Q6TQE1 (ZCH18_RAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 43.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Zinc finger CCCH domain-containing protein 18 Alternative name(s): Nuclear protein NHN1 | ||||
| Gene names |
| ||||
| Organism | Rattus norvegicus (Rat) [Reference proteome] | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 947 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Subcellular location | Nucleus Probable. |
| Sequence similarities | Contains 1 C3H1-type zinc finger. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Nucleus |
| Coding sequence diversity | Alternative splicing |
| Domain | Coiled coil Zinc-finger |
| Ligand | Metal-binding Zinc |
| PTM | Acetylation Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular_component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform A (identifier: Q6TQE1-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform B (identifier: Q6TQE1-2) The sequence of this isoform differs from the canonical sequence as follows: 223-223: M → MKDVVTPLSTLLPPIPNSIPLRGQV |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 947 | 947 | Zinc finger CCCH domain-containing protein 18 | PRO_0000311244 | |||||
Regions | |||||||||
| Zinc finger | 214 – 240 | 27 | C3H1-type | ||||||
| Coiled coil | 915 – 944 | 30 | Potential | ||||||
| Compositional bias | 5 – 204 | 200 | Glu-rich | ||||||
| Compositional bias | 254 – 291 | 38 | Pro-rich | ||||||
| Compositional bias | 397 – 595 | 199 | Arg-rich | ||||||
| Compositional bias | 527 – 741 | 215 | Ser-rich | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | N-acetylmethionine By similarity | ||||||
| Modified residue | 6 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 44 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 63 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 70 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 74 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 79 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 91 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 104 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 105 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 168 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 482 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 527 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 529 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 531 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 837 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 846 | 1 | Phosphoserine Ref.2 | ||||||
| Modified residue | 862 | 1 | Phosphoserine Ref.2 | ||||||
| Modified residue | 887 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 890 | 1 | Phosphoserine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 223 | 1 | M → MKDVVTPLSTLLPPIPNSIP LRGQV in isoform B. | VSP_029458 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Nhn1, a novel highly conserved nuclear protein." Hidalgo de Quintana J., Ponnambalam S., Walker J.H. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B). Strain: Wistar. |
| [2] | "Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS." Moser K., White F.M. J. Proteome Res. 5:98-104(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-846 AND SER-862, MASS SPECTROMETRY. Strain: Fischer. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY389807 mRNA. Translation: AAR92226.1. AY389808 mRNA. Translation: AAR92227.1. |
| IPI | IPI00400666. IPI00563982. |
| RefSeq | NP_958819.1. NM_201416.1. |
| UniGene | Rn.36848. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 10116.ENSRNOP00000048376. |
PTM databases | |
| PhosphoSite | Q6TQE1. |
Proteomic databases | |
| PaxDb | Q6TQE1. |
| PRIDE | Q6TQE1. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSRNOT00000039273; ENSRNOP00000035933; ENSRNOG00000028501. ENSRNOT00000045657; ENSRNOP00000048376; ENSRNOG00000028501. |
| GeneID | 292067. |
| KEGG | rno:292067. |
| UCSC | RGD:1303257. rat. |
Organism-specific databases | |
| CTD | 124245. |
| RGD | 1303257. Zc3h18. |
Phylogenomic databases | |
| eggNOG | NOG74292. |
| GeneTree | ENSGT00650000093061. |
| HOVERGEN | HBG103346. |
| KO | K13092. |
Gene expression databases | |
| Genevestigator | Q6TQE1. |
Family and domain databases | |
| InterPro | IPR000571. Znf_CCCH. [Graphical view] |
| SMART | SM00356. ZnF_C3H1. 1 hit. [Graphical view] |
| PROSITE | PS50103. ZF_C3H1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 633689. |
Entry information
| Entry name | ZCH18_RAT | ||||||||
| Accession | Primary (citable) accession number: Q6TQE1 Secondary accession number(s): Q6TQE2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |