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Protein

Solute carrier family 22 member 25

Gene

SLC22A25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.1.19.33. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 25
Alternative name(s):
Organic anion transporter UST6
Gene namesi
Name:SLC22A25Imported
Synonyms:UST61 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:32935. SLC22A25.

Subcellular locationi

  1. Membrane Sequence Analysis; Multi-pass membrane protein Sequence Analysis

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence Analysis
Transmembranei10 – 3021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini31 – 145115ExtracellularSequence AnalysisAdd
BLAST
Transmembranei146 – 16621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini167 – 17711CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei178 – 19821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini199 – 2046ExtracellularSequence Analysis
Transmembranei205 – 22521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini226 – 2349CytoplasmicSequence Analysis
Transmembranei235 – 25521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini256 – 2594ExtracellularSequence Analysis
Transmembranei260 – 28021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini281 – 34969CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei350 – 37021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini371 – 3777ExtracellularSequence Analysis
Transmembranei378 – 39821Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini399 – 4068CytoplasmicSequence Analysis
Transmembranei407 – 42721Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini428 – 4347ExtracellularSequence Analysis
Transmembranei435 – 45521Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini456 – 47015CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei471 – 49121Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini492 – 4943ExtracellularSequence Analysis
Transmembranei495 – 51521Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini516 – 54732CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403567.

Polymorphism and mutation databases

BioMutaiSLC22A25.
DMDMi296452891.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Solute carrier family 22 member 25PRO_0000328926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6T423.
PRIDEiQ6T423.

PTM databases

PhosphoSiteiQ6T423.

Expressioni

Tissue specificityi

Expressed exclusively in liver in both embryo and adult.1 Publication

Gene expression databases

BgeeiQ6T423.
CleanExiHS_SLC22A25.
ExpressionAtlasiQ6T423. baseline and differential.
GenevestigatoriQ6T423.

Organism-specific databases

HPAiHPA039390.

Structurei

3D structure databases

ProteinModelPortaliQ6T423.
SMRiQ6T423. Positions 154-184, 457-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238692.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ6T423.
KOiK08206.
OMAiIPSIIRG.
OrthoDBiEOG7J70FK.
PhylomeDBiQ6T423.
TreeFamiTF315847.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6T423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFQDLLDQV GGLGRFQILQ MVFLIMFNVI VYHQTQLENF AAFILDHRCW
60 70 80 90 100
VHILDNDTIP DNDPGTLSQD ALLRISIPFD SNLRPEKCRR FVHPQWKLIH
110 120 130 140 150
LNGTFPNTSE PDTEPCVDGW VYDQSSFPST IVTKWDLVCE SQPLNSVAKF
160 170 180 190 200
LFMAGMMVGG NLYGHLSDRF GRKFVLRWSY LQLAIVGTCA AFAPTILVYC
210 220 230 240 250
SLRFLAGAAT FSIIVNTVLL IVEWITHQFC AMALTLTLCA ASIGHITLGS
260 270 280 290 300
LAFVIRDQCI LQLVMSAPCF VFFLFSRWLA ESARWLIINN KPEEGLKELR
310 320 330 340 350
KAAHRNGMKN AEDILTMEVL KSTMKQELEA AQKKHSLCEL LRIPNICKRI
360 370 380 390 400
CFLSFVRFAS TIPFWGLTLH LQHLGNNVFL LQTLFGAVTL LANCVAPWAL
410 420 430 440 450
NHMSRRLSQM LLMFLLATCL LAIIFVPQEM QTLRVVLATL GVGAASLGIT
460 470 480 490 500
CSTAQENELI PSIIRGRATG ITGNFANIGG ALASLMMILS IYSRPLPWII
510 520 530 540
YGVFAILSGL VVLLLPETRN QPLLDSIQDV ENEGVNSLAA PQRSSVL
Length:547
Mass (Da):61,008
Last modified:May 18, 2010 - v2
Checksum:iA6964B2363FE68A0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891R → C.
Corresponds to variant rs35722529 [ dbSNP | Ensembl ].
VAR_057783
Natural varianti250 – 2501S → G.1 Publication
Corresponds to variant rs11231409 [ dbSNP | Ensembl ].
VAR_042576
Natural varianti300 – 3001R → T.1 Publication
Corresponds to variant rs11231397 [ dbSNP | Ensembl ].
VAR_042577
Natural varianti448 – 4481G → A.
Corresponds to variant rs17157907 [ dbSNP | Ensembl ].
VAR_057784
Natural varianti486 – 4861M → V.2 Publications
Corresponds to variant rs6591771 [ dbSNP | Ensembl ].
VAR_060287

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY437532 mRNA. Translation: AAR84082.1.
AP001880 Genomic DNA. No translation available.
AP003420 Genomic DNA. No translation available.
BC101316 mRNA. Translation: AAI01317.1.
CCDSiCCDS31592.1.
RefSeqiNP_955384.3. NM_199352.3.
XP_005274042.1. XM_005273985.2.
UniGeneiHs.332119.

Genome annotation databases

EnsembliENST00000306494; ENSP00000307443; ENSG00000196600.
GeneIDi387601.
KEGGihsa:387601.
UCSCiuc001nwr.1. human.

Polymorphism and mutation databases

BioMutaiSLC22A25.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY437532 mRNA. Translation: AAR84082.1.
AP001880 Genomic DNA. No translation available.
AP003420 Genomic DNA. No translation available.
BC101316 mRNA. Translation: AAI01317.1.
CCDSiCCDS31592.1.
RefSeqiNP_955384.3. NM_199352.3.
XP_005274042.1. XM_005273985.2.
UniGeneiHs.332119.

3D structure databases

ProteinModelPortaliQ6T423.
SMRiQ6T423. Positions 154-184, 457-485.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.1.19.33. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiQ6T423.

Polymorphism and mutation databases

BioMutaiSLC22A25.
DMDMi296452891.

Proteomic databases

PaxDbiQ6T423.
PRIDEiQ6T423.

Protocols and materials databases

DNASUi387601.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306494; ENSP00000307443; ENSG00000196600.
GeneIDi387601.
KEGGihsa:387601.
UCSCiuc001nwr.1. human.

Organism-specific databases

CTDi387601.
GeneCardsiGC11M062931.
H-InvDBHIX0017940.
HGNCiHGNC:32935. SLC22A25.
HPAiHPA039390.
MIMi610792. gene.
neXtProtiNX_Q6T423.
PharmGKBiPA162403567.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG238692.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ6T423.
KOiK08206.
OMAiIPSIIRG.
OrthoDBiEOG7J70FK.
PhylomeDBiQ6T423.
TreeFamiTF315847.

Miscellaneous databases

GeneWikiiSLC22A25.
GenomeRNAii387601.
NextBioi101445.
PROiQ6T423.
SOURCEiSearch...

Gene expression databases

BgeeiQ6T423.
CleanExiHS_SLC22A25.
ExpressionAtlasiQ6T423. baseline and differential.
GenevestigatoriQ6T423.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters."
    Eraly S.A., Monte J.C., Nigam S.K.
    Physiol. Genomics 18:12-24(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT VAL-486.
    Tissue: Liver1 Publication.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-250; THR-300 AND VAL-486.

Entry informationi

Entry nameiS22AP_HUMAN
AccessioniPrimary (citable) accession number: Q6T423
Secondary accession number(s): A4FU27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 18, 2010
Last modified: April 29, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.