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Q6TLV9

- Q6TLV9_CHICK

UniProt

Q6TLV9 - Q6TLV9_CHICK

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Protein
Submitted name:

Axin-related protein

Gene

AXIN2

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. armadillo repeat domain binding Source: RefGenome
  2. beta-catenin binding Source: RefGenome
  3. GTPase activator activity Source: RefGenome
  4. protein kinase binding Source: RefGenome

GO - Biological processi

  1. cell death Source: RefGenome
  2. cellular response to organic cyclic compound Source: RefGenome
  3. dorsal/ventral axis specification Source: RefGenome
  4. intramembranous ossification Source: RefGenome
  5. negative regulation of canonical Wnt signaling pathway Source: RefGenome
  6. negative regulation of osteoblast differentiation Source: RefGenome
  7. positive regulation of GTPase activity Source: GOC
  8. regulation of catenin import into nucleus Source: RefGenome
  9. termination of G-protein coupled receptor signaling pathway Source: InterPro
  10. Wnt signaling pathway involved in somitogenesis Source: RefGenome
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Axin-related proteinImported
Gene namesi
Name:AXIN2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: RefGenome
  2. cytoplasmic membrane-bounded vesicle Source: RefGenome
  3. cytoplasmic microtubule Source: RefGenome
  4. plasma membrane Source: RefGenome
  5. postsynaptic density Source: RefGenome
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ6TLV9.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006394.

Structurei

3D structure databases

ProteinModelPortaliQ6TLV9.
SMRiQ6TLV9. Positions 71-211, 758-837.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RGS domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG238205.
HOGENOMiHOG000231228.
HOVERGENiHBG004324.
KOiK04385.
PhylomeDBiQ6TLV9.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6TLV9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSAVLLAHL PDPGSSFRED APRPPVPGEE GDAPPCPQPH SSFLAKSQSF
60 70 80 90 100
PAMPVPAAPR RNENGLGEPE GSASPDSPLA RWTKSLHSLL GDQDGAYLFR
110 120 130 140 150
TFLEREKCVD TLDFWFACNG FRQMDLKDTK TSRVAKAIYK RYIENNSIVS
160 170 180 190 200
KQLKPATKTY IRDSIKKQQI DSIMFDQAQT EIQTVMEENA YQMFLTSDIY
210 220 230 240 250
LEYVRSGGEN PAYMSSNGLG SLKVVCGYLP TLNEEEEWSC ADFKSKMLPS
260 270 280 290 300
VVGLSSKTLR VTAGVRATET LENGYRSFKR NDPVNPYHVS SGYVFAPATS
310 320 330 340 350
ANDSEISSDA LTDDSMSMTD SSVDGIPPYR IGSKKQLQRE MHRSVKANGQ
360 370 380 390 400
VSLPHFPRTH RLPKEMTPVE PAAFAAELIS RLEKLKQEQE TMDSLEERLQ
410 420 430 440 450
QIKEDEEKEG LELPASLQSS REMVNPQHQQ HPLSLLPSGS YEEDPQAILD
460 470 480 490 500
EHLSRVLKTP GCQSPGMGRH SPRARSPDHL LGGKLQPSTA SPATCALLGK
510 520 530 540 550
GFITKQTTKH VHHHYIHHHA VPKTKEQIEA EAAQRVQCCC PAGSDYYCFS
560 570 580 590 600
KCKGHPKGTD PPLPPLEPFG RTGTLTKRPG RGVESIALLP GDGGLPGPSG
610 620 630 640 650
VQLPGGEADR AQNVWQWMLE SERQNKHKPH STQSTKKAYS SDFAKGAPSE
660 670 680 690 700
RPGRHHPWGP GSHPRGAQPA HPFIQDPAMP PLTPPNTLAQ LEEACRRLAE
710 720 730 740 750
VSKPQKQRCS TSNQQRDRNH STAVQGGNTP FCNASLTTED HKEPKKLPVV
760 770 780 790 800
HTSQSSELVV TYFFCGEEIP YRRMLKAQSL TLGHFKEQLS KKGNYRYYFK
810 820 830
KASDEFDCGA VFEEIWEDET ILPMYEGRIL GKVERID
Length:837
Mass (Da):92,943
Last modified:July 5, 2004 - v1
Checksum:iAFAC281E7C85257E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY394491 mRNA. Translation: AAQ84522.1.
RefSeqiNP_989822.1. NM_204491.1.
UniGeneiGga.8363.

Genome annotation databases

GeneIDi395152.
KEGGigga:395152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY394491 mRNA. Translation: AAQ84522.1 .
RefSeqi NP_989822.1. NM_204491.1.
UniGenei Gga.8363.

3D structure databases

ProteinModelPortali Q6TLV9.
SMRi Q6TLV9. Positions 71-211, 758-837.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000006394.

Proteomic databases

PaxDbi Q6TLV9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395152.
KEGGi gga:395152.

Organism-specific databases

CTDi 8313.

Phylogenomic databases

eggNOGi NOG238205.
HOGENOMi HOG000231228.
HOVERGENi HBG004324.
KOi K04385.
PhylomeDBi Q6TLV9.

Miscellaneous databases

NextBioi 20815243.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and embryonic expression of avian Axin2."
    Ding L., Gamel A.J., Dai F., Yusuf F., Brand-Saberi B.E.M.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6TLV9_CHICK
AccessioniPrimary (citable) accession number: Q6TLV9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)