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Protein
Submitted name:

Mitochondrial NADP(+)-dependent malic enzyme 3

Gene

ME3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Divalent metal cations. Prefers magnesium or manganese.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Proton donorUniRule annotation
Active sitei146 – 1461Proton acceptorUniRule annotation
Metal bindingi218 – 2181Divalent metal cationUniRule annotation
Metal bindingi219 – 2191Divalent metal cationUniRule annotation
Metal bindingi242 – 2421Divalent metal cationUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Mitochondrial NADP(+)-dependent malic enzyme 3Imported
Submitted name:
NADP-dependent malic enzyme, mitochondrialImported
Gene namesi
Name:ME3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:6985. ME3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30725.

PTM / Processingi

Proteomic databases

PeptideAtlasiQ6TCH8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352657.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 233182malicInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1257. Eukaryota.
COG0281. LUCA.
GeneTreeiENSGT00390000000754.
HOGENOMiHOG000042486.
HOVERGENiHBG063300.
KOiK00029.

Family and domain databases

Gene3Di3.40.50.10380. 1 hit.
InterProiIPR012301. Malic_N_dom.
IPR001891. Malic_OxRdtase.
[Graphical view]
PfamiPF00390. malic. 1 hit.
[Graphical view]
PIRSFiPIRSF000106. ME. 1 hit.
PRINTSiPR00072. MALOXRDTASE.
SMARTiSM01274. malic. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6TCH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTLEERLQ LGIHGLIPPC FLSQDVQLLR IMRYYERQQS DLDKYIILMT
60 70 80 90 100
LQDRNEKLFY RVLTSDVEKF MPIVYTPTVG LACQHYGLTF RRPRGLFITI
110 120 130 140 150
HDKGHLATML NSWPEDNIKA VVVTDGERIL GLGDLGCYGM GIPVGKLALY
160 170 180 190 200
TACGGVNPQQ CLPVLLDVGT NNEELLRDPL YIGLKHQRVH GKAYDDLLDE
210 220 230 240 250
FMQAVTDKFG INCLIQFEDF ANANAFRLLN KYRNKYCMFN DDIQDDFSRG

PKRSQLFFK
Length:259
Mass (Da):29,787
Last modified:July 5, 2004 - v1
Checksum:iFFFF9505A9CCC506
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001148 Genomic DNA. No translation available.
AP001831 Genomic DNA. No translation available.
AP002492 Genomic DNA. No translation available.
AY424278 mRNA. Translation: AAR04784.1.
RefSeqiNP_001014811.1. NM_001014811.1.
NP_006671.2. NM_006680.2.
UniGeneiHs.199743.

Genome annotation databases

EnsembliENST00000323418; ENSP00000315255; ENSG00000151376.
GeneIDi10873.
KEGGihsa:10873.
UCSCiuc058ggt.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001148 Genomic DNA. No translation available.
AP001831 Genomic DNA. No translation available.
AP002492 Genomic DNA. No translation available.
AY424278 mRNA. Translation: AAR04784.1.
RefSeqiNP_001014811.1. NM_001014811.1.
NP_006671.2. NM_006680.2.
UniGeneiHs.199743.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000352657.

Proteomic databases

PeptideAtlasiQ6TCH8.

Protocols and materials databases

DNASUi10873.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323418; ENSP00000315255; ENSG00000151376.
GeneIDi10873.
KEGGihsa:10873.
UCSCiuc058ggt.1. human.

Organism-specific databases

CTDi10873.
HGNCiHGNC:6985. ME3.
PharmGKBiPA30725.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1257. Eukaryota.
COG0281. LUCA.
GeneTreeiENSGT00390000000754.
HOGENOMiHOG000042486.
HOVERGENiHBG063300.
KOiK00029.

Miscellaneous databases

ChiTaRSiME3. human.
GenomeRNAii10873.

Family and domain databases

Gene3Di3.40.50.10380. 1 hit.
InterProiIPR012301. Malic_N_dom.
IPR001891. Malic_OxRdtase.
[Graphical view]
PfamiPF00390. malic. 1 hit.
[Graphical view]
PIRSFiPIRSF000106. ME. 1 hit.
PRINTSiPR00072. MALOXRDTASE.
SMARTiSM01274. malic. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Zhou G., Zhong G., Zheng G., Li H., Ke R., Shen C., Lin L., Yang S.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ6TCH8_HUMAN
AccessioniPrimary (citable) accession number: Q6TCH8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.