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Protein

FGFR1 oncogene partner 2 homolog

Gene

Fgfr1op2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in wound healing pathway underlying the favorable early wound closure characteristics of oral mucosa. Accelerates the collagen gel contraction in vitro.1 Publication

GO - Biological processi

  • response to wounding Source: RGD
  • wound healing Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
FGFR1 oncogene partner 2 homolog
Alternative name(s):
Wound-inducible transcript 3.0 protein
Short name:
Wit3.0
Gene namesi
Name:Fgfr1op2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1303233. Fgfr1op2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253FGFR1 oncogene partner 2 homologPRO_0000299044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei140 – 1401PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6TA25.

PTM databases

iPTMnetiQ6TA25.
PhosphoSiteiQ6TA25.

Expressioni

Inductioni

By wound, in oral mucosa undergoing tooth extraction.1 Publication

Gene expression databases

GenevisibleiQ6TA25. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039568.

Structurei

3D structure databases

ProteinModelPortaliQ6TA25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili5 – 104100Sequence analysisAdd
BLAST
Coiled coili160 – 22364Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SIKE family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHR3. Eukaryota.
ENOG410XS48. LUCA.
GeneTreeiENSGT00390000018003.
HOGENOMiHOG000294110.
HOVERGENiHBG055808.
InParanoidiQ6TA25.
OMAiHGCKEQE.
OrthoDBiEOG7BGHMV.
PhylomeDBiQ6TA25.
TreeFamiTF324337.

Family and domain databases

InterProiIPR008555. SIKE.
[Graphical view]
PANTHERiPTHR12186. PTHR12186. 2 hits.
PfamiPF05769. DUF837. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6TA25-1) [UniParc]FASTAAdd to basket

Also known as: Beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCTIEKALA DAKALVERLR DHDDAAESLI EQTTALSKRV EAMKQYQEEI
60 70 80 90 100
QELNEVARHR PRSTLVMGIQ QENRQIRELQ QENKELRTSL EEHQSALELI
110 120 130 140 150
MSKYREQMFR LLMASKKDDP GIIMKLKEQH SKIDMVHRNS CEGFFLDASR
160 170 180 190 200
HILEAPQHGL ERRHLEANQN ELQAHVDQIT EMAAVMRKAI EIDEQQGCKE
210 220 230 240 250
QERIFQLEQE NKGLREILQI TRESFLNLRK DDASESTSLS ALVTNSDLSL

RKS
Length:253
Mass (Da):29,374
Last modified:August 21, 2007 - v2
Checksum:i07A077BAB5071119
GO
Isoform 2 (identifier: Q6TA25-2) [UniParc]FASTAAdd to basket

Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     133-170: Missing.

Show »
Length:215
Mass (Da):24,950
Checksum:i4709C59555880914
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791L → F in AAR20448 (PubMed:12097305).Curated
Sequence conflicti79 – 791L → F in AAR20449 (PubMed:12097305).Curated
Sequence conflicti202 – 2021E → Q in AAR20448 (PubMed:12097305).Curated
Sequence conflicti202 – 2021E → Q in AAR20449 (PubMed:12097305).Curated
Sequence conflicti229 – 2291R → Q in AAR20448 (PubMed:12097305).Curated
Sequence conflicti229 – 2291R → Q in AAR20449 (PubMed:12097305).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei133 – 17038Missing in isoform 2. 1 PublicationVSP_027542Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY426739 mRNA. Translation: AAR20448.1.
AY426740 mRNA. Translation: AAR20449.1.
BC087696 mRNA. Translation: AAH87696.1.
RefSeqiNP_958824.1. NM_201421.1.
XP_006237750.1. XM_006237688.2. [Q6TA25-2]
UniGeneiRn.68658.

Genome annotation databases

EnsembliENSRNOT00000002476; ENSRNOP00000002476; ENSRNOG00000001811. [Q6TA25-2]
ENSRNOT00000042270; ENSRNOP00000039568; ENSRNOG00000001811. [Q6TA25-1]
GeneIDi362463.
KEGGirno:362463.
UCSCiRGD:1303233. rat. [Q6TA25-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY426739 mRNA. Translation: AAR20448.1.
AY426740 mRNA. Translation: AAR20449.1.
BC087696 mRNA. Translation: AAH87696.1.
RefSeqiNP_958824.1. NM_201421.1.
XP_006237750.1. XM_006237688.2. [Q6TA25-2]
UniGeneiRn.68658.

3D structure databases

ProteinModelPortaliQ6TA25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039568.

PTM databases

iPTMnetiQ6TA25.
PhosphoSiteiQ6TA25.

Proteomic databases

PaxDbiQ6TA25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002476; ENSRNOP00000002476; ENSRNOG00000001811. [Q6TA25-2]
ENSRNOT00000042270; ENSRNOP00000039568; ENSRNOG00000001811. [Q6TA25-1]
GeneIDi362463.
KEGGirno:362463.
UCSCiRGD:1303233. rat. [Q6TA25-1]

Organism-specific databases

CTDi26127.
RGDi1303233. Fgfr1op2.

Phylogenomic databases

eggNOGiENOG410IHR3. Eukaryota.
ENOG410XS48. LUCA.
GeneTreeiENSGT00390000018003.
HOGENOMiHOG000294110.
HOVERGENiHBG055808.
InParanoidiQ6TA25.
OMAiHGCKEQE.
OrthoDBiEOG7BGHMV.
PhylomeDBiQ6TA25.
TreeFamiTF324337.

Miscellaneous databases

PROiQ6TA25.

Gene expression databases

GenevisibleiQ6TA25. RN.

Family and domain databases

InterProiIPR008555. SIKE.
[Graphical view]
PANTHERiPTHR12186. PTHR12186. 2 hits.
PfamiPF05769. DUF837. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of wound inducible transcript (wit 3.0) differentially expressed in edentulous oral mucosa undergoing tooth extraction wound-healing."
    Sukotjo C., Abanmy A.A., Ogawa T., Nishimura I.
    J. Dent. Res. 81:229-235(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), INDUCTION.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Oral fibroblast expression of wound-inducible transcript 3.0 (wit3.0) accelerates the collagen gel contraction in vitro."
    Sukotjo C., Lin A., Song K., Ogawa T., Wu B., Nishimura I.
    J. Biol. Chem. 278:51527-51534(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiFGOP2_RAT
AccessioniPrimary (citable) accession number: Q6TA25
Secondary accession number(s): Q5PPH1, Q6TA26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: June 8, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.