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Q6TQE4

- Q6TQE4_MOUSE

UniProt

Q6TQE4 - Q6TQE4_MOUSE

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Protein
Submitted name: Peroxisome proliferator-activated receptor gamma 1
Gene
Pparg
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. drug binding Source: Ensembl
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  3. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
  4. steroid hormone receptor activity Source: InterPro
  5. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  2. cell maturation Source: Ensembl
  3. cellular response to insulin stimulus Source: Ensembl
  4. fatty acid oxidation Source: Ensembl
  5. glucose homeostasis Source: Ensembl
  6. heart development Source: Ensembl
  7. lipoprotein transport Source: Ensembl
  8. low-density lipoprotein particle receptor biosynthetic process Source: Ensembl
  9. monocyte differentiation Source: Ensembl
  10. negative regulation of acute inflammatory response Source: Ensembl
  11. negative regulation of cell growth Source: Ensembl
  12. negative regulation of cholesterol storage Source: Ensembl
  13. negative regulation of interferon-gamma-mediated signaling pathway Source: Ensembl
  14. negative regulation of receptor biosynthetic process Source: Ensembl
  15. negative regulation of sequestering of triglyceride Source: Ensembl
  16. negative regulation of smooth muscle cell proliferation Source: Ensembl
  17. negative regulation of telomerase activity Source: Ensembl
  18. organ regeneration Source: Ensembl
  19. peroxisome proliferator activated receptor signaling pathway Source: Ensembl
  20. positive regulation of fatty acid oxidation Source: Ensembl
  21. positive regulation of oligodendrocyte differentiation Source: Ensembl
  22. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  23. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  24. regulation of blood pressure Source: Ensembl
  25. regulation of fat cell differentiation Source: Ensembl
  26. response to caffeine Source: Ensembl
  27. response to cold Source: Ensembl
  28. response to drug Source: Ensembl
  29. response to estrogen Source: Ensembl
  30. response to low-density lipoprotein particle Source: Ensembl
  31. response to retinoic acid Source: Ensembl
  32. response to vitamin A Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Peroxisome proliferator-activated receptor gamma 1Imported
Gene namesi
Name:PpargImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiQ6TQE4.
GenevestigatoriQ6TQE4.

Structurei

3D structure databases

ProteinModelPortaliQ6TQE4.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG106004.
InParanoidiQ6TQE4.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR00398. STRDHORMONER.
SMARTiSM00430. HOLI. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q6TQE4-1 [UniParc]FASTAAdd to Basket

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PFVIYDMNSL MMGEDKIKFK HITPLQEQSK EVAIRIFQGC QFRSVEAVQE    50
ITEYAKNIPG FINLDLNDQV TLLKYGVHEI IYTMLASLMN KDGVLISEGQ 100
GFMTREFLKS LRKPFGDFME PKFEFAVKFN ALELDDSDLA IFIAVIILSG 150
DRPGLLNVKP IEDIQDNLLQ ALELQLKLNH PESSQLFAKV LQKMTDLRQI 200
VTEHVQLLHV IKKTETDMSL HPLLQEIYKD LY 232
Length:232
Mass (Da):26,703
Last modified:July 5, 2004 - v1
Checksum:iE661D47B57AF083D
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY389532, AY389530 Genomic DNA. Translation: AAQ89992.1.
AY389533, AY389531 Genomic DNA. Translation: AAQ89993.1.
AY389544, AY389542 Genomic DNA. Translation: AAQ89994.1.
UniGeneiMm.3020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY389532 , AY389530 Genomic DNA. Translation: AAQ89992.1 .
AY389533 , AY389531 Genomic DNA. Translation: AAQ89993.1 .
AY389544 , AY389542 Genomic DNA. Translation: AAQ89994.1 .
UniGenei Mm.3020.

3D structure databases

ProteinModelPortali Q6TQE4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106004.
InParanoidi Q6TQE4.

Gene expression databases

ArrayExpressi Q6TQE4.
Genevestigatori Q6TQE4.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
InterProi IPR003074. 1Cnucl_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
[Graphical view ]
PRINTSi PR01288. PROXISOMEPAR.
PR00398. STRDHORMONER.
SMARTi SM00430. HOLI. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Susceptibility to Crohn's disease is linked to PPARgamma in mouse and man."
    Sugawara K., Olson T., Moskaluk C.A., Stevens B., Hoang S., Kozaiwa K., Cominelli F., Ley K.F., McDuffie M.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AKR/JImported, C57BL/6JImported and SAMP1/YitFcImported.

Entry informationi

Entry nameiQ6TQE4_MOUSE
AccessioniPrimary (citable) accession number: Q6TQE4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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