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Protein

Peroxinectin A

Gene

poxA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei101Proton acceptorPROSITE-ProRule annotation1
Sitei233Transition state stabilizerPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Enzyme and pathway databases

ReactomeiR-DDI-209968. Thyroxine biosynthesis.
R-DDI-6798695. Neutrophil degranulation.

Protein family/group databases

PeroxiBasei4094. DdPxDo01.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxinectin A (EC:1.11.1.7)
Gene namesi
Name:poxA
ORF Names:DDB_G0277275
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277275. poxA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000038663022 – 531Peroxinectin AAdd BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Glycosylationi131N-linked (GlcNAc...)Sequence analysis1
Glycosylationi338N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6TMK4.

Expressioni

Developmental stagei

Expressed in late developmental stage, exclusively during culmination.2 Publications

Inductioni

Induced by srfA, during development. Down-regulated in grlA null-cells at 16 hours of starvation.2 Publications

Structurei

3D structure databases

ProteinModelPortaliQ6TMK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2408. Eukaryota.
ENOG410XPZ3. LUCA.
InParanoidiQ6TMK4.
OMAiEVASECP.
PhylomeDBiQ6TMK4.

Family and domain databases

Gene3Di1.10.640.10. 2 hits.
InterProiIPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PfamiPF03098. An_peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6TMK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLNLISFFI IFTILVSISN SQEFRSYTGE GNNKQNPKQG SIFTPFIRLA
60 70 80 90 100
NPIKFNKNGF PNITNQPSRA ISNIIFDQQT HIGSKEHLTD MFNMWGQFLI
110 120 130 140 150
HNMALSKPEP NSWPIKVPKC DQYFDPACIG NKTMNYFRTR ATEVPCDVGK
160 170 180 190 200
TVVDEDGKCY EQINSLGSYI DGNVLYGNSE EICKNLRSLS GGEMKMTVTD
210 220 230 240 250
VGDLPPKNVP GVPMDNDANL FPIDQLYSVG ERRGNENPGL LSIHTLLLRD
260 270 280 290 300
HNRLARKFAR LHPEWDDERV FQQSRSCIIE QIQKITYDEY LPTTLGSFPS
310 320 330 340 350
YTGYDANVNA QVSNEFTTTA FRFGHSEVGP FMEYYSENGT RLQPLPIKFS
360 370 380 390 400
YFNPHALNRG VEPLIRGLII NEEENIDIYM ISDLRNFLFG KPGQGGLDLA
410 420 430 440 450
SRNLQRNRDH GIPPYNSLRR QLGLRPVQTW SDITSDPQIQ NRLKNAYKSV
460 470 480 490 500
DDIDSYVGGL AEDHMEGSCV GQTFYLIIYE QFFRTRAGDR FWYETPEMRM
510 520 530
VNRECETTTF AEVIKRTTSN IGYVQPNVFR K
Length:531
Mass (Da):60,797
Last modified:July 5, 2004 - v1
Checksum:iE2444F8EAFADF9EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY392429 Genomic DNA. Translation: AAQ98871.1.
AAFI02000019 Genomic DNA. Translation: EAL68824.1.
RefSeqiXP_642775.1. XM_637683.1.

Genome annotation databases

EnsemblProtistsiEAL68824; EAL68824; DDB_G0277275.
GeneIDi8620966.
KEGGiddi:DDB_G0277275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY392429 Genomic DNA. Translation: AAQ98871.1.
AAFI02000019 Genomic DNA. Translation: EAL68824.1.
RefSeqiXP_642775.1. XM_637683.1.

3D structure databases

ProteinModelPortaliQ6TMK4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei4094. DdPxDo01.

Proteomic databases

PaxDbiQ6TMK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL68824; EAL68824; DDB_G0277275.
GeneIDi8620966.
KEGGiddi:DDB_G0277275.

Organism-specific databases

dictyBaseiDDB_G0277275. poxA.

Phylogenomic databases

eggNOGiKOG2408. Eukaryota.
ENOG410XPZ3. LUCA.
InParanoidiQ6TMK4.
OMAiEVASECP.
PhylomeDBiQ6TMK4.

Enzyme and pathway databases

ReactomeiR-DDI-209968. Thyroxine biosynthesis.
R-DDI-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ6TMK4.

Family and domain databases

Gene3Di1.10.640.10. 2 hits.
InterProiIPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PfamiPF03098. An_peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50292. PEROXIDASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOXA_DICDI
AccessioniPrimary (citable) accession number: Q6TMK4
Secondary accession number(s): Q54ZU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.