Reviewed, UniProtKB/Swiss-Prot Q6T4P5 (LPPR3_HUMAN)

Names and origin

Protein names

Recommended name:
    Lipid phosphate phosphatase-related protein type 3
    EC=3.1.3.4
Alternative name(s):
    PAP-2-like protein 2
    Plasticity-related gene 2 protein
      Short name=PRG-2

Gene names

Name:	LPPR3
Synonyms:	PHP2, PRG2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	718 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6T4P5-1)

Also known as: PRG-2a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6T4P5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     134-134: V → VG

Isoform 3 (identifier: Q6T4P5-3)

Also known as: PRG-2b;

The sequence of this isoform differs from the canonical sequence as follows:
     219-219: S → SVSPAPHCPSQALLLTRGEPSLTPTPMPQ

Isoform 4 (identifier: Q6T4P5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-392: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 718	718	Lipid phosphate phosphatase-related protein type 3		PRO_0000317529
Regions
	Transmembrane	18 – 38	21	Potential
	Transmembrane	70 – 90	21	Potential
	Transmembrane	133 – 153	21	Potential
	Transmembrane	207 – 227	21	Potential
	Transmembrane	233 – 253	21	Potential
	Transmembrane	263 – 283	21	Potential
	Compositional bias	437 – 461	25	Glu-rich
	Compositional bias	558 – 567	10	Poly-Ser
Amino acid modifications
	Glycosylation	169	1	N-linked (GlcNAc...) Potential
	Glycosylation	318	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 392	392	Missing in isoform 4.		VSP_031004
	Alternative sequence	134	1	V → VG in isoform 2.		VSP_031005
	Alternative sequence	219	1	S → SVSPAPHCPSQALLLTRGEP SLTPTPMPQ in isoform 3.		VSP_031006
	Natural variant	193	1	I → T: dbSNP rs1540615.		VAR_038544
	Natural variant	690	1	A → V: dbSNP rs3746136.		VAR_038545

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (PRG-2a) [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 8F065B5D48D2447D	FASTA	718	76,037
	10 20 30 40 50 60 MISTKEKNKI PKDSMTLLPC FYFVELPIVA SSIVSLYFLE LTDLFKPAKV GFQCYDRTLS 70 80 90 100 110 120 MPYVETNEEL IPLLMLLSLA FAAPAASIMV AEGMLYCLQS RLWGRAGGPA GAEGSINAGG 130 140 150 160 170 180 CNFNSFLRRT VRFVGVHVFG LCATALVTDV IQLATGYHTP FFLTVCKPNY TLLGTSCEVN 190 200 210 220 230 240 PYITQDICSG HDIHAILSAR KTFPSQHATL SAFAAVYVSM YFNSVISDTT KLLKPILVFA 250 260 270 280 290 300 FAIAAGVCGL TQITQYRSHP VDVYAGFLIG AGIAAYLACH AVGNFQAPPA EKPAAPAPAK 310 320 330 340 350 360 DALRALTQRG HDSVYQQNKS VSTDELGPPG RLEGAPRPVA REKTSLGSLK RASVDVDLLA 370 380 390 400 410 420 PRSPMAKENM VTFSHTLPRA SAPSLDDPAR RHMTIHVPLD ASRSKQLISE WKQKSLEGRG 430 440 450 460 470 480 LGLPDDASPG HLRAPAEPMA EEEEEEEDEE EEEEEEEEED EGPAPPSLYP TVQARPGLGP 490 500 510 520 530 540 RVILPPRAGP PPLVHIPEEG AQTGAGLSPK SGAGVRAKWL MMAEKSGAAV ANPPRLLQVI 550 560 570 580 590 600 AMSKAPGAPG PKAAETASSS SASSDSSQYR SPSDRDSASI VTIDAHAPHH PVVHLSAGGA 610 620 630 640 650 660 PWEWKAAGGG AKAEADGGYE LGDLARGFRG GAKPPGVSPG SSVSDVDQEE PRFGAVATVN 670 680 690 700 710 LATGEGLPPL GAADGALGPG SRESTLRRHA GGLGLAEREA EAEAEGYFRK MQARRFPD
	Isoform 2. Checksum: 1624D8A4139DAE6D	FASTA	719	76,094
	10 20 30 40 50 60 MISTKEKNKI PKDSMTLLPC FYFVELPIVA SSIVSLYFLE LTDLFKPAKV GFQCYDRTLS 70 80 90 100 110 120 MPYVETNEEL IPLLMLLSLA FAAPAASIMV AEGMLYCLQS RLWGRAGGPA GAEGSINAGG 130 140 150 160 170 180 CNFNSFLRRT VRFVGGVHVF GLCATALVTD VIQLATGYHT PFFLTVCKPN YTLLGTSCEV 190 200 210 220 230 240 NPYITQDICS GHDIHAILSA RKTFPSQHAT LSAFAAVYVS MYFNSVISDT TKLLKPILVF 250 260 270 280 290 300 AFAIAAGVCG LTQITQYRSH PVDVYAGFLI GAGIAAYLAC HAVGNFQAPP AEKPAAPAPA 310 320 330 340 350 360 KDALRALTQR GHDSVYQQNK SVSTDELGPP GRLEGAPRPV AREKTSLGSL KRASVDVDLL 370 380 390 400 410 420 APRSPMAKEN MVTFSHTLPR ASAPSLDDPA RRHMTIHVPL DASRSKQLIS EWKQKSLEGR 430 440 450 460 470 480 GLGLPDDASP GHLRAPAEPM AEEEEEEEDE EEEEEEEEEE DEGPAPPSLY PTVQARPGLG 490 500 510 520 530 540 PRVILPPRAG PPPLVHIPEE GAQTGAGLSP KSGAGVRAKW LMMAEKSGAA VANPPRLLQV 550 560 570 580 590 600 IAMSKAPGAP GPKAAETASS SSASSDSSQY RSPSDRDSAS IVTIDAHAPH HPVVHLSAGG 610 620 630 640 650 660 APWEWKAAGG GAKAEADGGY ELGDLARGFR GGAKPPGVSP GSSVSDVDQE EPRFGAVATV 670 680 690 700 710 NLATGEGLPP LGAADGALGP GSRESTLRRH AGGLGLAERE AEAEAEGYFR KMQARRFPD
	Isoform 3 (PRG-2b). Checksum: 4E34F82BA0A8C472	FASTA	746	78,946
	10 20 30 40 50 60 MISTKEKNKI PKDSMTLLPC FYFVELPIVA SSIVSLYFLE LTDLFKPAKV GFQCYDRTLS 70 80 90 100 110 120 MPYVETNEEL IPLLMLLSLA FAAPAASIMV AEGMLYCLQS RLWGRAGGPA GAEGSINAGG 130 140 150 160 170 180 CNFNSFLRRT VRFVGVHVFG LCATALVTDV IQLATGYHTP FFLTVCKPNY TLLGTSCEVN 190 200 210 220 230 240 PYITQDICSG HDIHAILSAR KTFPSQHATL SAFAAVYVSV SPAPHCPSQA LLLTRGEPSL 250 260 270 280 290 300 TPTPMPQMYF NSVISDTTKL LKPILVFAFA IAAGVCGLTQ ITQYRSHPVD VYAGFLIGAG 310 320 330 340 350 360 IAAYLACHAV GNFQAPPAEK PAAPAPAKDA LRALTQRGHD SVYQQNKSVS TDELGPPGRL 370 380 390 400 410 420 EGAPRPVARE KTSLGSLKRA SVDVDLLAPR SPMAKENMVT FSHTLPRASA PSLDDPARRH 430 440 450 460 470 480 MTIHVPLDAS RSKQLISEWK QKSLEGRGLG LPDDASPGHL RAPAEPMAEE EEEEEDEEEE 490 500 510 520 530 540 EEEEEEEDEG PAPPSLYPTV QARPGLGPRV ILPPRAGPPP LVHIPEEGAQ TGAGLSPKSG 550 560 570 580 590 600 AGVRAKWLMM AEKSGAAVAN PPRLLQVIAM SKAPGAPGPK AAETASSSSA SSDSSQYRSP 610 620 630 640 650 660 SDRDSASIVT IDAHAPHHPV VHLSAGGAPW EWKAAGGGAK AEADGGYELG DLARGFRGGA 670 680 690 700 710 720 KPPGVSPGSS VSDVDQEEPR FGAVATVNLA TGEGLPPLGA ADGALGPGSR ESTLRRHAGG 730 740 LGLAEREAEA EAEGYFRKMQ ARRFPD
	Isoform 4. Checksum: 8B6A6F7C76CDDD5A	FASTA	326	33,787
	10 20 30 40 50 60 MTIHVPLDAS RSKQLISEWK QKSLEGRGLG LPDDASPGHL RAPAEPMAEE EEEEEDEEEE 70 80 90 100 110 120 EEEEEEEDEG PAPPSLYPTV QARPGLGPRV ILPPRAGPPP LVHIPEEGAQ TGAGLSPKSG 130 140 150 160 170 180 AGVRAKWLMM AEKSGAAVAN PPRLLQVIAM SKAPGAPGPK AAETASSSSA SSDSSQYRSP 190 200 210 220 230 240 SDRDSASIVT IDAHAPHHPV VHLSAGGAPW EWKAAGGGAK AEADGGYELG DLARGFRGGA 250 260 270 280 290 300 KPPGVSPGSS VSDVDQEEPR FGAVATVNLA TGEGLPPLGA ADGALGPGSR ESTLRRHAGG 310 320 LGLAEREAEA EAEGYFRKMQ ARRFPD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting." Braeuer A.U., Savaskan N.E., Kuehn H., Prehn S., Ninnemann O., Nitsch R. Nat. Neurosci. 6:572-578(2003) [PubMed: 12730698] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Brain.
[2]	"A new brain specific member of the PAP-2 family." Ninnemann O., Braeuer A.U., Savaskan N., Nitsch R. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
[3]	"Lipid phosphate phosphatase related proteins." Morris A.J., Sigal Y.J., McDermott M., Sciorra V.A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[4]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Amygdala.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Embryo.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-416 (ISOFORM 1). Tissue: Eye.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF541282 mRNA. Translation: AAP57771.1. AY436785 mRNA. Translation: AAR10818.1. AF357888 mRNA. Translation: AAO85401.1. AY304517 mRNA. Translation: AAP72154.1. AL136596 mRNA. Translation: CAB66531.1. AK021597 mRNA. Translation: BAB13851.1. BC012339 mRNA. Translation: AAH12339.1.
IPI	IPI00016464. IPI00419236. IPI00884989. IPI00885019.
RefSeq	NP_079164.1.
UniGene	Hs.546439
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6T4P5. 2 interactions.
PTM databases
PhosphoSite	Q6T4P5.
Genome annotation databases
Ensembl	ENSG00000129951. Homo sapiens. [Contig view]
GeneID	79948.
KEGG	hsa:79948.
Organism-specific databases
GeneCards	GC19M000765.
MIM	610391. gene.
Phylogenomic databases
HOVERGEN	Q6T4P5.
OMA	Q6T4P5. QEEPRFG.
Enzyme and pathway databases
BRENDA	3.1.3.4. 247.
Gene expression databases
ArrayExpress	Q6T4P5.
Bgee	Q6T4P5.
CleanEx	HS_PRG2.
Family and domain databases
InterPro	IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	69912.
SOURCE	Search...

Entry information

Entry name

LPPR3_HUMAN

Accession

Primary (citable) accession number: Q6T4P5
Secondary accession number(s): Q86XQ4 , Q96EH1, Q9BQF9, Q9HAJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)