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Protein

Solute carrier family 22 member 25

Gene

SLC22A25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:G66-32719-MONOMER.

Protein family/group databases

TCDBi2.A.1.19.33. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 25
Alternative name(s):
Organic anion transporter UST6
Gene namesi
Name:SLC22A25Imported
Synonyms:UST61 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:32935. SLC22A25.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 145ExtracellularSequence analysisAdd BLAST115
Transmembranei146 – 166Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini167 – 177CytoplasmicSequence analysisAdd BLAST11
Transmembranei178 – 198Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini199 – 204ExtracellularSequence analysis6
Transmembranei205 – 225Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini226 – 234CytoplasmicSequence analysis9
Transmembranei235 – 255Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini256 – 259ExtracellularSequence analysis4
Transmembranei260 – 280Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini281 – 349CytoplasmicSequence analysisAdd BLAST69
Transmembranei350 – 370Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini371 – 377ExtracellularSequence analysis7
Transmembranei378 – 398Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini399 – 406CytoplasmicSequence analysis8
Transmembranei407 – 427Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini428 – 434ExtracellularSequence analysis7
Transmembranei435 – 455Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini456 – 470CytoplasmicSequence analysisAdd BLAST15
Transmembranei471 – 491Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini492 – 494ExtracellularSequence analysis3
Transmembranei495 – 515Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini516 – 547CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196600.
PharmGKBiPA162403567.

Polymorphism and mutation databases

BioMutaiSLC22A25.
DMDMi296452891.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003289261 – 547Solute carrier family 22 member 25Add BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6T423.
PeptideAtlasiQ6T423.
PRIDEiQ6T423.

PTM databases

iPTMnetiQ6T423.
PhosphoSitePlusiQ6T423.

Expressioni

Tissue specificityi

Expressed exclusively in liver in both embryo and adult.1 Publication

Gene expression databases

BgeeiENSG00000196600.
CleanExiHS_SLC22A25.
ExpressionAtlasiQ6T423. baseline and differential.

Organism-specific databases

HPAiHPA039390.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000307443.

Structurei

3D structure databases

ProteinModelPortaliQ6T423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ6T423.
KOiK08206.
OMAiAPWALNH.
OrthoDBiEOG091G04GS.
PhylomeDBiQ6T423.
TreeFamiTF315847.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6T423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFQDLLDQV GGLGRFQILQ MVFLIMFNVI VYHQTQLENF AAFILDHRCW
60 70 80 90 100
VHILDNDTIP DNDPGTLSQD ALLRISIPFD SNLRPEKCRR FVHPQWKLIH
110 120 130 140 150
LNGTFPNTSE PDTEPCVDGW VYDQSSFPST IVTKWDLVCE SQPLNSVAKF
160 170 180 190 200
LFMAGMMVGG NLYGHLSDRF GRKFVLRWSY LQLAIVGTCA AFAPTILVYC
210 220 230 240 250
SLRFLAGAAT FSIIVNTVLL IVEWITHQFC AMALTLTLCA ASIGHITLGS
260 270 280 290 300
LAFVIRDQCI LQLVMSAPCF VFFLFSRWLA ESARWLIINN KPEEGLKELR
310 320 330 340 350
KAAHRNGMKN AEDILTMEVL KSTMKQELEA AQKKHSLCEL LRIPNICKRI
360 370 380 390 400
CFLSFVRFAS TIPFWGLTLH LQHLGNNVFL LQTLFGAVTL LANCVAPWAL
410 420 430 440 450
NHMSRRLSQM LLMFLLATCL LAIIFVPQEM QTLRVVLATL GVGAASLGIT
460 470 480 490 500
CSTAQENELI PSIIRGRATG ITGNFANIGG ALASLMMILS IYSRPLPWII
510 520 530 540
YGVFAILSGL VVLLLPETRN QPLLDSIQDV ENEGVNSLAA PQRSSVL
Length:547
Mass (Da):61,008
Last modified:May 18, 2010 - v2
Checksum:iA6964B2363FE68A0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05778389R → C.Corresponds to variant rs35722529dbSNPEnsembl.1
Natural variantiVAR_042576250S → G.1 PublicationCorresponds to variant rs11231409dbSNPEnsembl.1
Natural variantiVAR_042577300R → T.1 PublicationCorresponds to variant rs11231397dbSNPEnsembl.1
Natural variantiVAR_057784448G → A.Corresponds to variant rs17157907dbSNPEnsembl.1
Natural variantiVAR_060287486M → V.2 PublicationsCorresponds to variant rs6591771dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY437532 mRNA. Translation: AAR84082.1.
AP001880 Genomic DNA. No translation available.
AP003420 Genomic DNA. No translation available.
BC101316 mRNA. Translation: AAI01317.1.
CCDSiCCDS31592.1.
RefSeqiNP_955384.3. NM_199352.3.
XP_016873176.1. XM_017017687.1.
UniGeneiHs.332119.

Genome annotation databases

EnsembliENST00000306494; ENSP00000307443; ENSG00000196600.
GeneIDi387601.
KEGGihsa:387601.
UCSCiuc001nwr.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY437532 mRNA. Translation: AAR84082.1.
AP001880 Genomic DNA. No translation available.
AP003420 Genomic DNA. No translation available.
BC101316 mRNA. Translation: AAI01317.1.
CCDSiCCDS31592.1.
RefSeqiNP_955384.3. NM_199352.3.
XP_016873176.1. XM_017017687.1.
UniGeneiHs.332119.

3D structure databases

ProteinModelPortaliQ6T423.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000307443.

Protein family/group databases

TCDBi2.A.1.19.33. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ6T423.
PhosphoSitePlusiQ6T423.

Polymorphism and mutation databases

BioMutaiSLC22A25.
DMDMi296452891.

Proteomic databases

PaxDbiQ6T423.
PeptideAtlasiQ6T423.
PRIDEiQ6T423.

Protocols and materials databases

DNASUi387601.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306494; ENSP00000307443; ENSG00000196600.
GeneIDi387601.
KEGGihsa:387601.
UCSCiuc001nwr.2. human.

Organism-specific databases

CTDi387601.
GeneCardsiSLC22A25.
H-InvDBHIX0017940.
HGNCiHGNC:32935. SLC22A25.
HPAiHPA039390.
MIMi610792. gene.
neXtProtiNX_Q6T423.
OpenTargetsiENSG00000196600.
PharmGKBiPA162403567.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ6T423.
KOiK08206.
OMAiAPWALNH.
OrthoDBiEOG091G04GS.
PhylomeDBiQ6T423.
TreeFamiTF315847.

Enzyme and pathway databases

BioCyciZFISH:G66-32719-MONOMER.

Miscellaneous databases

GeneWikiiSLC22A25.
GenomeRNAii387601.
PROiQ6T423.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196600.
CleanExiHS_SLC22A25.
ExpressionAtlasiQ6T423. baseline and differential.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22AP_HUMAN
AccessioniPrimary (citable) accession number: Q6T423
Secondary accession number(s): A4FU27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.