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Q6TCP8

- Q6TCP8_9HIV1

UniProt

Q6TCP8 - Q6TCP8_9HIV1

Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.UniRule annotationSAAS annotation
    The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.SAAS annotation

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
    3. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
    4. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral immunoevasionUniRule annotation, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein gp160UniRule annotation
    Gene namesi
    Name:envImported
    OrganismiHuman immunodeficiency virus 1Imported
    Taxonomic identifieri11676 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

    GO - Cellular componenti

    1. host cell endosome membrane Source: UniProtKB-SubCell
    2. host cell plasma membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. viral envelope Source: UniProtKB-KW
    5. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membraneSAAS annotation, Host endosomeSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationImported, Virion

    Pathology & Biotechi

    Keywords - Diseasei

    AIDSUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi149 – 1491N-linked (GlcNAc...)Imported
    Glycosylationi162 – 1621N-linked (GlcNAc...)Imported

    Keywords - PTMi

    Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3U2SX-ray1.80C/G125-244[»]
    4DQOX-ray2.44C125-244[»]
    ProteinModelPortaliQ6TCP8.
    SMRiQ6TCP8. Positions 82-470, 490-568, 606-639.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di2.170.40.20. 2 hits.
    InterProiIPR000777. HIV1_GP160.
    IPR000328. Retroviral_envelope_protein.
    [Graphical view]
    PfamiPF00516. GP120. 2 hits.
    PF00517. GP41. 1 hit.
    [Graphical view]
    SUPFAMiSSF56502. SSF56502. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q6TCP8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVKGILRNC QQWWIWGILG FWMLMICNVV GNLWVTVYYG VPVWKEAKTT    50
    LFCASDAKSY EREVHNVWAT HACVPTDPDP QELVMANVTE NFNMWKNDMV 100
    DQMHEDIISL WDQSLKPCVK LTPLCVTLNC TSPAAHNESE TRVKHCSFNI 150
    TTDVKDRKQK VNATFYDLDI VPLSSSDNSS NSSLYRLISC NTSTITQACP 200
    KVSFDPIPIH YCAPAGYAIL KCNNKTFSGK GPCSNVSTVQ CTHGIRPVVS 250
    TQLLLNGSLA EEEIVIRSEN LTDNAKTIIV HLNKSVEIEC IRPGNNTRKS 300
    IRLGPGQTFY ATGDVIGDIR KAYCKINGSE WNETLTKVSE KLKEYFNKTI 350
    RFAQHSGGDL EVTTHSFNCR GEFFYCNTSE LFNSNATESN ITLPCRIKQI 400
    INMWQGVGRA MYAPPIRGEI KCTSNITGLL LTRDGGNNNN STEEIFRPEG 450
    GNMRDNWRSE LYKYKVVEIK PLGIAPTEAK RRVVQREKRA VGIGAVFLGF 500
    LGAAGSTMGA ASITLTVQAR QLLSGIVQQQ SNLLRAIEAQ QHLLQLTVWG 550
    IKQLQARVLA IERYLQDQQL LGIWGCSGKL ICTTAVPWNS SWSNKSKEEI 600
    WGNMTWMQWD KEVSNYTFTI YQLLEESQYQ QEQNEKELLA LNKWNDLWSW 650
    FNITNWLWYI KIFIMIVGGL IGLRIIFAVL SIVNRVRQGY SPLSFQTLTP 700
    NPGGPDRLGR IEGEGGEQDK NRSIRLVNGF LALIWDDLWS LCRFSYHLLR 750
    DFILIVARAV ELLGRSSLKG LQRGWEALKY LGNLMQYWGL ELKRSAINLL 800
    DTTAVAVAEG TDRIIELAQG IYRAICNIPR RIRQGFEAAL Q 841
    Length:841
    Mass (Da):95,156
    Last modified:November 22, 2005 - v2
    Checksum:i1175F660B06DD6D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY424138 Genomic DNA. Translation: AAR09542.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY424138 Genomic DNA. Translation: AAR09542.2 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3U2S X-ray 1.80 C/G 125-244 [» ]
    4DQO X-ray 2.44 C 125-244 [» ]
    ProteinModelPortali Q6TCP8.
    SMRi Q6TCP8. Positions 82-470, 490-568, 606-639.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.170.40.20. 2 hits.
    InterProi IPR000777. HIV1_GP160.
    IPR000328. Retroviral_envelope_protein.
    [Graphical view ]
    Pfami PF00516. GP120. 2 hits.
    PF00517. GP41. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56502. SSF56502. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ZM109F.PB4Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ZM109F.PB4Imported.
    3. Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 125-244, GLYCOSYLATION AT ASN-149.
    4. "Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16."
      Pancera M., Shahzad-Ul-Hussan S., Doria-Rose N.A., McLellan J.S., Bailer R.T., Dai K., Loesgen S., Louder M.K., Staupe R.P., Yang Y., Zhang B., Parks R., Eudailey J., Lloyd K.E., Blinn J., Alam S.M., Haynes B.F., Amin M.N.
      , Wang L.X., Burton D.R., Koff W.C., Nabel G.J., Mascola J.R., Bewley C.A., Kwong P.D.
      Nat. Struct. Mol. Biol. 20:804-813(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS) OF 125-244, GLYCOSYLATION AT ASN-149 AND ASN-162.

    Entry informationi

    Entry nameiQ6TCP8_9HIV1
    AccessioniPrimary (citable) accession number: Q6TCP8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3