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Q6TCH4 (PAQR6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Progestin and adipoQ receptor family member 6
Alternative name(s):
Progestin and adipoQ receptor family member VI
Gene names
Name:PAQR6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expressed at a low level in brain. Ref.2

Sequence similarities

Belongs to the ADIPOR family.

Sequence caution

The sequence AAP97701.1 differs from that shown. Reason: Frameshift at position 338.

The sequence AAP97703.1 differs from that shown. Reason: Frameshift at position 241.

The sequence BAB15446.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionReceptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionreceptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6TCH4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6TCH4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.
     255-344: HSHQLFHICA...LEGGTQAKQQ → EGTPGPAREE...LRGEMHACPG
Isoform 3 (identifier: Q6TCH4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.
Isoform 4 (identifier: Q6TCH4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Progestin and adipoQ receptor family member 6
PRO_0000218850

Regions

Topological domain1 – 5151Cytoplasmic Potential
Transmembrane52 – 7221Helical; Potential
Topological domain73 – 8311Extracellular Potential
Transmembrane84 – 10421Helical; Potential
Topological domain105 – 1139Cytoplasmic Potential
Transmembrane114 – 13421Helical; Potential
Topological domain135 – 14713Extracellular Potential
Transmembrane148 – 16821Helical; Potential
Topological domain169 – 21749Cytoplasmic Potential
Transmembrane218 – 23821Helical; Potential
Topological domain239 – 25820Extracellular Potential
Transmembrane259 – 27921Helical; Potential
Topological domain280 – 29213Cytoplasmic Potential
Transmembrane293 – 31321Helical; Potential
Topological domain314 – 34431Extracellular Potential

Natural variations

Alternative sequence1 – 106106Missing in isoform 2 and isoform 3.
VSP_011484
Alternative sequence1 – 2424Missing in isoform 4.
VSP_011483
Alternative sequence255 – 34490HSHQL…QAKQQ → EGTPGPAREEAGADAFPEHR MNWATATSYSTSVQCWAPTS SWRQCWLIWDHAEPGWPHRN LPWAWQAQWPHWSWLQLGTY SLLLLSQPPCFGPPVHALCC RVAHWRGVPRPNNSEAPSLT LSWRGQRPGPSADEEPRFGP NQVGTHLSLEPTGAEERGHR REGREEEGCLGGLAECERDR EGALDGSGRSAEGLRGEMHA CPG in isoform 2.
VSP_011485
Isoform 2:
Natural variant2631E → K.
Corresponds to variant rs7513351 [ dbSNP | Ensembl ].

Experimental info

Sequence conflict1661L → P in AAR08372. Ref.2
Sequence conflict2241G → V in CAD38905. Ref.4
Sequence conflict240 – 2423HLP → QTD in AAP97703. Ref.1
Sequence conflict2441R → G in BAC04493. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 31, 2004. Version 2.
Checksum: BCFDD8A2210A6989

FASTA34437,989
        10         20         30         40         50         60 
MLSLKLPQLL QVHQVPRVFW EDGIMSGYRR PTSSALDCVL SSFQMTNETV NIWTHFLPTW 

        70         80         90        100        110        120 
YFLWRLLALA GGPGFRAEPY HWPLLVFLLP ACLYPFASCC AHTFSSMSPR MRHICYFLDY 

       130        140        150        160        170        180 
GALSLYSLGC AFPYAAYSMP ASWLHGHLHQ FFVPAAALNS FLCTGLSCYS RFLELESPGL 

       190        200        210        220        230        240 
SKVLRTGAFA YPFLFDNLPL FYRLGLCWGR GHGCGQEALS TSHGYHLFCA LLTGFLFASH 

       250        260        270        280        290        300 
LPERLAPGRF DYIGHSHQLF HICAVLGTHF QLEAVLADMG SRRAWLATQE PALGLAGTVA 

       310        320        330        340 
TLVLAAAGNL LIIAAFTATL LRAPSTCPLL QGGPLEGGTQ AKQQ 

« Hide

Isoform 2 [UniParc].

Checksum: 6C07E83A749F0DC9
Show »

FASTA35139,060
Isoform 3 [UniParc].

Checksum: D644B667D86E25BA
Show »

FASTA23825,814
Isoform 4 [UniParc].

Checksum: BF224F981D8A6BA1
Show »

FASTA32035,160

References

« Hide 'large scale' references
[1]Zan Q., Guo J.H., Yu L.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
Tissue: Brain.
[2]"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 126-344 (ISOFORMS 1/3/4).
Tissue: Small intestine, Subcommissural organ and Substantia nigra.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Amygdala.
[5]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 249-344 (ISOFORMS 1/3/4).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF455045 mRNA. Translation: AAP97701.1. Frameshift.
AF455047 mRNA. Translation: AAP97703.1. Frameshift.
AY424284 mRNA. Translation: AAR08372.1.
AK026325 mRNA. Translation: BAB15446.1. Different initiation.
AK095143 mRNA. Translation: BAC04493.1.
AK095197 mRNA. Translation: BAC04497.1.
AL834227 Transcribed RNA. Translation: CAD38905.2.
AL135927 Genomic DNA. Translation: CAI15542.1.
CH471121 Genomic DNA. Translation: EAW52976.1.
CH471121 Genomic DNA. Translation: EAW52977.1.
CH471121 Genomic DNA. Translation: EAW52979.1.
CH471121 Genomic DNA. Translation: EAW52983.1.
BC058509 mRNA. Translation: AAH58509.1.
RefSeqNP_001259033.1. NM_001272104.1.
NP_001259034.1. NM_001272105.1.
NP_001259036.1. NM_001272107.1.
NP_001259037.1. NM_001272108.1.
NP_001259038.1. NM_001272109.1.
NP_001259039.1. NM_001272110.1.
NP_001259040.1. NM_001272111.1.
NP_001259042.1. NM_001272113.1.
NP_079173.2. NM_024897.3.
NP_940798.1. NM_198406.2.
UniGeneHs.235873.

3D structure databases

ProteinModelPortalQ6TCH4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123026. 1 interaction.
STRING9606.ENSP00000338330.

PTM databases

PhosphoSiteQ6TCH4.

Polymorphism databases

DMDM51701773.

Proteomic databases

PaxDbQ6TCH4.
PRIDEQ6TCH4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000292291; ENSP00000292291; ENSG00000160781. [Q6TCH4-1]
ENST00000335852; ENSP00000338330; ENSG00000160781. [Q6TCH4-2]
ENST00000356983; ENSP00000349474; ENSG00000160781. [Q6TCH4-2]
ENST00000368270; ENSP00000357253; ENSG00000160781. [Q6TCH4-4]
GeneID79957.
KEGGhsa:79957.
UCSCuc001fnu.2. human. [Q6TCH4-1]
uc001fnz.2. human. [Q6TCH4-2]

Organism-specific databases

CTD79957.
GeneCardsGC01M156213.
HGNCHGNC:30132. PAQR6.
HPAHPA010843.
MIM614579. gene.
neXtProtNX_Q6TCH4.
PharmGKBPA134931897.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG283691.
HOVERGENHBG052505.
OMASCCAHTF.
OrthoDBEOG7D59NW.
PhylomeDBQ6TCH4.
TreeFamTF319738.

Gene expression databases

ArrayExpressQ6TCH4.
BgeeQ6TCH4.
CleanExHS_PAQR6.
GenevestigatorQ6TCH4.

Family and domain databases

InterProIPR004254. HlyIII-related.
[Graphical view]
PANTHERPTHR20855. PTHR20855. 1 hit.
PfamPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPAQR6. human.
GenomeRNAi79957.
NextBio69941.
PROQ6TCH4.
SOURCESearch...

Entry information

Entry namePAQR6_HUMAN
AccessionPrimary (citable) accession number: Q6TCH4
Secondary accession number(s): D3DVB4 expand/collapse secondary AC list , D3DVB6, Q5TCK9, Q6PDU0, Q7Z4Q7, Q7Z4Q9, Q8N121, Q8N3M2, Q9H621
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: April 16, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM