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Protein

Phospholipid phosphatase-related protein type 3

Gene

PLPPR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.1.3.4. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 3Curated (EC:3.1.3.4)
Alternative name(s):
Lipid phosphate phosphatase-related protein type 31 Publication
PAP-2-like protein 21 Publication
Plasticity-related gene 2 protein1 Publication
Short name:
PRG-21 Publication
Gene namesi
Name:PLPPR3Imported
Synonyms:LPPR31 Publication, PHP21 Publication, PRG2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23497. PLPPR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence analysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence analysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence analysisAdd
BLAST
Transmembranei207 – 22721HelicalSequence analysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiLPPR3.
DMDMi74723394.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 718718Phospholipid phosphatase-related protein type 3PRO_0000317529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis
Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence analysis
Modified residuei322 – 3221PhosphoserineBy similarity
Modified residuei353 – 3531PhosphoserineBy similarity
Modified residuei376 – 3761PhosphothreonineBy similarity
Modified residuei428 – 4281PhosphoserineBy similarity
Modified residuei508 – 5081PhosphoserineBy similarity
Modified residuei641 – 6411PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ6T4P5.
PaxDbiQ6T4P5.
PRIDEiQ6T4P5.

PTM databases

DEPODiQ6T4P5.
iPTMnetiQ6T4P5.
PhosphoSiteiQ6T4P5.

Expressioni

Gene expression databases

BgeeiQ6T4P5.
CleanExiHS_PRG2.
ExpressionAtlasiQ6T4P5. baseline and differential.
GenevisibleiQ6T4P5. HS.

Organism-specific databases

HPAiHPA052293.
HPA057034.

Interactioni

Protein-protein interaction databases

BioGridi123019. 6 interactions.
IntActiQ6T4P5. 2 interactions.
MINTiMINT-1383426.
STRINGi9606.ENSP00000352962.

Structurei

3D structure databases

ProteinModelPortaliQ6T4P5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi437 – 46125Glu-richAdd
BLAST
Compositional biasi558 – 56710Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITB3. Eukaryota.
ENOG410ZZ6F. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000043094.
HOVERGENiHBG103365.
InParanoidiQ6T4P5.
KOiK19582.
OMAiEPMAEEE.
PhylomeDBiQ6T4P5.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028685. LPPR3.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF14. PTHR10165:SF14. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6T4P5-1) [UniParc]FASTAAdd to basket

Also known as: PRG-2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISTKEKNKI PKDSMTLLPC FYFVELPIVA SSIVSLYFLE LTDLFKPAKV
60 70 80 90 100
GFQCYDRTLS MPYVETNEEL IPLLMLLSLA FAAPAASIMV AEGMLYCLQS
110 120 130 140 150
RLWGRAGGPA GAEGSINAGG CNFNSFLRRT VRFVGVHVFG LCATALVTDV
160 170 180 190 200
IQLATGYHTP FFLTVCKPNY TLLGTSCEVN PYITQDICSG HDIHAILSAR
210 220 230 240 250
KTFPSQHATL SAFAAVYVSM YFNSVISDTT KLLKPILVFA FAIAAGVCGL
260 270 280 290 300
TQITQYRSHP VDVYAGFLIG AGIAAYLACH AVGNFQAPPA EKPAAPAPAK
310 320 330 340 350
DALRALTQRG HDSVYQQNKS VSTDELGPPG RLEGAPRPVA REKTSLGSLK
360 370 380 390 400
RASVDVDLLA PRSPMAKENM VTFSHTLPRA SAPSLDDPAR RHMTIHVPLD
410 420 430 440 450
ASRSKQLISE WKQKSLEGRG LGLPDDASPG HLRAPAEPMA EEEEEEEDEE
460 470 480 490 500
EEEEEEEEED EGPAPPSLYP TVQARPGLGP RVILPPRAGP PPLVHIPEEG
510 520 530 540 550
AQTGAGLSPK SGAGVRAKWL MMAEKSGAAV ANPPRLLQVI AMSKAPGAPG
560 570 580 590 600
PKAAETASSS SASSDSSQYR SPSDRDSASI VTIDAHAPHH PVVHLSAGGA
610 620 630 640 650
PWEWKAAGGG AKAEADGGYE LGDLARGFRG GAKPPGVSPG SSVSDVDQEE
660 670 680 690 700
PRFGAVATVN LATGEGLPPL GAADGALGPG SRESTLRRHA GGLGLAEREA
710
EAEAEGYFRK MQARRFPD
Length:718
Mass (Da):76,037
Last modified:July 5, 2004 - v1
Checksum:i8F065B5D48D2447D
GO
Isoform 2 (identifier: Q6T4P5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-134: V → VG

Show »
Length:719
Mass (Da):76,094
Checksum:i1624D8A4139DAE6D
GO
Isoform 3 (identifier: Q6T4P5-3) [UniParc]FASTAAdd to basket

Also known as: PRG-2b

The sequence of this isoform differs from the canonical sequence as follows:
     219-219: S → SVSPAPHCPSQALLLTRGEPSLTPTPMPQ

Show »
Length:746
Mass (Da):78,946
Checksum:i4E34F82BA0A8C472
GO
Isoform 4 (identifier: Q6T4P5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-392: Missing.

Show »
Length:326
Mass (Da):33,787
Checksum:i8B6A6F7C76CDDD5A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti193 – 1931I → T.
Corresponds to variant rs1540615 [ dbSNP | Ensembl ].
VAR_038544
Natural varianti690 – 6901A → V.
Corresponds to variant rs3746136 [ dbSNP | Ensembl ].
VAR_038545

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 392392Missing in isoform 4. 1 PublicationVSP_031004Add
BLAST
Alternative sequencei134 – 1341V → VG in isoform 2. 1 PublicationVSP_031005
Alternative sequencei219 – 2191S → SVSPAPHCPSQALLLTRGEP SLTPTPMPQ in isoform 3. 3 PublicationsVSP_031006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541282 mRNA. Translation: AAP57771.1.
AY436785 mRNA. Translation: AAR10818.1.
AF357888 mRNA. Translation: AAO85401.1.
AY304517 mRNA. Translation: AAP72154.1.
AL136596 mRNA. Translation: CAB66531.1.
AK021597 mRNA. Translation: BAB13851.1.
BC012339 mRNA. Translation: AAH12339.1.
CCDSiCCDS12043.1. [Q6T4P5-3]
CCDS58636.1. [Q6T4P5-1]
RefSeqiNP_001257295.1. NM_001270366.1. [Q6T4P5-1]
NP_079164.1. NM_024888.2. [Q6T4P5-3]
XP_011526619.1. XM_011528317.1. [Q6T4P5-3]
UniGeneiHs.546439.
Hs.745399.

Genome annotation databases

EnsembliENST00000359894; ENSP00000352962; ENSG00000129951. [Q6T4P5-3]
ENST00000520876; ENSP00000430297; ENSG00000129951. [Q6T4P5-1]
GeneIDi79948.
KEGGihsa:79948.
UCSCiuc002lpx.3. human. [Q6T4P5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541282 mRNA. Translation: AAP57771.1.
AY436785 mRNA. Translation: AAR10818.1.
AF357888 mRNA. Translation: AAO85401.1.
AY304517 mRNA. Translation: AAP72154.1.
AL136596 mRNA. Translation: CAB66531.1.
AK021597 mRNA. Translation: BAB13851.1.
BC012339 mRNA. Translation: AAH12339.1.
CCDSiCCDS12043.1. [Q6T4P5-3]
CCDS58636.1. [Q6T4P5-1]
RefSeqiNP_001257295.1. NM_001270366.1. [Q6T4P5-1]
NP_079164.1. NM_024888.2. [Q6T4P5-3]
XP_011526619.1. XM_011528317.1. [Q6T4P5-3]
UniGeneiHs.546439.
Hs.745399.

3D structure databases

ProteinModelPortaliQ6T4P5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123019. 6 interactions.
IntActiQ6T4P5. 2 interactions.
MINTiMINT-1383426.
STRINGi9606.ENSP00000352962.

PTM databases

DEPODiQ6T4P5.
iPTMnetiQ6T4P5.
PhosphoSiteiQ6T4P5.

Polymorphism and mutation databases

BioMutaiLPPR3.
DMDMi74723394.

Proteomic databases

EPDiQ6T4P5.
PaxDbiQ6T4P5.
PRIDEiQ6T4P5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359894; ENSP00000352962; ENSG00000129951. [Q6T4P5-3]
ENST00000520876; ENSP00000430297; ENSG00000129951. [Q6T4P5-1]
GeneIDi79948.
KEGGihsa:79948.
UCSCiuc002lpx.3. human. [Q6T4P5-1]

Organism-specific databases

CTDi79948.
GeneCardsiLPPR3.
H-InvDBHIX0014563.
HGNCiHGNC:23497. PLPPR3.
HPAiHPA052293.
HPA057034.
MIMi610391. gene.
neXtProtiNX_Q6T4P5.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITB3. Eukaryota.
ENOG410ZZ6F. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000043094.
HOVERGENiHBG103365.
InParanoidiQ6T4P5.
KOiK19582.
OMAiEPMAEEE.
PhylomeDBiQ6T4P5.

Enzyme and pathway databases

BRENDAi3.1.3.4. 2681.

Miscellaneous databases

GenomeRNAii79948.
NextBioi69912.
PROiQ6T4P5.
SOURCEiSearch...

Gene expression databases

BgeeiQ6T4P5.
CleanExiHS_PRG2.
ExpressionAtlasiQ6T4P5. baseline and differential.
GenevisibleiQ6T4P5. HS.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028685. LPPR3.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF14. PTHR10165:SF14. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting."
    Braeuer A.U., Savaskan N.E., Kuehn H., Prehn S., Ninnemann O., Nitsch R.
    Nat. Neurosci. 6:572-578(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Brain.
  2. "A new brain specific member of the PAP-2 family."
    Ninnemann O., Braeuer A.U., Savaskan N., Nitsch R.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  3. "Lipid phosphate phosphatase related proteins."
    Morris A.J., Sigal Y.J., McDermott M., Sciorra V.A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Amygdala.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Embryo.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-416 (ISOFORM 1).
    Tissue: Eye.

Entry informationi

Entry nameiPLPR3_HUMAN
AccessioniPrimary (citable) accession number: Q6T4P5
Secondary accession number(s): Q86XQ4
, Q96EH1, Q9BQF9, Q9HAJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: April 13, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.