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Protein

Kelch-like protein 17

Gene

Klhl17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 17
Alternative name(s):
Actinfilin
Gene namesi
Name:Klhl17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2678948. Klhl17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640Kelch-like protein 17PRO_0000119120Add
BLAST

Proteomic databases

MaxQBiQ6TDP3.
PaxDbiQ6TDP3.
PRIDEiQ6TDP3.

PTM databases

PhosphoSiteiQ6TDP3.

Expressioni

Gene expression databases

BgeeiQ6TDP3.
CleanExiMM_KLHL17.
ExpressionAtlasiQ6TDP3. baseline and differential.
GenevisibleiQ6TDP3. MM.

Interactioni

Subunit structurei

Interacts with F-actin; the interaction disruptes the F-actin structures and leads to marked changes of neuronal morphology. Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts directly with PDZK1 (via PDZ1 domain); the interaction is important for integrity of actin cytoskeleton structures in neurons. Interacts with DLG4 and SYNGAP1. Interacts (via kelch repeats) with GRIK2 (via C-terminus); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway. Interacts with GRIK1. Interacts with (via BTB domain) CUL3; the interaction regulates surface GRIK2 expression (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231070. 2 interactions.
STRINGi10090.ENSMUSP00000101194.

Structurei

3D structure databases

ProteinModelPortaliQ6TDP3.
SMRiQ6TDP3. Positions 72-318, 340-621.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 15768BTBPROSITE-ProRule annotationAdd
BLAST
Domaini192 – 294103BACKAdd
BLAST
Repeati341 – 38747Kelch 1Add
BLAST
Repeati388 – 43447Kelch 2Add
BLAST
Repeati436 – 48146Kelch 3Add
BLAST
Repeati482 – 52847Kelch 4Add
BLAST
Repeati530 – 57546Kelch 5Add
BLAST
Repeati576 – 62247Kelch 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni287 – 639353Interaction with F-actinBy similarityAdd
BLAST
Regioni638 – 6403Interaction with PDZK1By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 5036Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118931.
HOGENOMiHOG000230814.
HOVERGENiHBG014286.
InParanoidiQ6TDP3.
KOiK10454.
OMAiLKSAHKY.
OrthoDBiEOG7ZWD17.
PhylomeDBiQ6TDP3.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030594. KLHL17.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF168. PTHR24412:SF168. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF50965. SSF50965. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6TDP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPRGERPAG RTQSPEHSSP GPGPEAPPPP QPPAPEAERA RPRQARPAAP
60 70 80 90 100
MEGAMQLLSR EGHSVAHNSK RHYHDAFVAM SRMRQRGLLC DIVLHVAAKE
110 120 130 140 150
IRAHKVVLAS CSPYFHAMFT NEMSESRQTH VTLHDIDPQA LDQLVQFAYT
160 170 180 190 200
AEIVVGEGNV QTLLPAASLL QLNGVRDACC KFLLSQLDPS NCLGIRGFAD
210 220 230 240 250
THSCSDLLKA AHRYVLQHFV DVAKTEEFML LPLKQVLELV SSDSLNVPSE
260 270 280 290 300
EDVYRAVLSW VKHDVDTRRQ HVPRLMKCVR LPLLSRDFLL GHVDAESLVR
310 320 330 340 350
HHPDCKDLLI EALKFHLLPE QRGVLGTSRT RPRRCEGAGP VLFAVGGGSL
360 370 380 390 400
FAIHGDCEAY DTRTDRWHVV ASMSTRRARV GVAAVGNRLY AVGGYDGTSD
410 420 430 440 450
LATVESYDPV TNTWQPEVSM GTRRSCLGVA ALHGLLYAAG GYDGASCLNS
460 470 480 490 500
AERYDPLTGT WTSIAAMSTR RRYVRVATLD GNLYAVGGYD SSSHLATVEK
510 520 530 540 550
YEPQVNSWTP VASMLSRRSS AGVAVLEGAL YVAGGNDGTS CLNSVERYST
560 570 580 590 600
KAGAWESVAP MNIRRSTHDL VAMDGWLYAV GGNDGSSSLN SIEKYNPRTN
610 620 630 640
KWVAASCMFT RRSSVGVAVL ELLNFPPPSS PTLSVSSTSL
Length:640
Mass (Da):69,732
Last modified:July 5, 2004 - v1
Checksum:i911D9F08883DA1BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY423764 mRNA. Translation: AAR03711.1.
CCDSiCCDS38999.1.
RefSeqiNP_938047.1. NM_198305.2.
UniGeneiMm.423038.

Genome annotation databases

EnsembliENSMUST00000105569; ENSMUSP00000101194; ENSMUSG00000078484.
GeneIDi231003.
KEGGimmu:231003.
UCSCiuc008wgs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY423764 mRNA. Translation: AAR03711.1.
CCDSiCCDS38999.1.
RefSeqiNP_938047.1. NM_198305.2.
UniGeneiMm.423038.

3D structure databases

ProteinModelPortaliQ6TDP3.
SMRiQ6TDP3. Positions 72-318, 340-621.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231070. 2 interactions.
STRINGi10090.ENSMUSP00000101194.

PTM databases

PhosphoSiteiQ6TDP3.

Proteomic databases

MaxQBiQ6TDP3.
PaxDbiQ6TDP3.
PRIDEiQ6TDP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105569; ENSMUSP00000101194; ENSMUSG00000078484.
GeneIDi231003.
KEGGimmu:231003.
UCSCiuc008wgs.2. mouse.

Organism-specific databases

CTDi339451.
MGIiMGI:2678948. Klhl17.

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118931.
HOGENOMiHOG000230814.
HOVERGENiHBG014286.
InParanoidiQ6TDP3.
KOiK10454.
OMAiLKSAHKY.
OrthoDBiEOG7ZWD17.
PhylomeDBiQ6TDP3.
TreeFamiTF329218.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi380354.
PROiQ6TDP3.
SOURCEiSearch...

Gene expression databases

BgeeiQ6TDP3.
CleanExiMM_KLHL17.
ExpressionAtlasiQ6TDP3. baseline and differential.
GenevisibleiQ6TDP3. MM.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030594. KLHL17.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF168. PTHR24412:SF168. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF50965. SSF50965. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Huang C.Q., Wu S.L., Shan Y.X.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Pancreas.

Entry informationi

Entry nameiKLH17_MOUSE
AccessioniPrimary (citable) accession number: Q6TDP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.