Q6TNP8 (VP26A_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vacuolar protein sorting-associated protein 26A

Alternative name(s):
Vesicle protein sorting 26A

Gene names

Name:	vps26a
ORF Names:	zgc:56673

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) By similarity.
Subunit structure	Component of the retromer complex By similarity.
Subcellular location	Cytoplasm. Endosome membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the VPS26 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Endosome Membrane
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW vacuolar transport Inferred from electronic annotation. Source: InterPro
Cellular component	endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell retromer complex Inferred from electronic annotation. Source: InterPro vesicle Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 327	327	Vacuolar protein sorting-associated protein 26A		PRO_0000247085
Experimental info
	Sequence conflict	11	1	V → A in AAH49342. Ref.2
	Sequence conflict	237	1	D → E in AAH49342. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q6TNP8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 636497E67FC4C928	FASTA	327	38,178
	10 20 30 40 50 60 MSFLGGLFGP VCEIDVILND AESRKTAELK TEEGKLEKHY LFYDGESVSG KVNINVKQTS 70 80 90 100 110 120 KRLEHQGIRI EFVGQIELFS DKSNTHEFVN LVKELALPGE LTQNRSYDFE FMQVEKPYES 130 140 150 160 170 180 YVGANVRLRY FLKVTIVRRL SDLVKEYDLI VHQLATYPDV NNSIKMEVGI EDCLHIEFEY 190 200 210 220 230 240 NKSKYHLKDV IVGKIYFLLV RIKIQHMELQ LIKKEMTGIG PSTTTETETV AKYEIMDGAP 250 260 270 280 290 300 VKGESIPIRL FLAGYDLTPT MRDVNKKFSV RYFLNLVLVD EEDRRYFKQQ EIVLWRKAPE 310 320 KMRKRNFHQR YESPEPRPSL SAEQPEM

References

[1]	"Hematopoietic gene expression profile in zebrafish kidney marrow." Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X., Look A.T., Chen Z. Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004) [PubMed: 15520368] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney marrow.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY391469 mRNA. Translation: AAQ91281.1. BC049342 mRNA. Translation: AAH49342.1. BC071350 mRNA. Translation: AAH71350.1.
IPI	IPI00511215.
RefSeq	NP_957201.1. NM_200907.1.
UniGene	Dr.32886.
3D structure databases
ProteinModelPortal	Q6TNP8.
SMR	Q6TNP8. Positions 6-299.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6TNP8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000078140; ENSDARP00000072602; ENSDARG00000056549.
GeneID	393881.
KEGG	dre:393881.
NMPDR	fig|7955.3.peg.26885.
Organism-specific databases
CTD	9559.
ZFIN	ZDB-GENE-040426-1108. vps26a.
Phylogenomic databases
eggNOG	fiNOG10084.
GeneTree	ENSGT00390000002588.
HOGENOM	HBG525567.
HOVERGEN	HBG082914.
OMA	PVCEIDV.
OrthoDB	EOG470THM.
PhylomeDB	Q6TNP8.
Gene expression databases
ArrayExpress	Q6TNP8.
Bgee	Q6TNP8.
Family and domain databases
InterPro	IPR005377. VPS26. [Graphical view]
Pfam	PF03643. Vps26. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VP26A_DANRE

Accession

Primary (citable) accession number: Q6TNP8
Secondary accession number(s): Q7ZUB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	July 5, 2004
Last modified:	September 21, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program