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Q6TMA8 (ANGL4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Angiopoietin-related protein 4
Alternative name(s):
Angiopoietin-like protein 4
Hepatic fibrinogen/angiopoietin-related protein
Short name=HFARP
Gene names
Name:Angptl4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation By similarity.

Subunit structure

Homooligomer. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix By similarity. Ref.1

Subcellular location

Secreted. Secretedextracellular spaceextracellular matrix. Note: The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 By similarity.

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Contains 1 fibrinogen C-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 405382Angiopoietin-related protein 4
PRO_0000009126

Regions

Domain178 – 400223Fibrinogen C-terminal
Coiled coil54 – 14693 Potential

Amino acid modifications

Glycosylation1761N-linked (GlcNAc...) Potential
Glycosylation2311N-linked (GlcNAc...) Potential
Glycosylation2371N-linked (GlcNAc...) Potential
Disulfide bond187 ↔ 215 By similarity
Disulfide bond340 ↔ 353 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6TMA8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 3C54185DE5989E46

FASTA40544,951
        10         20         30         40         50         60 
MRCAPTAGAA LVLCAATAGL LSAQGRPAQP EPPRFASWDE MNLLAHGLLQ LGHGLREHVE 

        70         80         90        100        110        120 
RTRGQLGALE RRMAACGNAC QGPKGTDPKD RVPEGQAPET LQSLQTQLKA QNSKIQQLFQ 

       130        140        150        160        170        180 
KVAQQQRYLS KQNLRIQNLQ SQIDLLTPTH LDNGVDKTSR GKRLPKMAQL IGLTPNATRL 

       190        200        210        220        230        240 
HRPPRDCQEL FQEGERHSGL FQIQPLGSPP FLVNCEMTSD GGWTVIQRRL NGSVDFNQSW 

       250        260        270        280        290        300 
EAYKDGFGDP QGEFWLGLEK MHSITGDRGS QLAVQLQDWD GNAKLLQFPI HLGGEDTAYS 

       310        320        330        340        350        360 
LQLTEPTANE LGATNVSPNG LSLPFSTWDQ DHDLRGDLNC AKSLSGGWWF GTCSHSNLNG 

       370        380        390        400 
QYFHSIPRQR QQRKKGIFWK TWKGRYYPLQ ATTLLIQPME ATAAS 

« Hide

References

« Hide 'large scale' references
[1]"Oligomerization and regulated proteolytic processing of angiopoietin-like protein 4."
Ge H., Yang G., Huang L., Motola D.L., Pourbahrami T., Li C.
J. Biol. Chem. 279:2038-2045(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT.
Strain: Wistar.
Tissue: Adipose tissue.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY393999 mRNA. Translation: AAQ93383.1.
BC078944 mRNA. Translation: AAH78944.1.
RefSeqNP_954546.1. NM_199115.2.
UniGeneRn.119611.

3D structure databases

ProteinModelPortalQ6TMA8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000010031.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000010031; ENSRNOP00000010031; ENSRNOG00000007545.
GeneID362850.
KEGGrno:362850.
UCSCRGD:735058. rat.

Organism-specific databases

CTD51129.
RGD735058. Angptl4.

Phylogenomic databases

eggNOGNOG281759.
GeneTreeENSGT00750000117415.
HOGENOMHOG000015386.
HOVERGENHBG001644.
InParanoidQ6TMA8.
KOK08767.
OMAVDFNRPW.
OrthoDBEOG7X9G60.
PhylomeDBQ6TMA8.
TreeFamTF329953.

Gene expression databases

GenevestigatorQ6TMA8.

Family and domain databases

Gene3D3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProIPR028793. ANGPTL4.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PANTHERPTHR19143:SF16. PTHR19143:SF16. 1 hit.
PfamPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMSSF56496. SSF56496. 1 hit.
PROSITEPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio681522.
PROQ6TMA8.

Entry information

Entry nameANGL4_RAT
AccessionPrimary (citable) accession number: Q6TMA8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families