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Q6TNF3

- Q6TNF3_BOVIN

UniProt

Q6TNF3 - Q6TNF3_BOVIN

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Protein
Submitted name:

Tranglutaminase 1

Gene

TGM1

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

Cofactori

Binds 1 calcium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei407 – 4071UniRule annotation
Active sitei466 – 4661UniRule annotation
Active sitei489 – 4891UniRule annotation
Metal bindingi529 – 5291CalciumUniRule annotation
Metal bindingi531 – 5311CalciumUniRule annotation
Metal bindingi578 – 5781CalciumUniRule annotation
Metal bindingi583 – 5831CalciumUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: InterPro

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tranglutaminase 1Imported
Gene namesi
Name:TGM1Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

PTM / Processingi

Proteomic databases

PaxDbiQ6TNF3.
PRIDEiQ6TNF3.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005119.

Structurei

3D structure databases

ProteinModelPortaliQ6TNF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
KOiK05619.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6TNF3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSPTPSSGG PRSDVGRWGG NPWQPPTTPS PEPEPEPDRR SRRGGRSFWA
60 70 80 90 100
RCCGCCSCRN TEDDDWGPER HGDRGGRGSG SRNRRPDSRG SDSRQPGSRD
110 120 130 140 150
SRRPGSRDSR RPGSRDSRRP GSRGSAVNAA GDGTIREGML VVTGVDLLSS
160 170 180 190 200
RSDQNRREHH TDEFEYDELI LRRGQPFQMV LFLSRPYESS DHVTLELCIG
210 220 230 240 250
NNPEVGKGTH VIIPVGKGGS GGWKAQVTKS SGQNLNLRVH TSPNAIIGKF
260 270 280 290 300
QFTIRTRCEA GEFQLPFDPR NEIYILFNPW CPEDIVYVDH EDWRQEYVLN
310 320 330 340 350
ESGRIYYGTE AQIGERTWNY GQFDHGVLDA CLYILDRRGM PYGGRGDPVS
360 370 380 390 400
VSRVISAMVN SLDDNGVLIG NWSGDYSRGT NPSAWVGSVE ILLSYLRTGN
410 420 430 440 450
SVPFGQCWVF AGVTTTVLRC LGLATRTVTN FNSAHDTDTS LTMDIYFDEN
460 470 480 490 500
MKPLEHLNHD SVWNFHVWND CWMKRPDLPS GFDGWQVVDA TPQETSSGIF
510 520 530 540 550
CCGPCSVQSI KNGLVYMKYD TPFIFAEVNS DKVYWQRQDD GSFKIVYVEE
560 570 580 590 600
KAIGSLIITK AIGSNMREDI THTYKHPEGS EAERKAVETA AAHGSKPNVY
610 620 630 640 650
ATRDSAEDVA VQVEAQDAVM GQDLMVSVVL TNRGSSLRTV KLHLYLSVTF
660 670 680 690 700
YTGVTGSVFK ESKKEVVLAP GASERVTMPV AYKEYRVHLV DQGAMLLNIS
710 720 730 740 750
GHVKENGQVL AKQHTFRLRT PDLSLTLLGA AVVGQECEVQ IVFKNPLPVT
760 770 780 790 800
LTNVVFRLEG SGLQRPKILN VGDIGGNETV TLRQTFVPVR PGPRQLIASL
810 820 830 840
DSPQLSQVHG VIQVDVAPAS GGGAFSDIRG SGRSGETIPM ASRGGA
Length:846
Mass (Da):93,105
Last modified:July 5, 2005 - v4
Checksum:i31B4A675365C4849
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY676606 mRNA. Translation: AAR26246.2.
RefSeqiNP_001010991.1. NM_001010991.1.
UniGeneiBt.736.

Genome annotation databases

GeneIDi407997.
KEGGibta:407997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY676606 mRNA. Translation: AAR26246.2 .
RefSeqi NP_001010991.1. NM_001010991.1.
UniGenei Bt.736.

3D structure databases

ProteinModelPortali Q6TNF3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000005119.

Proteomic databases

PaxDbi Q6TNF3.
PRIDEi Q6TNF3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 407997.
KEGGi bta:407997.

Organism-specific databases

CTDi 7051.

Phylogenomic databases

eggNOGi NOG80379.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
KOi K05619.

Miscellaneous databases

NextBioi 20818618.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Ichthyosis disorder in Chianina cattle: identification of the inherited transmission by pedigree analysis and sequencing of TGM1 candidate gene."
    Longeri M., Dardano S., Molteni L., Polli M., Parma P., Sironi G., Zanotti M., Succi G.
    (In) PROCEEDINGS OF THE 29TH CONFERENCE OF THE INTERNATIONAL SOCIETY OF ANIMAL GENETICS ISAG, pp.0-0, Blackwell Publishing, Edinburgh, United Kingdom (2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Skin biopsyImported.
  2. Longeri M., Parma P., Molteni L., Dardano S., Filippini F., Zanotti M.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Skin biopsyImported.

Entry informationi

Entry nameiQ6TNF3_BOVIN
AccessioniPrimary (citable) accession number: Q6TNF3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 70 of the entry and version 4 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)