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Q6TCP8

- Q6TCP8_9HIV1

UniProt

Q6TCP8 - Q6TCP8_9HIV1

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Protein
Envelope glycoprotein gp160
Gene
env
Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface By similarity.UniRule annotationSAAS annotations
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves By similarity.SAAS annotations

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
  3. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ApoptosisSAAS annotations, Fusion of virus membrane with host membraneSAAS annotations, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotations, Viral immunoevasionUniRule annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

  1. host cell endosome membrane Source: UniProtKB-SubCell
  2. host cell plasma membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotations, Host endosomeSAAS annotations, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationsImported, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi149 – 1491N-linked (GlcNAc...)Imported
Glycosylationi162 – 1621N-linked (GlcNAc...)Imported

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotations

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3U2SX-ray1.80C/G125-244[»]
4DQOX-ray2.44C125-244[»]
ProteinModelPortaliQ6TCP8.
SMRiQ6TCP8. Positions 82-470, 490-568, 606-639.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

Q6TCP8-1 [UniParc]FASTAAdd to Basket

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MRVKGILRNC QQWWIWGILG FWMLMICNVV GNLWVTVYYG VPVWKEAKTT    50
LFCASDAKSY EREVHNVWAT HACVPTDPDP QELVMANVTE NFNMWKNDMV 100
DQMHEDIISL WDQSLKPCVK LTPLCVTLNC TSPAAHNESE TRVKHCSFNI 150
TTDVKDRKQK VNATFYDLDI VPLSSSDNSS NSSLYRLISC NTSTITQACP 200
KVSFDPIPIH YCAPAGYAIL KCNNKTFSGK GPCSNVSTVQ CTHGIRPVVS 250
TQLLLNGSLA EEEIVIRSEN LTDNAKTIIV HLNKSVEIEC IRPGNNTRKS 300
IRLGPGQTFY ATGDVIGDIR KAYCKINGSE WNETLTKVSE KLKEYFNKTI 350
RFAQHSGGDL EVTTHSFNCR GEFFYCNTSE LFNSNATESN ITLPCRIKQI 400
INMWQGVGRA MYAPPIRGEI KCTSNITGLL LTRDGGNNNN STEEIFRPEG 450
GNMRDNWRSE LYKYKVVEIK PLGIAPTEAK RRVVQREKRA VGIGAVFLGF 500
LGAAGSTMGA ASITLTVQAR QLLSGIVQQQ SNLLRAIEAQ QHLLQLTVWG 550
IKQLQARVLA IERYLQDQQL LGIWGCSGKL ICTTAVPWNS SWSNKSKEEI 600
WGNMTWMQWD KEVSNYTFTI YQLLEESQYQ QEQNEKELLA LNKWNDLWSW 650
FNITNWLWYI KIFIMIVGGL IGLRIIFAVL SIVNRVRQGY SPLSFQTLTP 700
NPGGPDRLGR IEGEGGEQDK NRSIRLVNGF LALIWDDLWS LCRFSYHLLR 750
DFILIVARAV ELLGRSSLKG LQRGWEALKY LGNLMQYWGL ELKRSAINLL 800
DTTAVAVAEG TDRIIELAQG IYRAICNIPR RIRQGFEAAL Q 841
Length:841
Mass (Da):95,156
Last modified:November 22, 2005 - v2
Checksum:i1175F660B06DD6D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY424138 Genomic DNA. Translation: AAR09542.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY424138 Genomic DNA. Translation: AAR09542.2 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3U2S X-ray 1.80 C/G 125-244 [» ]
4DQO X-ray 2.44 C 125-244 [» ]
ProteinModelPortali Q6TCP8.
SMRi Q6TCP8. Positions 82-470, 490-568, 606-639.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.170.40.20. 2 hits.
InterProi IPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view ]
Pfami PF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
[Graphical view ]
SUPFAMi SSF56502. SSF56502. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ZM109F.PB4Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ZM109F.PB4Imported.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 125-244, GLYCOSYLATION AT ASN-149.
  4. "Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16."
    Pancera M., Shahzad-Ul-Hussan S., Doria-Rose N.A., McLellan J.S., Bailer R.T., Dai K., Loesgen S., Louder M.K., Staupe R.P., Yang Y., Zhang B., Parks R., Eudailey J., Lloyd K.E., Blinn J., Alam S.M., Haynes B.F., Amin M.N.
    , Wang L.X., Burton D.R., Koff W.C., Nabel G.J., Mascola J.R., Bewley C.A., Kwong P.D.
    Nat. Struct. Mol. Biol. 20:804-813(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS) OF 125-244, GLYCOSYLATION AT ASN-149 AND ASN-162.

Entry informationi

Entry nameiQ6TCP8_9HIV1
AccessioniPrimary (citable) accession number: Q6TCP8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: November 22, 2005
Last modified: March 19, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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