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Q6TLV9

- Q6TLV9_CHICK

UniProt

Q6TLV9 - Q6TLV9_CHICK

Protein
Submitted name:

Axin-related protein

Gene

AXIN2

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. armadillo repeat domain binding Source: RefGenome
    2. beta-catenin binding Source: RefGenome
    3. GTPase activator activity Source: RefGenome
    4. protein kinase binding Source: RefGenome
    5. signal transducer activity Source: InterPro

    GO - Biological processi

    1. cell death Source: RefGenome
    2. cellular response to organic cyclic compound Source: RefGenome
    3. dorsal/ventral axis specification Source: RefGenome
    4. intramembranous ossification Source: RefGenome
    5. negative regulation of canonical Wnt signaling pathway Source: RefGenome
    6. negative regulation of osteoblast differentiation Source: RefGenome
    7. positive regulation of GTPase activity Source: GOC
    8. regulation of catenin import into nucleus Source: RefGenome
    9. termination of G-protein coupled receptor signaling pathway Source: InterPro
    10. Wnt signaling pathway involved in somitogenesis Source: RefGenome

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Axin-related proteinImported
    Gene namesi
    Name:AXIN2Imported
    OrganismiGallus gallus (Chicken)Imported
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

    Subcellular locationi

    GO - Cellular componenti

    1. cell cortex Source: RefGenome
    2. cytoplasmic membrane-bounded vesicle Source: RefGenome
    3. cytoplasmic microtubule Source: RefGenome
    4. plasma membrane Source: RefGenome
    5. postsynaptic density Source: RefGenome

    PTM / Processingi

    Proteomic databases

    PaxDbiQ6TLV9.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000006394.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6TLV9.
    SMRiQ6TLV9. Positions 71-211, 758-837.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 RGS domain.UniRule annotation
    Contains RGS domain.SAAS annotation

    Phylogenomic databases

    eggNOGiNOG238205.
    HOGENOMiHOG000231228.
    HOVERGENiHBG004324.
    InParanoidiQ6TLV9.
    KOiK04385.
    PhylomeDBiQ6TLV9.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00021. DAX. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6TLV9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSAVLLAHL PDPGSSFRED APRPPVPGEE GDAPPCPQPH SSFLAKSQSF    50
    PAMPVPAAPR RNENGLGEPE GSASPDSPLA RWTKSLHSLL GDQDGAYLFR 100
    TFLEREKCVD TLDFWFACNG FRQMDLKDTK TSRVAKAIYK RYIENNSIVS 150
    KQLKPATKTY IRDSIKKQQI DSIMFDQAQT EIQTVMEENA YQMFLTSDIY 200
    LEYVRSGGEN PAYMSSNGLG SLKVVCGYLP TLNEEEEWSC ADFKSKMLPS 250
    VVGLSSKTLR VTAGVRATET LENGYRSFKR NDPVNPYHVS SGYVFAPATS 300
    ANDSEISSDA LTDDSMSMTD SSVDGIPPYR IGSKKQLQRE MHRSVKANGQ 350
    VSLPHFPRTH RLPKEMTPVE PAAFAAELIS RLEKLKQEQE TMDSLEERLQ 400
    QIKEDEEKEG LELPASLQSS REMVNPQHQQ HPLSLLPSGS YEEDPQAILD 450
    EHLSRVLKTP GCQSPGMGRH SPRARSPDHL LGGKLQPSTA SPATCALLGK 500
    GFITKQTTKH VHHHYIHHHA VPKTKEQIEA EAAQRVQCCC PAGSDYYCFS 550
    KCKGHPKGTD PPLPPLEPFG RTGTLTKRPG RGVESIALLP GDGGLPGPSG 600
    VQLPGGEADR AQNVWQWMLE SERQNKHKPH STQSTKKAYS SDFAKGAPSE 650
    RPGRHHPWGP GSHPRGAQPA HPFIQDPAMP PLTPPNTLAQ LEEACRRLAE 700
    VSKPQKQRCS TSNQQRDRNH STAVQGGNTP FCNASLTTED HKEPKKLPVV 750
    HTSQSSELVV TYFFCGEEIP YRRMLKAQSL TLGHFKEQLS KKGNYRYYFK 800
    KASDEFDCGA VFEEIWEDET ILPMYEGRIL GKVERID 837
    Length:837
    Mass (Da):92,943
    Last modified:July 5, 2004 - v1
    Checksum:iAFAC281E7C85257E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY394491 mRNA. Translation: AAQ84522.1.
    RefSeqiNP_989822.1. NM_204491.1.
    UniGeneiGga.8363.

    Genome annotation databases

    GeneIDi395152.
    KEGGigga:395152.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY394491 mRNA. Translation: AAQ84522.1 .
    RefSeqi NP_989822.1. NM_204491.1.
    UniGenei Gga.8363.

    3D structure databases

    ProteinModelPortali Q6TLV9.
    SMRi Q6TLV9. Positions 71-211, 758-837.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000006394.

    Proteomic databases

    PaxDbi Q6TLV9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395152.
    KEGGi gga:395152.

    Organism-specific databases

    CTDi 8313.

    Phylogenomic databases

    eggNOGi NOG238205.
    HOGENOMi HOG000231228.
    HOVERGENi HBG004324.
    InParanoidi Q6TLV9.
    KOi K04385.
    PhylomeDBi Q6TLV9.

    Miscellaneous databases

    NextBioi 20815243.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00021. DAX. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and embryonic expression of avian Axin2."
      Ding L., Gamel A.J., Dai F., Yusuf F., Brand-Saberi B.E.M.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ6TLV9_CHICK
    AccessioniPrimary (citable) accession number: Q6TLV9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)