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Protein

Progestin and adipoQ receptor family member 6

Gene

PAQR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. receptor activity Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Progestin and adipoQ receptor family member 6
Alternative name(s):
Progestin and adipoQ receptor family member VI
Gene namesi
Name:PAQR6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:30132. PAQR6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Topological domaini73 – 8311ExtracellularSequence AnalysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence AnalysisAdd
BLAST
Topological domaini105 – 1139CytoplasmicSequence Analysis
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Topological domaini135 – 14713ExtracellularSequence AnalysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST
Topological domaini169 – 21749CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence AnalysisAdd
BLAST
Topological domaini239 – 25820ExtracellularSequence AnalysisAdd
BLAST
Transmembranei259 – 27921HelicalSequence AnalysisAdd
BLAST
Topological domaini280 – 29213CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence AnalysisAdd
BLAST
Topological domaini314 – 34431ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931897.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Progestin and adipoQ receptor family member 6PRO_0000218850Add
BLAST

Proteomic databases

PaxDbiQ6TCH4.
PRIDEiQ6TCH4.

PTM databases

PhosphoSiteiQ6TCH4.

Expressioni

Tissue specificityi

Expressed at a low level in brain.1 Publication

Gene expression databases

BgeeiQ6TCH4.
CleanExiHS_PAQR6.
ExpressionAtlasiQ6TCH4. baseline and differential.
GenevestigatoriQ6TCH4.

Organism-specific databases

HPAiHPA010843.

Interactioni

Protein-protein interaction databases

BioGridi123026. 1 interaction.
STRINGi9606.ENSP00000338330.

Structurei

3D structure databases

ProteinModelPortaliQ6TCH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283691.
GeneTreeiENSGT00530000062965.
HOVERGENiHBG052505.
InParanoidiQ6TCH4.
OMAiSCCAHTF.
OrthoDBiEOG7D59NW.
PhylomeDBiQ6TCH4.
TreeFamiTF319738.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6TCH4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSLKLPQLL QVHQVPRVFW EDGIMSGYRR PTSSALDCVL SSFQMTNETV
60 70 80 90 100
NIWTHFLPTW YFLWRLLALA GGPGFRAEPY HWPLLVFLLP ACLYPFASCC
110 120 130 140 150
AHTFSSMSPR MRHICYFLDY GALSLYSLGC AFPYAAYSMP ASWLHGHLHQ
160 170 180 190 200
FFVPAAALNS FLCTGLSCYS RFLELESPGL SKVLRTGAFA YPFLFDNLPL
210 220 230 240 250
FYRLGLCWGR GHGCGQEALS TSHGYHLFCA LLTGFLFASH LPERLAPGRF
260 270 280 290 300
DYIGHSHQLF HICAVLGTHF QLEAVLADMG SRRAWLATQE PALGLAGTVA
310 320 330 340
TLVLAAAGNL LIIAAFTATL LRAPSTCPLL QGGPLEGGTQ AKQQ
Length:344
Mass (Da):37,989
Last modified:August 31, 2004 - v2
Checksum:iBCFDD8A2210A6989
GO
Isoform 2 (identifier: Q6TCH4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.
     255-344: HSHQLFHICA...LEGGTQAKQQ → EGTPGPAREE...LRGEMHACPG

Show »
Length:351
Mass (Da):39,060
Checksum:i6C07E83A749F0DC9
GO
Isoform 3 (identifier: Q6TCH4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Show »
Length:238
Mass (Da):25,814
Checksum:iD644B667D86E25BA
GO
Isoform 4 (identifier: Q6TCH4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Show »
Length:320
Mass (Da):35,160
Checksum:iBF224F981D8A6BA1
GO
Isoform 5 (identifier: Q6TCH4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-17: Missing.

Note: No experimental confirmation available.

Show »
Length:341
Mass (Da):37,637
Checksum:iC63AB1F9F872044B
GO

Sequence cautioni

The sequence AAP97701.1 differs from that shown. Reason: Frameshift at position 338. Curated
The sequence AAP97703.1 differs from that shown. Reason: Frameshift at position 241. Curated
The sequence BAB15446.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti166 – 1661L → P in AAR08372 (PubMed:16044242).Curated
Sequence conflicti224 – 2241G → V in CAD38905 (PubMed:17974005).Curated
Sequence conflicti240 – 2423HLP → QTD in AAP97703 (Ref. 1) Curated
Sequence conflicti244 – 2441R → G in BAC04493 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 2 (identifier: Q6TCH4-2)
Natural varianti263 – 2631E → K.
Corresponds to variant rs7513351 [ dbSNP | Ensembl ].

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 106106Missing in isoform 2 and isoform 3. 2 PublicationsVSP_011484Add
BLAST
Alternative sequencei1 – 2424Missing in isoform 4. 1 PublicationVSP_011483Add
BLAST
Alternative sequencei15 – 173Missing in isoform 5. 1 PublicationVSP_054538
Alternative sequencei255 – 34490HSHQL…QAKQQ → EGTPGPAREEAGADAFPEHR MNWATATSYSTSVQCWAPTS SWRQCWLIWDHAEPGWPHRN LPWAWQAQWPHWSWLQLGTY SLLLLSQPPCFGPPVHALCC RVAHWRGVPRPNNSEAPSLT LSWRGQRPGPSADEEPRFGP NQVGTHLSLEPTGAEERGHR REGREEEGCLGGLAECERDR EGALDGSGRSAEGLRGEMHA CPG in isoform 2. 1 PublicationVSP_011485Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455045 mRNA. Translation: AAP97701.1. Frameshift.
AF455047 mRNA. Translation: AAP97703.1. Frameshift.
AY424284 mRNA. Translation: AAR08372.1.
AK026325 mRNA. Translation: BAB15446.1. Different initiation.
AK095143 mRNA. Translation: BAC04493.1.
AK095197 mRNA. Translation: BAC04497.1.
AK316034 mRNA. Translation: BAH14405.1.
AL834227 Transcribed RNA. Translation: CAD38905.2.
AL135927 Genomic DNA. Translation: CAI15542.1.
CH471121 Genomic DNA. Translation: EAW52976.1.
CH471121 Genomic DNA. Translation: EAW52977.1.
CH471121 Genomic DNA. Translation: EAW52979.1.
CH471121 Genomic DNA. Translation: EAW52982.1.
CH471121 Genomic DNA. Translation: EAW52983.1.
BC058509 mRNA. Translation: AAH58509.1.
CCDSiCCDS1135.1. [Q6TCH4-2]
CCDS1136.1. [Q6TCH4-1]
CCDS60301.1. [Q6TCH4-5]
RefSeqiNP_001259033.1. NM_001272104.1. [Q6TCH4-1]
NP_001259034.1. NM_001272105.1. [Q6TCH4-5]
NP_001259036.1. NM_001272107.1. [Q6TCH4-3]
NP_001259037.1. NM_001272108.1.
NP_001259038.1. NM_001272109.1.
NP_001259039.1. NM_001272110.1.
NP_001259040.1. NM_001272111.1.
NP_001259041.1. NM_001272112.1.
NP_001259042.1. NM_001272113.1.
NP_079173.2. NM_024897.3. [Q6TCH4-2]
NP_940798.1. NM_198406.2. [Q6TCH4-1]
UniGeneiHs.235873.

Genome annotation databases

EnsembliENST00000292291; ENSP00000292291; ENSG00000160781. [Q6TCH4-1]
ENST00000335852; ENSP00000338330; ENSG00000160781. [Q6TCH4-2]
ENST00000356983; ENSP00000349474; ENSG00000160781. [Q6TCH4-5]
ENST00000368270; ENSP00000357253; ENSG00000160781. [Q6TCH4-4]
GeneIDi79957.
KEGGihsa:79957.
UCSCiuc001fnu.2. human. [Q6TCH4-1]
uc001fnz.2. human. [Q6TCH4-2]
uc010phg.2. human.

Polymorphism databases

DMDMi51701773.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455045 mRNA. Translation: AAP97701.1. Frameshift.
AF455047 mRNA. Translation: AAP97703.1. Frameshift.
AY424284 mRNA. Translation: AAR08372.1.
AK026325 mRNA. Translation: BAB15446.1. Different initiation.
AK095143 mRNA. Translation: BAC04493.1.
AK095197 mRNA. Translation: BAC04497.1.
AK316034 mRNA. Translation: BAH14405.1.
AL834227 Transcribed RNA. Translation: CAD38905.2.
AL135927 Genomic DNA. Translation: CAI15542.1.
CH471121 Genomic DNA. Translation: EAW52976.1.
CH471121 Genomic DNA. Translation: EAW52977.1.
CH471121 Genomic DNA. Translation: EAW52979.1.
CH471121 Genomic DNA. Translation: EAW52982.1.
CH471121 Genomic DNA. Translation: EAW52983.1.
BC058509 mRNA. Translation: AAH58509.1.
CCDSiCCDS1135.1. [Q6TCH4-2]
CCDS1136.1. [Q6TCH4-1]
CCDS60301.1. [Q6TCH4-5]
RefSeqiNP_001259033.1. NM_001272104.1. [Q6TCH4-1]
NP_001259034.1. NM_001272105.1. [Q6TCH4-5]
NP_001259036.1. NM_001272107.1. [Q6TCH4-3]
NP_001259037.1. NM_001272108.1.
NP_001259038.1. NM_001272109.1.
NP_001259039.1. NM_001272110.1.
NP_001259040.1. NM_001272111.1.
NP_001259041.1. NM_001272112.1.
NP_001259042.1. NM_001272113.1.
NP_079173.2. NM_024897.3. [Q6TCH4-2]
NP_940798.1. NM_198406.2. [Q6TCH4-1]
UniGeneiHs.235873.

3D structure databases

ProteinModelPortaliQ6TCH4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123026. 1 interaction.
STRINGi9606.ENSP00000338330.

PTM databases

PhosphoSiteiQ6TCH4.

Polymorphism databases

DMDMi51701773.

Proteomic databases

PaxDbiQ6TCH4.
PRIDEiQ6TCH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292291; ENSP00000292291; ENSG00000160781. [Q6TCH4-1]
ENST00000335852; ENSP00000338330; ENSG00000160781. [Q6TCH4-2]
ENST00000356983; ENSP00000349474; ENSG00000160781. [Q6TCH4-5]
ENST00000368270; ENSP00000357253; ENSG00000160781. [Q6TCH4-4]
GeneIDi79957.
KEGGihsa:79957.
UCSCiuc001fnu.2. human. [Q6TCH4-1]
uc001fnz.2. human. [Q6TCH4-2]
uc010phg.2. human.

Organism-specific databases

CTDi79957.
GeneCardsiGC01M156213.
HGNCiHGNC:30132. PAQR6.
HPAiHPA010843.
MIMi614579. gene.
neXtProtiNX_Q6TCH4.
PharmGKBiPA134931897.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG283691.
GeneTreeiENSGT00530000062965.
HOVERGENiHBG052505.
InParanoidiQ6TCH4.
OMAiSCCAHTF.
OrthoDBiEOG7D59NW.
PhylomeDBiQ6TCH4.
TreeFamiTF319738.

Miscellaneous databases

ChiTaRSiPAQR6. human.
GenomeRNAii79957.
NextBioi35480779.
PROiQ6TCH4.
SOURCEiSearch...

Gene expression databases

BgeeiQ6TCH4.
CleanExiHS_PAQR6.
ExpressionAtlasiQ6TCH4. baseline and differential.
GenevestigatoriQ6TCH4.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Zan Q., Guo J.H., Yu L.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    Tissue: Brain.
  2. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
    Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
    J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 126-344 (ISOFORMS 1/3/4).
    Tissue: Caudate nucleus, Small intestine, Subcommissural organ and Substantia nigra.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 249-344 (ISOFORMS 1/3/4).
    Tissue: Brain.

Entry informationi

Entry nameiPAQR6_HUMAN
AccessioniPrimary (citable) accession number: Q6TCH4
Secondary accession number(s): B7Z9R9
, D3DVB4, D3DVB6, Q5TCK9, Q6PDU0, Q7Z4Q7, Q7Z4Q9, Q8N121, Q8N3M2, Q9H621
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: February 4, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.