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Q6TLV9

- Q6TLV9_CHICK

UniProt

Q6TLV9 - Q6TLV9_CHICK

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Protein
Submitted name: Axin-related protein
Gene
AXIN2
Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome
  2. armadillo repeat domain binding Source: RefGenome
  3. beta-catenin binding Source: RefGenome
  4. protein kinase binding Source: RefGenome
  5. signal transducer activity Source: InterPro

GO - Biological processi

  1. Wnt signaling pathway involved in somitogenesis Source: RefGenome
  2. cell death Source: RefGenome
  3. cellular response to organic cyclic compound Source: RefGenome
  4. dorsal/ventral axis specification Source: RefGenome
  5. intramembranous ossification Source: RefGenome
  6. negative regulation of canonical Wnt signaling pathway Source: RefGenome
  7. negative regulation of osteoblast differentiation Source: RefGenome
  8. positive regulation of GTPase activity Source: GOC
  9. regulation of catenin import into nucleus Source: RefGenome
  10. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Axin-related proteinImported
Gene namesi
Name:AXIN2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: RefGenome
  2. cytoplasmic membrane-bounded vesicle Source: RefGenome
  3. cytoplasmic microtubule Source: RefGenome
  4. plasma membrane Source: RefGenome
  5. postsynaptic density Source: RefGenome
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ6TLV9.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006394.

Structurei

3D structure databases

ProteinModelPortaliQ6TLV9.
SMRiQ6TLV9. Positions 71-211, 758-837.

Family & Domainsi

Sequence similaritiesi

Contains 1 RGS domain.UniRule annotation
Contains RGS domain.SAAS annotations

Phylogenomic databases

eggNOGiNOG238205.
HOGENOMiHOG000231228.
HOVERGENiHBG004324.
InParanoidiQ6TLV9.
KOiK04385.
PhylomeDBiQ6TLV9.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6TLV9-1 [UniParc]FASTAAdd to Basket

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MSSAVLLAHL PDPGSSFRED APRPPVPGEE GDAPPCPQPH SSFLAKSQSF    50
PAMPVPAAPR RNENGLGEPE GSASPDSPLA RWTKSLHSLL GDQDGAYLFR 100
TFLEREKCVD TLDFWFACNG FRQMDLKDTK TSRVAKAIYK RYIENNSIVS 150
KQLKPATKTY IRDSIKKQQI DSIMFDQAQT EIQTVMEENA YQMFLTSDIY 200
LEYVRSGGEN PAYMSSNGLG SLKVVCGYLP TLNEEEEWSC ADFKSKMLPS 250
VVGLSSKTLR VTAGVRATET LENGYRSFKR NDPVNPYHVS SGYVFAPATS 300
ANDSEISSDA LTDDSMSMTD SSVDGIPPYR IGSKKQLQRE MHRSVKANGQ 350
VSLPHFPRTH RLPKEMTPVE PAAFAAELIS RLEKLKQEQE TMDSLEERLQ 400
QIKEDEEKEG LELPASLQSS REMVNPQHQQ HPLSLLPSGS YEEDPQAILD 450
EHLSRVLKTP GCQSPGMGRH SPRARSPDHL LGGKLQPSTA SPATCALLGK 500
GFITKQTTKH VHHHYIHHHA VPKTKEQIEA EAAQRVQCCC PAGSDYYCFS 550
KCKGHPKGTD PPLPPLEPFG RTGTLTKRPG RGVESIALLP GDGGLPGPSG 600
VQLPGGEADR AQNVWQWMLE SERQNKHKPH STQSTKKAYS SDFAKGAPSE 650
RPGRHHPWGP GSHPRGAQPA HPFIQDPAMP PLTPPNTLAQ LEEACRRLAE 700
VSKPQKQRCS TSNQQRDRNH STAVQGGNTP FCNASLTTED HKEPKKLPVV 750
HTSQSSELVV TYFFCGEEIP YRRMLKAQSL TLGHFKEQLS KKGNYRYYFK 800
KASDEFDCGA VFEEIWEDET ILPMYEGRIL GKVERID 837
Length:837
Mass (Da):92,943
Last modified:July 5, 2004 - v1
Checksum:iAFAC281E7C85257E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY394491 mRNA. Translation: AAQ84522.1.
RefSeqiNP_989822.1. NM_204491.1.
UniGeneiGga.8363.

Genome annotation databases

GeneIDi395152.
KEGGigga:395152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY394491 mRNA. Translation: AAQ84522.1 .
RefSeqi NP_989822.1. NM_204491.1.
UniGenei Gga.8363.

3D structure databases

ProteinModelPortali Q6TLV9.
SMRi Q6TLV9. Positions 71-211, 758-837.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000006394.

Proteomic databases

PaxDbi Q6TLV9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395152.
KEGGi gga:395152.

Organism-specific databases

CTDi 8313.

Phylogenomic databases

eggNOGi NOG238205.
HOGENOMi HOG000231228.
HOVERGENi HBG004324.
InParanoidi Q6TLV9.
KOi K04385.
PhylomeDBi Q6TLV9.

Miscellaneous databases

NextBioi 20815243.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and embryonic expression of avian Axin2."
    Ding L., Gamel A.J., Dai F., Yusuf F., Brand-Saberi B.E.M.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6TLV9_CHICK
AccessioniPrimary (citable) accession number: Q6TLV9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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