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Q6TCP8

- Q6TCP8_9HIV1

UniProt

Q6TCP8 - Q6TCP8_9HIV1

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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.UniRule annotationSAAS annotation
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.SAAS annotation

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
  3. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral immunoevasionUniRule annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

GO - Cellular componenti

  1. host cell endosome membrane Source: UniProtKB-SubCell
  2. host cell plasma membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host endosomeSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

PTM / Processingi

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3U2SX-ray1.80C/G125-244[»]
4DQOX-ray2.44C125-244[»]
ProteinModelPortaliQ6TCP8.
SMRiQ6TCP8. Positions 82-470, 490-568, 606-639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

Q6TCP8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVKGILRNC QQWWIWGILG FWMLMICNVV GNLWVTVYYG VPVWKEAKTT
60 70 80 90 100
LFCASDAKSY EREVHNVWAT HACVPTDPDP QELVMANVTE NFNMWKNDMV
110 120 130 140 150
DQMHEDIISL WDQSLKPCVK LTPLCVTLNC TSPAAHNESE TRVKHCSFNI
160 170 180 190 200
TTDVKDRKQK VNATFYDLDI VPLSSSDNSS NSSLYRLISC NTSTITQACP
210 220 230 240 250
KVSFDPIPIH YCAPAGYAIL KCNNKTFSGK GPCSNVSTVQ CTHGIRPVVS
260 270 280 290 300
TQLLLNGSLA EEEIVIRSEN LTDNAKTIIV HLNKSVEIEC IRPGNNTRKS
310 320 330 340 350
IRLGPGQTFY ATGDVIGDIR KAYCKINGSE WNETLTKVSE KLKEYFNKTI
360 370 380 390 400
RFAQHSGGDL EVTTHSFNCR GEFFYCNTSE LFNSNATESN ITLPCRIKQI
410 420 430 440 450
INMWQGVGRA MYAPPIRGEI KCTSNITGLL LTRDGGNNNN STEEIFRPEG
460 470 480 490 500
GNMRDNWRSE LYKYKVVEIK PLGIAPTEAK RRVVQREKRA VGIGAVFLGF
510 520 530 540 550
LGAAGSTMGA ASITLTVQAR QLLSGIVQQQ SNLLRAIEAQ QHLLQLTVWG
560 570 580 590 600
IKQLQARVLA IERYLQDQQL LGIWGCSGKL ICTTAVPWNS SWSNKSKEEI
610 620 630 640 650
WGNMTWMQWD KEVSNYTFTI YQLLEESQYQ QEQNEKELLA LNKWNDLWSW
660 670 680 690 700
FNITNWLWYI KIFIMIVGGL IGLRIIFAVL SIVNRVRQGY SPLSFQTLTP
710 720 730 740 750
NPGGPDRLGR IEGEGGEQDK NRSIRLVNGF LALIWDDLWS LCRFSYHLLR
760 770 780 790 800
DFILIVARAV ELLGRSSLKG LQRGWEALKY LGNLMQYWGL ELKRSAINLL
810 820 830 840
DTTAVAVAEG TDRIIELAQG IYRAICNIPR RIRQGFEAAL Q
Length:841
Mass (Da):95,156
Last modified:November 22, 2005 - v2
Checksum:i1175F660B06DD6D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424138 Genomic DNA. Translation: AAR09542.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424138 Genomic DNA. Translation: AAR09542.2 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3U2S X-ray 1.80 C/G 125-244 [» ]
4DQO X-ray 2.44 C 125-244 [» ]
ProteinModelPortali Q6TCP8.
SMRi Q6TCP8. Positions 82-470, 490-568, 606-639.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.170.40.20. 2 hits.
InterProi IPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view ]
Pfami PF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
[Graphical view ]
SUPFAMi SSF56502. SSF56502. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ZM109F.PB4Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ZM109F.PB4Imported.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 125-244, ACTIVE SITE, GLYCOSYLATION AT ASN-149.
  4. "Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16."
    Pancera M., Shahzad-Ul-Hussan S., Doria-Rose N.A., McLellan J.S., Bailer R.T., Dai K., Loesgen S., Louder M.K., Staupe R.P., Yang Y., Zhang B., Parks R., Eudailey J., Lloyd K.E., Blinn J., Alam S.M., Haynes B.F., Amin M.N.
    , Wang L.X., Burton D.R., Koff W.C., Nabel G.J., Mascola J.R., Bewley C.A., Kwong P.D.
    Nat. Struct. Mol. Biol. 20:804-813(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS) OF 125-244, ACTIVE SITE, GLYCOSYLATION AT ASN-149 AND ASN-162.

Entry informationi

Entry nameiQ6TCP8_9HIV1
AccessioniPrimary (citable) accession number: Q6TCP8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: November 22, 2005
Last modified: November 26, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3