Q6TCH7 (PAQR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Progestin and adipoQ receptor family member 3

Alternative name(s):
Progestin and adipoQ receptor family member III
Raf kinase trapping to Golgi
Short name=RKTG

Gene names

Name:

PAQR3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi. Ref.4
Subcellular location	Golgi apparatus membrane; Multi-pass membrane protein Ref.4.
Tissue specificity	Widely expressed in a range of tissues. Ref.1
Sequence similarities	Belongs to the ADIPOR family.
Sequence caution	The sequence BAG51571.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6TCH7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6TCH7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     265-311: GQLNYLGSSHQIWHILAVVMLYWWHQSTVYVMQYRHSKPCPDYVSHL → ENIFRWEITKRTLGGVNNSLQNLYLLV

Note: No experimental confirmation available.

Isoform 3 (identifier: Q6TCH7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     265-311: GQLNYLGSSHQIWHILAVVMLYWWHQSTVYVMQYRHSKPCPDYVSHL → ESLPR

Note: No experimental confirmation available.

Isoform 4 (identifier: Q6TCH7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     62-88: SLFILSNETVNIWSHLLGFFLFFTLGI → RSVCFALWAIIFFPAIGQKKHVEDGWH
     89-311: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Progestin and adipoQ receptor family member 3		PRO_0000218846
Regions
	Topological domain	1 – 73	73	Cytoplasmic Potential
	Transmembrane	74 – 96	23	Helical; Potential
	Topological domain	97 – 105	9	Lumenal Potential
	Transmembrane	106 – 128	23	Helical; Potential
	Topological domain	129 – 140	12	Cytoplasmic Potential
	Transmembrane	141 – 163	23	Helical; Potential
	Topological domain	164 – 172	9	Lumenal Potential
	Transmembrane	173 – 195	23	Helical; Potential
	Topological domain	196 – 201	6	Cytoplasmic Potential
	Transmembrane	202 – 224	23	Helical; Potential
	Topological domain	225 – 238	14	Lumenal Potential
	Transmembrane	239 – 256	18	Helical; Potential
	Topological domain	257 – 275	19	Cytoplasmic Potential
	Transmembrane	276 – 298	23	Helical; Potential
	Topological domain	299 – 311	13	Lumenal Potential
	Region	61 – 71	11	Golgi targeting
	Region	299 – 303	5	Golgi targeting
Natural variations
	Alternative sequence	62 – 88	27	SLFIL…FTLGI → RSVCFALWAIIFFPAIGQKK HVEDGWH in isoform 4.		VSP_011477
	Alternative sequence	89 – 311	223	Missing in isoform 4.		VSP_011478
	Alternative sequence	265 – 311	47	GQLNY…YVSHL → ENIFRWEITKRTLGGVNNSL QNLYLLV in isoform 2.		VSP_011479
	Alternative sequence	265 – 311	47	GQLNY…YVSHL → ESLPR in isoform 3.		VSP_011480
Experimental info
	Sequence conflict	30	1	L → Q in BAF83921. Ref.2
	Sequence conflict	258	1	V → A in AAR08369. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 31, 2004. Version 2. Checksum: 8C629920D0F8D785	FASTA	311	36,217
	10 20 30 40 50 60 MHQKLLKSAH YIELGSYQYW PVLVPRGIRL YTYEQIPGSL KDNPYITDGY RAYLPSRLCI 70 80 90 100 110 120 KSLFILSNET VNIWSHLLGF FLFFTLGIYD MTSVLPSASA SREDFVICSI CLFCFQVCML 130 140 150 160 170 180 CSVGYHLFSC HRSEKTCRRW MALDYAGISI GILGCYVSGV FYAFYCNNYW RQVYLITVLA 190 200 210 220 230 240 MILAVFFAQI HPNYLTQQWQ RLRSIIFCSV SGYGVIPTLH WVWLNGGIGA PIVQDFAPRV 250 260 270 280 290 300 IVMYMIALLA FLFYISKVPE RYFPGQLNYL GSSHQIWHIL AVVMLYWWHQ STVYVMQYRH 310 SKPCPDYVSH L
	Isoform 2 [UniParc]. Checksum: A11C6CD458D86096	FASTA	291	33,735
	10 20 30 40 50 60 MHQKLLKSAH YIELGSYQYW PVLVPRGIRL YTYEQIPGSL KDNPYITDGY RAYLPSRLCI 70 80 90 100 110 120 KSLFILSNET VNIWSHLLGF FLFFTLGIYD MTSVLPSASA SREDFVICSI CLFCFQVCML 130 140 150 160 170 180 CSVGYHLFSC HRSEKTCRRW MALDYAGISI GILGCYVSGV FYAFYCNNYW RQVYLITVLA 190 200 210 220 230 240 MILAVFFAQI HPNYLTQQWQ RLRSIIFCSV SGYGVIPTLH WVWLNGGIGA PIVQDFAPRV 250 260 270 280 290 IVMYMIALLA FLFYISKVPE RYFPENIFRW EITKRTLGGV NNSLQNLYLL V
	Isoform 3 [UniParc]. Checksum: 55B9A69DBEED4F92	FASTA	269	31,144
	10 20 30 40 50 60 MHQKLLKSAH YIELGSYQYW PVLVPRGIRL YTYEQIPGSL KDNPYITDGY RAYLPSRLCI 70 80 90 100 110 120 KSLFILSNET VNIWSHLLGF FLFFTLGIYD MTSVLPSASA SREDFVICSI CLFCFQVCML 130 140 150 160 170 180 CSVGYHLFSC HRSEKTCRRW MALDYAGISI GILGCYVSGV FYAFYCNNYW RQVYLITVLA 190 200 210 220 230 240 MILAVFFAQI HPNYLTQQWQ RLRSIIFCSV SGYGVIPTLH WVWLNGGIGA PIVQDFAPRV 250 260 IVMYMIALLA FLFYISKVPE RYFPESLPR
	Isoform 4 [UniParc]. Checksum: C7733512C770502E	FASTA	88	10,357
	10 20 30 40 50 60 MHQKLLKSAH YIELGSYQYW PVLVPRGIRL YTYEQIPGSL KDNPYITDGY RAYLPSRLCI 70 80 KRSVCFALWA IIFFPAIGQK KHVEDGWH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif." Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D. J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney and Teratocarcinoma.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4). Tissue: Testis.
[4]	"Characterization of the topology and functional domains of RKTG." Luo X., Feng L., Jiang X., Xiao F., Wang Z., Feng G.S., Chen Y. Biochem. J. 414:399-406(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY424281 mRNA. Translation: AAR08369.1. AK055774 mRNA. Translation: BAG51571.1. Different initiation. AK291232 mRNA. Translation: BAF83921.1. BC029604 mRNA. No translation available. BC031256 mRNA. Translation: AAH31256.1. BC047510 mRNA. Translation: AAH47510.1.
IPI	IPI00301648. IPI00329109. IPI00457115. IPI00457116.
RefSeq	NP_001035292.1. NM_001040202.1.
UniGene	Hs.657312.
3D structure databases
ProteinModelPortal	Q6TCH7.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-46464N.
PTM databases
PhosphoSite	Q6TCH7.
Polymorphism databases
DMDM	51701774.
Proteomic databases
PRIDE	Q6TCH7.
Protocols and materials databases
DNASU	152559.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295462; ENSP00000295462; ENSG00000163291. ENST00000395594; ENSP00000378959; ENSG00000163291. ENST00000511594; ENSP00000425080; ENSG00000163291. ENST00000512733; ENSP00000421981; ENSG00000163291. ENST00000512760; ENSP00000426875; ENSG00000163291. ENST00000515853; ENSP00000422357; ENSG00000163291.
GeneID	152559.
KEGG	hsa:152559.
UCSC	uc003hlp.1. human.
Organism-specific databases
CTD	152559.
GeneCards	GC04M079808.
H-InvDB	HIX0004326.
HGNC	HGNC:30130. PAQR3.
MIM	614577. gene.
neXtProt	NX_Q6TCH7.
PharmGKB	PA134952039.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1272.
HOGENOM	HOG000007783.
HOVERGEN	HBG053504.
InParanoid	Q6TCH7.
OMA	PTIHWVW.
Gene expression databases
ArrayExpress	Q6TCH7.
Bgee	Q6TCH7.
CleanEx	HS_PAQR3.
Genevestigator	Q6TCH7.
GermOnline	ENSG00000163291. Homo sapiens.
Family and domain databases
InterPro	IPR004254. HlyIII-related. [Graphical view]
PANTHER	PTHR20855. PTHR20855. 1 hit.
Pfam	PF03006. HlyIII. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PAQR3. human.
GenomeRNAi	152559.
NextBio	86976.
SOURCE	Search...

Entry information

Entry name

PAQR3_HUMAN

Accession

Primary (citable) accession number: Q6TCH7
Secondary accession number(s): A8K5B7 , B3KP59, Q6PIQ1, Q86X05, Q8NCP9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	August 31, 2004
Last modified:	April 3, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.