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Protein

Disintegrin gabonin-1

Gene
N/A
Organism
Bitis gabonica (Gaboon adder) (Gaboon viper)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The heterodimer bitisgabonin-1 is a potent inhibitor of the adhesion of the RGD-dependent integrin alpha-5/beta-1 (ITGA5/ITGB1) to immobilized fibronectin.1 Publication

Keywordsi

Molecular functionCell adhesion impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin gabonin-1
Alternative name(s):
Bitisgabonin-1
OrganismiBitis gabonica (Gaboon adder) (Gaboon viper)
Taxonomic identifieri8694 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeBitis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000032188021 – 471 PublicationAdd BLAST27
ChainiPRO_000032188148 – 128Disintegrin gabonin-1Add BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 76PROSITE-ProRule annotation
Disulfide bondi54Interchain (with C-265 in bitisgabonin)PROSITE-ProRule annotation
Disulfide bondi59Interchain (with C-270 in bitisgabonin)PROSITE-ProRule annotation
Disulfide bondi67 ↔ 73PROSITE-ProRule annotation
Disulfide bondi72 ↔ 97PROSITE-ProRule annotation
Disulfide bondi85 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Interactioni

Subunit structurei

Heterodimer with bitisgabonin (bitisgabonin-1 is the name of the heterodimer); disulfide-linked.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6T6T3.
SMRiQ6T6T3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 112DisintegrinPROSITE-ProRule annotationAdd BLAST66

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi89 – 91Cell attachment site3

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG051359.

Family and domain databases

Gene3Di4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR036436. Disintegrin_dom_sf.
PfamiView protein in Pfam
PF00200. Disintegrin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6T6T3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQVLLVIIC LAVFPYQGSS IILESGNVND YEIVYPKKVT VLPTGAMNSA
60 70 80 90 100
HPCCDPVTCK PKRGEHCISG PCCRNCKFLN AGTICKRGRG DSLHDYCTGV
110 120
TPDCPRNPNK GESDELEWSA AATGSVLM
Length:128
Mass (Da):13,792
Last modified:July 5, 2004 - v1
Checksum:iD283972AA0FB58EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY430404 mRNA. Translation: AAR24528.1.

Similar proteinsi

Entry informationi

Entry nameiDID1_BITGA
AccessioniPrimary (citable) accession number: Q6T6T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families