Q6TGZ5 (HPPD_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-hydroxyphenylpyruvate dioxygenase
EC=1.13.11.27

Alternative name(s):
4-hydroxyphenylpyruvic acid oxidase
Short name=4HPPD
Short name=HPD
Short name=HPPDase

Gene names

Name:	hpd
ORF Names:	zgc:56326

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Key enzyme in the degradation of tyrosine By similarity.
Catalytic activity	4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
Sequence similarities	Belongs to the 4HPPD family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from sequence or structural similarity. Source: UniProtKB lactoylglutathione lyase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	4-hydroxyphenylpyruvate dioxygenase		PRO_0000088392
Sites
	Metal binding	184	1	Iron By similarity
	Metal binding	267	1	Iron By similarity
	Metal binding	350	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6TGZ5 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: E689B499A97C8C33	FASTA	397	45,211
	10 20 30 40 50 60 MTSYTDKGEK PERGKFLNFH HIKFWVGNAK QAAVFYCDKF GFEPLAYKGL ETGSREVVSH 70 80 90 100 110 120 AVRQDKIIFV FESALNPGNE EMGEHMIKHG DGVKDVAFLV EDCDFLVKKA KERGAAVLKE 130 140 150 160 170 180 PWVEQDAGGK VKYAIVQTYG DTTHTFVEYL GPYKGLFLPG YKEPLFRDPL LPKLPSGHLS 190 200 210 220 230 240 FIDHIVGNQP DDEMVPVSDW YQKCLLFHRF WSIDDKQIHT EYSALRSIVV TNYEETIKMP 250 260 270 280 290 300 INEPAMGKKK SQIQEYIDYN GGPGVQHIAL NTSNIIQAIV NLRARGLEFL SAPDNYYESL 310 320 330 340 350 360 REKLKTAKIK VKEDLKTLQE LKILVDFDDK GYLLQIFTKP VQDRPTLFLE VIQRNNHFGF 370 380 390 GAGNFKSLFE AIEKDQDARG NLTVLTAQNQ SVSKAFQ

References

[1]	"Hematopoietic gene expression profile in zebrafish kidney marrow." Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X., Look A.T., Chen Z. Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004) [PubMed: 15520368] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney marrow.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY398361 mRNA. Translation: AAQ97794.1.
IPI	IPI00505489.
UniGene	Dr.77434.
3D structure databases
ProteinModelPortal	Q6TGZ5.
SMR	Q6TGZ5. Positions 8-367.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6TGZ5.
Proteomic databases
PRIDE	Q6TGZ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
ZFIN	ZDB-GENE-040426-986. zgc:56326.
Phylogenomic databases
eggNOG	fiNOG14241.
GeneTree	ENSGT00530000063474.
HOGENOM	HBG680392.
HOVERGEN	HBG005987.
InParanoid	Q6TGZ5.
OrthoDB	EOG4Q58PF.
Gene expression databases
ArrayExpress	Q6TGZ5.
Bgee	Q6TGZ5.
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_Fos-R_dOase. IPR018146. Glyoxalase_1_CS. [Graphical view]
PANTHER	PTHR11959. HPP_dOase. 1 hit.
Pfam	PF00903. Glyoxalase. 2 hits. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HPPD_DANRE

Accession

Primary (citable) accession number: Q6TGZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	July 5, 2004
Last modified:	September 21, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program