Q6TLV9 (Q6TLV9_CHICK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Axin-related protein EMBL AAQ84522.1

Gene names

Name:

AXIN2 EMBL AAQ84522.1

Organism

Gallus gallus (Chicken) EMBL AAQ84522.1

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	837 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 RGS domain. RuleBase RU003298

Ontologies

Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway involved in somitogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome cell death Inferred from Biological aspect of Ancestor. Source: RefGenome cellular response to organic cyclic compound Inferred from Biological aspect of Ancestor. Source: RefGenome dorsal/ventral axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome intramembranous ossification Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of canonical Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of osteoblast differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of catenin import into nucleus Inferred from Biological aspect of Ancestor. Source: RefGenome termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cell cortex Inferred from Biological aspect of Ancestor. Source: RefGenome cytoplasmic membrane-bounded vesicle Inferred from Biological aspect of Ancestor. Source: RefGenome cytoplasmic microtubule Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome postsynaptic density Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome armadillo repeat domain binding Inferred from Biological aspect of Ancestor. Source: RefGenome beta-catenin binding Inferred from Biological aspect of Ancestor. Source: RefGenome protein kinase binding Inferred from Biological aspect of Ancestor. Source: RefGenome signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6TLV9 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: AFAC281E7C85257E	FASTA	837	92,943
	10 20 30 40 50 60 MSSAVLLAHL PDPGSSFRED APRPPVPGEE GDAPPCPQPH SSFLAKSQSF PAMPVPAAPR 70 80 90 100 110 120 RNENGLGEPE GSASPDSPLA RWTKSLHSLL GDQDGAYLFR TFLEREKCVD TLDFWFACNG 130 140 150 160 170 180 FRQMDLKDTK TSRVAKAIYK RYIENNSIVS KQLKPATKTY IRDSIKKQQI DSIMFDQAQT 190 200 210 220 230 240 EIQTVMEENA YQMFLTSDIY LEYVRSGGEN PAYMSSNGLG SLKVVCGYLP TLNEEEEWSC 250 260 270 280 290 300 ADFKSKMLPS VVGLSSKTLR VTAGVRATET LENGYRSFKR NDPVNPYHVS SGYVFAPATS 310 320 330 340 350 360 ANDSEISSDA LTDDSMSMTD SSVDGIPPYR IGSKKQLQRE MHRSVKANGQ VSLPHFPRTH 370 380 390 400 410 420 RLPKEMTPVE PAAFAAELIS RLEKLKQEQE TMDSLEERLQ QIKEDEEKEG LELPASLQSS 430 440 450 460 470 480 REMVNPQHQQ HPLSLLPSGS YEEDPQAILD EHLSRVLKTP GCQSPGMGRH SPRARSPDHL 490 500 510 520 530 540 LGGKLQPSTA SPATCALLGK GFITKQTTKH VHHHYIHHHA VPKTKEQIEA EAAQRVQCCC 550 560 570 580 590 600 PAGSDYYCFS KCKGHPKGTD PPLPPLEPFG RTGTLTKRPG RGVESIALLP GDGGLPGPSG 610 620 630 640 650 660 VQLPGGEADR AQNVWQWMLE SERQNKHKPH STQSTKKAYS SDFAKGAPSE RPGRHHPWGP 670 680 690 700 710 720 GSHPRGAQPA HPFIQDPAMP PLTPPNTLAQ LEEACRRLAE VSKPQKQRCS TSNQQRDRNH 730 740 750 760 770 780 STAVQGGNTP FCNASLTTED HKEPKKLPVV HTSQSSELVV TYFFCGEEIP YRRMLKAQSL 790 800 810 820 830 TLGHFKEQLS KKGNYRYYFK KASDEFDCGA VFEEIWEDET ILPMYEGRIL GKVERID

References

[1]	"Cloning and embryonic expression of avian Axin2." Ding L., Gamel A.J., Dai F., Yusuf F., Brand-Saberi B.E.M. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY394491 mRNA. Translation: AAQ84522.1.
IPI	IPI00591754.
RefSeq	NP_989822.1. NM_204491.1.
UniGene	Gga.8363.
3D structure databases
HSSP	HSSP built from PDB template 1AGR based on UniProtKB P49799.
ProteinModelPortal	Q6TLV9.
SMR	Q6TLV9. Positions 71-211, 758-837.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000006394. Q6TLV9.
Proteomic databases
PaxDb	Q6TLV9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	395152.
KEGG	gga:395152.
Organism-specific databases
CTD	8313.
Phylogenomic databases
eggNOG	NOG238205.
HOGENOM	HOG000231228.
HOVERGEN	HBG004324.
InParanoid	Q6TLV9.
KO	K04385.
OrthoDB	EOG4X3H11.
Family and domain databases
Gene3D	1.10.196.10. 2 hits.
InterPro	IPR014936. Axin_b-cat-bd. IPR001158. DIX. IPR000342. Regulat_G_prot_signal. IPR024066. Regulat_G_prot_signal_dom1. IPR016137. Regulat_G_prot_signal_superfam. [Graphical view]
Pfam	PF08833. Axin_b-cat_bind. 1 hit. PF00778. DIX. 1 hit. PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
SMART	SM00021. DAX. 1 hit. SM00315. RGS. 1 hit. [Graphical view]
SUPFAM	SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS50841. DIX. 1 hit. PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20815243.

Entry information

Entry name

Q6TLV9_CHICK

Accession

Primary (citable) accession number: Q6TLV9

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)