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Q6T6T4 (CYT_BITGA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bitiscystatin

Short name=Cystatin
OrganismBitis gabonica (Gaboon adder) (Gaboon viper)
Taxonomic identifier8694 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeBitis

Protein attributes

Sequence length140 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits various C1 cysteine proteases including cathepsin L, papain and cathepsin B. This protein has no toxic activity and its function in the venom is unknown. It may play a role as housekeeping or regulatory protein By similarity.

Subcellular location

Secreted Ref.2.

Tissue specificity

Expressed by the venom gland. Ref.2

Sequence similarities

Belongs to the cystatin family.

Contains 1 cystatin domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionProtease inhibitor
Thiol protease inhibitor
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Ref.2
Chain27 – 140114Bitiscystatin
PRO_0000319471

Regions

Domain29 – 129101Cystatin
Motif73 – 775Secondary area of contact

Sites

Site291Reactive site By similarity

Amino acid modifications

Disulfide bond91 ↔ 107 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6T6T4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 771DA8853F7D7CE9

FASTA14015,900
        10         20         30         40         50         60 
MHSRLLVAAP HCLLLLLLLP SALPALKVGG LYPRDVMDPE VQEAAAFAVE NYNAQSTNDN 

        70         80         90        100        110        120 
YFKARRIVEA QSQVVSGVKY YLKMELAKTT CKKIAGKPKL YQEIQNCNLP PENQQEEITC 

       130        140 
HFEVWSRPWL QKTVLTKDEL 

« Hide

References

« Hide 'large scale' references
[1]"Bitis gabonica (Gaboon viper) snake venom gland: toward a catalog for the full-length transcripts (cDNA) and proteins."
Francischetti I.M.B., My-Pham V., Harrison J., Garfield M.K., Ribeiro J.M.C.
Gene 337:55-69(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Venom gland.
[2]"Snake venomics of Bitis gabonica gabonica. Protein family composition, subunit organization of venom toxins, and characterization of dimeric disintegrins bitisgabonin-1 and bitisgabonin-2."
Calvete J.J., Marcinkiewicz C., Sanz L.
J. Proteome Res. 6:326-336(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 27-41, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Venom.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY430403 mRNA. Translation: AAR24527.1.

3D structure databases

ProteinModelPortalQ6T6T4.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI25.012.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG009556.

Family and domain databases

InterProIPR027214. Cystatin.
IPR000010. Prot_inh_cystat.
IPR020381. Prot_inh_cystat_cons-reg.
IPR018073. Prot_inh_cystat_CS.
[Graphical view]
PANTHERPTHR11413. PTHR11413. 1 hit.
PfamPF00031. Cystatin. 1 hit.
[Graphical view]
ProDomPD001231. Prot_inh_cystat_cons-reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00043. CY. 1 hit.
[Graphical view]
PROSITEPS00287. CYSTATIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYT_BITGA
AccessionPrimary (citable) accession number: Q6T6T4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families