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Q6TEQ7 (ANXA2_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Annexin A2
Alternative name(s):
Annexin-2
Gene names
Name:ANXA2
Synonyms:ANX2
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity By similarity.

Subunit structure

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with DYSF By similarity. Interacts with ATP1B1. Interacts with COCH By similarity. Ref.1

Subcellular location

Secretedextracellular spaceextracellular matrixbasement membrane. Note: In the lamina beneath the plasma membrane By similarity.

Domain

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Post-translational modification

ISGylated By similarity.

Miscellaneous

It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

Sequence similarities

Belongs to the annexin family.

Contains 4 annexin repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 339338Annexin A2
PRO_0000288684

Regions

Repeat42 – 10261Annexin 1
Repeat114 – 17461Annexin 2
Repeat199 – 25961Annexin 3
Repeat274 – 33461Annexin 4
Region2 – 2423S100A10-binding site Potential

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue241Phosphotyrosine; by SRC By similarity
Modified residue261Phosphoserine; by PKC By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6TEQ7 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 91BE3A08FF76260E

FASTA33938,654
        10         20         30         40         50         60 
MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG VDEVTIVNIL 

        70         80         90        100        110        120 
TNRSNEQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG 

       130        140        150        160        170        180 
LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA 

       190        200        210        220        230        240 
EDGSVIDYEL IDQDARDLYD AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM 

       250        260        270        280        290        300 
LESIKKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 

       310        320        330 
LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD 

« Hide

References

[1]"Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility."
Barwe S.P., Anilkumar G., Moon S.Y., Zheng Y., Whitelegge J.P., Rajasekaran S.A., Rajasekaran A.K.
Mol. Biol. Cell 16:1082-1094(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ATP1B1.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Red velvet - Issue 86 of September 2007

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY422991 mRNA. Translation: AAR00321.1.
RefSeqNP_001002961.1. NM_001002961.1.
UniGeneCfa.138.

3D structure databases

ProteinModelPortalQ6TEQ7.
SMRQ6TEQ7. Positions 21-339.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-44616N.
MINTMINT-3375172.
STRING9615.ENSCAFP00000024537.

Proteomic databases

PaxDbQ6TEQ7.
PRIDEQ6TEQ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000026423; ENSCAFP00000024537; ENSCAFG00000016686.
GeneID403435.
KEGGcfa:403435.

Organism-specific databases

CTD302.

Phylogenomic databases

eggNOGNOG259189.
GeneTreeENSGT00680000099735.
HOGENOMHOG000158803.
HOVERGENHBG061815.
InParanoidQ6TEQ7.
OMAFIQQDTK.
OrthoDBEOG4KD6MM.

Family and domain databases

Gene3D1.10.220.10. 4 hits.
InterProIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
PANTHERPTHR10502. PTHR10502. 1 hit.
PTHR10502:SF18. PTHR10502:SF18. 1 hit.
PfamPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTSM00335. ANX. 4 hits.
[Graphical view]
SUPFAMSSF47874. Annexin. 1 hit.
PROSITEPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816953.

Entry information

Entry nameANXA2_CANFA
AccessionPrimary (citable) accession number: Q6TEQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: May 29, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries