Q6TH47 (STBPA_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
STAM-binding protein-like A
EC=3.4.19.-

Gene names

Name:	stambpa
Synonyms:	amsh, stambp

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains By similarity. Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes By similarity.
Cofactor	Binds 2 zinc ion per subunit By similarity.
Domain	The JAMM motif is essential for the protease activity By similarity.
Sequence similarities	Belongs to the peptidase M67C family. Contains 1 MPN (JAB/Mov34) domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 418	418	STAM-binding protein-like A		PRO_0000194872
Regions
	Domain	246 – 355	110	MPN
	Motif	329 – 342	14	JAMM motif
	Compositional bias	139 – 161	23	Gln-rich
Sites
	Metal binding	329	1	Zinc 1; catalytic By similarity
	Metal binding	331	1	Zinc 1; catalytic By similarity
	Metal binding	342	1	Zinc 1; catalytic By similarity
	Metal binding	344	1	Zinc 2 By similarity
	Metal binding	384	1	Zinc 2 By similarity
	Metal binding	390	1	Zinc 2 By similarity
	Metal binding	392	1	Zinc 2 By similarity
	Site	274	1	Indirect zinc-binding By similarity
Experimental info
	Sequence conflict	153	1	Q → H in AAH55512. Ref.2
	Sequence conflict	222	1	Q → E in AAQ97742. Ref.1
	Sequence conflict	382	1	G → V in AAQ97742. Ref.1
	Sequence conflict	395	1	D → N in AAQ97742. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6TH47 [UniParc]. Last modified October 5, 2010. Version 3. Checksum: 826B0EC26683BF3F	FASTA	418	47,510
	10 20 30 40 50 60 MSEHTDCSVS SEDRVRALTK LGSSVDVSED VPPRRYFRSG MEIIRMANIY ADEGNVEHAF 70 80 90 100 110 120 ILYNKYITLF IEKLPKHREY KTANIPEKKE TMRKLKEIAF PKAEELKKLL LKQYDKEHAE 130 140 150 160 170 180 YLVRKRAEDA ARAVEMLKQQ EQEAQRQRLA ELQQRQREQE QFSAFEEMIR RQELEKERRR 190 200 210 220 230 240 IVQEFSIPVS PTAPDVLLPD VHGPPQASLS PQTPPAGATN HQGLPAFDRS LKPSVPVSAG 250 260 270 280 290 300 HSALVNGLRQ LFVPAELCQR FLKLAETNTA RAVETCGILC GKLMKNAFTV THVIVPKQCG 310 320 330 340 350 360 GPDYCDTENE EELFLIQDQN DLITLGWIHT HPTQTAFLSS VDLHTHCSYQ MMLPESIAIV 370 380 390 400 410 CSPKFNETGY FRLTDYGMDD VGTCKQRGFH PHPKDPPLFA ASHHVSITDG SVTMLDLR

References

[1]	"Hematopoietic gene expression profile in zebrafish kidney marrow." Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X., Look A.T., Chen Z. Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004) [PubMed: 15520368] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney marrow.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: SJD.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY398309 mRNA. Translation: AAQ97742.1. BC055512 mRNA. Translation: AAH55512.1. BC171484 mRNA. Translation: AAI71484.1.
IPI	IPI00503835.
RefSeq	NP_956792.1. NM_200498.1.
UniGene	Dr.75634.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M67.006.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	797422.
KEGG	dre:797422.
Organism-specific databases
CTD	797422.
ZFIN	ZDB-GENE-040426-1551. stambpa.
Phylogenomic databases
eggNOG	fiNOG10623.
GeneTree	ENSGT00390000015439.
HOGENOM	HBG443817.
HOVERGEN	HBG058519.
InParanoid	Q6TH47.
OrthoDB	EOG4B5P58.
Gene expression databases
ArrayExpress	Q6TH47.
Bgee	Q6TH47.
Family and domain databases
InterPro	IPR000555. Mov34_MPN_PAD1. [Graphical view]
KO	K11866.
Pfam	PF01398. Mov34. 1 hit. [Graphical view]
SMART	SM00232. JAB_MPN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

STBPA_DANRE

Accession

Primary (citable) accession number: Q6TH47
Secondary accession number(s): B7ZV76, Q7SXP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	October 5, 2010
Last modified:	November 16, 2011
This is version 56 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program