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Q6T423

- S22AP_HUMAN

UniProt

Q6T423 - S22AP_HUMAN

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Protein
Solute carrier family 22 member 25
Gene
SLC22A25, UST6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.1.19.33. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 25
Alternative name(s):
Organic anion transporter UST6
Gene namesi
Synonyms:UST6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:32935. SLC22A25.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99Cytoplasmic Reviewed prediction
Transmembranei10 – 3021Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini31 – 145115Extracellular Reviewed prediction
Add
BLAST
Transmembranei146 – 16621Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini167 – 17711Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei178 – 19821Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini199 – 2046Extracellular Reviewed prediction
Transmembranei205 – 22521Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini226 – 2349Cytoplasmic Reviewed prediction
Transmembranei235 – 25521Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini256 – 2594Extracellular Reviewed prediction
Transmembranei260 – 28021Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini281 – 34969Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei350 – 37021Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini371 – 3777Extracellular Reviewed prediction
Transmembranei378 – 39821Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini399 – 4068Cytoplasmic Reviewed prediction
Transmembranei407 – 42721Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini428 – 4347Extracellular Reviewed prediction
Transmembranei435 – 45521Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini456 – 47015Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei471 – 49121Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini492 – 4943Extracellular Reviewed prediction
Transmembranei495 – 51521Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini516 – 54732Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403567.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Solute carrier family 22 member 25
PRO_0000328926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6T423.
PRIDEiQ6T423.

PTM databases

PhosphoSiteiQ6T423.

Expressioni

Tissue specificityi

Expressed exclusively in liver in both embryo and adult.1 Publication

Gene expression databases

ArrayExpressiQ6T423.
BgeeiQ6T423.
CleanExiHS_SLC22A25.
GenevestigatoriQ6T423.

Organism-specific databases

HPAiHPA039390.

Structurei

3D structure databases

ProteinModelPortaliQ6T423.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238692.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ6T423.
KOiK08206.
OMAiIPSIIRG.
OrthoDBiEOG7J70FK.
PhylomeDBiQ6T423.
TreeFamiTF315847.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6T423-1 [UniParc]FASTAAdd to Basket

« Hide

MAFQDLLDQV GGLGRFQILQ MVFLIMFNVI VYHQTQLENF AAFILDHRCW    50
VHILDNDTIP DNDPGTLSQD ALLRISIPFD SNLRPEKCRR FVHPQWKLIH 100
LNGTFPNTSE PDTEPCVDGW VYDQSSFPST IVTKWDLVCE SQPLNSVAKF 150
LFMAGMMVGG NLYGHLSDRF GRKFVLRWSY LQLAIVGTCA AFAPTILVYC 200
SLRFLAGAAT FSIIVNTVLL IVEWITHQFC AMALTLTLCA ASIGHITLGS 250
LAFVIRDQCI LQLVMSAPCF VFFLFSRWLA ESARWLIINN KPEEGLKELR 300
KAAHRNGMKN AEDILTMEVL KSTMKQELEA AQKKHSLCEL LRIPNICKRI 350
CFLSFVRFAS TIPFWGLTLH LQHLGNNVFL LQTLFGAVTL LANCVAPWAL 400
NHMSRRLSQM LLMFLLATCL LAIIFVPQEM QTLRVVLATL GVGAASLGIT 450
CSTAQENELI PSIIRGRATG ITGNFANIGG ALASLMMILS IYSRPLPWII 500
YGVFAILSGL VVLLLPETRN QPLLDSIQDV ENEGVNSLAA PQRSSVL 547
Length:547
Mass (Da):61,008
Last modified:May 18, 2010 - v2
Checksum:iA6964B2363FE68A0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891R → C.
Corresponds to variant rs35722529 [ dbSNP | Ensembl ].
VAR_057783
Natural varianti250 – 2501S → G.1 Publication
Corresponds to variant rs11231409 [ dbSNP | Ensembl ].
VAR_042576
Natural varianti300 – 3001R → T.1 Publication
Corresponds to variant rs11231397 [ dbSNP | Ensembl ].
VAR_042577
Natural varianti448 – 4481G → A.
Corresponds to variant rs17157907 [ dbSNP | Ensembl ].
VAR_057784
Natural varianti486 – 4861M → V.2 Publications
Corresponds to variant rs6591771 [ dbSNP | Ensembl ].
VAR_060287

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY437532 mRNA. Translation: AAR84082.1.
AP001880 Genomic DNA. No translation available.
AP003420 Genomic DNA. No translation available.
BC101316 mRNA. Translation: AAI01317.1.
CCDSiCCDS31592.1.
RefSeqiNP_955384.3. NM_199352.3.
XP_005274042.1. XM_005273985.1.
UniGeneiHs.332119.

Genome annotation databases

EnsembliENST00000306494; ENSP00000307443; ENSG00000196600.
GeneIDi387601.
KEGGihsa:387601.
UCSCiuc001nwr.1. human.

Polymorphism databases

DMDMi296452891.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY437532 mRNA. Translation: AAR84082.1 .
AP001880 Genomic DNA. No translation available.
AP003420 Genomic DNA. No translation available.
BC101316 mRNA. Translation: AAI01317.1 .
CCDSi CCDS31592.1.
RefSeqi NP_955384.3. NM_199352.3.
XP_005274042.1. XM_005273985.1.
UniGenei Hs.332119.

3D structure databases

ProteinModelPortali Q6T423.
ModBasei Search...

Protein family/group databases

TCDBi 2.A.1.19.33. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei Q6T423.

Polymorphism databases

DMDMi 296452891.

Proteomic databases

PaxDbi Q6T423.
PRIDEi Q6T423.

Protocols and materials databases

DNASUi 387601.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306494 ; ENSP00000307443 ; ENSG00000196600 .
GeneIDi 387601.
KEGGi hsa:387601.
UCSCi uc001nwr.1. human.

Organism-specific databases

CTDi 387601.
GeneCardsi GC11M062931.
H-InvDB HIX0017940.
HGNCi HGNC:32935. SLC22A25.
HPAi HPA039390.
MIMi 610792. gene.
neXtProti NX_Q6T423.
PharmGKBi PA162403567.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG238692.
HOGENOMi HOG000234569.
HOVERGENi HBG108433.
InParanoidi Q6T423.
KOi K08206.
OMAi IPSIIRG.
OrthoDBi EOG7J70FK.
PhylomeDBi Q6T423.
TreeFami TF315847.

Miscellaneous databases

GeneWikii SLC22A25.
GenomeRNAii 387601.
NextBioi 101445.
PROi Q6T423.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6T423.
Bgeei Q6T423.
CleanExi HS_SLC22A25.
Genevestigatori Q6T423.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters."
    Eraly S.A., Monte J.C., Nigam S.K.
    Physiol. Genomics 18:12-24(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT VAL-486.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-250; THR-300 AND VAL-486.

Entry informationi

Entry nameiS22AP_HUMAN
AccessioniPrimary (citable) accession number: Q6T423
Secondary accession number(s): A4FU27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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