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Protein

C3a anaphylatoxin chemotactic receptor

Gene

C3AR1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C3a anaphylatoxin chemotactic receptor
Short name:
C3AR
Short name:
C3a-R
Gene namesi
Name:C3AR1
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 46Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini47 – 57CytoplasmicSequence analysisAdd BLAST11
Transmembranei58 – 80Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini81 – 96ExtracellularSequence analysisAdd BLAST16
Transmembranei97 – 118Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini119 – 139CytoplasmicSequence analysisAdd BLAST21
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 337ExtracellularSequence analysisAdd BLAST177
Transmembranei338 – 357Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini358 – 374CytoplasmicSequence analysisAdd BLAST17
Transmembranei375 – 397Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini398 – 414ExtracellularSequence analysisAdd BLAST17
Transmembranei415 – 435Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini436 – 481CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692031 – 481C3a anaphylatoxin chemotactic receptorAdd BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...)Sequence analysis1
Modified residuei174SulfotyrosineBy similarity1
Modified residuei184SulfotyrosineBy similarity1
Glycosylationi194N-linked (GlcNAc...)Sequence analysis1
Modified residuei315SulfotyrosineBy similarity1
Modified residuei456PhosphoserineBy similarity1
Modified residuei460PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Structurei

3D structure databases

ProteinModelPortaliQ6TAC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG002433.
KOiK04009.

Family and domain databases

InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 2 hits.
PTHR24225:SF28. PTHR24225:SF28. 2 hits.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6TAC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPFSAETNS TDLLSQPWNE SPVILSMVIL SLTFLLGLPG NGLVLWVAGL
60 70 80 90 100
KMQRTVNTVW FLHLTLADLL CCLSLPFSLA HLALQGQWPY GRFLCKLIPS
110 120 130 140 150
IIVLNMFASV FLLTAITLDR CLVVFKPIWC QNHRNVGTAC TICGCIWVVA
160 170 180 190 200
FVMCIPVFVY REIFTTDNHS KCGYKFDLSG SLDYLDFYGN PLENRSLENI
210 220 230 240 250
FQLPGEMNDR LDPSSFQAND HPWTVTTAFH TQTFQRPSAD SLPKDSASHS
260 270 280 290 300
PYSNVFKPAG VASPKIPSGF PIEGHKTSPL DDSDAFLSTH LKLFPSAASN
310 320 330 340 350
SLYEYELPQD FQDYYSLGQF TYDNQVSTPL VAITITRLVV GFLLPSVIMI
360 370 380 390 400
ACYSFIVLRM QRGRFAKSQG KTLRVAVVVV TVFLVCWAPY HISGVLSLFT
410 420 430 440 450
DPETPLGKTL MSWDHVFTAL ASANSCFNPF LYALLGKDFR KKARQSIQSI
460 470 480
LEAAFSEELT HSTHCSSNNV FSERNSISTT V
Length:481
Mass (Da):53,578
Last modified:July 5, 2004 - v1
Checksum:i4C64DCBAB006BA4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY426336 mRNA. Translation: AAR06214.1.
RefSeqiNP_001306304.1. NM_001319375.1.
UniGeneiMfa.6273.

Genome annotation databases

GeneIDi102118947.
KEGGimcf:102118947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY426336 mRNA. Translation: AAR06214.1.
RefSeqiNP_001306304.1. NM_001319375.1.
UniGeneiMfa.6273.

3D structure databases

ProteinModelPortaliQ6TAC8.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102118947.
KEGGimcf:102118947.

Organism-specific databases

CTDi719.

Phylogenomic databases

HOVERGENiHBG002433.
KOiK04009.

Family and domain databases

InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 2 hits.
PTHR24225:SF28. PTHR24225:SF28. 2 hits.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC3AR_MACFA
AccessioniPrimary (citable) accession number: Q6TAC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.