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Q6T423 (S22AP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 22 member 25
Alternative name(s):
Organic anion transporter UST6
Gene names
Name:SLC22A25
Synonyms:UST6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length547 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expressed exclusively in liver in both embryo and adult. Ref.1

Sequence similarities

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 547547Solute carrier family 22 member 25
PRO_0000328926

Regions

Topological domain1 – 99Cytoplasmic Potential
Transmembrane10 – 3021Helical; Name=1; Potential
Topological domain31 – 145115Extracellular Potential
Transmembrane146 – 16621Helical; Name=2; Potential
Topological domain167 – 17711Cytoplasmic Potential
Transmembrane178 – 19821Helical; Name=3; Potential
Topological domain199 – 2046Extracellular Potential
Transmembrane205 – 22521Helical; Name=4; Potential
Topological domain226 – 2349Cytoplasmic Potential
Transmembrane235 – 25521Helical; Name=5; Potential
Topological domain256 – 2594Extracellular Potential
Transmembrane260 – 28021Helical; Name=6; Potential
Topological domain281 – 34969Cytoplasmic Potential
Transmembrane350 – 37021Helical; Name=7; Potential
Topological domain371 – 3777Extracellular Potential
Transmembrane378 – 39821Helical; Name=8; Potential
Topological domain399 – 4068Cytoplasmic Potential
Transmembrane407 – 42721Helical; Name=9; Potential
Topological domain428 – 4347Extracellular Potential
Transmembrane435 – 45521Helical; Name=10; Potential
Topological domain456 – 47015Cytoplasmic Potential
Transmembrane471 – 49121Helical; Name=11; Potential
Topological domain492 – 4943Extracellular Potential
Transmembrane495 – 51521Helical; Name=12; Potential
Topological domain516 – 54732Cytoplasmic Potential

Amino acid modifications

Glycosylation561N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential

Natural variations

Natural variant891R → C.
Corresponds to variant rs35722529 [ dbSNP | Ensembl ].
VAR_057783
Natural variant2501S → G. Ref.3
Corresponds to variant rs11231409 [ dbSNP | Ensembl ].
VAR_042576
Natural variant3001R → T. Ref.3
Corresponds to variant rs11231397 [ dbSNP | Ensembl ].
VAR_042577
Natural variant4481G → A.
Corresponds to variant rs17157907 [ dbSNP | Ensembl ].
VAR_057784
Natural variant4861M → V. Ref.1 Ref.3
Corresponds to variant rs6591771 [ dbSNP | Ensembl ].
VAR_060287

Sequences

Sequence LengthMass (Da)Tools
Q6T423 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: A6964B2363FE68A0

FASTA54761,008
        10         20         30         40         50         60 
MAFQDLLDQV GGLGRFQILQ MVFLIMFNVI VYHQTQLENF AAFILDHRCW VHILDNDTIP 

        70         80         90        100        110        120 
DNDPGTLSQD ALLRISIPFD SNLRPEKCRR FVHPQWKLIH LNGTFPNTSE PDTEPCVDGW 

       130        140        150        160        170        180 
VYDQSSFPST IVTKWDLVCE SQPLNSVAKF LFMAGMMVGG NLYGHLSDRF GRKFVLRWSY 

       190        200        210        220        230        240 
LQLAIVGTCA AFAPTILVYC SLRFLAGAAT FSIIVNTVLL IVEWITHQFC AMALTLTLCA 

       250        260        270        280        290        300 
ASIGHITLGS LAFVIRDQCI LQLVMSAPCF VFFLFSRWLA ESARWLIINN KPEEGLKELR 

       310        320        330        340        350        360 
KAAHRNGMKN AEDILTMEVL KSTMKQELEA AQKKHSLCEL LRIPNICKRI CFLSFVRFAS 

       370        380        390        400        410        420 
TIPFWGLTLH LQHLGNNVFL LQTLFGAVTL LANCVAPWAL NHMSRRLSQM LLMFLLATCL 

       430        440        450        460        470        480 
LAIIFVPQEM QTLRVVLATL GVGAASLGIT CSTAQENELI PSIIRGRATG ITGNFANIGG 

       490        500        510        520        530        540 
ALASLMMILS IYSRPLPWII YGVFAILSGL VVLLLPETRN QPLLDSIQDV ENEGVNSLAA 


PQRSSVL 

« Hide

References

« Hide 'large scale' references
[1]"Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters."
Eraly S.A., Monte J.C., Nigam S.K.
Physiol. Genomics 18:12-24(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT VAL-486.
Tissue: Liver.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-250; THR-300 AND VAL-486.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY437532 mRNA. Translation: AAR84082.1.
AP001880 Genomic DNA. No translation available.
AP003420 Genomic DNA. No translation available.
BC101316 mRNA. Translation: AAI01317.1.
RefSeqNP_955384.3. NM_199352.3.
XP_005274042.1. XM_005273985.1.
UniGeneHs.332119.

3D structure databases

ProteinModelPortalQ6T423.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB2.A.1.19.33. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteQ6T423.

Polymorphism databases

DMDM296452891.

Proteomic databases

PaxDbQ6T423.
PRIDEQ6T423.

Protocols and materials databases

DNASU387601.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306494; ENSP00000307443; ENSG00000196600.
GeneID387601.
KEGGhsa:387601.
UCSCuc001nwr.1. human.

Organism-specific databases

CTD387601.
GeneCardsGC11M062931.
H-InvDBHIX0017940.
HGNCHGNC:32935. SLC22A25.
HPAHPA039390.
MIM610792. gene.
neXtProtNX_Q6T423.
PharmGKBPA162403567.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG238692.
HOGENOMHOG000234569.
HOVERGENHBG108433.
InParanoidQ6T423.
KOK08206.
OMAIPSIIRG.
OrthoDBEOG7J70FK.
PhylomeDBQ6T423.
TreeFamTF315847.

Gene expression databases

ArrayExpressQ6T423.
BgeeQ6T423.
CleanExHS_SLC22A25.
GenevestigatorQ6T423.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC22A25.
GenomeRNAi387601.
NextBio101445.
PROQ6T423.
SOURCESearch...

Entry information

Entry nameS22AP_HUMAN
AccessionPrimary (citable) accession number: Q6T423
Secondary accession number(s): A4FU27
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM