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Q6TRW4

- PDS5B_RAT

UniProt

Q6TRW4 - PDS5B_RAT

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Protein
Sister chromatid cohesion protein PDS5 homolog B
Gene
Pds5b, Aprin, As3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi1247 – 125913A.T hook 1
Add
BLAST
DNA bindingi1287 – 129913A.T hook 2
Add
BLAST
DNA bindingi1371 – 138313A.T hook 3
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. mitotic sister chromatid cohesion Source: UniProtKB
  2. negative regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5 homolog B
Alternative name(s):
Androgen-induced proliferation inhibitor
Androgen-induced prostate proliferative shutoff-associated protein AS3
Gene namesi
Name:Pds5b
Synonyms:Aprin, As3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1310838. Pds5b.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14471447Sister chromatid cohesion protein PDS5 homolog B
PRO_0000287426Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1136 – 11361N6-acetyllysine By similarity
Modified residuei1162 – 11621Phosphoserine By similarity
Modified residuei1166 – 11661Phosphoserine By similarityBy similarity
Modified residuei1176 – 11761Phosphoserine By similarity
Modified residuei1182 – 11821Phosphoserine By similarity
Modified residuei1191 – 11911Phosphoserine By similarity
Modified residuei1257 – 12571Phosphoserine By similarityBy similarity
Modified residuei1259 – 12591Phosphoserine By similarity
Modified residuei1283 – 12831Phosphoserine By similarity
Modified residuei1357 – 13571Phosphoserine By similarityBy similarity
Modified residuei1366 – 13661Phosphothreonine By similarity
Modified residuei1369 – 13691Phosphothreonine By similarityBy similarity
Modified residuei1378 – 13781Phosphoserine By similarityBy similarity
Modified residuei1380 – 13801Phosphothreonine By similarity
Modified residuei1382 – 13821Phosphoserine By similarityBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6TRW4.
PRIDEiQ6TRW4.

PTM databases

PhosphoSiteiQ6TRW4.

Expressioni

Tissue specificityi

Highly expressed in intact prostate with levels decreasing after castration. Expressed exclusively in prostate cells inhibited from proliferating by long-term androgen exposure.1 Publication

Gene expression databases

GenevestigatoriQ6TRW4.

Interactioni

Subunit structurei

Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPAL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6TRW4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati383 – 41937HEAT
Add
BLAST

Sequence similaritiesi

Belongs to the PDS5 family.
Contains 1 HEAT repeat.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG268017.
HOGENOMiHOG000230672.
HOVERGENiHBG108241.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR017956. AT_hook_DNA-bd_motif.
[Graphical view]
SMARTiSM00384. AT_hook. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q6TRW4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAHSKTRTND GKITYPPGVK EISDKISKEE MVRRLKMVVK TFMDMDQDSE     50
EEKELYLNLA LHLASDFFLK HPDKDVRLLV ACCLADIFRI YAPEAPYTSP 100
DKLKDIFMFI TRQLKGLEDT KSPQFNRYFY LLENIAWVKS YNICFELEDS 150
NEIFTQLYRT LFSVINNGHN QKVHMHMVDL MSSIICEGDT VSQELLDTVL 200
VNLVPAHKNL NKQAYDLAKA LLKRTAQAIE PYITNFFNQV LMLGKTSISD 250
LSEHVFDLIL ELYNIDSHLL LSVLPQLEFK LKSNDNEERL QVVKLLAKMF 300
GAKDSELASQ NKPLWQCYLG RFNDIHVPIR LECVKFASHC LMNHPDLAKD 350
LTEYLKVRSH DPEEAIRHDV IVSIVTAAKK DILLVNDHLL NFVRERTLDK 400
RWRVRKEAMM GLAQIYKKYA LQSAAGKDAA KQICWVKDKL LHIYYQNSID 450
DRLLVERIFA QYMVPHNLET TERMKCLYYL YATLDLNAVK ALNEMWKCQN 500
LLRHQVKDLL DLIKQPKTDA SVKAIFSKVM VITRNLPDPG KAQDFMKKFT 550
QVLEDDEKIR KQLEALVSPT CSCKQAEGCV REITKKLGNP KQPTNPFLEM 600
IKFLLERIAP VHIDTESISA LIKQVNKSID GTADDEDEGV PTDQAIRAGL 650
ELLKVLSFTH PISFHSAETF ESLLACLKMD DEKVAEAALQ IFKNTGSKIE 700
EDFPHIRSAL LPVLHHKSKK GPPRQAKYAI HCIHAIFSSK ETQFAQIFEP 750
LHKSLDPSNL EHLITPLVTI GHIALLAPDQ FAAPLKSLVA TFIVKDLLMN 800
DRLPGKKTTK LWVPDEEVSP ETMVKIQAIK MMVRWLLGMK NNHSKSGTST 850
LRLLTTILHS DGDLTEQGKI SKPDMSRLRL AAGSAIVKLA QEPCYHEIIT 900
LEQYQLCALA INDECYQVRQ VFAQKLHKGL SRLRLPLEYM AICALCAKDP 950
VKERRAHARQ CLVKNITVRR EYLKQHAAVS EKLLSLLPEY VVPYTIHLLA 1000
HDPDYVKVQD IEQLKDVKEC LWFVLEILMA KNENNSHAFI RKMVENIKQT 1050
KDAQGPDDTK MNEKLYTVCD VAMNIIMSKS TTYSLESPKD PVLPARFFTQ 1100
PDKNFSNTKN YLPPEMKSFF TPGKPKTANV LGAVNKPLSS AGKQSQTKSS 1150
RMETVSNASS SSNPSSPGRI KGRLDSTEMD HSENEDYTMS SPLPGKKSDK 1200
REDSDLVRSE LEKPRSRKKA SVTDPEEKLG MDDLSKLVQE QKPKGSQRGR 1250
KRGHAASESE EQQWPEEKRH KEELLGNEDE QNSPPKKGKR GRPPKPLGGT 1300
SKEEPVVKTS KKGNKKKPAP PVVDEDEEEE RQMGNTEQKS KSKQQRTSKR 1350
AQQRAESPET SAVESTQSTP QKGRGRPSKT PSPSQPKKNI RVGRSKQVAT 1400
KENDSSEEMD VLQASSPVSD DTTQEGAEEE DISAGNVRRR SSKRERR 1447

Note: Gene prediction based on EST data.

Length:1,447
Mass (Da):164,459
Last modified:May 15, 2007 - v2
Checksum:i9EC8B4A03C320428
GO
Isoform 21 Publication (identifier: Q6TRW4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1354-1390: RAESPETSAVESTQSTPQKGRGRPSKTPSPSQPKKNI → S

Show »
Length:1,411
Mass (Da):160,614
Checksum:i74871AAFFA93E1ED
GO
Isoform 31 Publication (identifier: Q6TRW4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1207-1208: Missing.

Show »
Length:1,445
Mass (Da):164,204
Checksum:i5C63A886EC3E7C8F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1207 – 12082Missing in isoform 3. 1 Publication
VSP_052407
Alternative sequencei1354 – 139037RAESP…PKKNI → S in isoform 2. 1 Publication
VSP_052408Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03082233 Genomic DNA. No translation available.
AABR03082545 Genomic DNA. No translation available.
AY388627 mRNA. Translation: AAQ91374.1.
AY820182 mRNA. Translation: AAV68352.1.
AY820183 mRNA. Translation: AAV68353.1.
AY831451 Genomic DNA. Translation: AAW69306.1.
AY831452 mRNA. Translation: AAW69307.1.
AY836673 mRNA. Translation: AAW69308.1.
UniGeneiRn.105768.

Genome annotation databases

UCSCiRGD:1310838. rat. [Q6TRW4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03082233 Genomic DNA. No translation available.
AABR03082545 Genomic DNA. No translation available.
AY388627 mRNA. Translation: AAQ91374.1 .
AY820182 mRNA. Translation: AAV68352.1 .
AY820183 mRNA. Translation: AAV68353.1 .
AY831451 Genomic DNA. Translation: AAW69306.1 .
AY831452 mRNA. Translation: AAW69307.1 .
AY836673 mRNA. Translation: AAW69308.1 .
UniGenei Rn.105768.

3D structure databases

ProteinModelPortali Q6TRW4.
ModBasei Search...

PTM databases

PhosphoSitei Q6TRW4.

Proteomic databases

PaxDbi Q6TRW4.
PRIDEi Q6TRW4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:1310838. rat. [Q6TRW4-1 ]

Organism-specific databases

RGDi 1310838. Pds5b.

Phylogenomic databases

eggNOGi NOG268017.
HOGENOMi HOG000230672.
HOVERGENi HBG108241.

Miscellaneous databases

PROi Q6TRW4.

Gene expression databases

Genevestigatori Q6TRW4.

Family and domain databases

Gene3Di 1.25.10.10. 4 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR017956. AT_hook_DNA-bd_motif.
[Graphical view ]
SMARTi SM00384. AT_hook. 2 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 5 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "Aprin expression in rat olfactory epithelium."
    Weiler E., Farbman A.I.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-283, NUCLEOTIDE SEQUENCE [MRNA] OF 1110-1378 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1110-1264 (ISOFORM 3), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1327-1381 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1334-1420 (ISOFORM 2).
    Strain: Sprague-Dawley and Wistar.
    Tissue: Liver and Testis.
  3. "Expression of novel genes linked to the androgen-induced, proliferative shutoff in prostate cancer cells."
    Geck P., Szelei J., Jimenez J., Lin T.-M., Sonnenschein C., Soto A.M.
    J. Steroid Biochem. Mol. Biol. 63:211-218(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Mechanism of androgen action on cell proliferation: AS3 protein as a mediator of proliferative arrest in the rat prostate."
    Maffini M.V., Geck P., Powell C.E., Sonnenschein C., Soto A.M.
    Endocrinology 143:2708-2714(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPDS5B_RAT
AccessioniPrimary (citable) accession number: Q6TRW4
Secondary accession number(s): Q5G5U1
, Q5G6V7, Q5G6V8, Q5PY35, Q5PY36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: March 19, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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