Q6TGC4 (PADI6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein-arginine deiminase type-6
EC=3.5.3.15

Alternative name(s):
Peptidylarginine deiminase VI
Protein-arginine deiminase type VI

Gene names

Name:

PADI6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	686 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the deimination of arginine residues of proteins. May be involved in cytoskeletal reorganization in the egg and early embryo By similarity.
Catalytic activity	Protein L-arginine + H2O = protein L-citrulline + NH3.
Cofactor	Calcium By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Tissue specificity	Ovary, testis and peripheral blood leukocytes.
Sequence similarities	Belongs to the protein arginine deiminase family.
Sequence caution	The sequence AAR38850.1 differs from that shown. Reason: Erroneous initiation. The sequence CAD70706.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Ligand	Calcium
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	peptidyl-citrulline biosynthetic process from peptidyl-arginine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro protein-arginine deiminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 686	686	Protein-arginine deiminase type-6		PRO_0000220036
Regions
	Compositional bias	493 – 496	4	Poly-Leu
Experimental info
	Sequence conflict	615	1	M → I in AAR38850. Ref.1
	Sequence conflict	678	1	A → T in AAR38850. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6TGC4 [UniParc]. Last modified December 21, 2004. Version 2. Checksum: 8AD7E6B872C35B0D	FASTA	686	76,897
	10 20 30 40 50 60 MSFQSIIHLS LDSPVHAVCV LGTEICLDLS GCAPQKCQCF TIHGSGRVLI DVANTVISEK 70 80 90 100 110 120 EDATIWWPLS DPTYATVKMT SPSPSVDADK VSVTYYGPNE DAPVGTAVLY LTGIEVSLEV 130 140 150 160 170 180 DIYRNGQVEM SSDKQAKKKW IWGPSGWGAI LLVNCNPADV GQQLEDKKTK KVIFSEEITN 190 200 210 220 230 240 LSQMTLNVQG PSCILKKYRL VLHTSKEESK KARVYWPQKD NSSTFELVLG PDQHAYTLAL 250 260 270 280 290 300 LGNHLKETFY VEAIAFPSAE FSGLISYSVS LVEESQDPSI PETVLYKDTV VFRVAPCVFI 310 320 330 340 350 360 PCTQVPLEVY LCRELQLQGF VDTVTKLSEK SNSQVASVYE DPNRLGRWLQ DEMAFCYTQA 370 380 390 400 410 420 PHKTTSLILD TPQAADLDEF PMKYSLSPGI GYMIQDTEDH KVASMDSIGN LMVSPPVKVQ 430 440 450 460 470 480 GKEYPLGRVL IGSSFYPSAE GRAMSKTLRD FLYAQQVQAP VELYSDWLMT GHVDEFMCFI 490 500 510 520 530 540 PTDDKNEGKK GFLLLLASPS ACYKLFREKQ KEGYGDALLF DELRADQLLS NGREAKTIDQ 550 560 570 580 590 600 LLADESLKKQ NEYVEKCIHL NRDILKTELG LVEQDIIEIP QLFCLEKLTN IPSDQQPKRS 610 620 630 640 650 660 FARPYFPDLL RMIVMGKNLG IPKPFGPQIK GTCCLEEKIC CLLEPLGFKC TFINDFDCYL 670 680 TEVGDICACA NIRRVPFAFK WWKMVP

References

[1]	"Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6." Chavanas S., Mechin M.-C., Takahara H., Kawada A., Nachat R., Serre G., Simon M. Gene 330:19-27(2004) [PubMed: 15087120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Ovary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY422079 mRNA. Translation: AAR38850.1. Different initiation. AJ549502 Genomic DNA. Translation: CAD70706.1. Different initiation.
IPI	IPI00410495.
RefSeq	NP_997304.3. NM_207421.3.
UniGene	Hs.531598.
3D structure databases
ProteinModelPortal	Q6TGC4.
SMR	Q6TGC4. Positions 3-686.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6TGC4.
Polymorphism databases
DMDM	56749252.
Proteomic databases
PRIDE	Q6TGC4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	353238.
KEGG	hsa:353238.
Organism-specific databases
CTD	353238.
GeneCards	GC01P017698.
HGNC	HGNC:20449. PADI6.
MIM	610363. gene.
neXtProt	NX_Q6TGC4.
PharmGKB	PA134975206.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG053016.
InParanoid	Q6TGC4.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-11228.
Gene expression databases
ArrayExpress	Q6TGC4.
CleanEx	HS_PADI6.
Genevestigator	Q6TGC4.
Family and domain databases
InterPro	IPR008972. Cupredoxin. IPR004303. PAD. IPR013530. PAD_C. IPR013732. PAD_N. IPR013733. Prot_Arg_deaminase_cen_dom. IPR016296. Protein-arginine_deiminase_sub. [Graphical view]
KO	K01481.
PANTHER	PTHR10837. PAD. 1 hit.
Pfam	PF03068. PAD. 1 hit. PF08527. PAD_M. 1 hit. PF08526. PAD_N. 1 hit. [Graphical view]
PIRSF	PIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF110083. PAD_central. 1 hit.
ProtoNet	Search...
Other
DrugBank	DB00155. L-Citrulline.
SOURCE	Search...

Entry information

Entry name

PADI6_HUMAN

Accession

Primary (citable) accession number: Q6TGC4
Secondary accession number(s): Q70SX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.