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Q6TCP8 (Q6TCP8_9HIV1) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Envelope glycoprotein gp160 RuleBase RU004292
Gene names
Name:env EMBL AAR09542.2
OrganismHuman immunodeficiency virus 1 EMBL AAR09542.2
Taxonomic identifier11676 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length841 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface By similarity. RuleBase RU004292 SAAS SAAS000328

The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves By similarity. SAAS SAAS000328

Subcellular location

Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein By similarity SAAS SAAS000328.

Ontologies

Keywords
   Biological processApoptosis SAAS SAAS000328
Fusion of virus membrane with host membrane SAAS SAAS000328
Host-virus interaction
Viral attachment to host cell RuleBase RU004292 SAAS SAAS000328
Viral immunoevasion RuleBase RU004292
Viral penetration into host cytoplasm
Virus entry into host cell
   Cellular componentHost cell membrane SAAS SAAS000328
Host endosome SAAS SAAS000328
Host membrane
Membrane
Viral envelope protein RuleBase RU003294 SAAS SAAS000328 EMBL AAR09542.2
Virion
   DiseaseAIDS RuleBase RU003294
   DomainTransmembrane
Transmembrane helix SAAS SAAS000328
   PTMCleavage on pair of basic residues RuleBase RU004292
Disulfide bond SAAS SAAS000328
   Technical term3D-structure PDB 4DQO PDB 3U2S
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

evasion or tolerance by virus of host immune response

Inferred from electronic annotation. Source: UniProtKB-KW

membrane fusion involved in viral entry into host cell

Inferred from electronic annotation. Source: UniProtKB-KW

virion attachment to host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

host cell plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

viral envelope

Inferred from electronic annotation. Source: UniProtKB-KW

virion membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Glycosylation1491N-linked (GlcNAc...) PDB 4DQO PDB 3U2S
Glycosylation1621N-linked (GlcNAc...) PDB 4DQO

Sequences

Sequence LengthMass (Da)Tools
Q6TCP8 [UniParc].

Last modified November 22, 2005. Version 2.
Checksum: 1175F660B06DD6D8

FASTA84195,156
        10         20         30         40         50         60 
MRVKGILRNC QQWWIWGILG FWMLMICNVV GNLWVTVYYG VPVWKEAKTT LFCASDAKSY 

        70         80         90        100        110        120 
EREVHNVWAT HACVPTDPDP QELVMANVTE NFNMWKNDMV DQMHEDIISL WDQSLKPCVK 

       130        140        150        160        170        180 
LTPLCVTLNC TSPAAHNESE TRVKHCSFNI TTDVKDRKQK VNATFYDLDI VPLSSSDNSS 

       190        200        210        220        230        240 
NSSLYRLISC NTSTITQACP KVSFDPIPIH YCAPAGYAIL KCNNKTFSGK GPCSNVSTVQ 

       250        260        270        280        290        300 
CTHGIRPVVS TQLLLNGSLA EEEIVIRSEN LTDNAKTIIV HLNKSVEIEC IRPGNNTRKS 

       310        320        330        340        350        360 
IRLGPGQTFY ATGDVIGDIR KAYCKINGSE WNETLTKVSE KLKEYFNKTI RFAQHSGGDL 

       370        380        390        400        410        420 
EVTTHSFNCR GEFFYCNTSE LFNSNATESN ITLPCRIKQI INMWQGVGRA MYAPPIRGEI 

       430        440        450        460        470        480 
KCTSNITGLL LTRDGGNNNN STEEIFRPEG GNMRDNWRSE LYKYKVVEIK PLGIAPTEAK 

       490        500        510        520        530        540 
RRVVQREKRA VGIGAVFLGF LGAAGSTMGA ASITLTVQAR QLLSGIVQQQ SNLLRAIEAQ 

       550        560        570        580        590        600 
QHLLQLTVWG IKQLQARVLA IERYLQDQQL LGIWGCSGKL ICTTAVPWNS SWSNKSKEEI 

       610        620        630        640        650        660 
WGNMTWMQWD KEVSNYTFTI YQLLEESQYQ QEQNEKELLA LNKWNDLWSW FNITNWLWYI 

       670        680        690        700        710        720 
KIFIMIVGGL IGLRIIFAVL SIVNRVRQGY SPLSFQTLTP NPGGPDRLGR IEGEGGEQDK 

       730        740        750        760        770        780 
NRSIRLVNGF LALIWDDLWS LCRFSYHLLR DFILIVARAV ELLGRSSLKG LQRGWEALKY 

       790        800        810        820        830        840 
LGNLMQYWGL ELKRSAINLL DTTAVAVAEG TDRIIELAQG IYRAICNIPR RIRQGFEAAL 


Q 

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References

[1]"Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission."
Derdeyn C.A., Decker J.M., Bibollet-Ruche F., Mokili J.L., Muldoon M., Denham S.A., Heil M.L., Kasolo F., Musonda R., Hahn B.H., Shaw G.M., Korber B.T., Allen S., Hunter E.
Science 303:2019-2022(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ZM109F.PB4 EMBL AAR09542.2.
[2]Derdeyn C.A., Decker J.M., Bibollet-Ruche F., Mokili J.L., Muldow M., Denham S.A., Heil M.L., Lee J.Y., Kasolo F., Musonda R.H., Hahn B.H., Shaw G.M., Korber B.K., Allen S., Hunter E.
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ZM109F.PB4 EMBL AAR09542.2.
[3]"Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9."
McLellan J.S., Pancera M., Carrico C., Gorman J., Julien J.P., Khayat R., Louder R., Pejchal R., Sastry M., Dai K., O'Dell S., Patel N., Shahzad-ul-Hussan S., Yang Y., Zhang B., Zhou T., Zhu J., Boyington J.C. expand/collapse author list , Chuang G.Y., Diwanji D., Georgiev I., Kwon Y.D., Lee D., Louder M.K., Moquin S., Schmidt S.D., Yang Z.Y., Bonsignori M., Crump J.A., Kapiga S.H., Sam N.E., Haynes B.F., Burton D.R., Koff W.C., Walker L.M., Phogat S., Wyatt R., Orwenyo J., Wang L.X., Arthos J., Bewley C.A., Mascola J.R., Nabel G.J., Schief W.R., Ward A.B., Wilson I.A., Kwong P.D.
Nature 480:336-343(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 125-244, GLYCOSYLATION AT ASN-149.
[4]"Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16."
Pancera M., Shahzad-Ul-Hussan S., Doria-Rose N.A., McLellan J.S., Bailer R.T., Dai K., Loesgen S., Louder M.K., Staupe R.P., Yang Y., Zhang B., Parks R., Eudailey J., Lloyd K.E., Blinn J., Alam S.M., Haynes B.F., Amin M.N. expand/collapse author list , Wang L.X., Burton D.R., Koff W.C., Nabel G.J., Mascola J.R., Bewley C.A., Kwong P.D.
Nat. Struct. Mol. Biol. 20:804-813(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS) OF 125-244, GLYCOSYLATION AT ASN-149 AND ASN-162.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY424138 Genomic DNA. Translation: AAR09542.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3U2SX-ray1.80C/G125-244[»]
4DQOX-ray2.44C125-244[»]
ProteinModelPortalQ6TCP8.
SMRQ6TCP8. Positions 82-470, 490-568, 606-639.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.170.40.20. 2 hits.
InterProIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamPF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMSSF56502. SSF56502. 2 hits.
ProtoNetSearch...

Entry information

Entry nameQ6TCP8_9HIV1
AccessionPrimary (citable) accession number: Q6TCP8
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: November 22, 2005
Last modified: March 19, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)