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Q6T6T4

- CYT_BITGA

UniProt

Q6T6T4 - CYT_BITGA

Protein

Bitiscystatin

Gene
N/A
Organism
Bitis gabonica (Gaboon adder) (Gaboon viper)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Inhibits various C1 cysteine proteases including cathepsin L, papain and cathepsin B. This protein has no toxic activity and its function in the venom is unknown. It may play a role as housekeeping or regulatory protein By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei29 – 291Reactive siteBy similarity

    GO - Molecular functioni

    1. cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Thiol protease inhibitor

    Protein family/group databases

    MEROPSiI25.012.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bitiscystatin
    Short name:
    Cystatin
    OrganismiBitis gabonica (Gaboon adder) (Gaboon viper)
    Taxonomic identifieri8694 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeBitis

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 26261 PublicationAdd
    BLAST
    Chaini27 – 140114BitiscystatinPRO_0000319471Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi91 ↔ 107By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ6T6T4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 129101CystatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi73 – 775Secondary area of contact

    Sequence similaritiesi

    Belongs to the cystatin family.Curated
    Contains 1 cystatin domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG009556.

    Family and domain databases

    InterProiIPR027214. Cystatin.
    IPR000010. Prot_inh_cystat.
    IPR020381. Prot_inh_cystat_cons-reg.
    IPR018073. Prot_inh_cystat_CS.
    [Graphical view]
    PANTHERiPTHR11413. PTHR11413. 1 hit.
    PfamiPF00031. Cystatin. 1 hit.
    [Graphical view]
    ProDomiPD001231. Prot_inh_cystat_cons-reg. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00043. CY. 1 hit.
    [Graphical view]
    PROSITEiPS00287. CYSTATIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6T6T4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHSRLLVAAP HCLLLLLLLP SALPALKVGG LYPRDVMDPE VQEAAAFAVE    50
    NYNAQSTNDN YFKARRIVEA QSQVVSGVKY YLKMELAKTT CKKIAGKPKL 100
    YQEIQNCNLP PENQQEEITC HFEVWSRPWL QKTVLTKDEL 140
    Length:140
    Mass (Da):15,900
    Last modified:July 5, 2004 - v1
    Checksum:i771DA8853F7D7CE9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY430403 mRNA. Translation: AAR24527.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY430403 mRNA. Translation: AAR24527.1 .

    3D structure databases

    ProteinModelPortali Q6T6T4.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I25.012.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG009556.

    Family and domain databases

    InterProi IPR027214. Cystatin.
    IPR000010. Prot_inh_cystat.
    IPR020381. Prot_inh_cystat_cons-reg.
    IPR018073. Prot_inh_cystat_CS.
    [Graphical view ]
    PANTHERi PTHR11413. PTHR11413. 1 hit.
    Pfami PF00031. Cystatin. 1 hit.
    [Graphical view ]
    ProDomi PD001231. Prot_inh_cystat_cons-reg. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00043. CY. 1 hit.
    [Graphical view ]
    PROSITEi PS00287. CYSTATIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bitis gabonica (Gaboon viper) snake venom gland: toward a catalog for the full-length transcripts (cDNA) and proteins."
      Francischetti I.M.B., My-Pham V., Harrison J., Garfield M.K., Ribeiro J.M.C.
      Gene 337:55-69(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Venom gland.
    2. "Snake venomics of Bitis gabonica gabonica. Protein family composition, subunit organization of venom toxins, and characterization of dimeric disintegrins bitisgabonin-1 and bitisgabonin-2."
      Calvete J.J., Marcinkiewicz C., Sanz L.
      J. Proteome Res. 6:326-336(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-41, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Venom.

    Entry informationi

    Entry nameiCYT_BITGA
    AccessioniPrimary (citable) accession number: Q6T6T4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3