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Protein

Adenosine receptor A2a

Gene

ADORA2A

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2a
Gene namesi
Name:ADORA2A
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7ExtracellularBy similarity7
Transmembranei8 – 32Helical; Name=1By similarityAdd BLAST25
Topological domaini33 – 42CytoplasmicBy similarity10
Transmembranei43 – 66Helical; Name=2By similarityAdd BLAST24
Topological domaini67 – 77ExtracellularBy similarityAdd BLAST11
Transmembranei78 – 100Helical; Name=3By similarityAdd BLAST23
Topological domaini101 – 120CytoplasmicBy similarityAdd BLAST20
Transmembranei121 – 143Helical; Name=4By similarityAdd BLAST23
Topological domaini144 – 173ExtracellularBy similarityAdd BLAST30
Transmembranei174 – 198Helical; Name=5By similarityAdd BLAST25
Topological domaini199 – 234CytoplasmicBy similarityAdd BLAST36
Transmembranei235 – 258Helical; Name=6By similarityAdd BLAST24
Topological domaini259 – 266ExtracellularBy similarity8
Transmembranei267 – 290Helical; Name=7By similarityAdd BLAST24
Topological domaini291 – 412CytoplasmicBy similarityAdd BLAST122

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689981 – 412Adenosine receptor A2aAdd BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi71 ↔ 159PROSITE-ProRule annotation
Disulfide bondi74 ↔ 146PROSITE-ProRule annotation
Disulfide bondi77 ↔ 166PROSITE-ProRule annotation
Glycosylationi154N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi259 ↔ 262PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ6TLI7.

Interactioni

Subunit structurei

Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6TLI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni168 – 177Agonist bindingBy similarity10
Regioni246 – 253Agonist bindingBy similarity8
Regioni264 – 274Agonist bindingBy similarityAdd BLAST11

Domaini

The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106962.
InParanoidiQ6TLI7.
KOiK04266.

Family and domain databases

InterProiIPR001513. Adeno_A2A_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24246:SF28. PTHR24246:SF28. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00553. ADENOSINA2AR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6TLI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTVGSLVYI MVELAIALLA ILGNMLVCWA VWLNSNLQNV TNYFVVSLAA
60 70 80 90 100
ADIAVGVLAI PFAITISTGF CAACHGCLFI ACFVLVLTQS SIFSLLAIAI
110 120 130 140 150
DRYIAIRIPL RYNGLVTGTR AKGVIAVCWV LSFAIGLTPM LGWNNCHHWG
160 170 180 190 200
EGENQSQGCG EGQVACLFED VVPMNYMVYY NFFACVLVPL LLMLGVYLRI
210 220 230 240 250
FLAARRQLKQ METQPLPGER ARSTLQKEVH AAKSLAIIVG LFALCWLPLH
260 270 280 290 300
IINCFTFFCP ECPHAPLWLM YPAIILSHFN SVVNPFIYAY RIREFRHTFH
310 320 330 340 350
KIIRSHILRR QEPFKAGGTS ARALAAHGSD AEQVSLRLNG HPSGVCPNGS
360 370 380 390 400
APHPERRPNG YALGLVSRAS ARESPGDTGL PDVELLSHEL HGASPESPGL
410
EGPLAQDGAG VS
Length:412
Mass (Da):44,894
Last modified:July 5, 2004 - v1
Checksum:i24EA0CBF5BD761B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY394857 mRNA. Translation: AAQ95165.1.
RefSeqiNP_001075366.1. NM_001081897.1.
UniGeneiEca.12776.

Genome annotation databases

GeneIDi100034039.
KEGGiecb:100034039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY394857 mRNA. Translation: AAQ95165.1.
RefSeqiNP_001075366.1. NM_001081897.1.
UniGeneiEca.12776.

3D structure databases

ProteinModelPortaliQ6TLI7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ6TLI7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100034039.
KEGGiecb:100034039.

Organism-specific databases

CTDi135.

Phylogenomic databases

HOVERGENiHBG106962.
InParanoidiQ6TLI7.
KOiK04266.

Family and domain databases

InterProiIPR001513. Adeno_A2A_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24246:SF28. PTHR24246:SF28. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00553. ADENOSINA2AR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAA2AR_HORSE
AccessioniPrimary (citable) accession number: Q6TLI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.