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Q6TMA8

- ANGL4_RAT

UniProt

Q6TMA8 - ANGL4_RAT

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Protein

Angiopoietin-related protein 4

Gene

Angptl4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation By similarity.By similarity

GO - Molecular functioni

  1. enzyme inhibitor activity Source: RGD

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. negative regulation of catalytic activity Source: RGD
  4. negative regulation of endothelial cell apoptotic process Source: Ensembl
  5. negative regulation of lipoprotein lipase activity Source: RGD
  6. protein homooligomerization Source: RGD
  7. protein oligomerization Source: RGD
  8. regulation of lipid metabolic process Source: RGD
  9. response to hypoxia Source: RGD
  10. triglyceride homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiREACT_196408. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 4
Alternative name(s):
Angiopoietin-like protein 4
Hepatic fibrinogen/angiopoietin-related protein
Short name:
HFARP
Gene namesi
Name:Angptl4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi735058. Angptl4.

Subcellular locationi

Secreted. Secretedextracellular spaceextracellular matrix
Note: The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 By similarity.By similarity

GO - Cellular componenti

  1. blood microparticle Source: Ensembl
  2. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 405382Angiopoietin-related protein 4PRO_0000009126Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi187 ↔ 215PROSITE-ProRule annotation
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi340 ↔ 353PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

GenevestigatoriQ6TMA8.

Interactioni

Subunit structurei

Homooligomer. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix By similarity.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010031.

Structurei

3D structure databases

ProteinModelPortaliQ6TMA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini178 – 400223Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili54 – 14693Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG281759.
GeneTreeiENSGT00760000118861.
HOGENOMiHOG000015386.
HOVERGENiHBG001644.
InParanoidiQ6TMA8.
KOiK08767.
OMAiVDFNRPW.
OrthoDBiEOG7X9G60.
PhylomeDBiQ6TMA8.
TreeFamiTF329953.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR028793. ANGPTL4.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PANTHERiPTHR19143:SF16. PTHR19143:SF16. 1 hit.
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6TMA8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRCAPTAGAA LVLCAATAGL LSAQGRPAQP EPPRFASWDE MNLLAHGLLQ
60 70 80 90 100
LGHGLREHVE RTRGQLGALE RRMAACGNAC QGPKGTDPKD RVPEGQAPET
110 120 130 140 150
LQSLQTQLKA QNSKIQQLFQ KVAQQQRYLS KQNLRIQNLQ SQIDLLTPTH
160 170 180 190 200
LDNGVDKTSR GKRLPKMAQL IGLTPNATRL HRPPRDCQEL FQEGERHSGL
210 220 230 240 250
FQIQPLGSPP FLVNCEMTSD GGWTVIQRRL NGSVDFNQSW EAYKDGFGDP
260 270 280 290 300
QGEFWLGLEK MHSITGDRGS QLAVQLQDWD GNAKLLQFPI HLGGEDTAYS
310 320 330 340 350
LQLTEPTANE LGATNVSPNG LSLPFSTWDQ DHDLRGDLNC AKSLSGGWWF
360 370 380 390 400
GTCSHSNLNG QYFHSIPRQR QQRKKGIFWK TWKGRYYPLQ ATTLLIQPME

ATAAS
Length:405
Mass (Da):44,951
Last modified:July 5, 2004 - v1
Checksum:i3C54185DE5989E46
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY393999 mRNA. Translation: AAQ93383.1.
BC078944 mRNA. Translation: AAH78944.1.
RefSeqiNP_954546.1. NM_199115.2.
UniGeneiRn.119611.

Genome annotation databases

EnsembliENSRNOT00000010031; ENSRNOP00000010031; ENSRNOG00000007545.
GeneIDi362850.
KEGGirno:362850.
UCSCiRGD:735058. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY393999 mRNA. Translation: AAQ93383.1 .
BC078944 mRNA. Translation: AAH78944.1 .
RefSeqi NP_954546.1. NM_199115.2.
UniGenei Rn.119611.

3D structure databases

ProteinModelPortali Q6TMA8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000010031.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000010031 ; ENSRNOP00000010031 ; ENSRNOG00000007545 .
GeneIDi 362850.
KEGGi rno:362850.
UCSCi RGD:735058. rat.

Organism-specific databases

CTDi 51129.
RGDi 735058. Angptl4.

Phylogenomic databases

eggNOGi NOG281759.
GeneTreei ENSGT00760000118861.
HOGENOMi HOG000015386.
HOVERGENi HBG001644.
InParanoidi Q6TMA8.
KOi K08767.
OMAi VDFNRPW.
OrthoDBi EOG7X9G60.
PhylomeDBi Q6TMA8.
TreeFami TF329953.

Enzyme and pathway databases

Reactomei REACT_196408. PPARA activates gene expression.

Miscellaneous databases

NextBioi 681522.
PROi Q6TMA8.

Gene expression databases

Genevestigatori Q6TMA8.

Family and domain databases

Gene3Di 3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProi IPR028793. ANGPTL4.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view ]
PANTHERi PTHR19143:SF16. PTHR19143:SF16. 1 hit.
Pfami PF00147. Fibrinogen_C. 1 hit.
[Graphical view ]
SMARTi SM00186. FBG. 1 hit.
[Graphical view ]
SUPFAMi SSF56496. SSF56496. 1 hit.
PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Oligomerization and regulated proteolytic processing of angiopoietin-like protein 4."
    Ge H., Yang G., Huang L., Motola D.L., Pourbahrami T., Li C.
    J. Biol. Chem. 279:2038-2045(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT.
    Strain: Wistar.
    Tissue: Adipose tissue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiANGL4_RAT
AccessioniPrimary (citable) accession number: Q6TMA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3