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Protein
Submitted name:

Actin, alpha 2, smooth muscle, aorta

Gene

acta2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • blood circulation Source: ZFIN
  • heart contraction Source: ZFIN
  • mesenchyme migration Source: AgBase
  • positive regulation of gene expression Source: AgBase

Keywordsi

LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Actin, alpha 2, smooth muscle, aortaImported
Gene namesi
Name:acta2Imported
Synonyms:ACTA2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-030131-1229. acta2.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PaxDbiQ6TH51.
PRIDEiQ6TH51.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000066429.

Structurei

3D structure databases

ProteinModelPortaliQ6TH51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
HOVERGENiHBG003771.
KOiK12313.
PhylomeDBiQ6TH51.

Family and domain databases

InterProiView protein in InterPro
IPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiView protein in Pfam
PF00022. Actin. 1 hit.
PRINTSiPR00190. ACTIN.
SMARTiView protein in SMART
SM00268. ACTIN. 1 hit.
PROSITEiView protein in PROSITE
PS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6TH51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDDEESTAL VCDNGSGLCK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG
60 70 80 90 100
QKDSYVGDEA QSKRGILTLK YPIEHGIITN WDDMEKIWHH SFYNELRVAP
110 120 130 140 150
EEHPTLLTEA PLNPKANREK MTQIMFETFN VPAMYVAIQA VLSLYASGRT
160 170 180 190 200
TGIVLDSGDG VTHNVPIYEG YALPHAIMRL DLAGRDLTDY LMKILTERGY
210 220 230 240 250
SFVTTAEREI VRDIKEKLCY VALDFENEMA TAAFSSSLEK SYELPDGQVI
260 270 280 290 300
TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV
310 320 330 340 350
LSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS
360 370
LSTFQQMWIS KQEYDEAGPS IVHRKCF
Length:377
Mass (Da):42,055
Last modified:July 5, 2004 - v1
Checksum:iD85BF2D3EA41D9EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY398305 mRNA. Translation: AAQ97738.1.
UniGeneiDr.20277.

Genome annotation databases

KEGGidre:322509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY398305 mRNA. Translation: AAQ97738.1.
UniGeneiDr.20277.

3D structure databases

ProteinModelPortaliQ6TH51.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000066429.

Proteomic databases

PaxDbiQ6TH51.
PRIDEiQ6TH51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGidre:322509.

Organism-specific databases

ZFINiZDB-GENE-030131-1229. acta2.

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
HOVERGENiHBG003771.
KOiK12313.
PhylomeDBiQ6TH51.

Family and domain databases

InterProiView protein in InterPro
IPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiView protein in Pfam
PF00022. Actin. 1 hit.
PRINTSiPR00190. ACTIN.
SMARTiView protein in SMART
SM00268. ACTIN. 1 hit.
PROSITEiView protein in PROSITE
PS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6TH51_DANRE
AccessioniPrimary (citable) accession number: Q6TH51
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: February 15, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.