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Q6T6T4

- CYT_BITGA

UniProt

Q6T6T4 - CYT_BITGA

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Protein
Bitiscystatin
Gene
N/A
Organism
Bitis gabonica (Gaboon adder) (Gaboon viper)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits various C1 cysteine proteases including cathepsin L, papain and cathepsin B. This protein has no toxic activity and its function in the venom is unknown. It may play a role as housekeeping or regulatory protein By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei29 – 291Reactive site By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.012.

Names & Taxonomyi

Protein namesi
Recommended name:
Bitiscystatin
Short name:
Cystatin
OrganismiBitis gabonica (Gaboon adder) (Gaboon viper)
Taxonomic identifieri8694 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeBitis

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 Publication
Add
BLAST
Chaini27 – 140114Bitiscystatin
PRO_0000319471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi91 ↔ 107 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6T6T4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 129101Cystatin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi73 – 775Secondary area of contact

Sequence similaritiesi

Belongs to the cystatin family.
Contains 1 cystatin domain.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG009556.

Family and domain databases

InterProiIPR027214. Cystatin.
IPR000010. Prot_inh_cystat.
IPR020381. Prot_inh_cystat_cons-reg.
IPR018073. Prot_inh_cystat_CS.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
ProDomiPD001231. Prot_inh_cystat_cons-reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6T6T4-1 [UniParc]FASTAAdd to Basket

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MHSRLLVAAP HCLLLLLLLP SALPALKVGG LYPRDVMDPE VQEAAAFAVE    50
NYNAQSTNDN YFKARRIVEA QSQVVSGVKY YLKMELAKTT CKKIAGKPKL 100
YQEIQNCNLP PENQQEEITC HFEVWSRPWL QKTVLTKDEL 140
Length:140
Mass (Da):15,900
Last modified:July 5, 2004 - v1
Checksum:i771DA8853F7D7CE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY430403 mRNA. Translation: AAR24527.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY430403 mRNA. Translation: AAR24527.1 .

3D structure databases

ProteinModelPortali Q6T6T4.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I25.012.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG009556.

Family and domain databases

InterProi IPR027214. Cystatin.
IPR000010. Prot_inh_cystat.
IPR020381. Prot_inh_cystat_cons-reg.
IPR018073. Prot_inh_cystat_CS.
[Graphical view ]
PANTHERi PTHR11413. PTHR11413. 1 hit.
Pfami PF00031. Cystatin. 1 hit.
[Graphical view ]
ProDomi PD001231. Prot_inh_cystat_cons-reg. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00043. CY. 1 hit.
[Graphical view ]
PROSITEi PS00287. CYSTATIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bitis gabonica (Gaboon viper) snake venom gland: toward a catalog for the full-length transcripts (cDNA) and proteins."
    Francischetti I.M.B., My-Pham V., Harrison J., Garfield M.K., Ribeiro J.M.C.
    Gene 337:55-69(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Venom gland.
  2. "Snake venomics of Bitis gabonica gabonica. Protein family composition, subunit organization of venom toxins, and characterization of dimeric disintegrins bitisgabonin-1 and bitisgabonin-2."
    Calvete J.J., Marcinkiewicz C., Sanz L.
    J. Proteome Res. 6:326-336(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-41, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Venom.

Entry informationi

Entry nameiCYT_BITGA
AccessioniPrimary (citable) accession number: Q6T6T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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