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Q6TQE4

- Q6TQE4_MOUSE

UniProt

Q6TQE4 - Q6TQE4_MOUSE

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Protein
Submitted name:

Peroxisome proliferator-activated receptor gamma 1

Gene

Pparg

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. drug binding Source: Ensembl
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  3. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
  4. steroid hormone receptor activity Source: InterPro
  5. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  2. cell maturation Source: Ensembl
  3. cellular response to hyperoxia Source: Ensembl
  4. cellular response to insulin stimulus Source: Ensembl
  5. cellular response to prostaglandin E stimulus Source: Ensembl
  6. cellular response to retinoic acid Source: Ensembl
  7. cellular response to vitamin E Source: Ensembl
  8. fatty acid oxidation Source: Ensembl
  9. glucose homeostasis Source: Ensembl
  10. heart development Source: Ensembl
  11. lipoprotein transport Source: Ensembl
  12. low-density lipoprotein particle receptor biosynthetic process Source: Ensembl
  13. monocyte differentiation Source: Ensembl
  14. negative regulation of acute inflammatory response Source: Ensembl
  15. negative regulation of cell growth Source: Ensembl
  16. negative regulation of cholesterol storage Source: Ensembl
  17. negative regulation of collagen biosynthetic process Source: Ensembl
  18. negative regulation of interferon-gamma-mediated signaling pathway Source: Ensembl
  19. negative regulation of pancreatic stellate cell proliferation Source: Ensembl
  20. negative regulation of receptor biosynthetic process Source: Ensembl
  21. negative regulation of sequestering of triglyceride Source: Ensembl
  22. negative regulation of smooth muscle cell proliferation Source: Ensembl
  23. negative regulation of telomerase activity Source: Ensembl
  24. organ regeneration Source: Ensembl
  25. peroxisome proliferator activated receptor signaling pathway Source: Ensembl
  26. positive regulation of apoptotic process Source: Ensembl
  27. positive regulation of fatty acid oxidation Source: Ensembl
  28. positive regulation of oligodendrocyte differentiation Source: Ensembl
  29. positive regulation of phagocytosis, engulfment Source: Ensembl
  30. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  31. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  32. regulation of blood pressure Source: Ensembl
  33. regulation of fat cell differentiation Source: Ensembl
  34. response to caffeine Source: Ensembl
  35. response to cold Source: Ensembl
  36. response to diuretic Source: Ensembl
  37. response to estrogen Source: Ensembl
  38. response to immobilization stress Source: Ensembl
  39. response to low-density lipoprotein particle Source: Ensembl
  40. response to mechanical stimulus Source: Ensembl
  41. response to metformin Source: Ensembl
  42. response to starvation Source: Ensembl
  43. response to vitamin A Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.
REACT_234105. Nuclear Receptor transcription pathway.
REACT_252217. Transcriptional regulation of white adipocyte differentiation.

Names & Taxonomyi

Protein namesi
Submitted name:
Peroxisome proliferator-activated receptor gamma 1Imported
Gene namesi
Name:PpargImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. nucleus Source: UniProtKB-KW
  3. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

ExpressionAtlasiQ6TQE4. baseline and differential.
GenevestigatoriQ6TQE4.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ6TQE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG106004.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR00398. STRDHORMONER.
SMARTiSM00430. HOLI. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q6TQE4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
PFVIYDMNSL MMGEDKIKFK HITPLQEQSK EVAIRIFQGC QFRSVEAVQE
60 70 80 90 100
ITEYAKNIPG FINLDLNDQV TLLKYGVHEI IYTMLASLMN KDGVLISEGQ
110 120 130 140 150
GFMTREFLKS LRKPFGDFME PKFEFAVKFN ALELDDSDLA IFIAVIILSG
160 170 180 190 200
DRPGLLNVKP IEDIQDNLLQ ALELQLKLNH PESSQLFAKV LQKMTDLRQI
210 220 230
VTEHVQLLHV IKKTETDMSL HPLLQEIYKD LY
Length:232
Mass (Da):26,703
Last modified:July 5, 2004 - v1
Checksum:iE661D47B57AF083D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY389532, AY389530 Genomic DNA. Translation: AAQ89992.1.
AY389533, AY389531 Genomic DNA. Translation: AAQ89993.1.
AY389544, AY389542 Genomic DNA. Translation: AAQ89994.1.
UniGeneiMm.3020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY389532 , AY389530 Genomic DNA. Translation: AAQ89992.1 .
AY389533 , AY389531 Genomic DNA. Translation: AAQ89993.1 .
AY389544 , AY389542 Genomic DNA. Translation: AAQ89994.1 .
UniGenei Mm.3020.

3D structure databases

ProteinModelPortali Q6TQE4.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q6TQE4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106004.

Enzyme and pathway databases

Reactomei REACT_198602. PPARA activates gene expression.
REACT_234105. Nuclear Receptor transcription pathway.
REACT_252217. Transcriptional regulation of white adipocyte differentiation.

Gene expression databases

ExpressionAtlasi Q6TQE4. baseline and differential.
Genevestigatori Q6TQE4.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
InterProi IPR003074. 1Cnucl_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
[Graphical view ]
PRINTSi PR01288. PROXISOMEPAR.
PR00398. STRDHORMONER.
SMARTi SM00430. HOLI. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Susceptibility to Crohn's disease is linked to PPARgamma in mouse and man."
    Sugawara K., Olson T., Moskaluk C.A., Stevens B., Hoang S., Kozaiwa K., Cominelli F., Ley K.F., McDuffie M.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AKR/JImported, C57BL/6JImported and SAMP1/YitFcImported.

Entry informationi

Entry nameiQ6TQE4_MOUSE
AccessioniPrimary (citable) accession number: Q6TQE4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)