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Protein

Toll-like receptor 2

Gene

TLR2

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 2
Alternative name(s):
CD_antigen: CD282
Gene namesi
Name:TLR2
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 587ExtracellularSequence analysisAdd BLAST567
Transmembranei588 – 608HelicalSequence analysisAdd BLAST21
Topological domaini609 – 784CytoplasmicSequence analysisAdd BLAST176

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000036377321 – 784Toll-like receptor 2Add BLAST764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 37By similarity
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi353 ↔ 382By similarity
Glycosylationi414N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi432 ↔ 454By similarity
Glycosylationi442N-linked (GlcNAc...) asparagineSequence analysis1
Cross-linki754Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.By similarity
Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ6T752

Interactioni

Subunit structurei

Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei349Interaction with bacterial lipopeptideBy similarity1

Protein-protein interaction databases

STRINGi9796.ENSECAP00000015544

Structurei

3D structure databases

ProteinModelPortaliQ6T752
SMRiQ6T752
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati54 – 77LRR 1Add BLAST24
Repeati78 – 101LRR 2Add BLAST24
Repeati102 – 125LRR 3Add BLAST24
Repeati126 – 150LRR 4Add BLAST25
Repeati151 – 175LRR 5Add BLAST25
Repeati176 – 199LRR 6Add BLAST24
Repeati200 – 223LRR 7Add BLAST24
Repeati224 – 250LRR 8Add BLAST27
Repeati251 – 278LRR 9Add BLAST28
Repeati279 – 308LRR 10Add BLAST30
Repeati309 – 337LRR 11Add BLAST29
Repeati338 – 361LRR 12Add BLAST24
Repeati362 – 388LRR 13Add BLAST27
Repeati389 – 414LRR 14Add BLAST26
Repeati415 – 437LRR 15Add BLAST23
Repeati438 – 457LRR 16Add BLAST20
Repeati458 – 478LRR 17Add BLAST21
Repeati479 – 500LRR 18Add BLAST22
Repeati501 – 524LRR 19Add BLAST24
Domaini525 – 579LRRCTAdd BLAST55
Domaini639 – 784TIRPROSITE-ProRule annotationAdd BLAST146

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi761 – 778ATG16L1-binding motifAdd BLAST18

Domaini

Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.By similarity
The ATG16L1-binding motif mediates interaction with ATG16L1.By similarity

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
HOGENOMiHOG000110611
HOVERGENiHBG108574
InParanoidiQ6T752
KOiK10159

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR026906 LRR_5
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR027185 TLR2
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR24365:SF17 PTHR24365:SF17, 1 hit
PfamiView protein in Pfam
PF13306 LRR_5, 1 hit
PF13855 LRR_8, 2 hits
PF01463 LRRCT, 1 hit
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 9 hits
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6T752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHALWTVWV LGAVISLSKE GVPDQPSSLS CDPTGVCDGR SRSLNSIPSG
60 70 80 90 100
LTAAVKSLDL SNNKIASVGN SDLWKCVNLK ALRLGSNDIN TIEEDSFSSL
110 120 130 140 150
RSLEHLDLSN NHLSNLSSSW FRPLSSLKFL NLLGSTYKTL GETSLFSHLT
160 170 180 190 200
NLRILKVGNI HFTEIQGKDF AGLTFLEELE IDATNLQRYE PKSFKSIQNI
210 220 230 240 250
SHLILRMKQP VLLPEIILDT LSSLEYLELR DTYLNTFHFA EVSDPETNTL
260 270 280 290 300
IKKFTFRNVK ITDESFDEIV KLLNYISGVS EAEFDECTLD GLGEFRTPDI
310 320 330 340 350
DKIKVIGKLE TLTIRRLRIP QFYLFRDLSS IYSLTERVKR ITIENSKVFL
360 370 380 390 400
VPCSLSRHLK SLEYLDLSDN LMVEEYLKNS ACERAWPSLQ TLILRQNHLT
410 420 430 440 450
SLGKTGETLL TLKNLTKLDI SKNSFHSMPE TCQWPEKMKY LNLSSIRIDR
460 470 480 490 500
LTQCIPQTLE VLDISNNNLN SFSLILPQVK ELYISRNKLK TLPDASFLPM
510 520 530 540 550
LLVMRISRKT INTFSKEQLD SFQKLKTLEA GGNNFICSCE FLSFTQEEQA
560 570 580 590 600
LDQILIDWPE NYLCDSPSHV RGQRVQDTHL SVSECHRTAL VSAVCCALFL
610 620 630 640 650
SILLTGVLCH HFHGLWYMKM MWAWLQAKRK PRTAPQRDIC YDAFVSYSER
660 670 680 690 700
DSYWVENLMV QELEHFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTI
710 720 730 740 750
FVLSENFVKS EWCKYELDFS HFRLFDENND AAILILLEPI DKKAIPQRFC
760 770 780
KLRKIMNTKT YLEWPTDEAQ QEGFWLNLRA AIKS
Length:784
Mass (Da):90,164
Last modified:July 5, 2004 - v1
Checksum:i6E170C4DF7FDE5D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY429602 mRNA Translation: AAR08196.1
RefSeqiNP_001075265.1, NM_001081796.1
UniGeneiEca.12774

Genome annotation databases

GeneIDi100009701
KEGGiecb:100009701

Similar proteinsi

Entry informationi

Entry nameiTLR2_HORSE
AccessioniPrimary (citable) accession number: Q6T752
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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