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Protein

Kelch-like protein 24

Gene

KLHL24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 24
Alternative name(s):
Kainate receptor-interacting protein for GluR6
Short name:
KRIP6
Protein DRE1
Gene namesi
Name:KLHL24
Synonyms:DRE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25947. KLHL24.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671576.

Polymorphism and mutation databases

BioMutaiKLHL24.
DMDMi74722812.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Kelch-like protein 24PRO_0000261594Add
BLAST

Proteomic databases

EPDiQ6TFL4.
MaxQBiQ6TFL4.
PaxDbiQ6TFL4.
PRIDEiQ6TFL4.

PTM databases

iPTMnetiQ6TFL4.
PhosphoSiteiQ6TFL4.

Expressioni

Gene expression databases

BgeeiQ6TFL4.
CleanExiHS_KLHL24.
ExpressionAtlasiQ6TFL4. baseline and differential.
GenevisibleiQ6TFL4. HS.

Organism-specific databases

HPAiHPA056337.

Interactioni

Subunit structurei

Forms homodimers. Interacts with GRIK2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi120159. 18 interactions.
IntActiQ6TFL4. 3 interactions.
STRINGi9606.ENSP00000242810.

Structurei

3D structure databases

ProteinModelPortaliQ6TFL4.
SMRiQ6TFL4. Positions 46-297, 300-592.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 13368BTBPROSITE-ProRule annotationAdd
BLAST
Domaini168 – 270103BACKAdd
BLAST
Repeati314 – 36350Kelch 1Add
BLAST
Repeati365 – 40743Kelch 2Add
BLAST
Repeati408 – 45447Kelch 3Add
BLAST
Repeati456 – 50247Kelch 4Add
BLAST
Repeati504 – 54441Kelch 5Add
BLAST
Repeati546 – 59247Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00840000129689.
HOGENOMiHOG000230817.
HOVERGENiHBG108068.
InParanoidiQ6TFL4.
KOiK10461.
OMAiEAMDCFL.
OrthoDBiEOG7HHWRM.
PhylomeDBiQ6TFL4.
TreeFamiTF351654.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030596. KLHL24.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF257. PTHR24412:SF257. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 5 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6TFL4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLILGRRLN REDLGVRDSP ATKRKVFEMD PKSLTGHEFF DFSSGSSHAE
60 70 80 90 100
NILQIFNEFR DSRLFTDVII CVEGKEFPCH RAVLSACSSY FRAMFCNDHR
110 120 130 140 150
ESREMLVEIN GILAEAMECF LQYVYTGKVK ITTENVQYLF ETSSLFQISV
160 170 180 190 200
LRDACAKFLE EQLDPCNCLG IQRFADTHSL KTLFTKCKNF ALQTFEDVSQ
210 220 230 240 250
HEEFLELDKD ELIDYICSDE LVIGKEEMVF EAVMRWVYRA VDLRRPLLHE
260 270 280 290 300
LLTHVRLPLL HPNYFVQTVE VDQLIQNSPE CYQLLHEARR YHILGNEMMS
310 320 330 340 350
PRTRPRRSTG YSEVIVVVGG CERVGGFNLP YTECYDPVTG EWKSLAKLPE
360 370 380 390 400
FTKSEYAVCA LRNDILVSGG RINSRDVWIY NSQLNIWIRV ASLNKGRWRH
410 420 430 440 450
KMAVLLGKVY VVGGYDGQNR LSSVECYDSF SNRWTEVAPL KEAVSSPAVT
460 470 480 490 500
SCVGKLFVIG GGPDDNTCSD KVQSYDPETN SWLLRAAIPI AKRCITAVSL
510 520 530 540 550
NNLIYVAGGL TKAIYCYDPV EDYWMHVQNT FSRQENCGMS VCNGKIYILG
560 570 580 590 600
GRRENGEATD TILCYDPATS IITGVAAMPR PVSYHGCVTI HRYNEKCFKL
Length:600
Mass (Da):68,361
Last modified:July 5, 2004 - v1
Checksum:i54538E2BF447A56B
GO
Isoform 2 (identifier: Q6TFL4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     535-537: ENC → VIT
     538-600: Missing.

Note: No experimental confirmation available.
Show »
Length:537
Mass (Da):61,453
Checksum:i710C21C9D54A1E4E
GO

Sequence cautioni

The sequence BAA90921.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB15447.1 differs from that shown.Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti489 – 4891P → R in BAA90921 (PubMed:14702039).Curated
Sequence conflicti515 – 5151Y → C in BAB15447 (PubMed:14702039).Curated
Sequence conflicti536 – 5361N → D in AAI42994 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei535 – 5373ENC → VIT in isoform 2. 1 PublicationVSP_028644
Alternative sequencei538 – 60063Missing in isoform 2. 1 PublicationVSP_028645Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY422472 mRNA. Translation: AAR13703.1.
DQ925701 mRNA. Translation: ABI96896.1.
AK000066 mRNA. Translation: BAA90921.1. Different initiation.
AK026326 mRNA. Translation: BAB15447.1. Sequence problems.
BX648466 mRNA. Translation: CAI46031.1.
BX648812 mRNA. Translation: CAI46002.1.
BC142993 mRNA. Translation: AAI42994.1.
CCDSiCCDS3246.1. [Q6TFL4-1]
RefSeqiNP_060114.2. NM_017644.3. [Q6TFL4-1]
XP_005247609.1. XM_005247552.1. [Q6TFL4-1]
XP_005247610.1. XM_005247553.1. [Q6TFL4-1]
XP_005247611.1. XM_005247554.1. [Q6TFL4-1]
XP_005247612.1. XM_005247555.1. [Q6TFL4-1]
XP_005247613.1. XM_005247556.1. [Q6TFL4-1]
XP_006713737.1. XM_006713674.1. [Q6TFL4-1]
XP_011511239.1. XM_011512937.1. [Q6TFL4-1]
XP_011511240.1. XM_011512938.1. [Q6TFL4-1]
UniGeneiHs.407709.

Genome annotation databases

EnsembliENST00000242810; ENSP00000242810; ENSG00000114796. [Q6TFL4-1]
ENST00000454652; ENSP00000395012; ENSG00000114796. [Q6TFL4-1]
ENST00000476808; ENSP00000419010; ENSG00000114796. [Q6TFL4-2]
GeneIDi54800.
KEGGihsa:54800.
UCSCiuc003flv.4. human. [Q6TFL4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY422472 mRNA. Translation: AAR13703.1.
DQ925701 mRNA. Translation: ABI96896.1.
AK000066 mRNA. Translation: BAA90921.1. Different initiation.
AK026326 mRNA. Translation: BAB15447.1. Sequence problems.
BX648466 mRNA. Translation: CAI46031.1.
BX648812 mRNA. Translation: CAI46002.1.
BC142993 mRNA. Translation: AAI42994.1.
CCDSiCCDS3246.1. [Q6TFL4-1]
RefSeqiNP_060114.2. NM_017644.3. [Q6TFL4-1]
XP_005247609.1. XM_005247552.1. [Q6TFL4-1]
XP_005247610.1. XM_005247553.1. [Q6TFL4-1]
XP_005247611.1. XM_005247554.1. [Q6TFL4-1]
XP_005247612.1. XM_005247555.1. [Q6TFL4-1]
XP_005247613.1. XM_005247556.1. [Q6TFL4-1]
XP_006713737.1. XM_006713674.1. [Q6TFL4-1]
XP_011511239.1. XM_011512937.1. [Q6TFL4-1]
XP_011511240.1. XM_011512938.1. [Q6TFL4-1]
UniGeneiHs.407709.

3D structure databases

ProteinModelPortaliQ6TFL4.
SMRiQ6TFL4. Positions 46-297, 300-592.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120159. 18 interactions.
IntActiQ6TFL4. 3 interactions.
STRINGi9606.ENSP00000242810.

PTM databases

iPTMnetiQ6TFL4.
PhosphoSiteiQ6TFL4.

Polymorphism and mutation databases

BioMutaiKLHL24.
DMDMi74722812.

Proteomic databases

EPDiQ6TFL4.
MaxQBiQ6TFL4.
PaxDbiQ6TFL4.
PRIDEiQ6TFL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242810; ENSP00000242810; ENSG00000114796. [Q6TFL4-1]
ENST00000454652; ENSP00000395012; ENSG00000114796. [Q6TFL4-1]
ENST00000476808; ENSP00000419010; ENSG00000114796. [Q6TFL4-2]
GeneIDi54800.
KEGGihsa:54800.
UCSCiuc003flv.4. human. [Q6TFL4-1]

Organism-specific databases

CTDi54800.
GeneCardsiKLHL24.
HGNCiHGNC:25947. KLHL24.
HPAiHPA056337.
MIMi611295. gene.
neXtProtiNX_Q6TFL4.
PharmGKBiPA142671576.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00840000129689.
HOGENOMiHOG000230817.
HOVERGENiHBG108068.
InParanoidiQ6TFL4.
KOiK10461.
OMAiEAMDCFL.
OrthoDBiEOG7HHWRM.
PhylomeDBiQ6TFL4.
TreeFamiTF351654.

Miscellaneous databases

ChiTaRSiKLHL24. human.
GenomeRNAii54800.
PROiQ6TFL4.
SOURCEiSearch...

Gene expression databases

BgeeiQ6TFL4.
CleanExiHS_KLHL24.
ExpressionAtlasiQ6TFL4. baseline and differential.
GenevisibleiQ6TFL4. HS.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030596. KLHL24.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF257. PTHR24412:SF257. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 5 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Huang C.Q., Wu S.L., Liu S.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Function analysis on a microRNA encoded by HSV-1."
    Zhang X.-M., Liu L.-D., Li Q.-H.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-573 (ISOFORM 2).
    Tissue: Colon.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon endothelium and Rectum tumor.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiKLH24_HUMAN
AccessioniPrimary (citable) accession number: Q6TFL4
Secondary accession number(s): A5PLN8, Q9H620, Q9NXT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.