Reviewed,
UniProtKB/Swiss-Prot Q6TGZ5 (HPPD_DANRE)
Last modified
February 9, 2010.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 4-hydroxyphenylpyruvate dioxygenase EC=1.13.11.27 Alternative name(s): 4-hydroxyphenylpyruvic acid oxidase Short name=HPPDase Short name=4HPPD Short name=HPD | ||||
| Gene names |
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| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) | ||||
| Taxonomic identifier | 7955 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio |
Protein attributes
| Sequence length | 397 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. |
| Cofactor | Binds 1 iron ion per subunit By similarity. |
| Pathway | |
| Sequence similarities | Belongs to the 4HPPD family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Phenylalanine catabolism Tyrosine catabolism |
| Ligand | Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 4-hydroxyphenylpyruvate dioxygenase activity Inferred from electronic annotation. Source: EC iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW lactoylglutathione lyase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Hematopoietic gene expression profile in zebrafish kidney marrow." Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X., Look A.T., Chen Z. Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004) [PubMed: 15520368] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney marrow. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY398361 mRNA. Translation: AAQ97794.1. |
| IPI | IPI00505489. |
| UniGene | Dr.77434 |
3D structure databases | |
| SMR | Q6TGZ5. Positions 8-367. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q6TGZ5. |
Proteomic databases | |
| PRIDE | Q6TGZ5. |
Genome annotation databases | |
| Ensembl | ENSDART00000020472; ENSDARP00000016115; ENSDARG00000018351; Danio rerio. [Genome view] |
Organism-specific databases | |
| ZFIN | ZDB-GENE-040426-986. zgc:56326. |
Phylogenomic databases | |
| eggNOG | fiNOG14241. |
| HOGENOM | HBG680392. |
| HOVERGEN | Q6TGZ5. |
| InParanoid | Q6TGZ5. |
Enzyme and pathway databases | |
| BRENDA | 1.13.11.27. 96826. |
Gene expression databases | |
| ArrayExpress | Q6TGZ5. |
| Bgee | Q6TGZ5. |
Family and domain databases | |
| InterPro | IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_bleo-R_dOase. IPR018146. Glyoxalase_1_CS. [Graphical view] |
| PANTHER | PTHR11959. HPP_dOase. 1 hit. |
| Pfam | PF00903. Glyoxalase. 2 hits. [Graphical view] |
| PIRSF | PIRSF009283. HPP_dOase. 1 hit. |
| TIGRFAMs | TIGR01263. 4HPPD. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HPPD_DANRE | ||||||||
| Accession | Primary (citable) accession number: Q6TGZ5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Zebrafish annotation project | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


