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Protein

Calcium release-activated calcium channel protein 1

Gene

orai1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Ca2+ release-activated Ca2+ (CRAC) channel subunit which mediates Ca2+ influx following depletion of intracellular Ca2+ stores.By similarity

GO - Molecular functioni

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • positive regulation of calcium ion transport Source: UniProtKB
  • sarcomere organization Source: ZFIN
  • store-operated calcium entry Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Adaptive immunity, Calcium transport, Immunity, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium release-activated calcium channel protein 1
Alternative name(s):
Protein orai-1
Transmembrane protein 142A
Gene namesi
Name:orai1
Synonyms:tmem142a
ORF Names:zgc:109721
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050522-100. orai1b.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030CytoplasmicSequence analysisAdd
BLAST
Transmembranei31 – 4818HelicalSequence analysisAdd
BLAST
Topological domaini49 – 5810ExtracellularSequence analysis
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST
Topological domaini80 – 11233CytoplasmicSequence analysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST
Topological domaini134 – 15421ExtracellularSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST
Topological domaini176 – 22247CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Calcium release-activated calcium channel protein 1PRO_0000234385Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6TLE6.

Expressioni

Gene expression databases

BgeeiQ6TLE6.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000022726.

Family & Domainsi

Sequence similaritiesi

Belongs to the Orai family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4298. Eukaryota.
ENOG4110DSB. LUCA.
HOGENOMiHOG000246925.
HOVERGENiHBG081343.
InParanoidiQ6TLE6.
KOiK16056.
OrthoDBiEOG7G1V73.
PhylomeDBiQ6TLE6.
TreeFamiTF313576.

Family and domain databases

InterProiIPR012446. CRAC_channel.
[Graphical view]
PANTHERiPTHR31501. PTHR31501. 1 hit.
PfamiPF07856. Orai-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6TLE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMSRSEHSL QALSWRKLYL SRAKLKASSR TSALLSGFAM VAMVEVQLDT
60 70 80 90 100
NHDYPPGLLI AFSACTTVLV AVHLFALMVS TCILPNIEAV SNVHNLNSVK
110 120 130 140 150
ESPHERMHRH IELAWAFSTV IGTLLFLAGV VLLCWVKFLP IKPKGQKNGT
160 170 180 190 200
VSAGVAAAIT STSIMVPFGL VFIVFAVHFY RSLVSHKTDR QFQELEELED
210 220
LQNELDHREE VSTLQSPGSL YP
Length:222
Mass (Da):24,633
Last modified:May 16, 2006 - v2
Checksum:iA5B735B035D78894
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti129 – 1291G → E in AAQ94587 (PubMed:15520368).Curated
Sequence conflicti145 – 1451G → D in AAQ94587 (PubMed:15520368).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY394960 mRNA. Translation: AAQ94587.1.
BC094965 mRNA. Translation: AAH94965.1.
RefSeqiNP_991163.1. NM_205600.1.
UniGeneiDr.85339.

Genome annotation databases

GeneIDi402892.
KEGGidre:402892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY394960 mRNA. Translation: AAQ94587.1.
BC094965 mRNA. Translation: AAH94965.1.
RefSeqiNP_991163.1. NM_205600.1.
UniGeneiDr.85339.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000022726.

Proteomic databases

PaxDbiQ6TLE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi402892.
KEGGidre:402892.

Organism-specific databases

CTDi402892.
ZFINiZDB-GENE-050522-100. orai1b.

Phylogenomic databases

eggNOGiKOG4298. Eukaryota.
ENOG4110DSB. LUCA.
HOGENOMiHOG000246925.
HOVERGENiHBG081343.
InParanoidiQ6TLE6.
KOiK16056.
OrthoDBiEOG7G1V73.
PhylomeDBiQ6TLE6.
TreeFamiTF313576.

Miscellaneous databases

PROiQ6TLE6.

Gene expression databases

BgeeiQ6TLE6.

Family and domain databases

InterProiIPR012446. CRAC_channel.
[Graphical view]
PANTHERiPTHR31501. PTHR31501. 1 hit.
PfamiPF07856. Orai-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney marrow.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiCRCM1_DANRE
AccessioniPrimary (citable) accession number: Q6TLE6
Secondary accession number(s): Q504L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: July 6, 2016
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.