Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6TQE4

- Q6TQE4_MOUSE

UniProt

Q6TQE4 - Q6TQE4_MOUSE

Protein
Submitted name:

Peroxisome proliferator-activated receptor gamma 1

Gene

Pparg

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. drug binding Source: Ensembl
    2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    3. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
    4. steroid hormone receptor activity Source: InterPro
    5. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    2. cell maturation Source: Ensembl
    3. cellular response to insulin stimulus Source: Ensembl
    4. fatty acid oxidation Source: Ensembl
    5. glucose homeostasis Source: Ensembl
    6. heart development Source: Ensembl
    7. lipoprotein transport Source: Ensembl
    8. low-density lipoprotein particle receptor biosynthetic process Source: Ensembl
    9. monocyte differentiation Source: Ensembl
    10. negative regulation of acute inflammatory response Source: Ensembl
    11. negative regulation of cell growth Source: Ensembl
    12. negative regulation of cholesterol storage Source: Ensembl
    13. negative regulation of interferon-gamma-mediated signaling pathway Source: Ensembl
    14. negative regulation of receptor biosynthetic process Source: Ensembl
    15. negative regulation of sequestering of triglyceride Source: Ensembl
    16. negative regulation of smooth muscle cell proliferation Source: Ensembl
    17. negative regulation of telomerase activity Source: Ensembl
    18. organ regeneration Source: Ensembl
    19. peroxisome proliferator activated receptor signaling pathway Source: Ensembl
    20. positive regulation of fatty acid oxidation Source: Ensembl
    21. positive regulation of oligodendrocyte differentiation Source: Ensembl
    22. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    23. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    24. regulation of blood pressure Source: Ensembl
    25. regulation of fat cell differentiation Source: Ensembl
    26. response to caffeine Source: Ensembl
    27. response to cold Source: Ensembl
    28. response to drug Source: Ensembl
    29. response to estrogen Source: Ensembl
    30. response to low-density lipoprotein particle Source: Ensembl
    31. response to retinoic acid Source: Ensembl
    32. response to vitamin A Source: Ensembl

    Keywords - Molecular functioni

    ReceptorImported

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Peroxisome proliferator-activated receptor gamma 1Imported
    Gene namesi
    Name:PpargImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiQ6TQE4.
    GenevestigatoriQ6TQE4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6TQE4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG106004.
    InParanoidiQ6TQE4.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    InterProiIPR003074. 1Cnucl_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    [Graphical view]
    PRINTSiPR01288. PROXISOMEPAR.
    PR00398. STRDHORMONER.
    SMARTiSM00430. HOLI. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q6TQE4-1 [UniParc]FASTAAdd to Basket

    « Hide

    PFVIYDMNSL MMGEDKIKFK HITPLQEQSK EVAIRIFQGC QFRSVEAVQE    50
    ITEYAKNIPG FINLDLNDQV TLLKYGVHEI IYTMLASLMN KDGVLISEGQ 100
    GFMTREFLKS LRKPFGDFME PKFEFAVKFN ALELDDSDLA IFIAVIILSG 150
    DRPGLLNVKP IEDIQDNLLQ ALELQLKLNH PESSQLFAKV LQKMTDLRQI 200
    VTEHVQLLHV IKKTETDMSL HPLLQEIYKD LY 232
    Length:232
    Mass (Da):26,703
    Last modified:July 5, 2004 - v1
    Checksum:iE661D47B57AF083D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY389532, AY389530 Genomic DNA. Translation: AAQ89992.1.
    AY389533, AY389531 Genomic DNA. Translation: AAQ89993.1.
    AY389544, AY389542 Genomic DNA. Translation: AAQ89994.1.
    UniGeneiMm.3020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY389532 , AY389530 Genomic DNA. Translation: AAQ89992.1 .
    AY389533 , AY389531 Genomic DNA. Translation: AAQ89993.1 .
    AY389544 , AY389542 Genomic DNA. Translation: AAQ89994.1 .
    UniGenei Mm.3020.

    3D structure databases

    ProteinModelPortali Q6TQE4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106004.
    InParanoidi Q6TQE4.

    Gene expression databases

    ArrayExpressi Q6TQE4.
    Genevestigatori Q6TQE4.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    InterProi IPR003074. 1Cnucl_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    [Graphical view ]
    PRINTSi PR01288. PROXISOMEPAR.
    PR00398. STRDHORMONER.
    SMARTi SM00430. HOLI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Susceptibility to Crohn's disease is linked to PPARgamma in mouse and man."
      Sugawara K., Olson T., Moskaluk C.A., Stevens B., Hoang S., Kozaiwa K., Cominelli F., Ley K.F., McDuffie M.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: AKR/JImported, C57BL/6JImported and SAMP1/YitFcImported.

    Entry informationi

    Entry nameiQ6TQE4_MOUSE
    AccessioniPrimary (citable) accession number: Q6TQE4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)