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Protein
Submitted name:

Mitochondrial NADP(+)-dependent malic enzyme 3

Gene

ME3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Divalent metal cations. Prefers magnesium or manganese.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Proton donorUniRule annotation1
Active sitei146Proton acceptorUniRule annotation1
Metal bindingi218Divalent metal cationUniRule annotation1
Metal bindingi219Divalent metal cationUniRule annotation1
Metal bindingi242Divalent metal cationUniRule annotation1

GO - Molecular functioni

Keywordsi

LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Mitochondrial NADP(+)-dependent malic enzyme 3Imported
Submitted name:
NADP-dependent malic enzyme, mitochondrialImported
Gene namesi
Name:ME3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000151376.16.
HGNCiHGNC:6985. ME3.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151376.
PharmGKBiPA30725.

PTM / Processingi

Proteomic databases

MaxQBiQ6TCH8.

PTM databases

iPTMnetiQ6TCH8.

Expressioni

Gene expression databases

BgeeiENSG00000151376.
ExpressionAtlasiQ6TCH8. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 233malicInterPro annotationAdd BLAST182

Phylogenomic databases

eggNOGiKOG1257. Eukaryota.
COG0281. LUCA.
GeneTreeiENSGT00390000000754.
HOGENOMiHOG000042486.
HOVERGENiHBG063300.
KOiK00029.

Family and domain databases

Gene3Di3.40.50.10380. 1 hit.
InterProiView protein in InterPro
IPR012301. Malic_N_dom.
IPR037062. Malic_N_dom_sf.
IPR001891. Malic_OxRdtase.
PfamiView protein in Pfam
PF00390. malic. 1 hit.
PIRSFiPIRSF000106. ME. 1 hit.
PRINTSiPR00072. MALOXRDTASE.
SMARTiView protein in SMART
SM01274. malic. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6TCH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTLEERLQ LGIHGLIPPC FLSQDVQLLR IMRYYERQQS DLDKYIILMT
60 70 80 90 100
LQDRNEKLFY RVLTSDVEKF MPIVYTPTVG LACQHYGLTF RRPRGLFITI
110 120 130 140 150
HDKGHLATML NSWPEDNIKA VVVTDGERIL GLGDLGCYGM GIPVGKLALY
160 170 180 190 200
TACGGVNPQQ CLPVLLDVGT NNEELLRDPL YIGLKHQRVH GKAYDDLLDE
210 220 230 240 250
FMQAVTDKFG INCLIQFEDF ANANAFRLLN KYRNKYCMFN DDIQDDFSRG

PKRSQLFFK
Length:259
Mass (Da):29,787
Last modified:July 5, 2004 - v1
Checksum:iFFFF9505A9CCC506
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001148 Genomic DNA. No translation available.
AP001831 Genomic DNA. No translation available.
AP002492 Genomic DNA. No translation available.
AY424278 mRNA. Translation: AAR04784.1.
RefSeqiNP_001014811.1. NM_001014811.1.
NP_006671.2. NM_006680.2.
UniGeneiHs.199743.

Genome annotation databases

EnsembliENST00000323418; ENSP00000315255; ENSG00000151376.
GeneIDi10873.
KEGGihsa:10873.
UCSCiuc058ggt.1. human.

Similar proteinsi

Entry informationi

Entry nameiQ6TCH8_HUMAN
AccessioniPrimary (citable) accession number: Q6TCH8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported