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Protein

Phospholipid phosphatase-related protein type 3

Gene

PLPPR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciZFISH:HS13315-MONOMER.
BRENDAi3.1.3.4. 2681.
ReactomeiR-HSA-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 3Curated (EC:3.1.3.4)
Alternative name(s):
Lipid phosphate phosphatase-related protein type 31 Publication
PAP-2-like protein 21 Publication
Plasticity-related gene 2 protein1 Publication
Short name:
PRG-21 Publication
Gene namesi
Name:PLPPR3Imported
Synonyms:LPPR31 Publication, PHP21 Publication, PRG2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23497. PLPPR3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000129951.

Polymorphism and mutation databases

BioMutaiLPPR3.
DMDMi74723394.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175291 – 718Phospholipid phosphatase-related protein type 3Add BLAST718

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Glycosylationi318N-linked (GlcNAc...)Sequence analysis1
Modified residuei322PhosphoserineBy similarity1
Modified residuei353PhosphoserineBy similarity1
Modified residuei376PhosphothreonineBy similarity1
Modified residuei428PhosphoserineBy similarity1
Modified residuei508PhosphoserineBy similarity1
Modified residuei641PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ6T4P5.
PaxDbiQ6T4P5.
PeptideAtlasiQ6T4P5.
PRIDEiQ6T4P5.

PTM databases

DEPODiQ6T4P5.
iPTMnetiQ6T4P5.
PhosphoSitePlusiQ6T4P5.

Expressioni

Gene expression databases

BgeeiENSG00000129951.
CleanExiHS_PRG2.
ExpressionAtlasiQ6T4P5. baseline and differential.
GenevisibleiQ6T4P5. HS.

Organism-specific databases

HPAiHPA052293.
HPA057034.

Interactioni

Protein-protein interaction databases

BioGridi123019. 6 interactors.
IntActiQ6T4P5. 2 interactors.
MINTiMINT-1383426.
STRINGi9606.ENSP00000352962.

Structurei

3D structure databases

ProteinModelPortaliQ6T4P5.
SMRiQ6T4P5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi437 – 461Glu-richAdd BLAST25
Compositional biasi558 – 567Poly-Ser10

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITB3. Eukaryota.
ENOG410ZZ6F. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000043094.
HOVERGENiHBG103365.
InParanoidiQ6T4P5.
KOiK19582.
OMAiAKWLMMA.
PhylomeDBiQ6T4P5.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028685. LPPR3.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF14. PTHR10165:SF14. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6T4P5-1) [UniParc]FASTAAdd to basket
Also known as: PRG-2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISTKEKNKI PKDSMTLLPC FYFVELPIVA SSIVSLYFLE LTDLFKPAKV
60 70 80 90 100
GFQCYDRTLS MPYVETNEEL IPLLMLLSLA FAAPAASIMV AEGMLYCLQS
110 120 130 140 150
RLWGRAGGPA GAEGSINAGG CNFNSFLRRT VRFVGVHVFG LCATALVTDV
160 170 180 190 200
IQLATGYHTP FFLTVCKPNY TLLGTSCEVN PYITQDICSG HDIHAILSAR
210 220 230 240 250
KTFPSQHATL SAFAAVYVSM YFNSVISDTT KLLKPILVFA FAIAAGVCGL
260 270 280 290 300
TQITQYRSHP VDVYAGFLIG AGIAAYLACH AVGNFQAPPA EKPAAPAPAK
310 320 330 340 350
DALRALTQRG HDSVYQQNKS VSTDELGPPG RLEGAPRPVA REKTSLGSLK
360 370 380 390 400
RASVDVDLLA PRSPMAKENM VTFSHTLPRA SAPSLDDPAR RHMTIHVPLD
410 420 430 440 450
ASRSKQLISE WKQKSLEGRG LGLPDDASPG HLRAPAEPMA EEEEEEEDEE
460 470 480 490 500
EEEEEEEEED EGPAPPSLYP TVQARPGLGP RVILPPRAGP PPLVHIPEEG
510 520 530 540 550
AQTGAGLSPK SGAGVRAKWL MMAEKSGAAV ANPPRLLQVI AMSKAPGAPG
560 570 580 590 600
PKAAETASSS SASSDSSQYR SPSDRDSASI VTIDAHAPHH PVVHLSAGGA
610 620 630 640 650
PWEWKAAGGG AKAEADGGYE LGDLARGFRG GAKPPGVSPG SSVSDVDQEE
660 670 680 690 700
PRFGAVATVN LATGEGLPPL GAADGALGPG SRESTLRRHA GGLGLAEREA
710
EAEAEGYFRK MQARRFPD
Length:718
Mass (Da):76,037
Last modified:July 5, 2004 - v1
Checksum:i8F065B5D48D2447D
GO
Isoform 2 (identifier: Q6T4P5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-134: V → VG

Show »
Length:719
Mass (Da):76,094
Checksum:i1624D8A4139DAE6D
GO
Isoform 3 (identifier: Q6T4P5-3) [UniParc]FASTAAdd to basket
Also known as: PRG-2b

The sequence of this isoform differs from the canonical sequence as follows:
     219-219: S → SVSPAPHCPSQALLLTRGEPSLTPTPMPQ

Show »
Length:746
Mass (Da):78,946
Checksum:i4E34F82BA0A8C472
GO
Isoform 4 (identifier: Q6T4P5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-392: Missing.

Show »
Length:326
Mass (Da):33,787
Checksum:i8B6A6F7C76CDDD5A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038544193I → T.Corresponds to variant rs1540615dbSNPEnsembl.1
Natural variantiVAR_038545690A → V.Corresponds to variant rs3746136dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0310041 – 392Missing in isoform 4. 1 PublicationAdd BLAST392
Alternative sequenceiVSP_031005134V → VG in isoform 2. 1 Publication1
Alternative sequenceiVSP_031006219S → SVSPAPHCPSQALLLTRGEP SLTPTPMPQ in isoform 3. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541282 mRNA. Translation: AAP57771.1.
AY436785 mRNA. Translation: AAR10818.1.
AF357888 mRNA. Translation: AAO85401.1.
AY304517 mRNA. Translation: AAP72154.1.
AL136596 mRNA. Translation: CAB66531.1.
AK021597 mRNA. Translation: BAB13851.1.
BC012339 mRNA. Translation: AAH12339.1.
CCDSiCCDS12043.1. [Q6T4P5-3]
CCDS58636.1. [Q6T4P5-1]
RefSeqiNP_001257295.1. NM_001270366.1. [Q6T4P5-1]
NP_079164.1. NM_024888.2. [Q6T4P5-3]
XP_011526619.1. XM_011528317.2. [Q6T4P5-3]
UniGeneiHs.546439.
Hs.745399.

Genome annotation databases

EnsembliENST00000359894; ENSP00000352962; ENSG00000129951. [Q6T4P5-3]
ENST00000520876; ENSP00000430297; ENSG00000129951. [Q6T4P5-1]
GeneIDi79948.
KEGGihsa:79948.
UCSCiuc002lpx.3. human. [Q6T4P5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541282 mRNA. Translation: AAP57771.1.
AY436785 mRNA. Translation: AAR10818.1.
AF357888 mRNA. Translation: AAO85401.1.
AY304517 mRNA. Translation: AAP72154.1.
AL136596 mRNA. Translation: CAB66531.1.
AK021597 mRNA. Translation: BAB13851.1.
BC012339 mRNA. Translation: AAH12339.1.
CCDSiCCDS12043.1. [Q6T4P5-3]
CCDS58636.1. [Q6T4P5-1]
RefSeqiNP_001257295.1. NM_001270366.1. [Q6T4P5-1]
NP_079164.1. NM_024888.2. [Q6T4P5-3]
XP_011526619.1. XM_011528317.2. [Q6T4P5-3]
UniGeneiHs.546439.
Hs.745399.

3D structure databases

ProteinModelPortaliQ6T4P5.
SMRiQ6T4P5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123019. 6 interactors.
IntActiQ6T4P5. 2 interactors.
MINTiMINT-1383426.
STRINGi9606.ENSP00000352962.

PTM databases

DEPODiQ6T4P5.
iPTMnetiQ6T4P5.
PhosphoSitePlusiQ6T4P5.

Polymorphism and mutation databases

BioMutaiLPPR3.
DMDMi74723394.

Proteomic databases

EPDiQ6T4P5.
PaxDbiQ6T4P5.
PeptideAtlasiQ6T4P5.
PRIDEiQ6T4P5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359894; ENSP00000352962; ENSG00000129951. [Q6T4P5-3]
ENST00000520876; ENSP00000430297; ENSG00000129951. [Q6T4P5-1]
GeneIDi79948.
KEGGihsa:79948.
UCSCiuc002lpx.3. human. [Q6T4P5-1]

Organism-specific databases

CTDi79948.
GeneCardsiLPPR3.
H-InvDBHIX0014563.
HGNCiHGNC:23497. PLPPR3.
HPAiHPA052293.
HPA057034.
MIMi610391. gene.
neXtProtiNX_Q6T4P5.
OpenTargetsiENSG00000129951.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITB3. Eukaryota.
ENOG410ZZ6F. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000043094.
HOVERGENiHBG103365.
InParanoidiQ6T4P5.
KOiK19582.
OMAiAKWLMMA.
PhylomeDBiQ6T4P5.

Enzyme and pathway databases

BioCyciZFISH:HS13315-MONOMER.
BRENDAi3.1.3.4. 2681.
ReactomeiR-HSA-419408. Lysosphingolipid and LPA receptors.

Miscellaneous databases

GenomeRNAii79948.
PROiQ6T4P5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129951.
CleanExiHS_PRG2.
ExpressionAtlasiQ6T4P5. baseline and differential.
GenevisibleiQ6T4P5. HS.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028685. LPPR3.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF14. PTHR10165:SF14. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLPR3_HUMAN
AccessioniPrimary (citable) accession number: Q6T4P5
Secondary accession number(s): Q86XQ4
, Q96EH1, Q9BQF9, Q9HAJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.