Reviewed, UniProtKB/Swiss-Prot Q6T627 (OXLA_BITGA)

Names and origin

Protein names	Recommended name:     L-amino-acid oxidase       Short name=LAAO       Short name=LAO     EC=1.4.3.2
Organism	Bitis gabonica (Gaboon adder) (Gaboon viper)
Taxonomic identifier	8694 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Scleroglossa › Serpentes › Colubroidea › Viperidae › Viperinae › Bitis

Protein attributes

Sequence length	60 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids. Inhibits platelet aggregation. Has an ability to induce apoptosis and hemorrhage. Has an antibacterial activity By similarity.
Catalytic activity	An L-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2).
Cofactor	FAD By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	SecretedBy similarity.
Tissue specificity	Expressed by the venom gland.
Post-translational modification	Glycosylated By similarity.
Sequence similarities	Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

Ontologies

Keywords
Biological process	Apoptosis Blood coagulation
Cellular component	Secreted
Ligand	FAD Flavoprotein
Molecular function	Antibiotic Antimicrobial Oxidoreductase Toxin
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW blood coagulation Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-amino-acid oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›60	›60	L-amino-acid oxidase		PRO_0000315371
Regions
	Nucleotide binding	3 – 4	2	FAD By similarity
Sites
	Binding site	4	1	Substrate By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	60	1

Sequences

	Sequence		Length	Mass (Da)
	Q6T627-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 584937BED0A03B07	FASTA	60	7,323
	10 20 30 40 50 60 GPMRIPEKHR IVREYIRKFG LQLNEFVQET ENAWYYIKNI RKKVHEVKKD PGLLKYPVKP

References

[1]

"Bitis gabonica (Gaboon viper) snake venom gland: toward a catalog for the full-length transcripts (cDNA) and proteins." Francischetti I.M.B., My-Pham V., Harrison J., Garfield M.K., Ribeiro J.M.C. Gene 337:55-69(2004) [PubMed: 15276202] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Venom gland.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY434453 mRNA. Translation: AAR07363.1.
3D structure databases
SMR	Q6T627. Positions 1-60.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q6T627.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

OXLA_BITGA

Accession

Primary (citable) accession number: Q6T627

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	November 4, 2008
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Tox-Prot (Toxin Annotation Project)