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Q6TRW4

- PDS5B_RAT

UniProt

Q6TRW4 - PDS5B_RAT

Protein

Sister chromatid cohesion protein PDS5 homolog B

Gene

Pds5b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (15 May 2007)
      Previous versions | rss
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    Functioni

    Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi1247 – 125913A.T hook 1Sequence AnalysisAdd
    BLAST
    DNA bindingi1287 – 129913A.T hook 2Sequence AnalysisAdd
    BLAST
    DNA bindingi1371 – 138313A.T hook 3Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: InterPro

    GO - Biological processi

    1. mitotic sister chromatid cohesion Source: UniProtKB
    2. negative regulation of cell proliferation Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sister chromatid cohesion protein PDS5 homolog B
    Alternative name(s):
    Androgen-induced proliferation inhibitor
    Androgen-induced prostate proliferative shutoff-associated protein AS3
    Gene namesi
    Name:Pds5b
    Synonyms:Aprin, As31 Publication
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1310838. Pds5b.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14471447Sister chromatid cohesion protein PDS5 homolog BPRO_0000287426Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1136 – 11361N6-acetyllysineBy similarity
    Modified residuei1162 – 11621PhosphoserineBy similarity
    Modified residuei1166 – 11661PhosphoserineBy similarity
    Modified residuei1176 – 11761PhosphoserineBy similarity
    Modified residuei1182 – 11821PhosphoserineBy similarity
    Modified residuei1191 – 11911PhosphoserineBy similarity
    Modified residuei1257 – 12571PhosphoserineBy similarity
    Modified residuei1259 – 12591PhosphoserineBy similarity
    Modified residuei1283 – 12831PhosphoserineBy similarity
    Modified residuei1357 – 13571PhosphoserineBy similarity
    Modified residuei1366 – 13661PhosphothreonineBy similarity
    Modified residuei1369 – 13691PhosphothreonineBy similarity
    Modified residuei1378 – 13781PhosphoserineBy similarity
    Modified residuei1380 – 13801PhosphothreonineBy similarity
    Modified residuei1382 – 13821PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ6TRW4.
    PRIDEiQ6TRW4.

    PTM databases

    PhosphoSiteiQ6TRW4.

    Expressioni

    Tissue specificityi

    Highly expressed in intact prostate with levels decreasing after castration. Expressed exclusively in prostate cells inhibited from proliferating by long-term androgen exposure.1 Publication

    Gene expression databases

    GenevestigatoriQ6TRW4.

    Interactioni

    Subunit structurei

    Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPAL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6TRW4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati383 – 41937HEATSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PDS5 family.Curated
    Contains 3 A.T hook DNA-binding domains.Sequence Analysis
    Contains 1 HEAT repeat.Sequence Analysis

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG268017.
    HOGENOMiHOG000230672.
    HOVERGENiHBG108241.

    Family and domain databases

    Gene3Di1.25.10.10. 4 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR017956. AT_hook_DNA-bd_motif.
    [Graphical view]
    SMARTiSM00384. AT_hook. 2 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 5 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q6TRW4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAHSKTRTND GKITYPPGVK EISDKISKEE MVRRLKMVVK TFMDMDQDSE     50
    EEKELYLNLA LHLASDFFLK HPDKDVRLLV ACCLADIFRI YAPEAPYTSP 100
    DKLKDIFMFI TRQLKGLEDT KSPQFNRYFY LLENIAWVKS YNICFELEDS 150
    NEIFTQLYRT LFSVINNGHN QKVHMHMVDL MSSIICEGDT VSQELLDTVL 200
    VNLVPAHKNL NKQAYDLAKA LLKRTAQAIE PYITNFFNQV LMLGKTSISD 250
    LSEHVFDLIL ELYNIDSHLL LSVLPQLEFK LKSNDNEERL QVVKLLAKMF 300
    GAKDSELASQ NKPLWQCYLG RFNDIHVPIR LECVKFASHC LMNHPDLAKD 350
    LTEYLKVRSH DPEEAIRHDV IVSIVTAAKK DILLVNDHLL NFVRERTLDK 400
    RWRVRKEAMM GLAQIYKKYA LQSAAGKDAA KQICWVKDKL LHIYYQNSID 450
    DRLLVERIFA QYMVPHNLET TERMKCLYYL YATLDLNAVK ALNEMWKCQN 500
    LLRHQVKDLL DLIKQPKTDA SVKAIFSKVM VITRNLPDPG KAQDFMKKFT 550
    QVLEDDEKIR KQLEALVSPT CSCKQAEGCV REITKKLGNP KQPTNPFLEM 600
    IKFLLERIAP VHIDTESISA LIKQVNKSID GTADDEDEGV PTDQAIRAGL 650
    ELLKVLSFTH PISFHSAETF ESLLACLKMD DEKVAEAALQ IFKNTGSKIE 700
    EDFPHIRSAL LPVLHHKSKK GPPRQAKYAI HCIHAIFSSK ETQFAQIFEP 750
    LHKSLDPSNL EHLITPLVTI GHIALLAPDQ FAAPLKSLVA TFIVKDLLMN 800
    DRLPGKKTTK LWVPDEEVSP ETMVKIQAIK MMVRWLLGMK NNHSKSGTST 850
    LRLLTTILHS DGDLTEQGKI SKPDMSRLRL AAGSAIVKLA QEPCYHEIIT 900
    LEQYQLCALA INDECYQVRQ VFAQKLHKGL SRLRLPLEYM AICALCAKDP 950
    VKERRAHARQ CLVKNITVRR EYLKQHAAVS EKLLSLLPEY VVPYTIHLLA 1000
    HDPDYVKVQD IEQLKDVKEC LWFVLEILMA KNENNSHAFI RKMVENIKQT 1050
    KDAQGPDDTK MNEKLYTVCD VAMNIIMSKS TTYSLESPKD PVLPARFFTQ 1100
    PDKNFSNTKN YLPPEMKSFF TPGKPKTANV LGAVNKPLSS AGKQSQTKSS 1150
    RMETVSNASS SSNPSSPGRI KGRLDSTEMD HSENEDYTMS SPLPGKKSDK 1200
    REDSDLVRSE LEKPRSRKKA SVTDPEEKLG MDDLSKLVQE QKPKGSQRGR 1250
    KRGHAASESE EQQWPEEKRH KEELLGNEDE QNSPPKKGKR GRPPKPLGGT 1300
    SKEEPVVKTS KKGNKKKPAP PVVDEDEEEE RQMGNTEQKS KSKQQRTSKR 1350
    AQQRAESPET SAVESTQSTP QKGRGRPSKT PSPSQPKKNI RVGRSKQVAT 1400
    KENDSSEEMD VLQASSPVSD DTTQEGAEEE DISAGNVRRR SSKRERR 1447

    Note: Gene prediction based on EST data.Curated

    Length:1,447
    Mass (Da):164,459
    Last modified:May 15, 2007 - v2
    Checksum:i9EC8B4A03C320428
    GO
    Isoform 21 Publication (identifier: Q6TRW4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1354-1390: RAESPETSAVESTQSTPQKGRGRPSKTPSPSQPKKNI → S

    Show »
    Length:1,411
    Mass (Da):160,614
    Checksum:i74871AAFFA93E1ED
    GO
    Isoform 31 Publication (identifier: Q6TRW4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1207-1208: Missing.

    Show »
    Length:1,445
    Mass (Da):164,204
    Checksum:i5C63A886EC3E7C8F
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1207 – 12082Missing in isoform 3. 1 PublicationVSP_052407
    Alternative sequencei1354 – 139037RAESP…PKKNI → S in isoform 2. 1 PublicationVSP_052408Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03082233 Genomic DNA. No translation available.
    AABR03082545 Genomic DNA. No translation available.
    AY388627 mRNA. Translation: AAQ91374.1.
    AY820182 mRNA. Translation: AAV68352.1.
    AY820183 mRNA. Translation: AAV68353.1.
    AY831451 Genomic DNA. Translation: AAW69306.1.
    AY831452 mRNA. Translation: AAW69307.1.
    AY836673 mRNA. Translation: AAW69308.1.
    UniGeneiRn.105768.

    Genome annotation databases

    UCSCiRGD:1310838. rat. [Q6TRW4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03082233 Genomic DNA. No translation available.
    AABR03082545 Genomic DNA. No translation available.
    AY388627 mRNA. Translation: AAQ91374.1 .
    AY820182 mRNA. Translation: AAV68352.1 .
    AY820183 mRNA. Translation: AAV68353.1 .
    AY831451 Genomic DNA. Translation: AAW69306.1 .
    AY831452 mRNA. Translation: AAW69307.1 .
    AY836673 mRNA. Translation: AAW69308.1 .
    UniGenei Rn.105768.

    3D structure databases

    ProteinModelPortali Q6TRW4.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6TRW4.

    Proteomic databases

    PaxDbi Q6TRW4.
    PRIDEi Q6TRW4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:1310838. rat. [Q6TRW4-1 ]

    Organism-specific databases

    RGDi 1310838. Pds5b.

    Phylogenomic databases

    eggNOGi NOG268017.
    HOGENOMi HOG000230672.
    HOVERGENi HBG108241.

    Miscellaneous databases

    PROi Q6TRW4.

    Gene expression databases

    Genevestigatori Q6TRW4.

    Family and domain databases

    Gene3Di 1.25.10.10. 4 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR017956. AT_hook_DNA-bd_motif.
    [Graphical view ]
    SMARTi SM00384. AT_hook. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 5 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway1 Publication.
    2. "Aprin expression in rat olfactory epithelium."
      Weiler E., Farbman A.I.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-283, NUCLEOTIDE SEQUENCE [MRNA] OF 1110-1378 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1110-1264 (ISOFORM 3), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1327-1381 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1334-1420 (ISOFORM 2).
      Strain: Sprague-DawleyImported and WistarImported.
      Tissue: LiverImported and TestisImported.
    3. "Expression of novel genes linked to the androgen-induced, proliferative shutoff in prostate cancer cells."
      Geck P., Szelei J., Jimenez J., Lin T.-M., Sonnenschein C., Soto A.M.
      J. Steroid Biochem. Mol. Biol. 63:211-218(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. "Mechanism of androgen action on cell proliferation: AS3 protein as a mediator of proliferative arrest in the rat prostate."
      Maffini M.V., Geck P., Powell C.E., Sonnenschein C., Soto A.M.
      Endocrinology 143:2708-2714(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiPDS5B_RAT
    AccessioniPrimary (citable) accession number: Q6TRW4
    Secondary accession number(s): Q5G5U1
    , Q5G6V7, Q5G6V8, Q5PY35, Q5PY36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3