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Q6T423

- S22AP_HUMAN

UniProt

Q6T423 - S22AP_HUMAN

Protein

Solute carrier family 22 member 25

Gene

SLC22A25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.1.19.33. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 25
    Alternative name(s):
    Organic anion transporter UST6
    Gene namesi
    Name:SLC22A25Imported
    Synonyms:UST61 Publication
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:32935. SLC22A25.

    Subcellular locationi

    Membrane Sequence Analysis; Multi-pass membrane protein Sequence Analysis

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162403567.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 547547Solute carrier family 22 member 25PRO_0000328926Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ6T423.
    PRIDEiQ6T423.

    PTM databases

    PhosphoSiteiQ6T423.

    Expressioni

    Tissue specificityi

    Expressed exclusively in liver in both embryo and adult.1 Publication

    Gene expression databases

    ArrayExpressiQ6T423.
    BgeeiQ6T423.
    CleanExiHS_SLC22A25.
    GenevestigatoriQ6T423.

    Organism-specific databases

    HPAiHPA039390.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6T423.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99CytoplasmicSequence Analysis
    Topological domaini31 – 145115ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini167 – 17711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini199 – 2046ExtracellularSequence Analysis
    Topological domaini226 – 2349CytoplasmicSequence Analysis
    Topological domaini256 – 2594ExtracellularSequence Analysis
    Topological domaini281 – 34969CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini371 – 3777ExtracellularSequence Analysis
    Topological domaini399 – 4068CytoplasmicSequence Analysis
    Topological domaini428 – 4347ExtracellularSequence Analysis
    Topological domaini456 – 47015CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini492 – 4943ExtracellularSequence Analysis
    Topological domaini516 – 54732CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei178 – 19821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei350 – 37021Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei407 – 42721Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei435 – 45521Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei471 – 49121Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei495 – 51521Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238692.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    InParanoidiQ6T423.
    KOiK08206.
    OMAiIPSIIRG.
    OrthoDBiEOG7J70FK.
    PhylomeDBiQ6T423.
    TreeFamiTF315847.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6T423-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFQDLLDQV GGLGRFQILQ MVFLIMFNVI VYHQTQLENF AAFILDHRCW    50
    VHILDNDTIP DNDPGTLSQD ALLRISIPFD SNLRPEKCRR FVHPQWKLIH 100
    LNGTFPNTSE PDTEPCVDGW VYDQSSFPST IVTKWDLVCE SQPLNSVAKF 150
    LFMAGMMVGG NLYGHLSDRF GRKFVLRWSY LQLAIVGTCA AFAPTILVYC 200
    SLRFLAGAAT FSIIVNTVLL IVEWITHQFC AMALTLTLCA ASIGHITLGS 250
    LAFVIRDQCI LQLVMSAPCF VFFLFSRWLA ESARWLIINN KPEEGLKELR 300
    KAAHRNGMKN AEDILTMEVL KSTMKQELEA AQKKHSLCEL LRIPNICKRI 350
    CFLSFVRFAS TIPFWGLTLH LQHLGNNVFL LQTLFGAVTL LANCVAPWAL 400
    NHMSRRLSQM LLMFLLATCL LAIIFVPQEM QTLRVVLATL GVGAASLGIT 450
    CSTAQENELI PSIIRGRATG ITGNFANIGG ALASLMMILS IYSRPLPWII 500
    YGVFAILSGL VVLLLPETRN QPLLDSIQDV ENEGVNSLAA PQRSSVL 547
    Length:547
    Mass (Da):61,008
    Last modified:May 18, 2010 - v2
    Checksum:iA6964B2363FE68A0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti89 – 891R → C.
    Corresponds to variant rs35722529 [ dbSNP | Ensembl ].
    VAR_057783
    Natural varianti250 – 2501S → G.1 Publication
    Corresponds to variant rs11231409 [ dbSNP | Ensembl ].
    VAR_042576
    Natural varianti300 – 3001R → T.1 Publication
    Corresponds to variant rs11231397 [ dbSNP | Ensembl ].
    VAR_042577
    Natural varianti448 – 4481G → A.
    Corresponds to variant rs17157907 [ dbSNP | Ensembl ].
    VAR_057784
    Natural varianti486 – 4861M → V.2 Publications
    Corresponds to variant rs6591771 [ dbSNP | Ensembl ].
    VAR_060287

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY437532 mRNA. Translation: AAR84082.1.
    AP001880 Genomic DNA. No translation available.
    AP003420 Genomic DNA. No translation available.
    BC101316 mRNA. Translation: AAI01317.1.
    CCDSiCCDS31592.1.
    RefSeqiNP_955384.3. NM_199352.3.
    XP_005274042.1. XM_005273985.1.
    UniGeneiHs.332119.

    Genome annotation databases

    EnsembliENST00000306494; ENSP00000307443; ENSG00000196600.
    GeneIDi387601.
    KEGGihsa:387601.
    UCSCiuc001nwr.1. human.

    Polymorphism databases

    DMDMi296452891.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY437532 mRNA. Translation: AAR84082.1 .
    AP001880 Genomic DNA. No translation available.
    AP003420 Genomic DNA. No translation available.
    BC101316 mRNA. Translation: AAI01317.1 .
    CCDSi CCDS31592.1.
    RefSeqi NP_955384.3. NM_199352.3.
    XP_005274042.1. XM_005273985.1.
    UniGenei Hs.332119.

    3D structure databases

    ProteinModelPortali Q6T423.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.1.19.33. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q6T423.

    Polymorphism databases

    DMDMi 296452891.

    Proteomic databases

    PaxDbi Q6T423.
    PRIDEi Q6T423.

    Protocols and materials databases

    DNASUi 387601.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306494 ; ENSP00000307443 ; ENSG00000196600 .
    GeneIDi 387601.
    KEGGi hsa:387601.
    UCSCi uc001nwr.1. human.

    Organism-specific databases

    CTDi 387601.
    GeneCardsi GC11M062931.
    H-InvDB HIX0017940.
    HGNCi HGNC:32935. SLC22A25.
    HPAi HPA039390.
    MIMi 610792. gene.
    neXtProti NX_Q6T423.
    PharmGKBi PA162403567.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238692.
    HOGENOMi HOG000234569.
    HOVERGENi HBG108433.
    InParanoidi Q6T423.
    KOi K08206.
    OMAi IPSIIRG.
    OrthoDBi EOG7J70FK.
    PhylomeDBi Q6T423.
    TreeFami TF315847.

    Miscellaneous databases

    GeneWikii SLC22A25.
    GenomeRNAii 387601.
    NextBioi 101445.
    PROi Q6T423.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6T423.
    Bgeei Q6T423.
    CleanExi HS_SLC22A25.
    Genevestigatori Q6T423.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters."
      Eraly S.A., Monte J.C., Nigam S.K.
      Physiol. Genomics 18:12-24(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT VAL-486.
      Tissue: Liver1 Publication.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-250; THR-300 AND VAL-486.

    Entry informationi

    Entry nameiS22AP_HUMAN
    AccessioniPrimary (citable) accession number: Q6T423
    Secondary accession number(s): A4FU27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3