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Protein

Vitamin K epoxide reductase complex subunit 1

Gene

Vkorc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.4 Publications

Miscellaneous

The location of two cysteine active-site residues within a proposed transmembrane is consistent both with the known hydrophobic environment of the thiol redox site of the enzyme and with the lipophilicity of vitamin K and warfarin (coumadin).

Catalytic activityi

Phylloquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol.3 Publications

Enzyme regulationi

Inhibited by warfarin (coumadin).3 Publications

GO - Molecular functioni

GO - Biological processi

  • blood coagulation Source: UniProtKB
  • bone development Source: UniProtKB
  • drug metabolic process Source: RGD
  • peptidyl-glutamic acid carboxylation Source: UniProtKB
  • positive regulation of coagulation Source: RGD
  • regulation of blood coagulation Source: RGD
  • response to antibiotic Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organonitrogen compound Source: RGD
  • vitamin K metabolic process Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BRENDAi1.1.4.1 5301

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin K epoxide reductase complex subunit 1 (EC:1.17.4.43 Publications)
Alternative name(s):
Vitamin K1 2,3-epoxide reductase subunit 1
Gene namesi
Name:Vkorc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1303107 Vkorc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10LumenalSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 74CytoplasmicSequence analysisAdd BLAST43
Transmembranei75 – 94HelicalSequence analysisAdd BLAST20
Topological domaini95 – 100LumenalSequence analysis6
Transmembranei101 – 123HelicalSequence analysisAdd BLAST23
Topological domaini124 – 126CytoplasmicSequence analysis3
Transmembranei127 – 149HelicalSequence analysisAdd BLAST23
Topological domaini150 – 161LumenalBy similarityAdd BLAST12

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi132C → S: Loss of enzyme activity. 1 Publication1
Mutagenesisi135C → S: Loss of enzyme activity. 1 Publication1

Chemistry databases

GuidetoPHARMACOLOGYi2645

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916701 – 161Vitamin K epoxide reductase complex subunit 1Add BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi132 ↔ 135Redox-active

Keywords - PTMi

Disulfide bond, Quinone

Proteomic databases

PaxDbiQ6TEK4
PRIDEiQ6TEK4

Expressioni

Tissue specificityi

Highly expressed in liver. Detected at lower levels in lung, kidney and testis.1 Publication

Gene expression databases

BgeeiENSRNOG00000050828
ExpressionAtlasiQ6TEK4 baseline and differential
GenevisibleiQ6TEK4 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063977

Chemistry databases

BindingDBiQ6TEK4

Family & Domainsi

Domaini

The number of transmembrane domains and the membrane topology are controversial; supporting evidence is available both for models with three transmembrane domains and four transmembrane domains.By similarity

Sequence similaritiesi

Belongs to the VKOR family.Curated

Keywords - Domaini

Redox-active center, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0HT Eukaryota
ENOG4111UX7 LUCA
GeneTreeiENSGT00390000002103
HOGENOMiHOG000230752
HOVERGENiHBG076672
InParanoidiQ6TEK4
KOiK05357
OMAiQGKVKGH
OrthoDBiEOG091G0QTR
PhylomeDBiQ6TEK4
TreeFamiTF328467

Family and domain databases

Gene3Di1.20.1440.130, 1 hit
InterProiView protein in InterPro
IPR012932 VKOR
IPR038354 VKOR_sf
PfamiView protein in Pfam
PF07884 VKOR, 1 hit
SMARTiView protein in SMART
SM00756 VKc, 1 hit

Sequencei

Sequence statusi: Complete.

Q6TEK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTTWRSPGR LRLALCLAGL ALSLYALHVK AARARNEDYR ALCDVGTAIS
60 70 80 90 100
CSRVFSSRWG RGFGLVEHVL GADSILNQSN SIFGCMFYTI QLLLGCLRGR
110 120 130 140 150
WASILLILSS LVSVAGSLYL AWILFFVLYD FCIVCITTYA INAGLMLLSF
160
QKVPEHKVKK P
Length:161
Mass (Da):17,783
Last modified:July 5, 2004 - v1
Checksum:iBBCE9897B00807DD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti120L → Q Identified in warfarin-resistant animals; strongly reduces enzyme activity; abolishes inhibition by warfarin. 2 Publications1
Natural varianti128L → Q Identified in warfarin-resistant animals; moderately reduces enzyme activity; decreases inhibition by warfarin. 2 Publications1
Natural varianti139Y → C Identified in warfarin-resistant animals; strongly reduces enzyme activity; abolishes inhibition by warfarin. 2 Publications1
Natural varianti139Y → F Identified in warfarin-resistant animals; strongly reduces enzyme activity; abolishes inhibition by warfarin. 2 Publications1
Natural varianti139Y → S Identified in warfarin-resistant animals; strongly reduces enzyme activity; abolishes inhibition by warfarin. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY423047 mRNA Translation: AAR82917.1
RefSeqiNP_976080.1, NM_203335.2
UniGeneiRn.97942

Genome annotation databases

EnsembliENSRNOT00000073596; ENSRNOP00000063977; ENSRNOG00000050828
GeneIDi309004
KEGGirno:309004
UCSCiRGD:1303107 rat

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVKOR1_RAT
AccessioniPrimary (citable) accession number: Q6TEK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health