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Reviewed, UniProtKB/Swiss-Prot Q6TGZ5 (HPPD_DANRE)

Last modified November 4, 2008. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    4-hydroxyphenylpyruvate dioxygenase
    EC=1.13.11.27
Alternative name(s):
    4-hydroxyphenylpyruvic acid oxidase
      Short name=HPPDase
      Short name=4HPPD
      Short name=HPD
Gene names
Name: hpd
ORF Names: zgc:56326
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2).

Cofactor

Binds 1 iron ion per subunit By similarity.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 3/6.

Sequence similarities

Belongs to the 4HPPD family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3973974-hydroxyphenylpyruvate dioxygenase
PRO_0000088392

Sites

Metal binding1841Iron By similarity
Metal binding2671Iron By similarity
Metal binding3501Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6TGZ5-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: E689B499A97C8C33

FASTA39745,211
        10         20         30         40         50         60 
MTSYTDKGEK PERGKFLNFH HIKFWVGNAK QAAVFYCDKF GFEPLAYKGL ETGSREVVSH 

        70         80         90        100        110        120 
AVRQDKIIFV FESALNPGNE EMGEHMIKHG DGVKDVAFLV EDCDFLVKKA KERGAAVLKE 

       130        140        150        160        170        180 
PWVEQDAGGK VKYAIVQTYG DTTHTFVEYL GPYKGLFLPG YKEPLFRDPL LPKLPSGHLS 

       190        200        210        220        230        240 
FIDHIVGNQP DDEMVPVSDW YQKCLLFHRF WSIDDKQIHT EYSALRSIVV TNYEETIKMP 

       250        260        270        280        290        300 
INEPAMGKKK SQIQEYIDYN GGPGVQHIAL NTSNIIQAIV NLRARGLEFL SAPDNYYESL 

       310        320        330        340        350        360 
REKLKTAKIK VKEDLKTLQE LKILVDFDDK GYLLQIFTKP VQDRPTLFLE VIQRNNHFGF 

       370        380        390 
GAGNFKSLFE AIEKDQDARG NLTVLTAQNQ SVSKAFQ 

« Hide

References

[1]"Hematopoietic gene expression profile in zebrafish kidney marrow."
Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X., Look A.T., Chen Z.
Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004) [PubMed: 15520368] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney marrow.

Cross-references

Sequence databases

AY398361 mRNA. Translation: AAQ97794.1.
UniGeneDr.77434

3D structure databases

SMRQ6TGZ5. Positions 8-367.
ModBaseSearch...

Genome annotation databases

EnsemblENSDARG00000018351. Danio rerio. [Contig view]

Organism-specific databases

ZFINZDB-GENE-040426-986. zgc:56326.

Phylogenomic databases

HOGENOMQ6TGZ5.
HOVERGENQ6TGZ5.

Gene expression databases

ArrayExpressQ6TGZ5.

Family and domain databases

InterProIPR005956. 4OHPhenylPyrv_dOase.
IPR004360. Glyas_bleo-R_dOase.
[Graphical view]
PANTHERPTHR11959. HPP_dOase. 1 hit.
PfamPF00903. Glyoxalase. 2 hits.
[Graphical view]
PIRSFPIRSF009283. HPP_dOase. 1 hit.
TIGRFAMsTIGR01263. 4HPPD. 1 hit.
BLOCKSSearch...
ProtoNetSearch...

Entry information

Entry nameHPPD_DANRE
AccessionPrimary (citable) accession number: Q6TGZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: November 4, 2008
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectZebrafish annotation project

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents