Q6T6T4 (CYT_BITGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Cystatin
Organism	Bitis gabonica (Gaboon adder) (Gaboon viper)
Taxonomic identifier	8694 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Lepidosauria › Squamata › Scleroglossa › Serpentes › Colubroidea › Viperidae › Viperinae › Bitis

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted Ref.2.
Tissue specificity	Expressed by the venom gland. Ref.2
Sequence similarities	Belongs to the cystatin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Protease inhibitor Thiol protease inhibitor
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 140	116	Cystatin		PRO_0000319471
Regions
	Motif	73 – 77	5	Secondary area of contact
Sites
	Site	29	1	Reactive site By similarity
Amino acid modifications
	Disulfide bond	91 ↔ 107		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6T6T4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 771DA8853F7D7CE9	FASTA	140	15,900
	10 20 30 40 50 60 MHSRLLVAAP HCLLLLLLLP SALPALKVGG LYPRDVMDPE VQEAAAFAVE NYNAQSTNDN 70 80 90 100 110 120 YFKARRIVEA QSQVVSGVKY YLKMELAKTT CKKIAGKPKL YQEIQNCNLP PENQQEEITC 130 140 HFEVWSRPWL QKTVLTKDEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bitis gabonica (Gaboon viper) snake venom gland: toward a catalog for the full-length transcripts (cDNA) and proteins." Francischetti I.M.B., My-Pham V., Harrison J., Garfield M.K., Ribeiro J.M.C. Gene 337:55-69(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Venom gland.
[2]	"Snake venomics of Bitis gabonica gabonica. Protein family composition, subunit organization of venom toxins, and characterization of dimeric disintegrins bitisgabonin-1 and bitisgabonin-2." Calvete J.J., Marcinkiewicz C., Sanz L. J. Proteome Res. 6:326-336(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 66-79, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY. Tissue: Venom.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY430403 mRNA. Translation: AAR24527.1.
3D structure databases
HSSP	HSSP built from PDB template 1YVB based on UniProtKB P01038.
ProteinModelPortal	Q6T6T4.
ModBase	Search...
Protein family/group databases
MEROPS	I25.012.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG009556.
Family and domain databases
InterPro	IPR027214. Cystatin. IPR000010. Prot_inh_cystat. IPR020381. Prot_inh_cystat_cons-reg. IPR018073. Prot_inh_cystat_CS. [Graphical view]
PANTHER	PTHR11413. PTHR11413. 1 hit.
Pfam	PF00031. Cystatin. 1 hit. [Graphical view]
ProDom	PD001231. Prot_inh_cystat_cons-reg. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00043. CY. 1 hit. [Graphical view]
PROSITE	PS00287. CYSTATIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYT_BITGA

Accession

Primary (citable) accession number: Q6T6T4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 5, 2004
Last modified:	March 6, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program