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Q6TNF3

- Q6TNF3_BOVIN

UniProt

Q6TNF3 - Q6TNF3_BOVIN

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Protein
Submitted name: Tranglutaminase 1
Gene
TGM1
Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

Cofactori

Binds 1 calcium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei407 – 4071 By similarityUniRule annotation
Active sitei466 – 4661 By similarityUniRule annotation
Active sitei489 – 4891 By similarityUniRule annotation
Metal bindingi529 – 5291Calcium By similarity
Metal bindingi531 – 5311Calcium By similarity
Metal bindingi578 – 5781Calcium By similarity
Metal bindingi583 – 5831Calcium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tranglutaminase 1Imported
Gene namesi
Name:TGM1Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

PTM / Processingi

Proteomic databases

PaxDbiQ6TNF3.
PRIDEiQ6TNF3.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005119.

Structurei

3D structure databases

ProteinModelPortaliQ6TNF3.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ6TNF3.
KOiK05619.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6TNF3-1 [UniParc]FASTAAdd to Basket

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MPSPTPSSGG PRSDVGRWGG NPWQPPTTPS PEPEPEPDRR SRRGGRSFWA    50
RCCGCCSCRN TEDDDWGPER HGDRGGRGSG SRNRRPDSRG SDSRQPGSRD 100
SRRPGSRDSR RPGSRDSRRP GSRGSAVNAA GDGTIREGML VVTGVDLLSS 150
RSDQNRREHH TDEFEYDELI LRRGQPFQMV LFLSRPYESS DHVTLELCIG 200
NNPEVGKGTH VIIPVGKGGS GGWKAQVTKS SGQNLNLRVH TSPNAIIGKF 250
QFTIRTRCEA GEFQLPFDPR NEIYILFNPW CPEDIVYVDH EDWRQEYVLN 300
ESGRIYYGTE AQIGERTWNY GQFDHGVLDA CLYILDRRGM PYGGRGDPVS 350
VSRVISAMVN SLDDNGVLIG NWSGDYSRGT NPSAWVGSVE ILLSYLRTGN 400
SVPFGQCWVF AGVTTTVLRC LGLATRTVTN FNSAHDTDTS LTMDIYFDEN 450
MKPLEHLNHD SVWNFHVWND CWMKRPDLPS GFDGWQVVDA TPQETSSGIF 500
CCGPCSVQSI KNGLVYMKYD TPFIFAEVNS DKVYWQRQDD GSFKIVYVEE 550
KAIGSLIITK AIGSNMREDI THTYKHPEGS EAERKAVETA AAHGSKPNVY 600
ATRDSAEDVA VQVEAQDAVM GQDLMVSVVL TNRGSSLRTV KLHLYLSVTF 650
YTGVTGSVFK ESKKEVVLAP GASERVTMPV AYKEYRVHLV DQGAMLLNIS 700
GHVKENGQVL AKQHTFRLRT PDLSLTLLGA AVVGQECEVQ IVFKNPLPVT 750
LTNVVFRLEG SGLQRPKILN VGDIGGNETV TLRQTFVPVR PGPRQLIASL 800
DSPQLSQVHG VIQVDVAPAS GGGAFSDIRG SGRSGETIPM ASRGGA 846
Length:846
Mass (Da):93,105
Last modified:July 5, 2005 - v4
Checksum:i31B4A675365C4849
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY676606 mRNA. Translation: AAR26246.2.
RefSeqiNP_001010991.1. NM_001010991.1.
UniGeneiBt.736.

Genome annotation databases

GeneIDi407997.
KEGGibta:407997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY676606 mRNA. Translation: AAR26246.2 .
RefSeqi NP_001010991.1. NM_001010991.1.
UniGenei Bt.736.

3D structure databases

ProteinModelPortali Q6TNF3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000005119.

Proteomic databases

PaxDbi Q6TNF3.
PRIDEi Q6TNF3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 407997.
KEGGi bta:407997.

Organism-specific databases

CTDi 7051.

Phylogenomic databases

eggNOGi NOG80379.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
InParanoidi Q6TNF3.
KOi K05619.

Miscellaneous databases

NextBioi 20818618.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Ichthyosis disorder in Chianina cattle: identification of the inherited transmission by pedigree analysis and sequencing of TGM1 candidate gene."
    Longeri M., Dardano S., Molteni L., Polli M., Parma P., Sironi G., Zanotti M., Succi G.
    (In) PROCEEDINGS OF THE 29TH CONFERENCE OF THE INTERNATIONAL SOCIETY OF ANIMAL GENETICS ISAG, pp.0-0, Blackwell Publishing, Edinburgh, United Kingdom (2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Skin biopsyImported.
  2. Longeri M., Parma P., Molteni L., Dardano S., Filippini F., Zanotti M.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Skin biopsyImported.

Entry informationi

Entry nameiQ6TNF3_BOVIN
AccessioniPrimary (citable) accession number: Q6TNF3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2005
Last modified: July 9, 2014
This is version 68 of the entry and version 4 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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