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Protein

Peroxinectin A

Gene

poxA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei101Proton acceptorPROSITE-ProRule annotation1
Sitei233Transition state stabilizerPROSITE-ProRule annotation1

GO - Molecular functioni

  • heme binding Source: dictyBase
  • iodide peroxidase activity Source: dictyBase
  • peroxidase activity Source: dictyBase
  • thiocyanate peroxidase activity Source: dictyBase

GO - Biological processi

  • defense response to bacterium Source: dictyBase
  • hydrogen peroxide catabolic process Source: UniProtKB-KW
  • immune response Source: dictyBase
  • response to oxidative stress Source: InterPro

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide

Enzyme and pathway databases

ReactomeiR-DDI-209968 Thyroxine biosynthesis
R-DDI-6798695 Neutrophil degranulation

Protein family/group databases

PeroxiBasei4094 DdPxDo01

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxinectin A (EC:1.11.1.7)
Gene namesi
Name:poxA
ORF Names:DDB_G0277275
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277275 poxA

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: dictyBase
  • extracellular region Source: dictyBase

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000038663022 – 531Peroxinectin AAdd BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6TMK4

Expressioni

Developmental stagei

Expressed in late developmental stage, exclusively during culmination.2 Publications

Inductioni

Induced by srfA, during development. Down-regulated in grlA null-cells at 16 hours of starvation.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0191269

Structurei

Secondary structure

1531
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 29Combined sources3
Beta strandi32 – 36Combined sources5
Turni37 – 40Combined sources4
Beta strandi42 – 45Combined sources4
Helixi68 – 75Combined sources8
Helixi90 – 100Combined sources11
Turni101 – 103Combined sources3
Beta strandi108 – 112Combined sources5
Turni122 – 124Combined sources3
Beta strandi137 – 139Combined sources3
Beta strandi141 – 144Combined sources4
Beta strandi148 – 150Combined sources3
Beta strandi159 – 164Combined sources6
Helixi173 – 176Combined sources4
Helixi180 – 186Combined sources7
Beta strandi197 – 199Combined sources3
Beta strandi202 – 204Combined sources3
Helixi223 – 225Combined sources3
Helixi232 – 235Combined sources4
Helixi238 – 261Combined sources24
Helixi267 – 288Combined sources22
Helixi290 – 295Combined sources6
Helixi314 – 318Combined sources5
Helixi320 – 323Combined sources4
Helixi324 – 327Combined sources4
Beta strandi330 – 335Combined sources6
Beta strandi341 – 346Combined sources6
Helixi347 – 349Combined sources3
Turni350 – 352Combined sources3
Helixi354 – 357Combined sources4
Helixi362 – 370Combined sources9
Beta strandi376 – 378Combined sources3
Helixi382 – 385Combined sources4
Beta strandi389 – 391Combined sources3
Helixi399 – 410Combined sources12
Helixi415 – 421Combined sources7
Helixi430 – 433Combined sources4
Helixi437 – 446Combined sources10
Helixi450 – 452Combined sources3
Helixi455 – 461Combined sources7
Beta strandi469 – 471Combined sources3
Helixi472 – 487Combined sources16
Helixi496 – 501Combined sources6
Turni502 – 504Combined sources3
Helixi510 – 517Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6ERCX-ray2.50A/B21-531[»]
ProteinModelPortaliQ6TMK4
SMRiQ6TMK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
InParanoidiQ6TMK4
OMAiWIDQKPY
PhylomeDBiQ6TMK4

Family and domain databases

Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS50292 PEROXIDASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6TMK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLNLISFFI IFTILVSISN SQEFRSYTGE GNNKQNPKQG SIFTPFIRLA
60 70 80 90 100
NPIKFNKNGF PNITNQPSRA ISNIIFDQQT HIGSKEHLTD MFNMWGQFLI
110 120 130 140 150
HNMALSKPEP NSWPIKVPKC DQYFDPACIG NKTMNYFRTR ATEVPCDVGK
160 170 180 190 200
TVVDEDGKCY EQINSLGSYI DGNVLYGNSE EICKNLRSLS GGEMKMTVTD
210 220 230 240 250
VGDLPPKNVP GVPMDNDANL FPIDQLYSVG ERRGNENPGL LSIHTLLLRD
260 270 280 290 300
HNRLARKFAR LHPEWDDERV FQQSRSCIIE QIQKITYDEY LPTTLGSFPS
310 320 330 340 350
YTGYDANVNA QVSNEFTTTA FRFGHSEVGP FMEYYSENGT RLQPLPIKFS
360 370 380 390 400
YFNPHALNRG VEPLIRGLII NEEENIDIYM ISDLRNFLFG KPGQGGLDLA
410 420 430 440 450
SRNLQRNRDH GIPPYNSLRR QLGLRPVQTW SDITSDPQIQ NRLKNAYKSV
460 470 480 490 500
DDIDSYVGGL AEDHMEGSCV GQTFYLIIYE QFFRTRAGDR FWYETPEMRM
510 520 530
VNRECETTTF AEVIKRTTSN IGYVQPNVFR K
Length:531
Mass (Da):60,797
Last modified:July 5, 2004 - v1
Checksum:iE2444F8EAFADF9EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY392429 Genomic DNA Translation: AAQ98871.1
AAFI02000019 Genomic DNA Translation: EAL68824.1
RefSeqiXP_642775.1, XM_637683.1

Genome annotation databases

EnsemblProtistsiEAL68824; EAL68824; DDB_G0277275
GeneIDi8620966
KEGGiddi:DDB_G0277275

Similar proteinsi

Entry informationi

Entry nameiPOXA_DICDI
AccessioniPrimary (citable) accession number: Q6TMK4
Secondary accession number(s): Q54ZU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health