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Protein

C3a anaphylatoxin chemotactic receptor

Gene

C3AR1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C3a anaphylatoxin chemotactic receptor
Short name:
C3AR
Short name:
C3a-R
Gene namesi
Name:C3AR1
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4623Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 5711CytoplasmicSequence analysisAdd
BLAST
Transmembranei58 – 8023Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini81 – 9616ExtracellularSequence analysisAdd
BLAST
Transmembranei97 – 11822Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 13921CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 337177ExtracellularSequence analysisAdd
BLAST
Transmembranei338 – 35720Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini358 – 37417CytoplasmicSequence analysisAdd
BLAST
Transmembranei375 – 39723Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini398 – 41417ExtracellularSequence analysisAdd
BLAST
Transmembranei415 – 43521Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini436 – 48146CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481C3a anaphylatoxin chemotactic receptorPRO_0000069203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence analysis
Modified residuei174 – 1741SulfotyrosineBy similarity
Modified residuei184 – 1841SulfotyrosineBy similarity
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence analysis
Modified residuei315 – 3151SulfotyrosineBy similarity
Modified residuei456 – 4561PhosphoserineBy similarity
Modified residuei460 – 4601PhosphothreonineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Structurei

3D structure databases

ProteinModelPortaliQ6TAC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG002433.

Family and domain databases

InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 2 hits.
PTHR24225:SF28. PTHR24225:SF28. 2 hits.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6TAC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPFSAETNS TDLLSQPWNE SPVILSMVIL SLTFLLGLPG NGLVLWVAGL
60 70 80 90 100
KMQRTVNTVW FLHLTLADLL CCLSLPFSLA HLALQGQWPY GRFLCKLIPS
110 120 130 140 150
IIVLNMFASV FLLTAITLDR CLVVFKPIWC QNHRNVGTAC TICGCIWVVA
160 170 180 190 200
FVMCIPVFVY REIFTTDNHS KCGYKFDLSG SLDYLDFYGN PLENRSLENI
210 220 230 240 250
FQLPGEMNDR LDPSSFQAND HPWTVTTAFH TQTFQRPSAD SLPKDSASHS
260 270 280 290 300
PYSNVFKPAG VASPKIPSGF PIEGHKTSPL DDSDAFLSTH LKLFPSAASN
310 320 330 340 350
SLYEYELPQD FQDYYSLGQF TYDNQVSTPL VAITITRLVV GFLLPSVIMI
360 370 380 390 400
ACYSFIVLRM QRGRFAKSQG KTLRVAVVVV TVFLVCWAPY HISGVLSLFT
410 420 430 440 450
DPETPLGKTL MSWDHVFTAL ASANSCFNPF LYALLGKDFR KKARQSIQSI
460 470 480
LEAAFSEELT HSTHCSSNNV FSERNSISTT V
Length:481
Mass (Da):53,578
Last modified:July 5, 2004 - v1
Checksum:i4C64DCBAB006BA4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY426336 mRNA. Translation: AAR06214.1.
RefSeqiNP_001306304.1. NM_001319375.1.
UniGeneiMfa.6273.

Genome annotation databases

GeneIDi102118947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY426336 mRNA. Translation: AAR06214.1.
RefSeqiNP_001306304.1. NM_001319375.1.
UniGeneiMfa.6273.

3D structure databases

ProteinModelPortaliQ6TAC8.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102118947.

Organism-specific databases

CTDi719.

Phylogenomic databases

HOVERGENiHBG002433.

Family and domain databases

InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 2 hits.
PTHR24225:SF28. PTHR24225:SF28. 2 hits.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC3AR_MACFA
AccessioniPrimary (citable) accession number: Q6TAC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.