNSHAFI RKMVENIKQT
1060 1070 1080 1090 1100
KDAQGPDDTK MNEKLYTVCD VAMNIIMSKS TTYSLESPKD PVLPARFFTQ
1110 1120 1130 1140 1150
PDKNFSNTKN YLPPEMKSFF TPGKPKTANV LGAVNKPLSS AGKQSQTKSS
1160 1170 1180 1190 1200
RMETVSNASS SSNPSSPGRI KGRLDSTEMD HSENEDYTMS SPLPGKKSDK
1210 1220 1230 1240 1250
REDSDLVRSE LEKPRSRKKA SVTDPEEKLG MDDLSKLVQE QKPKGSQRGR
1260 1270 1280 1290 1300
KRGHAASESE EQQWPEEKRH KEELLGNEDE QNSPPKKGKR GRPPKPLGGT
1310 1320 1330 1340 1350
SKEEPVVKTS KKGNKKKPAP PVVDEDEEEE RQMGNTEQKS KSKQQRTSKR
1360 1370 1380 1390 1400
AQQRAESPET SAVESTQSTP QKGRGRPSKT PSPSQPKKNI RVGRSKQVAT
1410 1420 1430 1440
KENDSSEEMD VLQASSPVSD DTTQEGAEEE DISAGNVRRR SSKRERR
Note: Gene prediction based on EST data.Curated
Length:1,447
Mass (Da):164,459
Last modified:May 15, 2007 - v2
Checksum:i9EC8B4A03C320428
GO
Isoform 21 Publication (identifier: Q6TRW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1354-1390: RAESPETSAVESTQSTPQKGRGRPSKTPSPSQPKKNI → S

Show »
Length:1,411
Mass (Da):160,614
Checksum:i74871AAFFA93E1ED
GO
Isoform 31 Publication (identifier: Q6TRW4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1207-1208: Missing.

Show »
Length:1,445
Mass (Da):164,204
Checksum:i5C63A886EC3E7C8F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0524071207 – 1208Missing in isoform 3. 1 Publication2
Alternative sequenceiVSP_0524081354 – 1390RAESP…PKKNI → S in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03082233 Genomic DNA. No translation available.
AABR03082545 Genomic DNA. No translation available.
AY388627 mRNA. Translation: AAQ91374.1.
AY820182 mRNA. Translation: AAV68352.1.
AY820183 mRNA. Translation: AAV68353.1.
AY831451 Genomic DNA. Translation: AAW69306.1.
AY831452 mRNA. Translation: AAW69307.1.
AY836673 mRNA. Translation: AAW69308.1.
UniGeneiRn.105768.

Genome annotation databases

UCSCiRGD:1310838. rat. [Q6TRW4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03082233 Genomic DNA. No translation available.
AABR03082545 Genomic DNA. No translation available.
AY388627 mRNA. Translation: AAQ91374.1.
AY820182 mRNA. Translation: AAV68352.1.
AY820183 mRNA. Translation: AAV68353.1.
AY831451 Genomic DNA. Translation: AAW69306.1.
AY831452 mRNA. Translation: AAW69307.1.
AY836673 mRNA. Translation: AAW69308.1.
UniGeneiRn.105768.

3D structure databases

ProteinModelPortaliQ6TRW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063199.

PTM databases

iPTMnetiQ6TRW4.
PhosphoSitePlusiQ6TRW4.

Proteomic databases

PaxDbiQ6TRW4.
PeptideAtlasiQ6TRW4.
PRIDEiQ6TRW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:1310838. rat. [Q6TRW4-1]

Organism-specific databases

RGDi1310838. Pds5b.

Phylogenomic databases

eggNOGiKOG1525. Eukaryota.
ENOG410XQW7. LUCA.
HOGENOMiHOG000230672.
HOVERGENiHBG108241.
InParanoidiQ6TRW4.

Miscellaneous databases

PROiQ6TRW4.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPDS5B_RAT
AccessioniPrimary (citable) accession number: Q6TRW4
Secondary accession number(s): Q5G5U1
, Q5G6V7, Q5G6V8, Q5PY35, Q5PY36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 2, 2016
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.