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Q6T6K9 (XYLA_FERGO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Xylose isomerase
EC=5.3.1.5
Gene names
Name:xylA
OrganismFervidobacterium gondwanense
Taxonomic identifier44754 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Fervidobacterium

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-xylose = D-xylulose. HAMAP-Rule MF_00455

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the xylose isomerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Pentose shunt
Xylose metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
Gene Ontology (GO)
   Biological_processD-xylose metabolic process

Inferred from electronic annotation. Source: HAMAP

pentose-phosphate shunt

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: HAMAP

xylose isomerase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Xylose isomerase HAMAP-Rule MF_00455
PRO_0000195778

Sites

Active site971 By similarity
Active site1001 By similarity
Metal binding2281Magnesium 1 By similarity
Metal binding2641Magnesium 1 By similarity
Metal binding2641Magnesium 2 By similarity
Metal binding2671Magnesium 2 By similarity
Metal binding2921Magnesium 1 By similarity
Metal binding3031Magnesium 2 By similarity
Metal binding3051Magnesium 2 By similarity
Metal binding3341Magnesium 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6T6K9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: DA371167297A475C

FASTA43349,696
        10         20         30         40         50         60 
MYFNVEKVVY EGPSSKNLLA YKFYNPEEEI AGKKMRDWFR FAVAYWHTFN SRGEDPFGSA 

        70         80         90        100        110        120 
TFERPWFKKD PMDTAFAKVD ALFEFCEKTG VEYFTFHDRD LAHEGLTLRE SNKILDKVVE 

       130        140        150        160        170        180 
KIKEYMKSSN VKLLWGTANL FSHPRYAQGA ATSPNPLVFS YAASQVKKML DVTKELGGLG 

       190        200        210        220        230        240 
YVLWGGREGY DNLLLTDSAL EEKLFARFLE MVVEYKERIG FNGVLMIEPK PKEPTKHQYD 

       250        260        270        280        290        300 
FDASTVLYFL KKHNLFEHFK LNIEANHATL AGHTFAHELR VARLNGKLGS IDANRGDLLL 

       310        320        330        340        350        360 
GWDTDQFPTD VYETTFAMYE VLENNGLDCG FNFDAKVRRA SIDPEDIVYA HVSSMDAFAL 

       370        380        390        400        410        420 
GLKLAVKLRE KVKPMIEERY SEYNSEIGMK ILEGKTTLDE LSSYVEDLTD VRVKSLKQEL 

       430 
LEMVINDVIF GGR

« Hide

References

[1]"Isolation, expression and characterization of a glucose isomerase produced by the thermophilic bacterium Fervidobacterium gondwanense."
Kluskens L., Geerling A.C.M., Zeilstra J., de Vos W.M., van der Oost J. IV
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY431100 Genomic DNA. Translation: AAR07504.1.

3D structure databases

ProteinModelPortalQ6T6K9.
SMRQ6T6K9. Positions 5-429.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.20.20.150. 1 hit.
HAMAPMF_00455. Xylose_isom_A.
InterProIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSPR00688. XYLOSISMRASE.
SUPFAMSSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMsTIGR02630. xylose_isom_A. 1 hit.
PROSITEPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXYLA_FERGO
AccessionPrimary (citable) accession number: Q6T6K9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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