Q6TCH4 (PAQR6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Progestin and adipoQ receptor family member 6

Alternative name(s):
Progestin and adipoQ receptor family member VI

Gene names

Name:

PAQR6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed at a low level in brain. Ref.2
Sequence similarities	Belongs to the ADIPOR family.
Sequence caution	The sequence AAP97701.1 differs from that shown. Reason: Frameshift at position 338. The sequence AAP97703.1 differs from that shown. Reason: Frameshift at position 241. The sequence BAB15446.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6TCH4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6TCH4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.
     255-344: HSHQLFHICA...LEGGTQAKQQ → EGTPGPAREE...LRGEMHACPG

Isoform 3 (identifier: Q6TCH4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Isoform 4 (identifier: Q6TCH4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Progestin and adipoQ receptor family member 6		PRO_0000218850
Regions
	Topological domain	1 – 51	51	Cytoplasmic Potential
	Transmembrane	52 – 72	21	Helical; Potential
	Topological domain	73 – 83	11	Extracellular Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Topological domain	105 – 113	9	Cytoplasmic Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Topological domain	135 – 147	13	Extracellular Potential
	Transmembrane	148 – 168	21	Helical; Potential
	Topological domain	169 – 217	49	Cytoplasmic Potential
	Transmembrane	218 – 238	21	Helical; Potential
	Topological domain	239 – 258	20	Extracellular Potential
	Transmembrane	259 – 279	21	Helical; Potential
	Topological domain	280 – 292	13	Cytoplasmic Potential
	Transmembrane	293 – 313	21	Helical; Potential
	Topological domain	314 – 344	31	Extracellular Potential
Natural variations
	Alternative sequence	1 – 106	106	Missing in isoform 2 and isoform 3.		VSP_011484
	Alternative sequence	1 – 24	24	Missing in isoform 4.		VSP_011483
	Alternative sequence	255 – 344	90	HSHQL…QAKQQ → EGTPGPAREEAGADAFPEHR MNWATATSYSTSVQCWAPTS SWRQCWLIWDHAEPGWPHRN LPWAWQAQWPHWSWLQLGTY SLLLLSQPPCFGPPVHALCC RVAHWRGVPRPNNSEAPSLT LSWRGQRPGPSADEEPRFGP NQVGTHLSLEPTGAEERGHR REGREEEGCLGGLAECERDR EGALDGSGRSAEGLRGEMHA CPG in isoform 2.		VSP_011485
Isoform 2:
	Natural variant	263	1	E → K. Corresponds to variant rs7513351 [ dbSNP | Ensembl ].
Experimental info
	Sequence conflict	166	1	L → P in AAR08372. Ref.2
	Sequence conflict	224	1	G → V in CAD38905. Ref.4
	Sequence conflict	240 – 242	3	HLP → QTD in AAP97703. Ref.1
	Sequence conflict	244	1	R → G in BAC04493. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 31, 2004. Version 2. Checksum: BCFDD8A2210A6989	FASTA	344	37,989
	10 20 30 40 50 60 MLSLKLPQLL QVHQVPRVFW EDGIMSGYRR PTSSALDCVL SSFQMTNETV NIWTHFLPTW 70 80 90 100 110 120 YFLWRLLALA GGPGFRAEPY HWPLLVFLLP ACLYPFASCC AHTFSSMSPR MRHICYFLDY 130 140 150 160 170 180 GALSLYSLGC AFPYAAYSMP ASWLHGHLHQ FFVPAAALNS FLCTGLSCYS RFLELESPGL 190 200 210 220 230 240 SKVLRTGAFA YPFLFDNLPL FYRLGLCWGR GHGCGQEALS TSHGYHLFCA LLTGFLFASH 250 260 270 280 290 300 LPERLAPGRF DYIGHSHQLF HICAVLGTHF QLEAVLADMG SRRAWLATQE PALGLAGTVA 310 320 330 340 TLVLAAAGNL LIIAAFTATL LRAPSTCPLL QGGPLEGGTQ AKQQ
	Isoform 2 [UniParc]. Checksum: 6C07E83A749F0DC9	FASTA	351	39,060
	10 20 30 40 50 60 MSPRMRHICY FLDYGALSLY SLGCAFPYAA YSMPASWLHG HLHQFFVPAA ALNSFLCTGL 70 80 90 100 110 120 SCYSRFLELE SPGLSKVLRT GAFAYPFLFD NLPLFYRLGL CWGRGHGCGQ EALSTSHGYH 130 140 150 160 170 180 LFCALLTGFL FASHLPERLA PGRFDYIGEG TPGPAREEAG ADAFPEHRMN WATATSYSTS 190 200 210 220 230 240 VQCWAPTSSW RQCWLIWDHA EPGWPHRNLP WAWQAQWPHW SWLQLGTYSL LLLSQPPCFG 250 260 270 280 290 300 PPVHALCCRV AHWRGVPRPN NSEAPSLTLS WRGQRPGPSA DEEPRFGPNQ VGTHLSLEPT 310 320 330 340 350 GAEERGHRRE GREEEGCLGG LAECERDREG ALDGSGRSAE GLRGEMHACP G
	Isoform 3 [UniParc]. Checksum: D644B667D86E25BA	FASTA	238	25,814
	10 20 30 40 50 60 MSPRMRHICY FLDYGALSLY SLGCAFPYAA YSMPASWLHG HLHQFFVPAA ALNSFLCTGL 70 80 90 100 110 120 SCYSRFLELE SPGLSKVLRT GAFAYPFLFD NLPLFYRLGL CWGRGHGCGQ EALSTSHGYH 130 140 150 160 170 180 LFCALLTGFL FASHLPERLA PGRFDYIGHS HQLFHICAVL GTHFQLEAVL ADMGSRRAWL 190 200 210 220 230 ATQEPALGLA GTVATLVLAA AGNLLIIAAF TATLLRAPST CPLLQGGPLE GGTQAKQQ
	Isoform 4 [UniParc]. Checksum: BF224F981D8A6BA1	FASTA	320	35,160
	10 20 30 40 50 60 MSGYRRPTSS ALDCVLSSFQ MTNETVNIWT HFLPTWYFLW RLLALAGGPG FRAEPYHWPL 70 80 90 100 110 120 LVFLLPACLY PFASCCAHTF SSMSPRMRHI CYFLDYGALS LYSLGCAFPY AAYSMPASWL 130 140 150 160 170 180 HGHLHQFFVP AAALNSFLCT GLSCYSRFLE LESPGLSKVL RTGAFAYPFL FDNLPLFYRL 190 200 210 220 230 240 GLCWGRGHGC GQEALSTSHG YHLFCALLTG FLFASHLPER LAPGRFDYIG HSHQLFHICA 250 260 270 280 290 300 VLGTHFQLEA VLADMGSRRA WLATQEPALG LAGTVATLVL AAAGNLLIIA AFTATLLRAP 310 320 STCPLLQGGP LEGGTQAKQQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Zan Q., Guo J.H., Yu L. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). Tissue: Brain.
[2]	"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif." Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D. J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 126-344 (ISOFORMS 1/3/4). Tissue: Small intestine, Subcommissural organ and Substantia nigra.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Amygdala.
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 249-344 (ISOFORMS 1/3/4). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF455045 mRNA. Translation: AAP97701.1. Frameshift. AF455047 mRNA. Translation: AAP97703.1. Frameshift. AY424284 mRNA. Translation: AAR08372.1. AK026325 mRNA. Translation: BAB15446.1. Different initiation. AK095143 mRNA. Translation: BAC04493.1. AK095197 mRNA. Translation: BAC04497.1. AL834227 Transcribed RNA. Translation: CAD38905.2. AL135927 Genomic DNA. Translation: CAI15542.1. CH471121 Genomic DNA. Translation: EAW52976.1. CH471121 Genomic DNA. Translation: EAW52977.1. CH471121 Genomic DNA. Translation: EAW52979.1. CH471121 Genomic DNA. Translation: EAW52983.1. BC058509 mRNA. Translation: AAH58509.1.
IPI	IPI00166043. IPI00398297. IPI00456911. IPI00456912.
RefSeq	NP_001259033.1. NM_001272104.1. NP_001259036.1. NM_001272107.1. NP_079173.2. NM_024897.3. NP_940798.1. NM_198406.2.
UniGene	Hs.235873.
3D structure databases
ProteinModelPortal	Q6TCH4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000338330.
PTM databases
PhosphoSite	Q6TCH4.
Polymorphism databases
DMDM	51701773.
Proteomic databases
PaxDb	Q6TCH4.
PRIDE	Q6TCH4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000292291; ENSP00000292291; ENSG00000160781. ENST00000335852; ENSP00000338330; ENSG00000160781. ENST00000356983; ENSP00000349474; ENSG00000160781. ENST00000360733; ENSP00000353961; ENSG00000160781. ENST00000368270; ENSP00000357253; ENSG00000160781.
GeneID	79957.
KEGG	hsa:79957.
UCSC	uc001fnu.1. human. uc001fnz.1. human.
Organism-specific databases
CTD	79957.
GeneCards	GC01M156213.
HGNC	HGNC:30132. PAQR6.
HPA	HPA010843.
MIM	614579. gene.
neXtProt	NX_Q6TCH4.
PharmGKB	PA134931897.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG283691.
HOVERGEN	HBG052505.
OMA	SCCAHTF.
OrthoDB	EOG4GHZPV.
Gene expression databases
ArrayExpress	Q6TCH4.
Bgee	Q6TCH4.
CleanEx	HS_PAQR6.
Genevestigator	Q6TCH4.
GermOnline	ENSG00000160781. Homo sapiens.
Family and domain databases
InterPro	IPR004254. HlyIII-related. [Graphical view]
PANTHER	PTHR20855. PTHR20855. 1 hit.
Pfam	PF03006. HlyIII. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PAQR6. human.
GenomeRNAi	79957.
NextBio	69941.
SOURCE	Search...

Entry information

Entry name

PAQR6_HUMAN

Accession

Primary (citable) accession number: Q6TCH4
Secondary accession number(s): D3DVB4 , D3DVB6, Q5TCK9, Q6PDU0, Q7Z4Q7, Q7Z4Q9, Q8N121, Q8N3M2, Q9H621

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	August 31, 2004
Last modified:	April 3, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.