Q6TNF3 (Q6TNF3_BOVIN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Tranglutaminase 1 EMBL AAR26246.2

Gene names

Name:

TGM1 EMBL AAR26246.2

Organism

Bos taurus (Bovine) EMBL AAR26246.2

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	846 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Cofactor

Binds 1 calcium ion per subunit By similarity. PIRSR PIRSR000459-2

Ontologies

Keywords
Ligand	Calcium PIRSR PIRSR000459-2 Metal-binding PIRSR PIRSR000459-2
Gene Ontology (GO)
Biological_process	peptide cross-linking Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein-glutamine gamma-glutamyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	407	1	By similarity PIRSR PIRSR000459-1
	Active site	466	1	By similarity PIRSR PIRSR000459-1
	Active site	489	1	By similarity PIRSR PIRSR000459-1
	Metal binding	529	1	Calcium By similarity PIRSR PIRSR000459-2
	Metal binding	531	1	Calcium By similarity PIRSR PIRSR000459-2
	Metal binding	578	1	Calcium By similarity PIRSR PIRSR000459-2
	Metal binding	583	1	Calcium By similarity PIRSR PIRSR000459-2

Sequences

	Sequence		Length	Mass (Da)
	Q6TNF3 [UniParc]. Last modified July 5, 2005. Version 4. Checksum: 31B4A675365C4849	FASTA	846	93,105
	10 20 30 40 50 60 MPSPTPSSGG PRSDVGRWGG NPWQPPTTPS PEPEPEPDRR SRRGGRSFWA RCCGCCSCRN 70 80 90 100 110 120 TEDDDWGPER HGDRGGRGSG SRNRRPDSRG SDSRQPGSRD SRRPGSRDSR RPGSRDSRRP 130 140 150 160 170 180 GSRGSAVNAA GDGTIREGML VVTGVDLLSS RSDQNRREHH TDEFEYDELI LRRGQPFQMV 190 200 210 220 230 240 LFLSRPYESS DHVTLELCIG NNPEVGKGTH VIIPVGKGGS GGWKAQVTKS SGQNLNLRVH 250 260 270 280 290 300 TSPNAIIGKF QFTIRTRCEA GEFQLPFDPR NEIYILFNPW CPEDIVYVDH EDWRQEYVLN 310 320 330 340 350 360 ESGRIYYGTE AQIGERTWNY GQFDHGVLDA CLYILDRRGM PYGGRGDPVS VSRVISAMVN 370 380 390 400 410 420 SLDDNGVLIG NWSGDYSRGT NPSAWVGSVE ILLSYLRTGN SVPFGQCWVF AGVTTTVLRC 430 440 450 460 470 480 LGLATRTVTN FNSAHDTDTS LTMDIYFDEN MKPLEHLNHD SVWNFHVWND CWMKRPDLPS 490 500 510 520 530 540 GFDGWQVVDA TPQETSSGIF CCGPCSVQSI KNGLVYMKYD TPFIFAEVNS DKVYWQRQDD 550 560 570 580 590 600 GSFKIVYVEE KAIGSLIITK AIGSNMREDI THTYKHPEGS EAERKAVETA AAHGSKPNVY 610 620 630 640 650 660 ATRDSAEDVA VQVEAQDAVM GQDLMVSVVL TNRGSSLRTV KLHLYLSVTF YTGVTGSVFK 670 680 690 700 710 720 ESKKEVVLAP GASERVTMPV AYKEYRVHLV DQGAMLLNIS GHVKENGQVL AKQHTFRLRT 730 740 750 760 770 780 PDLSLTLLGA AVVGQECEVQ IVFKNPLPVT LTNVVFRLEG SGLQRPKILN VGDIGGNETV 790 800 810 820 830 840 TLRQTFVPVR PGPRQLIASL DSPQLSQVHG VIQVDVAPAS GGGAFSDIRG SGRSGETIPM ASRGGA

References

[1]

"Ichthyosis disorder in Chianina cattle: identification of the inherited transmission by pedigree analysis and sequencing of TGM1 candidate gene." Longeri M., Dardano S., Molteni L., Polli M., Parma P., Sironi G., Zanotti M., Succi G. (In) PROCEEDINGS OF THE 29TH CONFERENCE OF THE INTERNATIONAL SOCIETY OF ANIMAL GENETICS ISAG, pp.0-0, Blackwell Publishing, Edinburgh, United Kingdom (2004) Cited for: NUCLEOTIDE SEQUENCE. Tissue: Skin biopsy EMBL AAR26246.2.

[2]

Longeri M., Parma P., Molteni L., Dardano S., Filippini F., Zanotti M. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Skin biopsy EMBL AAR26246.2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY676606 mRNA. Translation: AAR26246.2.
IPI	IPI00705964.
RefSeq	NP_001010991.1. NM_001010991.1.
UniGene	Bt.736.
3D structure databases
ProteinModelPortal	Q6TNF3.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000005119. Q6TNF3.
Proteomic databases
PaxDb	Q6TNF3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	407997.
KEGG	bta:407997.
Organism-specific databases
CTD	7051.
Phylogenomic databases
eggNOG	NOG80379.
HOGENOM	HOG000231695.
HOVERGEN	HBG004342.
InParanoid	Q6TNF3.
KO	K05619.
OrthoDB	EOG4VX24R.
Family and domain databases
Gene3D	2.60.40.10. 3 hits.
InterPro	IPR023608. Gln_gamma-glutamylTfrase_euk. IPR013783. Ig-like_fold. IPR014756. Ig_E-set. IPR002931. Transglutaminase-like. IPR008958. Transglutaminase_C. IPR013808. Transglutaminase_CS. IPR001102. Transglutaminase_N. [Graphical view]
PANTHER	PTHR11590. PTHR11590. 1 hit.
Pfam	PF00927. Transglut_C. 2 hits. PF01841. Transglut_core. 1 hit. PF00868. Transglut_N. 1 hit. [Graphical view]
PIRSF	PIRSF000459. TGM_EBP42. 1 hit.
SMART	SM00460. TGc. 1 hit. [Graphical view]
SUPFAM	SSF81296. Ig_E-set. 1 hit. SSF49309. Transglut_C. 2 hits.
PROSITE	PS00547. TRANSGLUTAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20818618.

Entry information

Entry name

Q6TNF3_BOVIN

Accession

Primary (citable) accession number: Q6TNF3

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2005
Last modified:	April 3, 2013
This is version 60 of the entry and version 4 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)